{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:21:13Z","timestamp":1789154473451,"version":"build-2803163510"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H<jats:sub>2<\/jats:sub>S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H<jats:sub>2<\/jats:sub>S biogenesis has been reported in a variety of vascular diseases and H<jats:sub>2<\/jats:sub>S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H<jats:sub>2<\/jats:sub>S-induced vasodilation. This review aimed to summarize and discuss the role of H<jats:sub>2<\/jats:sub>S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.<\/jats:p>","DOI":"10.3389\/fphar.2022.911704","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:13:22Z","timestamp":1654085602000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao-Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"613989","DOI":"10.3389\/fphar.2021.613989","article-title":"GYY4137 and Sodium Hydrogen Sulfide Relaxations Are Inhibited by L-Cysteine and KV7 Channel Blockers in Rat Small Mesenteric Arteries","volume":"12","author":"Abramavicius","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1515\/jcim-2020-0060","article-title":"Hydrogen Sulfide as a Mediator of Endothelium-dependent Relaxation Evoked by Moringa Oleifera Leaf Extract in Mesenteric Arterial Beds Isolated from L-NAME Hypertensive Rats","volume":"18","author":"Aekthammarat","year":"2020","journal-title":"J. Complement. Integr. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00210-011-0608-z","article-title":"Mechanism of Vasorelaxation and Role of Endogenous Hydrogen Sulfide Production in Mouse Aorta","volume":"383","author":"Al-Magableh","year":"2011","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"488","DOI":"10.4103\/1673-5374.320967","article-title":"The Short Form of the SUR1 and its Functional Implications in the Damaged Brain","volume":"17","author":"Alquisiras-Burgos","year":"2022","journal-title":"Neural. Regen. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1161\/CIRCULATIONAHA.118.036854","article-title":"HuR-ry up: How Hydrogen Sulfide Protects against Atherosclerosis","volume":"139","author":"Barton","year":"2019","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4454","DOI":"10.1002\/ehf2.13669","article-title":"Levosimendan-induced Venodilation Is Mediated by Opening of Potassium Channels","volume":"8","author":"Burkhoff","year":"2021","journal-title":"Esc. Heart. Fail."},{"key":"B7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ejphar.2019.03.019","article-title":"Potassium Channels Contribute to the Increased Sensitivity of the Rabbit Carotid Artery to Hydrogen Sulfide in Diabetes","volume":"853","author":"Centeno","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00424-014-1526-y","article-title":"Hydrogen Sulfide Impairs Shear Stress-Induced Vasodilation in Mouse Coronary Arteries","volume":"467","author":"Chai","year":"2015","journal-title":"Pflugers. Arch."},{"key":"B9","doi-asserted-by":"publisher","first-page":"H2316","DOI":"10.1152\/ajpheart.00331.2004","article-title":"Hydrogen Sulfide-Induced Relaxation of Resistance Mesenteric Artery Beds of Rats","volume":"287","author":"Cheng","year":"2004","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.exer.2013.10.004","article-title":"Pharmacological Actions of the Slow Release Hydrogen Sulfide Donor GYY4137 on Phenylephrine-Induced Tone in Isolated Bovine Ciliary Artery","volume":"116","author":"Chitnis","year":"2013","journal-title":"Exp. Eye. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/s0006-291x(03)00256-0","article-title":"The Regulatory Effect of Hydrogen Sulfide on Hypoxic Pulmonary Hypertension in Rats","volume":"302","author":"Chunyu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"105039","DOI":"10.1016\/j.phrs.2020.105039","article-title":"Searching for Novel Hydrogen Sulfide Donors: The Vascular Effects of Two Thiourea Derivatives","volume":"159","author":"Citi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1161\/CIRCULATIONAHA.119.045344","article-title":"CD4+ T-Cell Endogenous Cystathionine \u03b3 Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation","volume":"142","author":"Cui","year":"2020","journal-title":"Circulation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"H728","DOI":"10.1152\/ajpheart.00404.2021","article-title":"Hydrogen Sulfide-dependent Microvascular Vasodilation Is Improved Following Chronic Sulfhydryl-Donating Antihypertensive Pharmacotherapy in Adults with Hypertension","volume":"321","author":"Dillon","year":"2021","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/fcp.12461","article-title":"Potassium Channels in Vascular Smooth Muscle: a Pathophysiological and Pharmacological Perspective","volume":"33","author":"Dogan","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1139\/cjpp-2020-0302","article-title":"Modulation of Hydrogen Sulfide Synthesis Improves Heart Function and Endothelium-dependent Vasorelaxation in Diabetes","volume":"99","author":"Dorofeyeva","year":"2021","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1161\/HYPERTENSIONAHA.116.08964","article-title":"Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults","volume":"69","author":"Greaney","year":"2017","journal-title":"Hypertension"},{"key":"B18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00210-019-01752-w","article-title":"Vasorelaxation Elicited by Endogenous and Exogenous Hydrogen Sulfide in Mouse Mesenteric Arteries","volume":"393","author":"Hart","year":"2020","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/bph.12424","article-title":"KV 7 Channels Are Involved in Hypoxia-Induced Vasodilatation of Porcine Coronary Arteries","volume":"171","author":"Hedegaard","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"112641","DOI":"10.1016\/j.biopha.2022.112641","article-title":"Protective Role of Activating PPAR\u03b3 in Advanced Glycation End Products-Induced Impairment of Coronary Artery Vasodilation via Inhibiting P38 Phosphorylation and Reactive Oxygen Species Production","volume":"147","author":"Hua","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"H1446","DOI":"10.1152\/ajpheart.00506.2012","article-title":"Hydrogen Sulfide Dilates Rat Mesenteric Arteries by Activating Endothelial Large-Conductance Ca\u00b2\u207a-Activated K\u207a Channels and Smooth Muscle Ca\u00b2\u207a Sparks","volume":"304","author":"Jackson-Weaver","year":"2013","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1161\/CIRCRESAHA.110.228999","article-title":"Intermittent Hypoxia in Rats Increases Myogenic Tone through Loss of Hydrogen Sulfide Activation of Large-Conductance Ca2+-Activated Potassium Channels","volume":"108","author":"Jackson-Weaver","year":"2011","journal-title":"Circ. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e41951","DOI":"10.1371\/journal.pone.0041951","article-title":"Differential Effects of Cystathionine-\u03b3-lyase-dependent Vasodilatory H2S in Periadventitial Vasoregulation of Rat and Mouse Aortas","volume":"7","author":"K\u00f6hn","year":"2012","journal-title":"PLoS. One."},{"key":"B24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.exer.2015.04.001","article-title":"Inhibitory Action of Novel Hydrogen Sulfide Donors on Bovine Isolated Posterior Ciliary Arteries","volume":"134","author":"Kulkarni-Chitnis","year":"2015","journal-title":"Exp. Eye. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1113\/JP270054","article-title":"Evidence for a Functional Vasodilatatory Role for Hydrogen Sulphide in the Human Cutaneous Microvasculature","volume":"593","author":"Kutz","year":"2015","journal-title":"J. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.tins.2010.06.004","article-title":"BK Channel Activation: Structural and Functional Insights","volume":"33","author":"Lee","year":"2010","journal-title":"Trends. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cell.2016.12.028","article-title":"Structure of a Pancreatic ATP-Sensitive Potassium Channel","volume":"168","author":"Li","year":"2017","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/s41401-020-00549-5","article-title":"The Baroreflex Afferent Pathway Plays a Critical Role in H2S-Mediated Autonomic Control of Blood Pressure Regulation under Physiological and Hypertensive Conditions","volume":"42","author":"Li","year":"2021","journal-title":"Acta. Pharmacol. Sin."},{"key":"B29","doi-asserted-by":"publisher","first-page":"H2088","DOI":"10.1152\/ajpheart.01290.2010","article-title":"Hydrogen Sulfide Dilates Cerebral Arterioles by Activating Smooth Muscle Cell Plasma Membrane KATP Channels","volume":"300","author":"Liang","year":"2011","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.2147\/COPD.S314349","article-title":"Relationship between Endogenous Hydrogen Sulfide and Pulmonary Vascular Indexes on High-Resolution Computed Tomography in Patients with Chronic Obstructive Pulmonary Disease","volume":"16","author":"Liao","year":"2021","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1253\/circj.cj-11-0890","article-title":"Effects of H\u2082S on Myogenic Responses in Rat Cerebral Arterioles","volume":"76","author":"Liu","year":"2012","journal-title":"Circ. J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s11010-017-3264-x","article-title":"Decreased Coronary Arteriolar Response to KCa Channel Opener after Cardioplegic Arrest in Diabetic Patients","volume":"445","author":"Liu","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.3390\/cells9091956","article-title":"Clinical Importance of the Human Umbilical Artery Potassium Channels","volume":"9","author":"Lorigo","year":"2020","journal-title":"Cells"},{"key":"B34","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/fcp.12658","article-title":"Mechanisms Underlying the Vasorelaxant Effect of Hydrogen Sulfide on Human Saphenous Vein","volume":"35","author":"Marinko","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B35","first-page":"737","article-title":"Vasomotor Effects of Hydrogen Sulfide in Human Umbilical Vessels","volume":"68","author":"Mohammed","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"H1437","DOI":"10.1152\/ajpheart.00465.2016","article-title":"Hydrogen Sulfide-Induced Vasodilation Mediated by Endothelial TRPV4 Channels","volume":"311","author":"Naik","year":"2016","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12423","article-title":"Regulation of Voltage-Gated Potassium Channels in Vascular Smooth Muscle during Hypertension and Metabolic Disorders","volume":"25","author":"Nieves-Cintr\u00f3n","year":"2018","journal-title":"Microcirculation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.cca.2014.10.037","article-title":"Hydrogen Sulfide in Signaling Pathways","volume":"439","author":"Olas","year":"2015","journal-title":"Clin. Chim. Acta."},{"key":"B40","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bbrep.2017.09.010","article-title":"Vasoconstriction Triggered by Hydrogen Sulfide: Evidence for Na+, K+, 2Cl-cotransport and L-type Ca2+ Channel-Mediated Pathway","volume":"12","author":"Orlov","year":"2017","journal-title":"Biochem. Biophys. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1177\/0271678X19878284","article-title":"Vasodilator Effects of Sulforaphane in Cerebral Circulation: A Critical Role of Endogenously Produced Hydrogen Sulfide and Arteriolar Smooth Muscle KATP and BK Channels in the Brain","volume":"40","author":"Parfenova","year":"2020","journal-title":"J. Cereb. Blood. Flow. Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.3760\/cma.j.issn.0366-6999.20132503","article-title":"Role of BK(Ca) Channels in Diabetic Vascular Complications","volume":"127","author":"Qian","year":"2014","journal-title":"Chin. Med. J. Engl."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12425","article-title":"Molecular Determinants of Beta-Adrenergic Signaling to Voltage-Gated K+ Channels in the Cerebral Circulation","volume":"25","author":"Rhee","year":"2018","journal-title":"Microcirculation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3390\/cells10061477","article-title":"Hydrogen Sulfide Metabolism and Pulmonary Hypertension","volume":"10","author":"Roubenne","year":"2021","journal-title":"Cells"},{"key":"B45","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nrn1992.8","article-title":"High-conductance Potassium Channels of the SLO Family","volume":"7","author":"Salkoff","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1097\/HJH.0b013e32833c20d5","article-title":"Systemic Peripheral Artery Relaxation by KCNQ Channel Openers and Hydrogen Sulfide","volume":"28","author":"Schleifenbaum","year":"2010","journal-title":"J. Hypertens."},{"key":"B47","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/FJC.0000000000000917","article-title":"Anticontractile Effect of Perivascular Adipose Tissue but Not of Endothelium Is Enhanced by Hydrogen Sulfide Stimulation in Hypertensive Pregnant Rat Aortae","volume":"76","author":"Souza-Paula","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00210-012-0779-2","article-title":"An Investigation of the Mechanisms of Hydrogen Sulfide-Induced Vasorelaxation in Rat Middle Cerebral Arteries","volume":"385","author":"Streeter","year":"2012","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","article-title":"Potential Biomarkers Predicting Risk of Pulmonary Hypertension in Congenital Heart Disease: the Role of Homocysteine and Hydrogen Sulfide","volume":"127","author":"Sun","year":"2014","journal-title":"Chin. Med. J. Engl."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3760\/j.issn:0253-3758.2007.12.016","article-title":"Plasma Hydrogen Sulfide and Homocysteine Levels in Hypertensive Patients with Different Blood Pressure Levels and Complications","volume":"35","author":"Sun","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"B51","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00109-014-1227-1","article-title":"Hydrogen Sulfide Upregulates KATP Channel Expression in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats","volume":"93","author":"Sun","year":"2015","journal-title":"J. Mol. Med. Berl."},{"key":"B52","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/ars.2011.4451","article-title":"Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and its Complications","volume":"17","author":"Szabo","year":"2012","journal-title":"Antioxid. Redox. Signal."},{"key":"B53","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1080\/10641963.2017.1313847","article-title":"Early Short-Term Treatment with Exogenous Hydrogen Sulfide Postpones the Transition from Prehypertension to Hypertension in Spontaneously Hypertensive Rat","volume":"40","author":"Tain","year":"2018","journal-title":"Clin. Exp. Hypertens."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1124\/mol.105.017467","article-title":"Direct Stimulation of K(ATP) Channels by Exogenous and Endogenous Hydrogen Sulfide in Vascular Smooth Muscle Cells","volume":"68","author":"Tang","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1089\/ars.2012.4805","article-title":"H\u2082S Is an Endothelium-Derived Hyperpolarizing Factor","volume":"19","author":"Tang","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"B56","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/bph.14700","article-title":"Anomalous Kv7 Channel Activity in Human Malignant Hyperthermia Syndrome Unmasks a Key Role for H2S and Persulfidation in Skeletal Muscle","volume":"177","author":"Vellecco","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3748\/wjg.v20.i4.1079","article-title":"Role of Hydrogen Sulfide in Portal Hypertension and Esophagogastric Junction Vascular Disease","volume":"20","author":"Wang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The Role of H2S Bioavailability in Endothelial Dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends. Pharmacol. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1111\/bph.15607","article-title":"Endothelium-derived Hydrogen Sulfide Acts as a Hyperpolarizing Factor and Exerts Neuroprotective Effects via Activation of Large-Conductance Ca2+ -activated K+ Channels","volume":"178","author":"Wen","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/j.1476-5381.2012.02187.x","article-title":"Hydrogen Sulphide-Mediated Vasodilatation Involves the Release of Neurotransmitters from Sensory Nerves in Pressurized Mesenteric Small Arteries Isolated from Rats","volume":"168","author":"White","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"7075682","DOI":"10.1155\/2016\/7075682","article-title":"Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway","volume":"2016","author":"Wu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/ki.2010.325","article-title":"The BK Potassium Channel in the Vascular Smooth Muscle and Kidney: \u03b1- and \u03b2-subunits","volume":"78","author":"Wu","year":"2010","journal-title":"Kidney. Int."},{"key":"B63","doi-asserted-by":"publisher","first-page":"H605","DOI":"10.1152\/ajpheart.00171.2015","article-title":"Analysis of Cardiovascular Responses to the H2S Donors Na2S and NaHS in the Rat","volume":"309","author":"Yoo","year":"2015","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.911704\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:13:28Z","timestamp":1654085608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.911704\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":63,"alternative-id":["10.3389\/fphar.2022.911704"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.911704","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"article-number":"911704"}}