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Pharmacol."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by abnormal accumulation of hepatic fat and inflammatory response with complex pathogenesis. Over activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome triggers the secretion of interleukin (IL)-1\u03b2 and IL-18, induces pyroptosis, and promotes the release of a large number of pro-inflammatory proteins. All of which contribute to the development of NAFLD. There is a great deal of evidence indicating that plant-derived active ingredients are effective and safe for NAFLD management. This review aims to summarize the research progress of 31 active plant-derived components (terpenoids, flavonoids, alkaloids, and phenols) that alleviate lipid deposition, inflammation, and pyroptosis by acting on the NLRP3 inflammasome studied in both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> NAFLD models. These studies confirmed that the NLRP3 inflammasome and its related genes play a key role in NAFLD amelioration, providing a starting point for further study on the correlation of plant-derived compounds treatment with the NLRP3 inflammasome and NAFLD.<\/jats:p>","DOI":"10.3389\/fphar.2022.896899","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T07:35:40Z","timestamp":1660030540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Plant-derived bioactive compounds regulate the NLRP3 inflammasome to treat NAFLD"],"prefix":"10.3389","volume":"13","author":[{"given":"Qian","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QinMei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"874","DOI":"10.4161\/cc.7.7.5617","article-title":"The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver","volume":"7","author":"Beyer","year":"2008","journal-title":"Cell Cycle"},{"key":"B2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.plipres.2005.09.003","article-title":"Biogenesis, molecular regulation and function of plant isoprenoids","volume":"44","author":"Bouvier","year":"2005","journal-title":"Prog. 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