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Pharmacol."],"abstract":"<jats:p>Neutral polysaccharides (NHSPs) from the mushroom <jats:italic>Hohenbuehelia<\/jats:italic><jats:italic>serotina<\/jats:italic> were purified by D301\/D152 resin ion-exchange chromatography and DEAE-cellulose anion exchange chromatography. The weight-average molecular weight (M<jats:sub>W<\/jats:sub>) and number-average molecular weight (Mn) of NHSP were 1,821 and 820.55\u00a0kDa, respectively. A monosaccharide component analysis showed that NHSP was composed of glucose, galactose, and mannose in molar ratio 2.6:2.1:1.0. FT-IR and NMR (<jats:sup>1<\/jats:sup>H and HSQC) spectroscopic analyses revealed that NHSP contained mainly 1,3-linked \u03b2-D-glucose, 1,4-linked \u03b2-D-glucose, 1,6-linked \u03b2-D-mannose, 1,6-linked \u03b1-D-mannose, and 1,6-linked \u03b2-D-galactose. The thermogravimetric analysis (TGA) showed that NHSP has good thermal stability below 250\u00b0C. NHSP notably reduced the blood glucose level (hypoglycemic effect) at dose 200\u00a0mg\/kg for 21\u00a0days in a type 2 diabetic mouse model. NHSP reduced the liver index significantly, suggesting that it may help prevent hepatic steatosis or hepatomegaly.<\/jats:p>","DOI":"10.3389\/fphar.2022.883653","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T05:05:55Z","timestamp":1651727155000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Neutral Polysaccharides From Hohenbuehelia serotina With Hypoglycemic Effects in a Type 2 Diabetic Mouse Model"],"prefix":"10.3389","volume":"13","author":[{"given":"Qinghong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhe","family":"Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.carbpol.2013.07.018","article-title":"Antitumor and Immunomodulatory Activities of a Polysaccharide from Artemisia Argyi","volume":"98","author":"Bao","year":"2013","journal-title":"Carbohydr. 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