{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:38:50Z","timestamp":1787881130061,"version":"build-2784847793"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Both patency maintenance and neoangiogenesis contribute to cerebrovascular bypass efficacy. However, the combined impact of the aforementioned two indicators on postoperative revascularization following superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass has been less well elucidated. Meanwhile, there is a paucity of evidence with conflicting results about postoperative aspirin therapy.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> The objective of the study was to investigate the correlation between aspirin use and STA-MCA bypass efficacy, including patency, postoperative neoangiogenesis, and follow-up outcomes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 181 MMD patients (201 procedures) undergoing STA-MCA bypass at our institution (2017\u20132019) were retrospectively reviewed. The bypass efficacy level and postoperative complications were compared between aspirin and non-aspirin groups.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among 95 PS-matched pairs, the aspirin group presented a significantly more favorable bypass efficacy than the non-aspirin group [odds ratio (OR) 2.23, 95% confidence interval (CI) 1.11\u20134.61; <jats:italic>p<\/jats:italic> = 0.026]. Multivariate logistic regression analysis confirmed the profound impact of aspirin as an independent predictor of bypass efficacy [adjusted OR 2.91, 95% CI 1.34\u20136.68; <jats:italic>p<\/jats:italic> = 0.009]. A remarkable negative correlation was found between bypass efficacy and the rate of ischemic complications (Phi = \u22120.521). Postoperative aspirin therapy was associated with a non-significant trend toward a lower incidence of ischemic events [OR 0.73, 95% CI 0.23\u20132.19; <jats:italic>p<\/jats:italic> = 0.580]. No significant difference in bleeding rates was observed between aspirin and control groups [OR 1.00, 95% CI 0.12\u20138.48; <jats:italic>p<\/jats:italic> = 1.000].<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Among patients undergoing STA-MCA bypass procedures, bypass efficacy is a good predictor of follow-up outcomes. Postoperative aspirin therapy can improve patency, neoangiogenesis, and overall bypass efficacy, thereby protecting against postoperative ischemic complications.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold><jats:ext-link>http:\/\/www.chictr.org.cn\/<\/jats:ext-link>, identifier CTR2100046178.<\/jats:p>","DOI":"10.3389\/fphar.2022.841174","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T04:41:46Z","timestamp":1651552906000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Aspirin Therapy on Bypass Efficacy and Survival of Patients Receiving Direct Cerebral Revascularization"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanxiao","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S116","DOI":"10.1227\/NEU.0000000000000229","article-title":"Advances and Surgical Considerations in the Treatment of Moyamoya Disease","volume":"74","author":"Arias","year":"2014","journal-title":"Neurosurgery"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.053","article-title":"Surgical Revascularization in North American Adults with Moyamoya Phenomenon: Long-Term Angiographic Follow-Up","volume":"24","author":"Arias","year":"2015","journal-title":"J. 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