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Pharmacol."],"abstract":"<jats:p><jats:bold>Aim of the study:<\/jats:bold> To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5\/MyD88\/NF-\u03baB signaling pathway and critical targets of the intestinal mucosal barrier was detected by immunochemical analysis techniques.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> SBP significantly ameliorated the symptoms of TNBS-induced colitis in rats and reduced the secretion of pro-inflammatory cytokines. SBP could effectively strengthen epithelial barrier integrity in TNBS-induced colitis by increasing the secretion of mucin and tight junction and inhibiting apoptosis. Furthermore, we identified the crucial role of the TLR5\/MyD88\/NF-\u03baB signaling pathway in exerting the therapeutic effect of SBP.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of our study suggest that SBP has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis.<\/jats:p>","DOI":"10.3389\/fphar.2022.883918","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:04:12Z","timestamp":1651136652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5\/MyD88\/NF-\u03baB Pathway"],"prefix":"10.3389","volume":"13","author":[{"given":"Kehan","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haomeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.cgh.2020.01.028","article-title":"Changing Global Epidemiology of Inflammatory Bowel Diseases: Sustaining Health Care Delivery into the 21st Century","volume":"18","author":"Ananthakrishnan","year":"2020","journal-title":"Clin. 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