{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:36:17Z","timestamp":1788838577232,"version":"build-2803163510"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Endotoxins and other harmful substances may cause an increase in permeability in endothelial cells (ECs) monolayers, as well as ECs shrinkage and death to induce lung damage. Lipopolysaccharide (LPS) can impair endothelial progenitor cells (EPCs) functions, including proliferation, migration, and tube formation. EPCs can migrate to the damaged area, differentiate into ECs, and participate in vascular repair, which improves pulmonary capillary endothelial dysfunction and maintains the integrity of the endothelial barrier. Hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) contributes to the repairment of lung injury and the damage of ECs. We therefore speculate that H\n                    <jats:sub>2<\/jats:sub>\n                    protects the EPCs against LPS-induced damage, and it\u2019s mechanism will be explored. The bone marrow-derived EPCs from ICR Mice were treated with LPS to establish a damaged model. Then EPCs were incubated with H\n                    <jats:sub>2<\/jats:sub>\n                    , and treated with PI3K inhibitor LY294002 and endothelial nitric oxide synthase (eNOS) inhibitor L-NAME. MTT assay, transwell assay and tube formation assay were used to detect the proliferation, migration and angiogenesis of EPCs. The expression levels of target proteins were detected by Western blot. Results found that H\n                    <jats:sub>2<\/jats:sub>\n                    repaired EPCs proliferation, migration and tube formation functions damaged by LPS. LY294002 and L-NAME significantly inhibited the repaired effect of H\n                    <jats:sub>2<\/jats:sub>\n                    on LPS-induced dysfunctions of EPCs. H\n                    <jats:sub>2<\/jats:sub>\n                    also restored levels of phosphor-AKT (p-AKT), eNOS and phosphor-eNOS (p-eNOS) suppressed by LPS. LY294002 significantly inhibited the increase of p-AKT and eNOS and p-eNOS expression exposed by H\n                    <jats:sub>2<\/jats:sub>\n                    . L-NAME significantly inhibited the increase of eNOS and p-eNOS expression induced by H\n                    <jats:sub>2<\/jats:sub>\n                    . H\n                    <jats:sub>2<\/jats:sub>\n                    repairs the dysfunctions of EPCs induced by LPS, which is mediated by PI3K\/AKT\/eNOS signaling pathway.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.894812","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T01:21:01Z","timestamp":1652318461000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K\/AKT\/eNOS Pathway"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingjie","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangmin","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of Putative Progenitor Endothelial Cells for Angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/shk.0000000000000872","article-title":"Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can Be Tracked In Vivo Using Molecular Imaging","volume":"48","author":"Audi","year":"2017","journal-title":"Shock"},{"key":"B3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute Lung Injury: A Clinical and Molecular Review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. 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