{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:15:25Z","timestamp":1753892125065,"version":"3.41.2"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Jidabokuippo (JDI) (\u6cbb\u6253\u64b2\u4e00\u65b9) has been used in Japan to alleviate contusion-induced swelling and pain since medieval times.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold>This review investigated the effects of JDI on various symptoms in patients with trauma or static blood<jats:sup>[TM1]<\/jats:sup>. The PubMed and Igaku Chuo Zasshi databases were searched until 24 December 2021. We summarize the benefits of applying JDI to inflammatory conditions, including bruises.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>JDI has been used to resolve blood<jats:sup>[TM1]<\/jats:sup>stasis, regulate qi in trauma patients, and treat inflammatory swelling and pain caused by rheumatoid arthritis and cellulitis. As the adverse event rate associated with JDI is low (1.3%), JDI is considered a safe drug.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>JDI can be used to resolve blood<jats:sup>[TM1]<\/jats:sup>stasis in trauma patients without adverse events associated with nonsteroidal anti-inflammatory drugs.<\/jats:p>","DOI":"10.3389\/fphar.2022.853012","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T07:04:37Z","timestamp":1653289477000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Application of Traditional Japanese Drug Jidabokuippo in a Modern Society"],"prefix":"10.3389","volume":"13","author":[{"given":"Hajime","family":"Nakae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Irie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"B1","first-page":"12","article-title":"Therapeutic Effects of Jidabokuippo for Painful Swelling from Head Injury","volume":"6","author":"Akiyama","year":"2020","journal-title":"J. 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