{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:40:14Z","timestamp":1780638014252,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Stevens-Johnson syndrome (SJS) has been reported as a serious adverse effect in patients treated with vancomycin or linezolid, and there is currently a lack of real-world studies comparing specific differences in adverse effects of SJS.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> According to the FDA\u2019s Adverse Event Reporting System (FAERS), from January 2004 to July 2021, the data of suspected SJS after the use of vancomycin and linezolid were analyzed by imbalance and Bayesian analysis. The onset time, fatality rate and hospitalization rate of vancomycin-associated SJS and linezolid-associated SJS were also investigated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 276 cases of vancomycin-related SJS reports and 63 cases of linezolid-related SJS reports were identified. These two drugs are more common in middle-aged patients (45\u201364\u00a0years) than other age groups, and less common in underage children (&amp;lt;18). Among them, linezolid-related SJS is more common in middle-aged and elderly patients (45\u201374\u00a0years old) than other groups. Except for unspecified data, in vancomycin-associated SJS cases, there are more men than women (49.28% vs 43.84%), while in linezolid-associated SJS cases, the proportion of men and women is almost equal (44.44%). From the point of view of the areas where adverse reactions were reported, about 1\/2 of the reports on Vancomycin-related SJS came from North America, and 1\/3 of the reports came from Europe. The median onset time of Linezolid-related SJS was 5\u00a0days (interquartile range [IQR] 2\u20137.75), which was significantly earlier than that of Vancomycin-related SJS (12\u00a0days, IQR 4\u201320) (Mann-Whitney test, <jats:italic>p<\/jats:italic> &amp;lt; 0.0001). There were no significant differences in mortality and hospitalization rates after vancomycin and linezolid caused SJS.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The analysis of faers data provides a comprehensive overview of the adverse reactions of SJS caused by the use of vancomycin and linezolid, and can warn clinical workers to timely intervene and continuously monitor the patients at risk of SJS when using such drugs.<\/jats:p>","DOI":"10.3389\/fphar.2022.872854","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T06:56:41Z","timestamp":1651129001000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Stevens-Johnson Syndrome Following Vancomycin and Linezolid: A Real-World Analysis of Post-Marketing Surveillance Data"],"prefix":"10.3389","volume":"13","author":[{"given":"Ming","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Dong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2500\/108854196778645029","article-title":"Vancomycin-Induced Stevens-Johnson Syndrome","volume":"17","author":"Alexander","year":"1996","journal-title":"Allergy Asthma Proc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s40266-016-0420-z","article-title":"Intravenous Vancomycin Dosing in the Elderly: A Focus on Clinical Issues and Practical Application","volume":"33","author":"Barber","year":"2016","journal-title":"Drugs Aging."},{"key":"B3","volume-title":"The State of Aging and Health in America 2013","year":"2013"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jdermsci.2020.02.003","article-title":"SJS\/TEN 2019: From Science to Translation","volume":"98","author":"Chang","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1592\/phco.25.2.308.56953","article-title":"Probable Vancomycin-Associated Toxic Epidermal Necrolysis","volume":"25","author":"Craycraft","year":"2005","journal-title":"Pharmacotherapy."},{"key":"B6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/00031305.1999.10474456","article-title":"Bayesian Data Mining in Large Frequency Tables, with an Application to the FDA Spontaneous Reporting System","volume":"53","author":"DuMouchel","year":"1999","journal-title":"The Am. Statistician."},{"key":"B7","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/pds.677","article-title":"Use of Proportional Reporting Ratios (PRRs) for Signal Generation from Spontaneous Adverse Drug Reaction Reports","volume":"10","author":"Evans","year":"2001","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"B8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1086\/520193","article-title":"Surveillance of Antimicrobial Use and Antimicrobial Resistance in United States Hospitals: Project ICARE Phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Hospitals","volume":"29","author":"Fridkin","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1345\/aph.1C515","article-title":"A Brief Primer on Automated Signal Detection","volume":"37","author":"Hauben","year":"2003","journal-title":"Ann. Pharmacother."},{"key":"B10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1517\/14740338.4.5.929","article-title":"The Role of Data Mining in Pharmacovigilance","volume":"4","author":"Hauben","year":"2005","journal-title":"Expert Opin. Drug Saf."},{"key":"B11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0091-6749(03)80563-8","article-title":"Early Diagnosis Is Key in Vancomycin-Induced Linear IgA Bullous Dermatosis and Stevens-Johnson Syndrome","volume":"104","author":"Jones","year":"2004","journal-title":"J. Am. Osteopath Assoc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0732-8893(98)00108-4","article-title":"Epidemiologic Trends in Nosocomial and Community-Acquired Infections Due to Antibiotic-Resistant Gram-Positive Bacteria: the Role of Streptogramins and Other Newer Compounds","volume":"33","author":"Jones","year":"1999","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2174\/1389200216666151001121004","article-title":"Linezolid Induced Adverse Drug Reactions - an Update","volume":"16","author":"Kishor","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1177\/106002809202601206","article-title":"Stevens-Johnson-type Reaction with Vancomycin Treatment","volume":"26","author":"Laurencin","year":"1992","journal-title":"Ann. Pharmacother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s40261-017-0503-6","article-title":"Can Disproportionality Analysis of Post-marketing Case Reports Be Used for Comparison of Drug Safety Profiles?","volume":"37","author":"Michel","year":"2017","journal-title":"Clin. Drug Investig."},{"key":"B16","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.anai.2016.03.030","article-title":"Immune-mediated Reactions to Vancomycin: A Systematic Case Review and Analysis","volume":"116","author":"Minhas","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.12816\/0006220","article-title":"Drug-induced Linear IgA Bullous Dermatosis Simulating Toxic Epidermal Necrolysis","volume":"62","author":"Nasr","year":"2014","journal-title":"J. Med. Liban"},{"key":"B18","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/S0196655304005425","article-title":"National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992 through June 2004, Issued October 2004","volume":"32","year":"2004","journal-title":"Am. J. Infect. Control."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1002\/sim.2473","article-title":"Extending the Methods Used to Screen the WHO Drug Safety Database towards Analysis of Complex Associations and Improved Accuracy for Rare Events","volume":"25","author":"Nor\u00e9n","year":"2006","journal-title":"Stat. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/pds.2014","article-title":"Selected Control Events and Reporting Odds Ratio in Signal Detection Methodology","volume":"19","author":"Ooba","year":"2010","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"B21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.numecd.2018.02.014","article-title":"Pharmacovigilance of Sodium-Glucose Co-transporter-2 Inhibitors: What a Clinician Should Know on Disproportionality Analysis of Spontaneous Reporting Systems","volume":"28","author":"Raschi","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2165\/00002018-200225060-00001","article-title":"Use of Screening Algorithms and Computer Systems to Efficiently Signal higher-Than-expected Combinations of Drugs and Events in the US FDA's Spontaneous Reports Database","volume":"25","author":"Szarfman","year":"2002","journal-title":"Drug Saf."},{"key":"B23","first-page":"227","article-title":"Explaining Odds Ratios","volume":"19","author":"Szumilas","year":"2010","journal-title":"J. Can. Acad. Child. Adolesc. Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/pds.668","article-title":"A Comparison of Measures of Disproportionality for Signal Detection in Spontaneous Reporting Systems for Adverse Drug Reactions","volume":"11","author":"Van Puijenbroek","year":"2002","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"B25","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1365-2230.2004.01649.x","article-title":"Vancomycin-induced Linear IgA Bullous Disease Presenting as Toxic Epidermal Necrolysis","volume":"29","author":"Waldman","year":"2004","journal-title":"Clin. Exp. Dermatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jaip.2017.11.023","article-title":"SJS\/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation","volume":"6","author":"White","year":"2018","journal-title":"J. Allergy Clin. Immunol. Pract."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.872854\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T06:56:46Z","timestamp":1651129006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.872854\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":26,"alternative-id":["10.3389\/fphar.2022.872854"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.872854","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"article-number":"872854"}}