{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:14:05Z","timestamp":1788441245037,"version":"build-2803163510"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013078","name":"Natural Science Research Project of Guizhou Provincial Education Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>As an important traditional medicine of Buyi and Miao ethnic groups in Guizhou, <jats:italic>Sabia parviflora<\/jats:italic> Wall. provides antiviral properties against hepatitis, eliminates wind and dampness, and exhibits anti-inflammatory and pain relief properties. It has also been shown to treat rheumatoid arthritis (RA) and other diseases. However, the pharmacodynamic mechanism of <jats:italic>S. parviflora<\/jats:italic> Wall. for RA has not been reported. In this study, we identified the effective compounds of <jats:italic>S. parviflora<\/jats:italic> Wall<jats:italic>.<\/jats:italic> leaves against RA and discussed the mechanism against complete Freund\u2019s adjuvant-induced arthritis (AIA) based on inflammatory proteins and transient receptor potential (TRP) proteins. <jats:italic>S. parviflora<\/jats:italic> Wall. leaf extracts (0.64\u00a0g\/kg, 0.32\u00a0g\/kg, and 0.16\u00a0g\/kg, once daily) were given orally for 21\u00a0days. On the 15th day of complete Freund\u2019s adjuvant-induced RA, the effects of this medicine on RA rats were investigated. <jats:italic>S. parviflora<\/jats:italic> Wall. extracts increased body weight, decreased foot swelling, and reduced thymus and spleen indices in model rats. Most of pannus in the synovial tissue of RA rats disappeared upon treatment, and the local inflammatory cells were greatly reduced when given the fraction of n-butanol (0.64\u00a0g\/kg\/d, 0.32\u00a0g\/kg\/d, and 0.16\u00a0g\/kg\/d) of 70% alcohol-soluble fraction of <jats:italic>S. parviflora<\/jats:italic> Wall. leaves. In addition, the release of inflammatory factors such as tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-15 (IL-15), and vascular endothelial growth factor (VEGF) in the RA rat serum was inhibited. The active compounds inhibited the expression of TNF-\u03b1, IL-1\u03b2, IL-6, IL-10, IL-15 and nuclear factor kappa-Bp65 (NF-\u03baBp65) inflammatory protein and TRP protein transient receptor potential melastatin-5 (TRPM-5) and transient receptor potential channel-6 (TRPC-6), to reduce the expression of VEGF in synovial tissue of RA rats and relieve redness and edema. High-performance liquid chromatography identified six flavonoids and three triterpenoid saponins as active compounds. These findings suggest <jats:italic>S. parviflora<\/jats:italic> Wall. leaves may play a role in RA treatment by inhibiting the release of inflammatory factors as well as participating in the inflammatory protein expression in the NF-\u03baB pathway and TRP protein family.<\/jats:p>","DOI":"10.3389\/fphar.2022.880350","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T07:23:57Z","timestamp":1655364237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Antirheumatoid Arthritic Effects of Sabia parviflora Wall. Leaf Extracts via the NF-\u03baB Pathway and Transient Receptor Potential Protein Family"],"prefix":"10.3389","volume":"13","author":[{"given":"Yongqiang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and Management of Rheumatoid Arthritis: a Review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"153036","DOI":"10.1016\/j.phymed.2019.153036","article-title":"Genkwanin Ameliorates Adjuvant-Induced Arthritis in Rats through Inhibiting JAK\/STAT and NF-\u039ab Signaling Pathways","volume":"63","author":"Bao","year":"2019","journal-title":"Phytomedicine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.16343\/j.cnki.issn.2095-512x2019.02.030","article-title":"Research Progress of VEGF in the Occurrence, Development and Treatment of Rheumatoid Arthritis","volume":"41","author":"Bi","year":"2019","journal-title":"J. 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