{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:14:47Z","timestamp":1783145687728,"version":"3.54.6"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>There is now sufficient evidence to support that vitamin D deficiency may predispose to SARS-CoV-2 infection and increase COVID-19 severity and mortality. It has been suggested that vitamin D<jats:sub>3<\/jats:sub> supplementation may be used prophylactically as an affordable and safe strategy that could be added to the existing COVID-19 standard treatment. This multicenter, single-blinded, prospective randomized pilot clinical trial aimed to evaluate the safety, tolerability, and effectiveness of 10,000 IU\/day in comparison with 2000 IU\/day of cholecalciferol supplementation for 14\u00a0days to reduce the duration and severity of COVID-19 in 85 hospitalized individuals. The median age of the participants was 65\u00a0years (Interquartile range (IQR): 53\u201374), most of them (71%) were men and the mean baseline of 25-hydroxyvitamin D (25(OH)D) in serum was 15\u00a0ng\/ml (standard deviation (SD):6). After 14\u00a0days of supplementation, serum 25(OH)D levels were significantly increased in the group who received 10,000IU\/day (<jats:italic>p<\/jats:italic> &amp;lt; 0.0001) (<jats:italic>n<\/jats:italic> = 44) in comparison with the 2,000IU\/day group (<jats:italic>n<\/jats:italic> = 41), especially in overweight and obese participants, and the higher dose was well tolerated. A fraction of the individuals in our cohort (10\/85) developed acute respiratory distress syndrome (ARDS). The median length of hospital stay in these patients with ARDS was significantly different in the participants assigned to the 10,000IU\/day group (<jats:italic>n<\/jats:italic> = 4; 7 days; IQR: 4\u201313) and the 2,000IU\/day group (<jats:italic>n<\/jats:italic> = 6; 27 days; IQR: 12\u201345) (<jats:italic>p<\/jats:italic> = 0.04). Moreover, the inspired oxygen fraction was reduced 7.6-fold in the high dose group (<jats:italic>p<\/jats:italic> = 0.049). In terms of blood parameters, we did not identify overall significant improvements, although the platelet count showed a modest but significant difference in those patients who were supplemented with the higher dose (<jats:italic>p<\/jats:italic> = 0.0492). In conclusion, the administration of 10,000IU\/day of vitamin D<jats:sub>3<\/jats:sub> for 14\u00a0days in association with the standard clinical care during hospitalization for COVID-19 was safe, tolerable, and beneficial, thereby helping to improve the prognosis during the recovery process.<\/jats:p>","DOI":"10.3389\/fphar.2022.863587","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T05:57:15Z","timestamp":1656914235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Miguel","family":"Cervero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"L\u00f3pez-Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Novella-Mena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ryan-Murua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Taboada-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rodr\u00edguez-Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Vig\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayte","family":"Coiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.amjms.2021.06.005","article-title":"Low Serum Levels of 25-Hydroxyvitamin D Accompany Severe COVID-19 Because it Is a Negative Acute Phase Reactant","volume":"362","author":"Antonelli","year":"2021","journal-title":"Am. 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