{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:26:51Z","timestamp":1791318411943,"version":"4.3.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Four new carboxylates complexes with general formula R<jats:sub>2<\/jats:sub>SnL<jats:sub>2<\/jats:sub> and R<jats:sub>3<\/jats:sub>SnL, where R = <jats:italic>n<\/jats:italic>-butyl (<jats:bold>1<\/jats:bold>, <jats:bold>3<\/jats:bold>), methyl (<jats:bold>2<\/jats:bold>, <jats:bold>4<\/jats:bold>) and L = 4-Chlorophenoxyacetate, were synthesized in significant yields. FT-IR analysis revealed a chelating (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>) and a bridging bidentate (<jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold>) coordination modes for the carboxylate ligand in solid state which was further confirmed by the single crystal X-ray analysis of complex <jats:bold>4<\/jats:bold>. The NMR data (<jats:sup>1<\/jats:sup>H, <jats:sup>13<\/jats:sup>C and <jats:sup>119<\/jats:sup>Sn) revealed a higher coordination number around the tin center in R<jats:sub>2<\/jats:sub>SnL<jats:sub>2<\/jats:sub> (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>) compared to R<jats:sub>3<\/jats:sub>SnL (<jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold>). A close matching was observed between the experimental and calculated structures (obtained at B3LYP\/6-31G* + LANL2DZ basis set). Quantum chemical analysis indicates that the carboxylate moiety has the major contribution in the formation of filled and unfilled orbitals as well as in ligand to ligand intramolecular charge transfer during the electronic transitions. The cytotoxicity data of the screened compounds evaluated against lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) revealed that <jats:bold>1<\/jats:bold>, <jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold> have shown dose dependent cytotoxic effects while <jats:bold>HL<\/jats:bold> and <jats:bold>2<\/jats:bold> have shown steady and low cytotoxic activities. The antibacterial activity of complexes <jats:bold>1\u20134<\/jats:bold> is higher than that of <jats:bold>HL<\/jats:bold>. Molecular docking study showed an intercalation binding mode for complex <jats:bold>3<\/jats:bold> with DNA (docking score = \u22123.6005) involving four polar interactions. Complex <jats:bold>3<\/jats:bold> docking with tubulin (PDB ID 1SA0) with colchicine as a target protein resulted in three polar interactions (docking score \u22125.2957). Further, the docking analysis of the <jats:bold>HL<\/jats:bold> and <jats:bold>1\u20134<\/jats:bold> has shown an adequate interactions with the coronavirus SARS-CoV-2 spike protein, nucleocapsid protein and human angiotensin converting enzyme (ACE2).<\/jats:p>","DOI":"10.3389\/fphar.2022.864336","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:26:29Z","timestamp":1649175989000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Synthesis, Characterization, Biological Activity and Molecular Docking Studies of Novel Organotin(IV) Carboxylates"],"prefix":"10.3389","volume":"13","author":[{"given":"Niaz","family":"Muhammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukhtar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sirajuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Tumanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelbasset","family":"Chafik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"Solak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Mavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabbir","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaukat","family":"Shujah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah G.","family":"Al-Sehemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e4943","DOI":"10.1002\/aoc.4943","article-title":"Fabrication, Spectroscopic Characterization, Calf Thymus DNA Binding Investigation, Antioxidant and Anticancer Activities of Some Antibiotic Azomethine Cu (II), Pd (II), Zn (II) and Cr (III) Complexes","volume":"33","author":"Abu Dief","year":"2019","journal-title":"Appl. Organomet. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"117700","DOI":"10.1016\/j.saa.2019.117700","article-title":"Synthesis and Characterization of New Cr(III), Fe(III) and Cu(II) Complexes Incorporating Multi-Substituted Aryl Imidazole Ligand: Structural, DFT, DNA Binding, and Biological Implications","volume":"228","author":"Abu-Dief","year":"2020","journal-title":"Spectrochim Acta A. Mol. Biomol. Spectrosc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"131017","DOI":"10.1016\/j.molstruc.2021.131017","article-title":"Tailoring, Structural Elucidation, DFT Calculation, DNA Interaction and Pharmaceutical Applications of Some Aryl Hydrazone Mn(II), Cu(II) and Fe(III) Complexes","volume":"1244","author":"Abu-Dief","year":"","journal-title":"J. Mol. Struct."},{"key":"B4","doi-asserted-by":"publisher","first-page":"115277","DOI":"10.1016\/j.molliq.2021.115277","article-title":"Synthesis and Characterization of Fe(III), Pd(II) and Cu(II)-thiazole Complexes; DFT, Pharmacophore Modeling, Iin-Vvitro Assay and DNA Binding Studies","volume":"326","author":"Abu-Dief","year":"","journal-title":"J. Mol. Liquids"},{"key":"B5","article-title":"Dalton Trans","volume":"1349","author":"Addison","year":"1984","journal-title":"J. Chem. Soc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"111022","DOI":"10.1016\/j.jinorgbio.2020.111022","article-title":"Novel Triorganotin Complexes Based on Phosphonic Acid Ligands: Syntheses, Structures and In Vitro Cytostatic Activity","volume":"206","author":"An","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"B7","volume-title":"Purification of Laboratory Chemicals","author":"Armarego","year":"2003"},{"key":"B8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.4315\/0362-028x-66.4.668","article-title":"Antimicrobial Effect of Spices and Herbs on Shigella Sonnei and Shigella Flexneri","volume":"66","author":"Bagamboula","year":"2003","journal-title":"J. Food Prot."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1016\/j.ica.2008.05.006","article-title":"Synthesis, Spectroscopic Characterization, and crystal Structures of Two Chlorodiorganotin (IV) 4-(2-methoxyphenyl) Piperazine-1-Carbodithioates","volume":"361","author":"Barsan","year":"2008","journal-title":"Inorg. Chim. Acta"},{"key":"B10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/aoc.1378","article-title":"Antimicrobial Activity of Organotin(IV) Compounds: a Review","volume":"22","author":"Basu Baul","year":"2008","journal-title":"Appl. Organometal. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.molstruc.2019.04.066","article-title":"Synthesis, Structural Properties, DFT Studies, Antimicrobial Activities and DNA Binding Interactions of Two Newly Synthesized Organotin(IV) Carboxylates","volume":"1191","author":"Butt","year":"2019","journal-title":"J. Mol. Struct."},{"key":"B12","doi-asserted-by":"publisher","first-page":"104107","DOI":"10.1063\/1.2345197","article-title":"LANL2DZ Basis Sets Recontracted in the Framework of Density Functional Theory","volume":"125","author":"Chiodo","year":"2006","journal-title":"J. Chem. Phys."},{"key":"B13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/bf01569539","article-title":"Toxic Effects of Tin Compounds on Microorganisms","volume":"4","author":"Cooney","year":"1989","journal-title":"J. Ind. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"119172","DOI":"10.1016\/j.ica.2019.119172","article-title":"Synthesis, Structural Characterization and Antimicrobial Activities of triorganotin(IV)azo-carboxylates Derived from Ortho\/para-Amino Benzoic Acids and \u03b2-naphthol","volume":"498","author":"Debnath","year":"2019","journal-title":"Inorg. Chim. Acta"},{"key":"B15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1107\/s0021889808042726","article-title":"OLEX2: a Complete Structure Solution, Refinement and Analysis Program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1007\/s00044-011-9916-6","article-title":"Diorganotin (IV) Derivative of 2-thiophene Acetic Acid: Characterizations and Biological Activities of {[n-Bu2SnO2C-CH2-C4h3s]2o}2","volume":"21","author":"Ettouhami","year":"2012","journal-title":"Med. Chem. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/cmdc.200600307","article-title":"Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity","volume":"2","author":"Fracchiolla","year":"2007","journal-title":"ChemMedChem"},{"key":"B18","first-page":"310","volume-title":"Gaussian 16. Revision A","author":"Frisch","year":"2016"},{"key":"B19","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1590\/s0103-50532003000600003","article-title":"An Overview of Forty Years Organotin Chemistry Developed at the Free Universities of Brussels ULB and VUB","volume":"14","author":"Gielen","year":"2003","journal-title":"J. Braz. Chem. Soc."},{"key":"B20","volume-title":"Tin Chemistry: Fundamentals, Frontiers, and Applications","author":"Gielen","year":"2008"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.jinorgbio.2008.07.009","article-title":"Study of the cytotoxic activity of di and triphenyltin (IV) carboxylate complexes","volume":"102","author":"G\u00f3mez-Ruiz","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ccr.2007.12.026","article-title":"Antiproliferative and Anti-tumor Activity of Organotin Compounds","volume":"253","author":"Hadjikakou","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"102885","DOI":"10.1039\/c5ra18445b","article-title":"Study of the Effect of Molecular Structure and Alkyl Groups Bound with Tin(iv) on Their Cytotoxicity of Organotin(iv) 2-Phenyl-4-Selenazole Carboxylates","volume":"5","author":"Hong","year":"2015","journal-title":"RSC Adv."},{"key":"B52","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1515\/MGMC.1994.17.5.293","article-title":"Phenyltin Diethyldithiocarbamates: Solid State and Solution Structures and in vitro Anti-tumour Activity","volume":"17","author":"Hook","year":"1994","journal-title":"Main Group Met. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1107\/S0021889811043202","article-title":"ShelXle: a Qt Graphical User Interface for SHELXL","volume":"44","author":"H\u00fcbschle","year":"2011","journal-title":"J. Appl. Cryst."},{"key":"B25","volume-title":"Molecular Operating Environment (MOE)","author":"Inc","year":"2016"},{"key":"B26","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jinorgbio.2006.11.002","article-title":"Cobalt Complexes of Terpyridine Ligand: crystal Structure and Photocleavage of DNA","volume":"101","author":"Indumathy","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jorganchem.2012.10.006","article-title":"Synthesis, Characterization, crystal Structures and Electrochemical Studies of Organotin(IV) Carboxylates","volume":"723","author":"Iqbal","year":"2013","journal-title":"J. Organomet. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1039\/c0mt00007h","article-title":"Synthesis and Biological Applications of Ionic Triphenyltin(iv) Chloride Carboxylate Complexes with Exceptionally High Cytotoxicity","volume":"2","author":"Kalu\u0111erovi\u0107","year":"2010","journal-title":"Metallomics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jinorgbio.2009.01.014","article-title":"Organotin Meclofenamic Complexes: Synthesis, crystal Structures and Antiproliferative Activity of the First Complexes of Meclofenamic Acid - Novel Anti-tuberculosis Agents","volume":"103","author":"Kovala-Demertzi","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"B30","first-page":"29","article-title":"A Review on the Design and Development of EGFR Tyrosine Kinase Inhibitors in Cancer Therapy","volume":"5","author":"Mubeen","year":"2012","journal-title":"Int. J. Ther. Appl."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1016\/j.jorganchem.2009.06.036","article-title":"Organotin(IV) 4-nitrophenylethanoates: Synthesis, Structural Characteristics and Intercalative Mode of Interaction with DNA","volume":"694","author":"Muhammad","year":"2009","journal-title":"J. Organomet. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s11094-019-02064-2","article-title":"Theoretical and Experimental In Vitro Antifungal and Antitumor Activities of Organotin(IV) Derivatives of 3-(4-Nitrophenyl)-2-Methylacrylic Acid","volume":"53","author":"Muhammad","year":"2019","journal-title":"Pharm. Chem. J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1080\/00958972.2014.898755","article-title":"Synthesis and Structural Characterization of Monomeric and Polymeric Supramolecular Organotin(IV) 4-chlorophenylethanoates","volume":"67","author":"Muhammad","year":"2014","journal-title":"J. Coord. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2905840","article-title":"Design and In Vitro Biological Evaluation of a Novel Organotin (IV) Complex with 1-(4-Carboxyphenyl)-3-Ethyl-3-Methylpyrrolidine-2, 5-dione","author":"Panteli\u0107","year":"2019","journal-title":"J. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2010.11.011","article-title":"Induction of Cell Cycle Arrest and DNA Damage by the HDAC Inhibitor Panobinostat (LBH589) and the Lipid Peroxidation End Product 4-hydroxynonenal in Prostate Cancer Cells","volume":"50","author":"Pettazzoni","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"B36","volume-title":"CrysAlis PRO Software System","author":"Rigaku","year":"2018"},{"key":"B37","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/pharmaceutics13020226","article-title":"Novel green Biosynthesis of 5-fluorouracil Chromium Nanoparticles Using Harpullia Pendula Extract for Treatment of Colorectal Cancer","volume":"13","author":"Saddik","year":"2021","journal-title":"Pharmaceutics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0010-8545(89)80003-7","article-title":"Organotin Compounds and Cancer Chemotherapy","volume":"95","author":"Saxena","year":"1989","journal-title":"Coord. Chem. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"SHELXT-integrated Space-Group and Crystals-Structure Determination","volume":"71","author":"Scheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect. A: Found. Adv."},{"key":"B40","doi-asserted-by":"publisher","first-page":"10467","DOI":"10.1039\/c5dt00862j","article-title":"Organotin(IV) Based Anti-HCV Drugs: Synthesis, Characterization and Biochemical Activity","volume":"44","author":"Shah","year":"2015","journal-title":"Dalton Trans."},{"key":"B41","volume-title":"SHELXS-97, Program for Crystal Structure Determination","author":"Sheldrick","year":""},{"key":"B42","volume-title":"SHELXL-97-2, Program for Crystal Structure Refinement","author":"Sheldrick","year":""},{"key":"B43","volume-title":"Shelxtl V6. 1 Software Reference Manual","author":"Sheldrick","year":"2009"},{"key":"B44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jorganchem.2014.02.010","article-title":"Homobimetallic Organotin(IV) Complexes with Hexadentate Schiff Base: Synthesis, crystal Structure and Antimicrobial Studies","volume":"759","author":"Shujah","year":"2014","journal-title":"J. Organomet. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ejmech.2014.07.028","article-title":"Potentially Bioactive Organotin(IV) Compounds: Synthesis, Characterization, In Vitro Bioactivities and Interaction with SS-DNA","volume":"84","author":"Sirajuddin","year":"","journal-title":"Eur. J. Med. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.poly.2012.03.048","article-title":"Synthesis, Characterization, Biological Screenings and Interaction with Calf Thymus DNA as Well as Electrochemical Studies of Adducts Formed by Azomethine [2-((3,5-dimethylphenylimino) methyl) phenol] and Organotin (IV) Chlorides","volume":"40","author":"Sirajuddin","year":"2012","journal-title":"Polyhedron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"57505","DOI":"10.1039\/c4ra10487k","article-title":"Organotin(iv) Carboxylate Derivatives as a New Addition to Anticancer and Antileishmanial Agents: Design, Physicochemical Characterization and Interaction with Salmon Sperm DNA","volume":"4","author":"Sirajuddin","year":"","journal-title":"RSC Adv."},{"key":"B48","doi-asserted-by":"publisher","first-page":"129600","DOI":"10.1016\/j.molstruc.2020.129600","article-title":"Organotin(IV) Derivatives Based on 2-((2-methoxyphenyl)carbamoyl)benzoic Acid: Synthesis, Spectroscopic Characterization, Assessment of Antibacterial, DNA Interaction, Anticancer and Antileishmanial Potentials","volume":"1229","author":"Sirajuddin","year":"2021","journal-title":"J. Mol. Struct."},{"key":"B49","first-page":"1162311627","article-title":"Abinitio calculation of vibrational absorption and circular Dichroismspectrausingdensityfunctionalforcefields","volume":"98","author":"Stephenspj","year":"1994","journal-title":"TheJournalofPhysicalChemistry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jphotobiol.2016.02.028","article-title":"Pharmacological Investigations and Petra\/Osiris\/Molinspiration (POM) Analyses of Newly Synthesized Potentially Bioactive Organotin(IV) Carboxylates","volume":"158","author":"Tariq","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"B51","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jorganchem.2012.09.011","article-title":"Synthesis, Spectroscopic Characterization, X-ray Structures, Biological Screenings, DNA Interaction Study and Catalytic Activity of Organotin(IV) 3-(4-Flourophenyl)-2-Methylacrylic Acid Derivatives","volume":"723","author":"Tariq","year":"2013","journal-title":"J. Organomet. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jinorgbio.2009.12.006","article-title":"On the Bioreactivity of Triorganotin Aminobenzoates. Investigation of Trialkyl and Triarylyltin(IV) Esters of 3-amino and 4-aminobenzoic Acids","volume":"104","author":"Tzimopoulos","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/02603599708032742","article-title":"Inorganic Chromophores: Optical Charge Transfer in Coordination Compounds","volume":"19","author":"Vogler","year":"1997","journal-title":"Comments Inorg. Chem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"128255","DOI":"10.1016\/j.molstruc.2020.128255","article-title":"A 24-membered Macrocyclic Triorganotin(IV) Carboxylate: Synthesis, Characterization, crystal Structure, and Antitumor Activity","volume":"1216","author":"Xiao","year":"2020","journal-title":"J. Mol. Struct."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9843","DOI":"10.1021\/jp807643p","article-title":"Assessment of the \"6-31+G** + LANL2DZ\" Mixed Basis Set Coupled with Density Functiona Theory Methods and the Effective Core Potential: Prediction of Heats of Formation and Ionization Potentials for First-Row-Transition-Metal Complexes","volume":"113","author":"Yang","year":"2009","journal-title":"J. Phys. Chem. A."},{"key":"B58","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/hc.20628","article-title":"Synthesis, Characterization, and In Vitro Antimicrobial Activities of Organotin (IV) Complexes of Schiff Bases with ONO\u2010type Donor Atoms","volume":"21","author":"Yeni\u015fehirli","year":"2010","journal-title":"Heteroatom Chem."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.864336\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:26:43Z","timestamp":1649176003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.864336\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":57,"alternative-id":["10.3389\/fphar.2022.864336"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.864336","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"article-number":"864336"}}