{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:31:00Z","timestamp":1789061460814,"version":"build-2803163510"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973316 82173807"],"award-info":[{"award-number":["81973316 82173807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Alcoholic liver disease (ALD) is a worldwide healthcare problem featured by inflammation, reactive oxygen species (ROS), and lipid dysregulation. Roxadustat is used for chronic kidney disease anemia treatment. As a specific inhibitor of prolyl hydroxylase, it can maintain high levels of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1), through which it can further influence many important pathways, including the three featured in ALD. However, its effects on ALD remain to be elucidated. In this study, we used chronic and acute ALD mouse models to investigate the protective effects of roxadustat <jats:italic>in vivo<\/jats:italic>. Our results showed that long- and short-term alcohol exposure caused rising activities of serum transaminases, liver lipid accumulation, and morphology changes, which were reversed by roxadustat. Roxadustat-reduced fatty liver was mainly contributed by the reducing sterol-responsive element-binding protein 1c (SREBP1c) pathway, and enhancing \u03b2-oxidation through inducing peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) and carnitine palmitoyltransferase 1A (CPT1A) expression. Long-term alcohol treatment induced the infiltration of monocytes\/macrophages to hepatocytes, as well as inflammatory cytokine expression, which were also blocked by roxadustat. Moreover, roxadustat attenuated alcohol caused ROS generation in the liver of those two mouse models mainly by reducing cytochrome P450 2E1 (CYP2E1) and enhancing superoxidase dismutase 1 (SOD1) expression. <jats:italic>In vitro<\/jats:italic>, we found roxadustat reduced inflammation and lipid accumulation mainly <jats:italic>via<\/jats:italic> HIF-1\u03b1 regulation. Taken together, our study demonstrates that activation of HIF-1\u03b1 can ameliorate ALD, which is contributed by reduced hepatic lipid synthesis, inflammation, and oxidative stress. This study suggested that roxadustat could be a potential drug for ALD treatment.<\/jats:p>","DOI":"10.3389\/fphar.2022.895710","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T07:22:01Z","timestamp":1652167321000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Roxadustat, a Hypoxia-Inducible Factor 1\u03b1 Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Yongyao","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunyuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/039463200301600304","article-title":"Metadoxine in the Treatment of Acute and Chronic Alcoholism: a Review","volume":"16","author":"Addolorato","year":"2003","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mam.2007.09.004","article-title":"Oxidative Mechanisms in the Pathogenesis of Alcoholic Liver Disease","volume":"29","author":"Albano","year":"2008","journal-title":"Mol. Aspects Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1002\/hep.510250422","article-title":"Chronic Enteral Ethanol Treatment Causes Hypoxia in Rat Liver Tissue In Vivo","volume":"25","author":"Arteel","year":"1997","journal-title":"Hepatology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/s0022-2275(20)40613-3","article-title":"Effects of Ethanol on Lipid Metabolism","volume":"20","author":"Baraona","year":"1979","journal-title":"J. Lipid Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/1091581817737232","article-title":"Evaluation of the Carcinogenic Potential of Roxadustat (FG-4592), a Small Molecule Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase in CD-1 Mice and sprague Dawley Rats","volume":"36","author":"Beck","year":"2017","journal-title":"Int. J. Toxicol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse Model of Chronic and Binge Ethanol Feeding (The NIAAA Model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","article-title":"Pathogenesis of Alcoholic Liver Disease: Role of Oxidative Metabolism","volume":"20","author":"Ceni","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/hep.27921","article-title":"Short- or Long-Term High-Fat Diet Feeding Plus Acute Ethanol Binge Synergistically Induce Acute Liver Injury in Mice: an Important Role for CXCL1","volume":"62","author":"Chang","year":"2015","journal-title":"Hepatology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3109\/00498254.2015.1020353","article-title":"Decreased Carboxylesterases Expression and Hydrolytic Activity in Type 2 Diabetic Mice through Akt\/mTOR\/HIF-1\u03b1\/Stra13 Pathway","volume":"45","author":"Chen","year":"2015","journal-title":"Xenobiotica"},{"key":"B10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cmet.2017.07.012","article-title":"Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis","volume":"26","author":"Chitraju","year":"2017","journal-title":"Cell Metab"},{"key":"B11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.brainresbull.2003.09.013","article-title":"Open Field Locomotor Effects in Rats after Intraventricular Injections of Ethanol and the Ethanol Metabolites Acetaldehyde and Acetate","volume":"62","author":"Correa","year":"2003","journal-title":"Brain Res. Bull."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1253\/circj.CJ-19-1039","article-title":"Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice","volume":"84","author":"Deguchi","year":"2020","journal-title":"Circ. J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1172\/jci25256","article-title":"Polyunsaturated Fatty Acids Suppress Glycolytic and Lipogenic Genes through the Inhibition of ChREBP Nuclear Protein Translocation","volume":"115","author":"Dentin","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1136\/annrheumdis-2012-202021","article-title":"Understanding the Side Effects of Glucocorticoid Therapy: Shining a Light on a Drug Everyone Thinks They Know","volume":"71","author":"Dixon","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"27997","DOI":"10.1074\/jbc.M302140200","article-title":"Peroxisome Proliferator-Activated Receptor Alpha (PPARalpha) Agonist Treatment Reverses PPARalpha Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethanol-Fed Mice","volume":"278","author":"Fischer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1074\/jbc.M008791200","article-title":"The Transcriptional and DNA Binding Activity of Peroxisome Proliferator-Activated Receptor Alpha Is Inhibited by Ethanol Metabolism. A Novel Mechanism for the Development of Ethanol-Induced Fatty Liver","volume":"276","author":"Galli","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"405","DOI":"10.20524\/aog.2017.0152","article-title":"Iron Deficiency Anemia in Chronic Liver Disease: Etiopathogenesis, Diagnosis and Treatment","volume":"30","author":"Gkamprela","year":"2017","journal-title":"Ann. Gastroenterol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.3748\/wjg.15.4653","article-title":"Spectrum of Anemia Associated with Chronic Liver Disease","volume":"15","author":"Gonzalez-Casas","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1172\/jci137556","article-title":"Hypoxia-inducible Factors and Diabetes","volume":"130","author":"Gunton","year":"2020","journal-title":"J. Clin. Invest."},{"key":"B20","first-page":"133","article-title":"Hepatic Lipid Metabolism","volume-title":"Molecular Pathology of Liver DiseasesMolecular Pathology Library","author":"Huang","year":"2010"},{"key":"B21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.toxlet.2020.06.009","article-title":"Roxadustat Attenuates Experimental Pulmonary Fibrosis In Vitro and In Vivo","volume":"331","author":"Huang","year":"2020","journal-title":"Toxicol. Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jphs.2019.12.002","article-title":"Effects of Orally Active Hypoxia Inducible Factor Alpha Prolyl Hydroxylase Inhibitor, FG4592 on Renal Fibrogenic Potential in Mouse Unilateral Ureteral Obstruction Model","volume":"142","author":"Kabei","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen Sensing by Metazoans: the central Role of the HIF Hydroxylase Pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cel."},{"key":"B24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/mi.2013.29","article-title":"Contribution of Epithelial Innate Immunity to Systemic protection Afforded by Prolyl Hydroxylase Inhibition in Murine Colitis","volume":"7","author":"Keely","year":"2014","journal-title":"Mucosal Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.phrs.2016.11.003","article-title":"Hypoxia-Inducible Factor Prolyl 4-hydroxylase Inhibition in Cardiometabolic Diseases","volume":"114","author":"Koivunen","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13046-020-01782-w","article-title":"Alcoholic Fatty Liver Disease Inhibited the Co-expression of Fmo5 and PPAR\u03b1 to Activate the NF-\u03baB Signaling Pathway, Thereby Reducing Liver Injury via Inducing Gut Microbiota Disturbance","volume":"40","author":"Kong","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nrneph.2015.82","article-title":"Anaemia in Kidney Disease: Harnessing Hypoxia Responses for Therapy","volume":"11","author":"Koury","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/014107688908200307","article-title":"Impaired Renal Tubular Function in Chronic Alcoholics","volume":"82","author":"Labib","year":"1989","journal-title":"J. R. Soc. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice","volume":"13","author":"Li","year":"2011","journal-title":"Cel Metab"},{"key":"B30","doi-asserted-by":"publisher","first-page":"101109","DOI":"10.1016\/j.redox.2019.101109","article-title":"HIF-1\u03b1 Protects against Oxidative Stress by Directly Targeting Mitochondria","volume":"25","author":"Li","year":"2019","journal-title":"Redox Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/0006-291x(70)90982-4","article-title":"Hepatic Microsomal Ethanol Oxidizing System (MEOS): Differentiation from Alcohol Dehydrogenase and NADPH Oxidase","volume":"40","author":"Lieber","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.alcohol.2004.07.008","article-title":"Alcoholic Fatty Liver: its Pathogenesis and Mechanism of Progression to Inflammation and Fibrosis","volume":"34","author":"Lieber","year":"2004","journal-title":"Alcohol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3389\/fphar.2020.01191","article-title":"Antianemia Drug Roxadustat (FG-4592) Protects against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways","volume":"11","author":"Long","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.3748\/wjg.v10.i16.2423","article-title":"Risk Factors for Alcoholic Liver Disease in China","volume":"10","author":"Lu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1002\/hep.22222","article-title":"Cytochrome P450 2E1 Contributes to Ethanol-Induced Fatty Liver in Mice","volume":"47","author":"Lu","year":"2008","journal-title":"Hepatology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.jhep.2017.06.014","article-title":"Hepatocyte-derived Macrophage Migration Inhibitory Factor Mediates Alcohol-Induced Liver Injury in Mice and Patients","volume":"67","author":"Marin","year":"2017","journal-title":"J. Hepatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/s1590-8658(02)80111-6","article-title":"Increased Liver Echogenicity at Ultrasound Examination Reflects Degree of Steatosis but Not of Fibrosis in Asymptomatic Patients with Mild\/moderate Abnormalities of Liver Transaminases","volume":"34","author":"Mathiesen","year":"2002","journal-title":"Dig. Liver Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.metabol.2008.03.010","article-title":"Increased Oxidative Stress Precedes the Onset of High-Fat Diet-Induced Insulin Resistance and Obesity","volume":"57","author":"Matsuzawa-Nagata","year":"2008","journal-title":"Metabolism"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3390\/nu10101457","article-title":"Gut Microbiota's Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics","volume":"10","author":"Meng","year":"2018","journal-title":"Nutrients"},{"key":"B40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/s1360-1385(02)02312-9","article-title":"Oxidative Stress, Antioxidants and Stress Tolerance","volume":"7","author":"Mittler","year":"2002","journal-title":"Trends Plant Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/cancers10010011","article-title":"Local Acetaldehyde-An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis","volume":"10","author":"Nieminen","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0203410","DOI":"10.1371\/journal.pone.0203410","article-title":"Alcohol Use Disorder Tied to Development of Chronic Kidney Disease: A Nationwide Database Analysis","volume":"13","author":"Pan","year":"2018","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ultrasmedbio.2018.10.011","article-title":"Utilizing Contrast-Enhanced Ultrasound Imaging for Evaluating Fatty Liver Disease Progression in Pre-clinical Mouse Models","volume":"45","author":"Pandit","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"B44","first-page":"258","article-title":"Role of Acetaldehyde in Mediating the Pharmacological and Behavioral Effects of Alcohol","volume":"29","author":"Quertemont","year":"2006","journal-title":"Alcohol. Res. Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.2337\/db14-0472","article-title":"HIF Prolyl 4-hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects against Obesity and Metabolic Dysfunction","volume":"63","author":"Rahtu-Korpela","year":"2014","journal-title":"Diabetes"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/612089","article-title":"Peroxisome Proliferator-Activated Receptor Alpha Target Genes","volume":"2010","author":"Rakhshandehroo","year":"2010","journal-title":"PPAR Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cmet.2017.10.008","article-title":"Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis","volume":"27","author":"Sanchez-Gurmaches","year":"2018","journal-title":"Cel Metab"},{"key":"B48","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3109\/0886022x.2011.649678","article-title":"Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney","volume":"34","author":"S\u00f6nmez","year":"2012","journal-title":"Ren. Fail."},{"key":"B49","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1681\/asn.2019060582","article-title":"Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice","volume":"31","author":"Sugahara","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/s0168-8278(02)00442-7","article-title":"Anti-tumor Necrosis Factor-Alpha Monoclonal Antibody Therapy in Severe Alcoholic Hepatitis","volume":"38","author":"Tilg","year":"2003","journal-title":"J. Hepatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/hep.1840090223","article-title":"Incomplete Compensation of Enhanced Hepatic Oxygen Consumption in Rats with Alcoholic Centrilobular Liver Necrosis","volume":"9","author":"Tsukamoto","year":"1989","journal-title":"Hepatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/978-1-4899-5181-6_27","article-title":"Alcohol: its Effect on the Kidney","author":"Van Thiel","year":"1977","journal-title":"Adv. Exp. Med. Biol."},{"key":"B53","first-page":"283","article-title":"Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms","volume":"38","author":"Varga","year":"2017","journal-title":"Alcohol. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrm4074","article-title":"Transcriptional Regulation of Hepatic Lipogenesis","volume":"16","author":"Wang","year":"2015","journal-title":"Nat. Rev. Mol. Cel. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3748\/wjg.v25.i12.1445","article-title":"Growing burden of Alcoholic Liver Disease in China: A Review","volume":"25","author":"Wang","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"15870","DOI":"10.1074\/jbc.RA120.015623","article-title":"Ascorbic Acid Enhances Low-Density Lipoprotein Receptor Expression by Suppressing Proprotein Convertase Subtilisin\/kexin 9 Expression","volume":"295","author":"Wang","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4842","DOI":"10.1039\/d0fo03475d","article-title":"Polysaccharide MCP Extracted from Morchella Esculenta Reduces Atherosclerosis in LDLR-Deficient Mice","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"B58","doi-asserted-by":"publisher","first-page":"E388","DOI":"10.1152\/ajpendo.00179.2013","article-title":"Adipose Tissue Inflammation Contributes to Short-Term High-Fat Diet-Induced Hepatic Insulin Resistance","volume":"305","author":"Wiedemann","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metabendocrinol. Metab."},{"key":"B59","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pharmthera.2017.06.007","article-title":"Targeting Inflammation for the Treatment of Alcoholic Liver Disease","volume":"180","author":"Xu","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"B60","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/s41419-021-03980-6","article-title":"Depdc5 Deficiency Exacerbates Alcohol-Induced Hepatic Steatosis via Suppression of PPAR\u03b1 Pathway","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"582455","DOI":"10.3389\/fnagi.2020.582455","article-title":"LongShengZhi Capsule Attenuates Alzheimer-like Pathology in APP\/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation","volume":"12","author":"Yin","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jhep.2018.10.037","article-title":"Effect of Ethanol on Lipid Metabolism","volume":"70","author":"You","year":"2019","journal-title":"J. Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.cmet.2019.09.016","article-title":"Adipocyte Hypoxia-Inducible Factor 2\u03b1 Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism","volume":"30","author":"Zhang","year":"2019","journal-title":"Cel Metab"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.895710\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T07:22:07Z","timestamp":1652167327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.895710\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":63,"alternative-id":["10.3389\/fphar.2022.895710"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.895710","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"article-number":"895710"}}