{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:22:26Z","timestamp":1791393746654,"version":"4.3.3"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at the early to late reproductive stage (15\u201335\u00a0years). Currently, PCOS affects 1 in every 10 women worldwide. It is characterized majorly by a raised level of androgens such as testosterone and a large number of ovarian cysts (more than 10) that cause anovulation, infertility, and irregular menstrual cycle. PCOS is also related to other endocrine and metabolic abnormalities, such as obesity, hirsutism, acne, diabetes, insulin resistance, and glucose impairment. PCOS can be treated with allopathic, ayurvedic, and natural or herbal medications along with lifestyle modifications. Herbal medicines remained in demand for numerous reasons such as high cost and side effects associated with the use of allopathic medicine and our traditional norms, which have helped humans to use more herbal products for their health benefits. Estrogenic and nonestrogenic phytochemicals present in various plant species such as\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    L. [Fabaceae],\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    (L.) Burm. f. [Asphodelaceae],\n                    <jats:italic>Silybum marianum<\/jats:italic>\n                    (L.). Gaertn. [Asteraceae],\n                    <jats:italic>Serenoa repens<\/jats:italic>\n                    (W.Bartram) Small [Arecaceae],\n                    <jats:italic>Actaea racemosa<\/jats:italic>\n                    L. [Ranunculaceae], and\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    (Oliv.) Diels [\n                    <jats:italic>Apiaceae<\/jats:italic>\n                    ] are effective and harmless. Herbal medicines are found to be cost-effective, efficacious, and a highly esteemed source of management\/treatment for PCOS than allopathic medicines. In this literature review, diagnosis, signs, and symptoms of PCOS; causes of hormonal imbalance; and risk factors associated with PCOS and their management are discussed briefly, and the focus was to find out the role of herbal remedies in PCOS management.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.874914","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T03:44:26Z","timestamp":1658115866000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":98,"title":["Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies"],"prefix":"10.3389","volume":"13","author":[{"given":"Ling-Hui","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaqat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik Hassan","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Younas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Mahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakhria A.","family":"Al-Joufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaymaa Najm","family":"Abed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"B1","article-title":"Hydroalcoholic Extract of Red Clover (trifolium Pretense) Improves Hormonal Balances after Induction of Polycystic Ovary Syndrome in Rats","volume-title":"INTERNATIONAL CONGRESS OF LABORATORY AND CLINIC","author":"Abbasian","year":"2017"},{"key":"B2","volume-title":"Contemporary Endocrinology: Androgen Excess Disorders in Women","author":"Abbott","year":"2006"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1210\/endo-108-4-1441","article-title":"Insulin Enhancement of Luteinizing Hormone and Follicle-Stimulating Hormone Release by Cultured Pituitary Cells","volume":"108","author":"Adashi","year":"1981","journal-title":"Endocrinology"},{"key":"B4","article-title":"Effect of Camomile (Anthemis Nobilis) Aqueous-Alcoholic Extract on Female Rats Estrogen Hormone (Polycystic Ovary Model)","volume-title":"IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY","author":"Amir","year":"2007"},{"key":"B5","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bpobgyn.2004.05.007","article-title":"Hirsutism and Acne in Polycystic Ovary Syndrome","volume":"18","author":"Archer","year":"2004","journal-title":"Best. 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