{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:16:07Z","timestamp":1781871367348,"version":"3.54.5"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Protein\u2013energy wasting (PEW) is highly prevalent in hemodialysis (HD) patients, which is associated with poor quality of life, complications, and an increased risk of mortality. A prospective study in HD patients with 2\u00a0months of oral energy supplements (OESs) was performed.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 37 HD patients with PEW were finally enrolled in this prospective study and were randomized into the OES group (<jats:italic>n<\/jats:italic> = 19), which received oral energy supplementation (300\u00a0kcal) and dietary recommendations, while patients in the non-OES group (<jats:italic>n<\/jats:italic> = 18) received only dietary recommendations. The study duration was 2\u00a0months. The nutritional status of the patients was evaluated by laboratory indexes, body composition parameters, and the modified quantitative subjective global assessment (MQSGA) and malnutrition-inflammation score (MIS). Quality of life was evaluated by the Short Form Health Survey Questionnaire (SF-36).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 2\u00a0months of therapy, a significant increase in serum albumin [39.6 (37.6\u201345.8) vs. 43.4 (39.1\u201346.7) g\/L; <jats:italic>p =<\/jats:italic> 0.018], hemoglobin (101.0 \u00b1 13.6\u00a0g\/L vs. 111.8 \u00b1 11.7\u00a0g\/L; <jats:italic>p =<\/jats:italic> 0.042), and dietary energy intake (29.17 \u00b1 3.22\u00a0kcal\/kg\/day vs. 33.60 \u00b1 2.72\u00a0kcal\/kg\/day, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) was observed in the comparisons of baseline in the OES group. Moreover, the OES group demonstrated significant amelioration in MQSGA [9 (8\u201313) vs. 8 (7\u201312), <jats:italic>p<\/jats:italic> &amp;lt; 0.001] and MIS [5 (3\u201310) vs. 3 (2\u20138), <jats:italic>p<\/jats:italic> &amp;lt; 0.001], physical functioning (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), and mental health (<jats:italic>p =<\/jats:italic> 0.046) subsections of SF-36 compared with the baseline. No electrolyte disorders or dyslipidemia were observed in the OES group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> OES in HD patients with PEW can significantly ameliorate energy supply, nutritional status, anemia, and quality of life.<\/jats:p>","DOI":"10.3389\/fphar.2022.839803","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T04:33:08Z","timestamp":1666326788000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral energy supplementation improves nutritional status in hemodialysis patients with protein\u2013energy wasting: A pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Aiya","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000355796","article-title":"A \"nephrological\" approach to physical activity","volume":"39","author":"Aucella","year":"2014","journal-title":"Kidney Blood Press. 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