{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:28:44Z","timestamp":1790450924133,"version":"4.1.0"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005740","name":"Universidad Nacional del Sur","doi-asserted-by":"publisher","award":["PGI: 24\/B291 PGI: 24\/B261 PGI: 24\/Q108"],"award-info":[{"award-number":["PGI: 24\/B291 PGI: 24\/B261 PGI: 24\/Q108"]}],"id":[{"id":"10.13039\/501100005740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2019-0480 PICT 2020-1734 PICT 2018-03164 PICT 2020-01826"],"award-info":[{"award-number":["PICT 2019-0480 PICT 2020-1734 PICT 2018-03164 PICT 2020-01826"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Conventional treatments comprise drugs that only attenuate some of the symptoms, but fail to arrest or delay neuronal proteotoxicity that characterizes these diseases. Due to their diverse biological activities, imidazole rings are intensively explored as powerful scaffolds for the development of new bioactive molecules. By using <jats:italic>C. elegans,<\/jats:italic> our work aims to explore novel biological roles for these compounds. To this end, we have tested the <jats:italic>in vivo<\/jats:italic> anti-proteotoxic effects of imidazolium salts<jats:italic>.<\/jats:italic> Since NDs have been largely linked to impaired antioxidant defense mechanisms, we focused on 1-Mesityl-3-(3-sulfonatopropyl) imidazolium (MSI), one of the imidazolium salts that we identified as capable of improving iron-induced oxidative stress resistance in wild-type animals. By combining mutant and gene expression analysis we have determined that this protective effect depends on the activation of the Heat Shock Transcription Factor (HSF-1), whereas it is independent of other canonical cytoprotective molecules such as abnormal Dauer Formation-16 (DAF-16\/FOXO) and Skinhead-1 (SKN-1\/Nrf2). To delve deeper into the biological roles of MSI, we analyzed the impact of this compound on previously established <jats:italic>C. elegans<\/jats:italic> models of protein aggregation. We found that MSI ameliorates \u03b2-amyloid-induced paralysis in worms expressing the pathological protein involved in Alzheimer\u2019s Disease. Moreover, this compound also delays age-related locomotion decline in other proteotoxic <jats:italic>C. elegans<\/jats:italic> models, suggesting a broad protective effect. Taken together, our results point to MSI as a promising anti-proteotoxic compound and provide proof of concept of the potential of imidazole derivatives in the development of novel therapies to retard age-related proteotoxic diseases.<\/jats:p>","DOI":"10.3389\/fphar.2022.908696","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T06:17:32Z","timestamp":1653373052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["1-Mesityl-3-(3-Sulfonatopropyl) Imidazolium Protects Against Oxidative Stress and Delays Proteotoxicity in C. elegans"],"prefix":"10.3389","volume":"13","author":[{"given":"Natalia","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Veuthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Fabian","family":"Silbestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Rayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s10856-020-6361-4","article-title":"\u03b2-Cyclodextrin Coating: Improving Biocompatibility of Magnetic Nanocomposites for Biomedical Applications","volume":"31","author":"Agotegaray","year":"2020","journal-title":"J. Mater Sci. Mater Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.5483\/bmbrep.2016.49.2.261","article-title":"The Role of insulin\/IGF-1 Signaling in the Longevity of Model Invertebrates, C. elegans and D. melanogaster","volume":"49","author":"Altintas","year":"2016","journal-title":"BMB Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1146\/annurev-biochem-060809-095203","article-title":"Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease","volume":"80","author":"Anckar","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1016\/j.polymer.2010.02.006","article-title":"Imidazole- and Imidazolium-Containing Polymers for Biology and Material Science Applications","volume":"51","author":"Anderson","year":"2010","journal-title":"Polymer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion Body Formation Reduces Levels of Mutant Huntingtin and the Risk of Neuronal Death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.exger.2009.02.010","article-title":"Reserpine Ameliorates Abeta Toxicity in the Alzheimer's Disease Model in Caenorhabditis elegans","volume":"44","author":"Arya","year":"2009","journal-title":"Exp. Gerontol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1126\/science.1067389","article-title":"Chaperone Suppression of Alpha-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease","volume":"295","author":"Auluck","year":"2002","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1126\/science.1253168","article-title":"HSF-1-mediated Cytoskeletal Integrity Determines Thermotolerance and Life Span","volume":"346","author":"Baird","year":"2014","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"132712","DOI":"10.1016\/j.molstruc.2022.132712","article-title":"An Overview on Applications of SwissADME Web Tool in the Design and Development of Anticancer, Antitubercular and Antimicrobial Agents: A Medicinal Chemist's Perspective","volume":"1259","author":"Bakchi","year":"2022","journal-title":"J. Mol. Struct."},{"key":"B10","first-page":"163","volume-title":"Nervous System Ageing","author":"B\u00e9nard","year":"2016"},{"key":"B11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/s0070-2153(09)01206-x","article-title":"Looking beyond Development: Maintaining Nervous System Architecture","volume":"87","author":"B\u00e9nard","year":"2009","journal-title":"Curr. Top. Dev. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s13311-013-0192-7","article-title":"Natural Compounds May Open New Routes to Treatment of Amyloid Diseases","volume":"10","author":"Bieschke","year":"2013","journal-title":"Neurotherapeutics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0007021","DOI":"10.1371\/journal.pntd.0007021","article-title":"Diisopropylphenyl-imidazole (DII): A New Compound that Exerts Anthelmintic Activity through Novel Molecular Mechanisms","volume":"12","author":"Blanco","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative Stress and Parkinson's Disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051135","article-title":"A Supramolecular Approach to Structure-Based Design with A Focus on Synthons Hierarchy in Ornithine-Derived Ligands: Review, Synthesis, Experimental and In Silico Studies","volume":"25","author":"Bojarska","year":"2020","journal-title":"Molecules"},{"key":"B16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The Genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"7597","DOI":"10.1523\/jneurosci.0990-06.2006","article-title":"Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model","volume":"26","author":"Brignull","year":"2006","journal-title":"J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1073\/pnas.0405775102","article-title":"Longer Lifespan, Altered Metabolism, and Stress Resistance in Drosophila from Ablation of Cells Making Insulin-like Ligands","volume":"102","author":"Broughton","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/416507a","article-title":"Inherent Toxicity of Aggregates Implies a Common Mechanism for Protein Misfolding Diseases","volume":"416","author":"Bucciantini","year":"2002","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-2202-10-84","article-title":"Fast, Automated Measurement of Nematode Swimming (Thrashing) without Morphometry","volume":"10","author":"Buckingham","year":"2009","journal-title":"BMC Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrn1809","article-title":"Neural Plasticity in the Ageing Brain","volume":"7","author":"Burke","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2105607","DOI":"10.1155\/2019\/2105607","article-title":"Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View","volume":"2019","author":"Cenini","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1021\/cb300166p","article-title":"Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation","volume":"7","author":"Chafekar","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"23103","DOI":"10.3390\/ijms141123103","article-title":"Oxidative Stress Mechanisms Underlying Parkinson's Disease-Associated Neurodegeneration in C. elegans","volume":"14","author":"Chakraborty","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.8303295","article-title":"Green Fluorescent Protein as a Marker for Gene Expression","volume":"263","author":"Chalfie","year":"1994","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.3390\/molecules26164843","article-title":"Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in C. elegans Model of Parkinson's Disease","volume":"26","author":"Chalorak","year":"2021","journal-title":"Molecules"},{"key":"B27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","article-title":"Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress over the Last Decade","volume":"86","author":"Chiti","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1128\/MCB.01811-08","article-title":"The WD40 Repeat Protein WDR-23 Functions with the CUL4\/DDB1 Ubiquitin Ligase to Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans","volume":"29","author":"Choe","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3791\/50357","article-title":"In Vivo neuronal Calcium Imaging in C. elegans","volume":"74","author":"Chung","year":"2013","journal-title":"J. Vis. Exp."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1126\/science.1124646","article-title":"Opposing Activities Protect against Age-Onset Proteotoxicity","volume":"313","author":"Cohen","year":"2006","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrn2474","article-title":"The Insulin Paradox: Aging, Proteotoxicity and Neurodegeneration","volume":"9","author":"Cohen","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41586-019-1352-7","article-title":"Whole-animal Connectomes of Both Caenorhabditis elegans Sexes","volume":"571","author":"Cook","year":"2019","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"15022","DOI":"10.1038\/npjparkd.2015.22","article-title":"Delaying Aging Is Neuroprotective in Parkinson's Disease: a Genetic Analysis in C. elegans Models","volume":"1","author":"Cooper","year":"2015","journal-title":"NPJ Park. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.expneurol.2018.09.001","article-title":"\u03b1-Synuclein Expression from a Single Copy Transgene Increases Sensitivity to Stress and Accelerates Neuronal Loss in Genetic Models of Parkinson's Disease","volume":"310","author":"Cooper","year":"2018","journal-title":"Exp. Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1242\/jeb.135327","article-title":"Inhibition of the Oxidative Stress Response by Heat Stress in Caenorhabditis elegans","volume":"219","author":"Crombie","year":"2016","journal-title":"J. Exp. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nrd4578","article-title":"Mitigating Risk in Academic Preclinical Drug Discovery","volume":"14","author":"Dahlin","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"B37","doi-asserted-by":"publisher","first-page":"12045","DOI":"10.1073\/pnas.90.24.12045","article-title":"apl-1, a Caenorhabditis elegans Gene Encoding a Protein Related to the Human Beta-Amyloid Protein Precursor","volume":"90","author":"Daigle","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B38","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg to Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e1000450","DOI":"10.1371\/journal.pbio.1000450","article-title":"Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans","volume":"8","author":"David","year":"2010","journal-title":"PLoS Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41586-019-1524-5","article-title":"The Flight Response Impairs Cytoprotective Mechanisms by Activating the Insulin Pathway","volume":"573","author":"De Rosa","year":"2019","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1038\/s41467-019-09477-3","article-title":"Different Soluble Aggregates of A\u03b242 Can Give Rise to Cellular Toxicity through Different Mechanisms","volume":"10","author":"De","year":"2019","journal-title":"Nat. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.1038\/s41598-018-25984-7","article-title":"Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1\/DAF-16 Signalling","volume":"8","author":"Devagi","year":"2018","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1091\/mbc.e09-02-0170","article-title":"Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus","volume":"20","author":"Douglas","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1021\/jm000292e","article-title":"Prediction of Drug Absorption Using Multivariate Statistics","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"012066","DOI":"10.1088\/1742-6596\/1853\/1\/012066","article-title":"Multi Target-Directed Imidazole Derivatives for Neurodegenerative Diseases","volume":"1853","author":"Eliewi","year":"2021","journal-title":"J. Phys. Conf. Ser."},{"key":"B47","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1515\/revneuro.2010.21.3.187","article-title":"Structural Brain Changes in Aging: Courses, Causes and Cognitive Consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4161\/auto.4776","article-title":"Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of Beta-Amyloid Peptide in C. elegans","volume":"3","author":"Florez-McClure","year":"2007","journal-title":"Autophagy"},{"key":"B49","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending Healthy Life Span-Ffrom Yeast to Humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"B50","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1074\/jbc.M703339200","article-title":"Suppression of In Vivo Beta-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein","volume":"283","author":"Fonte","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.bj.2018.02.005","article-title":"Nrf2 Activation Attenuates the Early Suppression of Mitochondrial Respiration Due to the \u03b1-synuclein Overexpression","volume":"41","author":"Fu","year":"2018","journal-title":"Biomed. J."},{"key":"B52","doi-asserted-by":"publisher","first-page":"26188","DOI":"10.1074\/jbc.M710521200","article-title":"Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-Induced Neurodegeneration through Induction of Multiple Molecular Chaperones","volume":"283","author":"Fujikake","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"34908","DOI":"10.1074\/jbc.M506288200","article-title":"Active HSF1 Significantly Suppresses Polyglutamine Aggregate Formation in Cellular and Mouse Models","volume":"280","author":"Fujimoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ejmech.2014.01.030","article-title":"Benzimidazole: an Emerging Scaffold for Analgesic and Anti-inflammatory Agents","volume":"76","author":"Gaba","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e1000399","DOI":"10.1371\/journal.pgen.1000399","article-title":"Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity","volume":"5","author":"Gidalevitz","year":"2009","journal-title":"PLoS Genet."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009704","article-title":"The Stress of Protein Misfolding: from Single Cells to Multicellular Organisms","volume":"3","author":"Gidalevitz","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative Disease: Models, Mechanisms, and a New Hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Model Mech."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e00721","DOI":"10.1002\/prp2.721","article-title":"Drug Discovery: Insights from the Invertebrate Caenorhabditis elegans","volume":"9","author":"Giunti","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"B60","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1474-9726.2009.00459.x","article-title":"Different Dietary Restriction Regimens Extend Lifespan by Both Independent and Overlapping Genetic Pathways in C. elegans","volume":"8","author":"Greer","year":"2009","journal-title":"Aging Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"8613209","DOI":"10.1155\/2018\/8613209","article-title":"Inhibition of Protein Aggregation by Several Antioxidants","volume":"2018","author":"Hasanba\u0161i\u0107","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nbt.2786","article-title":"Clinical Development Success Rates for Investigational Drugs","volume":"32","author":"Hay","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.biocel.2013.02.012","article-title":"Role of \u03b1-synuclein Aggregation and the Nuclear Factor E2-Related Factor 2\/heme Oxygenase-1 Pathway in Iron-Induced Neurotoxicity","volume":"45","author":"He","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1111\/j.1471-4159.2008.05227.x","article-title":"Dopamine-induced Toxicity Is Synergistically Potentiated by Simultaneous HSP-90 and Akt Inhibition in Oligodendrocyte Progenitors","volume":"105","author":"Hemdan","year":"2008","journal-title":"J. Neurochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exger.2015.09.006","article-title":"Caenorhabditis elegans DAF-16\/FOXO Transcription Factor and its Mammalian Homologs Associate with Age-Related Disease","volume":"72","author":"Hesp","year":"2015","journal-title":"Exp. Gerontol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0014-19.2019","article-title":"In-Vivo Quantitative Image Analysis of Age-Related Morphological Changes of C. elegans Neurons Reveals a Correlation between Neurite Bending and Novel Neurite Outgrowths","volume":"6","author":"Hess","year":"2019","journal-title":"eNeuro"},{"key":"B67","doi-asserted-by":"publisher","first-page":"E4376","DOI":"10.1073\/pnas.1411649111","article-title":"Proteopathic Tau Seeding Predicts Tauopathy In Vivo","volume":"111","author":"Holmes","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1523\/jneurosci.5478-10.2011","article-title":"Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice","volume":"31","author":"Hoshino","year":"2011","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1126\/science.1083701","article-title":"Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor","volume":"300","author":"Hsu","year":"2003","journal-title":"Science"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer Mechanisms and Therapeutic Strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"6288","DOI":"10.1007\/s12035-015-9517-3","article-title":"A Systematic RNAi Screen of Neuroprotective Genes Identifies Novel Modulators of Alpha-Synuclein-Associated Effects in Transgenic Caenorhabditis elegans","volume":"53","author":"Jadiya","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.bbrc.2011.09.010","article-title":"Anti-Parkinsonian Effects of Bacopa Monnieri: Insights from Transgenic and Pharmacological Caenorhabditis elegans Models of Parkinson's Disease","volume":"413","author":"Jadiya","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative Stress in Parkinson's Disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective Role of Sirt1 in Mammalian Models of Huntington's Disease through Activation of Multiple Sirt1 Targets","volume":"18","author":"Jiang","year":"2011","journal-title":"Nat. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0047-6374(84)90150-7","article-title":"Arresting Development Arrests Aging in the Nematode Caenorhabditis elegans","volume":"28","author":"Johnson","year":"1984","journal-title":"Mech. Ageing Dev."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1074\/jbc.M110.177238","article-title":"A Cys-Loop Mutation in the Caenorhabditis elegans Nicotinic Receptor Subunit UNC-63 Impairs but Does Not Abolish Channel Function","volume":"286","author":"Jones","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding Function in Novel Targets: C. elegans as a Model Organism","volume":"5","author":"Kaletta","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"B78","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1101\/gad.1723409","article-title":"Systemic Regulation of Starvation Response in Caenorhabditis elegans","volume":"23","author":"Kang","year":"2009","journal-title":"Genes Dev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"B80","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans Mutant that Lives Twice as Long as Wild Type","volume":"366","author":"Kenyon","year":"1993","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The Genetics of Ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"B82","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1385\/1-59745-151-7:253","article-title":"Intracellular Ca2+ Imaging in C. elegans","volume":"351","author":"Kerr","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.compbiolchem.2018.05.008","article-title":"Computer-aided Drug Design and Virtual Screening of Targeted Combinatorial Libraries of Mixed-Ligand Transition Metal Complexes of 2-butanone Thiosemicarbazone","volume":"75","author":"Khan","year":"2018","journal-title":"Comput. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1080\/713803536","article-title":"Geldanamycin Induces Heat Shock Protein Expression through Activation of HSF1 in K562 Erythroleukemic Cells","volume":"48","author":"Kim","year":"1999","journal-title":"IUBMB Life"},{"key":"B85","doi-asserted-by":"publisher","first-page":"19548","DOI":"10.1038\/srep19548","article-title":"How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid \u03b2 Aggregation on Brain Lipid Bilayer?","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"B86","first-page":"67","article-title":"Geraniol, a Component of Plant Essential Oils-A Review of its Pharmacological Activities","volume":"7","author":"Kumar","year":"2015","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"14337","DOI":"10.1038\/ncomms14337","article-title":"Hormetic Heat Stress and HSF-1 Induce Autophagy to Improve Survival and Proteostasis in C. elegans","volume":"8","author":"Kumsta","year":"2017","journal-title":"Nat. Commun."},{"key":"B88","doi-asserted-by":"publisher","first-page":"13091","DOI":"10.1073\/pnas.95.22.13091","article-title":"The Genetics of Caloric Restriction in Caenorhabditis elegans","volume":"95","author":"Lakowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B89","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1046\/j.1471-4159.2003.01809.x","article-title":"Dopaminergic Neuronal Loss and Motor Deficits in Caenorhabditis elegans Overexpressing Human Alpha-Synuclein","volume":"86","author":"Lakso","year":"2003","journal-title":"J. Neurochem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1093\/hmg\/dds143","article-title":"\u03b1-Synuclein Expression and Nrf2 Deficiency Cooperate to Aggravate Protein Aggregation, Neuronal Death and Inflammation in Early-Stage Parkinson's Disease","volume":"21","author":"Lastres-Becker","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1038\/ncomms3753","article-title":"Soluble Forms of polyQ-Expanded Huntingtin rather Than Large Aggregates Cause Endoplasmic Reticulum Stress","volume":"4","author":"Leitman","year":"2013","journal-title":"Nat. Commun."},{"key":"B92","first-page":"711","article-title":"Kynuramines Induce Overexpression of Heat Shock Proteins in Pancreatic Cancer Cells via 5-hydroxytryptamine and MT1\/MT2 Receptors","volume":"66","author":"Leja-Szpak","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.3390\/ijms20163896","article-title":"Causative Links between Protein Aggregation and Oxidative Stress: A Review","volume":"20","author":"L\u00e9vy","year":"2019","journal-title":"Ijms"},{"key":"B94","doi-asserted-by":"publisher","first-page":"16208","DOI":"10.1523\/jneurosci.2911-10.2010","article-title":"Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy","volume":"30","author":"Liachko","year":"2010","journal-title":"J. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of Human Beta-Amyloid Peptide in Transgenic Caenorhabditis elegans","volume":"92","author":"Link","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B96","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s1056-8719(00)00107-6","article-title":"Drug-like Properties and the Causes of Poor Solubility and Poor Permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B97","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/j.1365-3040.2011.02278.x","article-title":"The Role of Class A1 Heat Shock Factors (HSFA1s) in Response to Heat and Other Stresses in Arabidopsis","volume":"34","author":"Liu","year":"2011","journal-title":"Plant Cell Environ."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/biot.201000183","article-title":"Modeling Human Diseases in Caenorhabditis elegans","volume":"5","author":"Markaki","year":"2010","journal-title":"Biotechnol. J."},{"key":"B99","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1017\/S0031182005008668","article-title":"Drug Resistance and Neurotransmitter Receptors of Nematodes: Recent Studies on the Mode of Action of Levamisole","volume":"131","author":"Martin","year":"2005","journal-title":"Parasitology"},{"key":"B100","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1021\/jm0492002","article-title":"A Bioavailability Score","volume":"48","author":"Martin","year":"2005","journal-title":"J. Med. Chem."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.4172\/2329-9533.1000158","article-title":"A Computational Approach for Mutational Analysis of KRAS Snps and Toxicity Prediction of Screened Compounds of Lethal G12R KRAS SNP","volume":"7","author":"Masood","year":"2018","journal-title":"J. Appl. Bioinforma. Comput. Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1750-1326-7-57","article-title":"Utility of an Improved Model of Amyloid-Beta (A\u03b21-42) Toxicity in Caenorhabditis elegans for Drug Screening for Alzheimer's Disease","volume":"7","author":"McColl","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"B103","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.cmet.2010.08.004","article-title":"Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans","volume":"12","author":"McColl","year":"2010","journal-title":"Cell Metab."},{"key":"B104","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molmed.2004.12.002","article-title":"Polyglutamine Expansion Diseases: Failing to Deliver","volume":"11","author":"Morfini","year":"2005","journal-title":"Trends Mol. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1101\/gad.1657108","article-title":"Proteotoxic Stress and Inducible Chaperone Networks in Neurodegenerative Disease and Aging","volume":"22","author":"Morimoto","year":"2008","journal-title":"Genes Dev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1101\/sqb.2012.76.010637","article-title":"The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease","volume":"76","author":"Morimoto","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The Threshold for Polyglutamine-Expansion Protein Aggregation and Cellular Toxicity Is Dynamic and Influenced by Aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B108","doi-asserted-by":"publisher","first-page":"7841","DOI":"10.1073\/pnas.140202897","article-title":"Hsp70 and Hsp40 Chaperones Can Inhibit Self-Assembly of Polyglutamine Proteins into Amyloid-like Fibrils","volume":"97","author":"Muchowski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1021\/jm015507e","article-title":"Simple Selection Criteria for Drug-like Chemical Matter","volume":"44","author":"Muegge","year":"2001","journal-title":"J. Med. Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.164.1","article-title":"Insulin\/Insulin-Like Growth Factor Signaling in C. elegans","author":"Murphy","year":"2013","journal-title":"WormBook"},{"key":"B111","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1073\/pnas.1604885113","article-title":"Extended Survival of Misfolded G85R SOD1-Linked ALS Mice by Transgenic Expression of Chaperone Hsp110","volume":"113","author":"Nagy","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B112","doi-asserted-by":"publisher","first-page":"9613090","DOI":"10.1155\/2019\/9613090","article-title":"Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B113","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1007\/s12035-015-9337-5","article-title":"Oxidative Stress in Neurodegenerative Diseases","volume":"53","author":"Niedzielska","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"21611","DOI":"10.1038\/srep21611","article-title":"Natural Thioallyl Compounds Increase Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating SKN-1\/Nrf","volume":"6","author":"Ogawa","year":"2016","journal-title":"Sci. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cell.2010.11.050","article-title":"Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions","volume":"144","author":"Olzscha","year":"2011","journal-title":"Cell"},{"key":"B116","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuro.2021.10.012","article-title":"Dihydropyrimidinone-derived Selenoesters Efficacy and Safety in an In Vivo Model of A\u03b2 Aggregation","volume":"88","author":"Pereira","year":"2022","journal-title":"Neurotoxicology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1091\/mbc.11.7.2335","article-title":"The Skn7 Response Regulator of Saccharomyces cerevisiae Interacts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress","volume":"11","author":"Raitt","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1002\/mnfr.201400014","article-title":"Amyloid-beta (A\u03b21-42)-Induced Paralysis in Caenorhabditis elegans Is Inhibited by the Polyphenol Quercetin through Activation of Protein Degradation Pathways","volume":"58","author":"Regitz","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00394-015-0894-1","article-title":"Resveratrol Reduces Amyloid-Beta (A\u03b21-42)-Induced Paralysis through Targeting Proteostasis in an Alzheimer Model of Caenorhabditis elegans","volume":"55","author":"Regitz","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"B120","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.tig.2013.01.010","article-title":"Worms under Stress: C. elegans Stress Response and its Relevance to Complex Human Disease and Aging","volume":"29","author":"Rodriguez","year":"2013","journal-title":"Trends Genet."},{"key":"B121","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/sqb.2007.72.068","article-title":"Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-Sensitive Strains","volume":"72","author":"Samuelson","year":"2007","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0264-9","article-title":"Metformin Treatment Reduces Motor and Neuropsychiatric Phenotypes in the zQ175 Mouse Model of Huntington Disease","volume":"51","author":"Sanchis","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/s0092-8674(00)81782-1","article-title":"Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions","volume":"95","author":"Saudou","year":"1998","journal-title":"Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.tma.2020.07.002","article-title":"The Heat Shock Transcription Factor HSF-1 Protects Caenorhabditis elegans from Peroxide Stress","volume":"4","author":"Servello","year":"2020","journal-title":"Translat. Med. Aging"},{"key":"B125","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2174\/1389557517666170228113656","article-title":"Imidazole: An Essential Edifice for the Identification of New Lead Compounds and Drug Development","volume":"18","author":"Shalmali","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"B126","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.2174\/1381612822666160226144333","article-title":"Imidazole Derivatives as Potential Therapeutic Agents","volume":"22","author":"Sharma","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1093\/hmg\/10.12.1307","article-title":"Geldanamycin Activates a Heat Shock Response and Inhibits Huntingtin Aggregation in a Cell Culture Model of Huntington's Disease","volume":"10","author":"Sittler","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"B128","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13065-020-00730-1","article-title":"Synthesis and Therapeutic Potential of Imidazole Containing Compounds","volume":"15","author":"Siwach","year":"2021","journal-title":"BMC Chem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1046\/j.1461-0248.2003.00528.x","article-title":"The Evolutionary and Ecological Role of Heat Shock Proteins","volume":"6","author":"S\u00f8rensen","year":"2003","journal-title":"Ecol. Lett."},{"key":"B130","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10522-008-9139-5","article-title":"Reserpine Can Confer Stress Tolerance and Lifespan Extension in the Nematode C. elegans","volume":"9","author":"Srivastava","year":"2008","journal-title":"Biogerontology"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07836","article-title":"Lipid-mediated Regulation of SKN-1\/Nrf in Response to Germ Cell Absence","volume":"4","author":"Steinbaugh","year":"2015","journal-title":"Elife"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.101.1","article-title":"Maintenance of C. elegans","author":"Stiernagle","year":"2006","journal-title":"WormBook"},{"key":"B133","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1096\/fj.03-0376fje","article-title":"Expression of the Small Heat-Shock Protein Hsp16-2 in Caenorhabditis elegans Is Suppressed by Ginkgo Biloba Extract EGb 761","volume":"17","author":"Strayer","year":"2004","journal-title":"FASEB J."},{"key":"B134","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40035-017-0077-5","article-title":"Protein Misfolding in Neurodegenerative Diseases: Implications and Strategies","volume":"6","author":"Sweeney","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"B135","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.arr.2011.12.006","article-title":"Dietary Restriction in Rats and Mice: a Meta-Analysis and Review of the Evidence for Genotype-dependent Effects on Lifespan","volume":"11","author":"Swindell","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"B136","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nature01108","article-title":"Specific Aspartyl and Calpain Proteases Are Required for Neurodegeneration in C. elegans","volume":"419","author":"Syntichaki","year":"2002","journal-title":"Nature"},{"key":"B137","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1093\/hmg\/ddr203","article-title":"Neuron-specific Proteotoxicity of Mutant Ataxin-3 in C. elegans: Rescue by the DAF-16 and HSF-1 Pathways","volume":"20","author":"Teixeira-Castro","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124455","article-title":"Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1\/Parkin Pathway in Models of Parkinson's Disease in Caenorhabditis elegans and the SH-Sy5y Cell Line","volume":"21","author":"Tsai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"142ra97","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1\u03b1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B140","doi-asserted-by":"publisher","first-page":"16010","DOI":"10.1038\/npjamd.2016.10","article-title":"Lifespan-regulating Genes in C. elegans","volume":"2","author":"Uno","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e1000027","DOI":"10.1371\/journal.pgen.1000027","article-title":"C. elegans Model Identifies Genetic Modifiers of Alpha-Synuclein Inclusion Formation during Aging","volume":"4","author":"van Ham","year":"2008","journal-title":"PLoS Genet."},{"key":"B142","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/s0197-4580(99)00087-1","article-title":"Mechanisms of Life Span Determination in Caenorhabditis elegans","volume":"20","author":"Vanfleteren","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"B143","doi-asserted-by":"publisher","first-page":"E7474","DOI":"10.1073\/pnas.1608928113","article-title":"Protein Aggregation as a Cellular Response to Oxidative Stress Induced by Heme and Iron","volume":"113","author":"Vasconcellos","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular Properties that Influence the Oral Bioavailability of Drug Candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"611904","DOI":"10.3389\/fnins.2020.611904","article-title":"Preventing Neurodegeneration by Controlling Oxidative Stress: The Role of OXR1","volume":"14","author":"Volkert","year":"2020","journal-title":"Front. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The Structure of the Nervous System of the Nematode Caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In Vivo demonstration that Alpha-Synuclein Oligomers Are Toxic","volume":"108","author":"Winner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1093\/hmg\/ddn025","article-title":"Heterodimer Formation of Wild-type and Amyotrophic Lateral Sclerosis-Causing Mutant Cu\/Zn-Superoxide Dismutase Induces Toxicity Independent of Protein Aggregation","volume":"17","author":"Witan","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B149","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1126\/science.aad2033","article-title":"Cytoplasmic Protein Aggregates Interfere with Nucleocytoplasmic Transport of Protein and RNA","volume":"351","author":"Woerner","year":"2016","journal-title":"Science"},{"key":"B150","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/b978-0-12-384878-9.00015-7","article-title":"Watching Worms Whither: Modeling Neurodegeneration in C. elegans","volume":"100","author":"Wolozin","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"34916","DOI":"10.1038\/srep34916","article-title":"Multiple Discrete Soluble Aggregates Influence Polyglutamine Toxicity in a Huntington's Disease Model System","volume":"6","author":"Xi","year":"2016","journal-title":"Sci. Rep."},{"key":"B152","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/jnc.13575","article-title":"Walking the Tightrope: Proteostasis and Neurodegenerative Disease","volume":"137","author":"Yerbury","year":"2016","journal-title":"J. Neurochem."},{"key":"B153","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1091\/mbc.E10-08-0721","article-title":"Genome-wide Analysis of Yeast Stress Survival and Tolerance Acquisition to Analyze the Central Trade-Off between Growth Rate and Cellular Robustness","volume":"22","author":"Zakrzewska","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"B154","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/bj20110621","article-title":"Inhibition of Polyglutamine-Mediated Proteotoxicity by Astragalus Membranaceus Polysaccharide through the DAF-16\/FOXO Transcription Factor in Caenorhabditis elegans","volume":"441","author":"Zhang","year":"2012","journal-title":"Biochem. J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.908696\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T06:17:43Z","timestamp":1653373063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.908696\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":154,"alternative-id":["10.3389\/fphar.2022.908696"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.908696","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,24]]},"article-number":"908696"}}