{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:06:51Z","timestamp":1790780811266,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Selective serotonin reuptake inhibitors (SSRIs) are widely used for a variety of diseases, and their impact on semen quality is unclear. We performed a systematic search in PubMed and Embase, and after a strict screening, we included 4 studies with a total of 222 male participants. In result, SSRIs reduced normal sperm morphology (95% CI [\u221216.29, \u22123.77],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002), sperm concentration (95%CI [\u221243.88, \u22124.18],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02), sperm motility (95%CI [\u221223.46, \u22120.47],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) and sperm DNA fragmentation index (DFI) (95% CI [6.66,21.93],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0002), without a statistically significant effect on semen volume (95%CI [\u22120.75,0.65],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.89). Moreover, the impact on both sperm morphology and sperm concentration were observed within the 3-month period of SSRIs use. In general, our meta-analysis showed that SSRIs have a negative effect on semen quality. More larger, randomized, well-controlled clinical studies should be conducted to support our conclusion.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.911489","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T05:27:39Z","timestamp":1663133259000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of SSRIs on Semen quality: A systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiarong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kancheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuteng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengqing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"E1621","DOI":"10.3390\/ijms21051621","article-title":"Proteomic analyses of human sperm cells: Understanding the role of proteins and molecular pathways affecting male reproductive health","volume":"21","author":"Agarwal","year":"2020","journal-title":"Int. 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