{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:34Z","timestamp":1790009674715,"version":"4.0.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014760","name":"Ministry of Ecology and Environment, The People\u2019s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013801","name":"Minzu University of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> In southwest China, especially in Nujiang, lacquer oil from the drupes of <jats:italic>Toxicodendron vernicifluum<\/jats:italic> (Stokes) F. A. Barkley, including black lacquer oil (BLO) and white lacquer oil (WLO), is one of the most important edible oils for the local people. Through the field investigation, the locals believe that lacquer oil has benefits for parturient women and for the treatment of \u201cYuezi\u201d disease. However, studies on bioactivities and the chemical compositions of lacquer oil are limited.<\/jats:p><jats:p><jats:bold>Purpose:<\/jats:bold> This study was designed to reveal the mystery of lacquer oil for the treatment of \u201cYuezi\u201d disease by testing its anti-inflammatory and anti-postpartum depressant activities and related bioactive compounds.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The anti-inflammatory effects of lacquer oil were examined by establishing a lipopolysaccharide (LPS)-induced RAW264.7 cell inflammation model and detecting the level of pro-inflammatory factors such as NO, IL-6 and TNF-\u03b1. The antidepressant effects of lacquer oil were studied by building a mouse model of postpartum depression (PPD), and the animal behavior changes of PPD model mice were assessed by open field test (OFT), forced swimming test (FST) and tail suspension test (TST). The chemical profiles of BLO and WLO were detected by lipidomic and the untargeted metabolomic research methods based on UPLC-MS\/MS.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The results showed that BLO and WLO exerted anti-inflammatory effects by reducing the release of pro-inflammatory factors and BLO had better anti-inflammatory effects than WLO. While only BLO had anti-postpartum depressant activities, as evidenced by the significantly reduced the immobility time of the BLO-treated PPD mice in TST and FST compared to the PPD model mice. The comparative lipidomic analysis revealed that BLO contained high levels of Diacylglycerols (DAG) and Diacylglyceryl trimethylhomoserines (DGTS) but low level of ceramides (Cer), sphingomyelines (SM), phosphatidylcholines (PC) and phosphatidylethanolamines (PE) compared with WLO. Metabolomics analysis showed that there were 57 chemical markers between BLO and WLO, of which 17 potential biomarkers have been declared to possess anti-inflammatory and\/or antidepressant activities.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The findings of this study furnish a scientific support for the traditional uses of lacquer oil for the treatment of \u201cYuezi\u201d disease from anti-inflammation and anti-postpartum depression perspective.<\/jats:p>","DOI":"10.3389\/fphar.2022.914951","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T04:40:44Z","timestamp":1655095244000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Lipidomic and Metabolomic Analyses Reveal the Mystery of Lacquer Oil from Toxicodendron vernicifluum for the Treatment of \u201cYuezi\u201d Disease in Nujiang, China: From Anti-Inflammation and Anti-Postpartum Depression Perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Liya","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3390\/brainsci10100733","article-title":"Antidepressant-like Properties of Fish Oil on Postpartum Depression-like Rats Model: Involvement of Serotonergic System","volume":"10","author":"Abdul Aziz","year":"2020","journal-title":"Brain Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1111\/aogs.12008","article-title":"Postpartum Infections: Occurrence, Healthcare Contacts and Association with Breastfeeding","volume":"91","author":"Ahnfeldt-Mollerup","year":"2012","journal-title":"Acta. Obstet. Gynecol. Scand."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1007\/s10811-012-9967-1","article-title":"New Diacylglyceryltrimethylhomoserines from the Marine Microalga Nannochloropsis Granulata and Their Nitric Oxide Inhibitory Activity","volume":"25","author":"Banskota","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3390\/molecules23040965","article-title":"The Role of Catechins in Cellular Responses to Oxidative Stress","volume":"23","author":"Bernatoniene","year":"2018","journal-title":"Molecules"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S115","DOI":"10.3233\/JIN-170072","article-title":"Fish Oil and Depression: The Skinny on Fats","volume":"16","author":"Burhani","year":"2017","journal-title":"J. Integr. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"743171","DOI":"10.1155\/2013\/743171","article-title":"Experimental Evidence of \u03c9-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases","volume":"2013","author":"Calviello","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.5546\/aap.2020.eng.154","article-title":"Postpartum Depression: Risks and Early Detection","volume":"118","author":"Ceriani Cernadas","year":"2020","journal-title":"Arch. Argent. Pediatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"104755","DOI":"10.1016\/j.phrs.2020.104755","article-title":"A Review of Pharmacological and Pharmacokinetic Properties of Stachydrine","volume":"155","author":"Cheng","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"951","DOI":"10.3349\/ymj.2015.56.4.951","article-title":"The Effects of a High Fat Diet Containing Diacylglycerol on Bone in C57BL\/6J Mice","volume":"56","author":"Choi","year":"2015","journal-title":"Yonsei Med. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s11011-017-0147-5","article-title":"Trigonelline Insulates against Oxidative Stress, Proinflammatory Cytokines and Restores BDNF Levels in Lipopolysaccharide Induced Cognitive Impairment in Adult Mice","volume":"33","author":"Chowdhury","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/13543776.2019.1568410","article-title":"Systematic Review and Technological Prospection: Ethyl Ferulate, a Phenylpropanoid with Antioxidant and Neuroprotective Actions","volume":"29","author":"Cunha","year":"2019","journal-title":"Expert. Opin. Ther. Pat."},{"key":"B12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/biof.1256","article-title":"Phloretin-Induced Cytoprotective Effects on Mammalian Cells: A Mechanistic View and Future Directions","volume":"42","author":"de Oliveira","year":"2016","journal-title":"Biofactors"},{"key":"B13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00210-018-1509-1","article-title":"Neuroprotective Evidence of Alpha-Lipoic Acid and Desvenlafaxine on Memory Deficit in a Neuroendocrine Model of Depression","volume":"391","author":"de Sousa","year":"2018","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/JMDH.S77766","article-title":"Role of Betaine in Improving the Antidepressant Effect of S-Adenosyl-Methionine in Patients with Mild-To-Moderate Depression","volume":"8","author":"Di Pierro","year":"2015","journal-title":"J. Multidiscip. Healthc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/s1286-4579(02)01613-1","article-title":"Toll Receptors, CD14, and Macrophage Activation and Deactivation by LPS","volume":"4","author":"Dobrovolskaia","year":"2002","journal-title":"Microbes Infect."},{"key":"B16","volume-title":"Flora Reipublicae Popularis Sinicae","year":"1980"},{"key":"B17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3969\/j.issn.1674-9391.2015.05.007","article-title":"The Lacquer Oil Diet Culture Theory of Lisu Nationality","volume":"6","author":"Gao","year":"2015","journal-title":"J. Ethnol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s12272-020-01285-4","article-title":"Phytochemical and Pharmacological Properties of Myristica Fragrans Houtt.: An Updated Review","volume":"43","author":"Ha","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"B19","first-page":"2","article-title":"Ethnobotanical Study on the Use of Toxicodendron Vernicifluum ( Stokes) F. A. Barkl. By Nu Nationality","volume":"4","author":"Han","year":"2012","journal-title":"J. Orig. Ecol. Natl. Cult."},{"key":"B20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.13422\/j.cnki.syfjx.20191302","article-title":"Effect of Isopimpinellin on Expression of Inhibitory Neurotransmitter and Receptor Genes in Primary Hippocampal Neurons","volume":"25","author":"Hao","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"B21","doi-asserted-by":"publisher","first-page":"8227","DOI":"10.1021\/acs.jafc.9b02680","article-title":"Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2\/ARE Signaling Pathway in PC12 Cells","volume":"67","author":"Hou","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"B22","first-page":"103","article-title":"The Ethnobotany and Development Strategy of \u201cBa Qi\u201d","volume":"43","author":"Hu","year":"2007","journal-title":"Sci. Silvae Sin."},{"key":"B23","doi-asserted-by":"publisher","first-page":"9501427","DOI":"10.1155\/2018\/9501427","article-title":"2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways","volume":"2018","author":"Jiang","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s12272-019-01174-5","article-title":"Hesperetin Inhibits Neuroinflammation on Microglia by Suppressing Inflammatory Cytokines and MAPK Pathways","volume":"42","author":"Jo","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.lfs.2013.02.006","article-title":"Anti-inflammatory Properties of Potato Glycoalkaloids in Stimulated Jurkat and Raw 264.7 Mouse Macrophages","volume":"92","author":"Kenny","year":"2013","journal-title":"Life Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.intimp.2018.06.019","article-title":"Trigonelline Mitigates Lipopolysaccharide-Induced Learning and Memory Impairment in the Rat Due to its Anti-oxidative and Anti-inflammatory Effect","volume":"61","author":"Khalili","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4062\/biomolther.2012.072","article-title":"Antidepressant-like Effects of Lycii Radicis Cortex and Betaine in the Forced Swimming Test in Rats","volume":"21","author":"Kim","year":"2013","journal-title":"Biomol. Ther. Seoul."},{"key":"B28","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1055\/s-0042-118188","article-title":"Anti-inflammatory Effects of Nortrachelogenin in Murine J774 Macrophages and in Carrageenan-Induced Paw Edema Model in the Mouse","volume":"83","author":"Laavola","year":"2017","journal-title":"Planta Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7132","DOI":"10.3390\/molecules16087132","article-title":"Anti-Inflammatory Effect of Myristicin on Raw 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid","volume":"16","author":"Lee","year":"2011","journal-title":"Molecules"},{"key":"B30","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1080\/08923973.2019.1680688","article-title":"Dl-Malic Acid as a Component of Alpha-Hydroxy Acids: Effect on 2,4-Dinitrochlorobenzene-Induced Inflammation in Atopic Dermatitis-like Skin Lesions In Vitro and In Vivo","volume":"41","author":"Lee","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1080\/10408398.2019.1650001","article-title":"Production, Safety, Health Effects and Applications of Diacylglycerol Functional Oil in Food Systems: A Review","volume":"60","author":"Lee","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3892\/etm.2017.4569","article-title":"Coumarins from the Roots of Angelica Dahurica Cause Anti-allergic Inflammation","volume":"14","author":"Li","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/jfpp.15047","article-title":"Analysis of Lacquer Oil Component in Four Main Producing Areas in Nujiang and Different Processing Methods Based on GC-MS and PCA","volume":"45","author":"Li","year":"2020","journal-title":"China Oils Fats"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12974-020-02069-9","article-title":"Microglial Deletion and Inhibition Alleviate Behavior of Post-traumatic Stress Disorder in Mice","volume":"18","author":"Li","year":"","journal-title":"J. Neuroinflamm."},{"key":"B43","doi-asserted-by":"publisher","first-page":"113476","DOI":"10.1016\/j.jep.2020.113476","article-title":"Traditional Uses, Phytochemistry, and Pharmacology of Toxicodendron Vernicifluum (Stokes) F.A. Barkley - A Review","volume":"267","author":"Li","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B34","first-page":"18","article-title":"Fatty Acids from the Seed Fats of Paint Tree","volume":"29","author":"Lin","year":"2002","journal-title":"Yunnan Chem. Technol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1007\/s00213-016-4359-x","article-title":"Betaine Enhances Antidepressant-like, but Blocks Psychotomimetic Effects of Ketamine in Mice","volume":"233","author":"Lin","year":"2016","journal-title":"Psychopharmacol. Berl."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nhs.12146","article-title":"\"Doing the Month\": Postpartum Practices in Chinese Women","volume":"17","author":"Liu","year":"2015","journal-title":"Nurs. Health Sci."},{"key":"B37","first-page":"131","article-title":"Ethnobotanical Studies in Gaoligong Mountains: I. The Lemo People","author":"Long","year":"1999","journal-title":"Acta. Bot. Yunnan"},{"key":"B38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1023\/a:1023911114431","article-title":"Lacquer-based Agroforestry System in Western Yunnan, China","volume":"57","author":"Long","year":"2003","journal-title":"Agroforest. Syst."},{"key":"B39","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide Modification in Gram-Negative Bacteria during Chronic Infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.6133\/apjcn.2016.25.2.03","article-title":"Self-reported Health Problems Related to Traditional Dietary Practices in Postpartum Women from Urban, Suburban and Rural Areas of Hubei Province, China: the 'zu\u00f2 Yu\u00e8zi'","volume":"25","author":"Mao","year":"2016","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1248\/cpb.53.387","article-title":"Inhibitors of Nitric Oxide Production from the Flowers of Angelica Furcijuga: Structures of Hyuganosides IV and V","volume":"53","author":"Matsuda","year":"2005","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of Inflammation, Neurogenic Inflammation, and Neuroinflammation in Pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J. Anesth."},{"key":"B44","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.1111\/jcmm.14551","article-title":"Stachydrine Prevents LPS-Induced Bone Loss by Inhibiting Osteoclastogenesis via NF-\u03baB and Akt Signalling","volume":"23","author":"Meng","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"458","DOI":"10.2174\/1568026615666150114161358","article-title":"Lipoic Acid: Its Antioxidant and Anti-inflammatory Role and Clinical Applications","volume":"15","author":"Moura","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3390\/nu11030648","article-title":"Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4\/NF-\u03baB Signaling","volume":"11","author":"Muhammad","year":"2019","journal-title":"Nutrients"},{"key":"B47","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.abb.2004.11.013","article-title":"Dehydrodiisoeugenol, an Isoeugenol Dimer, Inhibits Lipopolysaccharide-Stimulated Nuclear Factor Kappa B Activation and Cyclooxygenase-2 Expression in Macrophages","volume":"434","author":"Murakami","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"B48","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jad.2017.05.022","article-title":"Brain Antioxidant Effect of Mirtazapine and Reversal of Sedation by its Combination with Alpha-Lipoic Acid in a Model of Depression Induced by Corticosterone","volume":"219","author":"Oliveira","year":"2017","journal-title":"J. Affect. Disord."},{"key":"B49","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.yfrne.2018.12.001","article-title":"Pathophysiological Mechanisms Implicated in Postpartum Depression","volume":"52","author":"Payne","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3630","DOI":"10.3390\/ijms20153630","article-title":"Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites","volume":"20","author":"Pervin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.phymed.2016.11.014","article-title":"Fargesin Exerts Anti-inflammatory Effects in THP-1 Monocytes by Suppressing PKC-dependent AP-1 and NF-\u0138B Signaling","volume":"24","author":"Pham","year":"2017","journal-title":"Phytomedicine"},{"key":"B52","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1242\/dmm.024935","article-title":"Identification of Benzopyrone as a Common Structural Feature in Compounds with Anti-inflammatory Activity in a Zebrafish Phenotypic Screen","volume":"9","author":"Robertson","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"B53","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/biom9040127","article-title":"Antioxidant, Anti-Lung Cancer, and Anti-Bacterial Activities of Toxicodendron Vernicifluum","volume":"9","author":"Saravanakumar","year":"2019","journal-title":"Biomolecules"},{"key":"B54","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/bf02489414","article-title":"Betaine Lipids","volume":"105","author":"Sato","year":"1992","journal-title":"Bot. Mag. Tokyo."},{"key":"B55","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1089\/ars.2004.6.811","article-title":"Ethyl Ferulate, a Lipophilic Polyphenol, Induces HO-1 and Protects Rat Neurons against Oxidative Stress","volume":"6","author":"Scapagnini","year":"2004","journal-title":"Antioxid. Redox. Signal."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s10787-021-00827-6","article-title":"Protective Effect of (+)-catechin against Lipopolysaccharide-Induced Inflammatory Response in RAW 264.7 Cells through Downregulation of NF-\u03baB and P38 MAPK","volume":"29","author":"Sunil","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00041433-200302000-00006","article-title":"Diacylglycerol on Lipid Metabolism","volume":"14","author":"Tada","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s00011-017-1079-6","article-title":"Biochemical and Clinical Relevance of Alpha Lipoic Acid: Antioxidant and Anti-inflammatory Activity, Molecular Pathways and Therapeutic Potential","volume":"66","author":"Tibullo","year":"2017","journal-title":"Inflamm. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1249\/mss.0000000000000136","article-title":"Home-Based Active Video Games to Promote Weight Loss during the Postpartum Period","volume":"46","author":"Tripette","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1080\/14786419.2018.1448808","article-title":"Antidepressant-like Effect of Casimiroa Pubescens Root Extracts","volume":"33","author":"Ubaldo-Su\u00e1rez","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.13863\/j.issn1001-4454.2014.12.035","article-title":"Study on the Antidepressant Effect and Mechanism of Praeruptorin A in CUMS Rats","volume":"37","author":"Wang","year":"2014","journal-title":"J. Chin. Med. Mat."},{"key":"B63","first-page":"68","article-title":"Analysis of Fatty Acid Components of Lacquer Seed Oil and Wax in Nujiang Prefecture","volume":"34","author":"Wang","year":"2019","journal-title":"J. Chin. Cereals Oils Assoc."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e0251578","DOI":"10.1371\/journal.pone.0251578","article-title":"Ethyl Ferulate Contributes to the Inhibition of the Inflammatory Responses in Murine Raw 264.7 Macrophage Cells and Acute Lung Injury in Mice","volume":"16","author":"Wang","year":"2021","journal-title":"PLoS ONE"},{"key":"B65","first-page":"3+5","article-title":"Lacquer Wax ( Oil ) and its Comprehensive Utilization","volume":"22","author":"Wang","year":"2013","journal-title":"Chin. J. Ethnomed. Ethnopharm."},{"key":"B66","volume-title":"Maternal Mortality: Levels and Trends 2000 to 2017","year":"2019"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1038\/s41401-021-00742-0","article-title":"Ethyl Ferulate Protects against Lipopolysaccharide-Induced Acute Lung Injury by Activating Ampk\/Nrf2 Signaling Pathway","volume":"42","author":"Wu","year":"2021","journal-title":"Acta. Pharmacol. Sin."},{"key":"B68","volume-title":"Study on Constituents of Lacquer Oil in Nujiang and Investigation of its Current Situation and Tracking Evaluation of Some Local Food Safety Standards in Yunnan Province","author":"Xie","year":"2019"},{"key":"B69","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1139\/gen-2021-0043","article-title":"Proteomic and Lipidomics Analyses of High Fatty Acid Ahdgat3 Transgenic Soybean Reveals the Key Lipase Gene Associated with the Lipid Internal Mechanism","volume":"65","author":"Xu","year":"2022","journal-title":"Genome"},{"key":"B70","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/ptr.3295","article-title":"Praeruptorin A Inhibits Lipopolysaccharide-Induced Inflammatory Response in Murine Macrophages through Inhibition of NF-\u03baB Pathway Activation","volume":"25","author":"Yu","year":"2011","journal-title":"Phytother. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.theriogenology.2022.01.020","article-title":"Metabolomic Profiling of Dezhou Donkey Sperm Associated with Freezability","volume":"181","author":"Yu","year":"2022","journal-title":"Theriogenology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.3390\/molecules23061380","article-title":"Anti-inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice","volume":"23","author":"Yue","year":"2018","journal-title":"Molecules"},{"key":"B73","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.psyneuen.2016.01.013","article-title":"Postpartum Estrogen Withdrawal Impairs Hippocampal Neurogenesis and Causes Depression- and Anxiety-like Behaviors in Mice","volume":"66","author":"Zhang","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B74","first-page":"1","article-title":"The Resources and Exploitation of the Seeds from Rhus Vernicifua","volume":"36","author":"Zhang","year":"2017","journal-title":"Chin. Wild Plant Resour."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3389\/fimmu.2018.01070","article-title":"Betaine in Inflammation: Mechanistic Aspects and Applications","volume":"9","author":"Zhao","year":"2018","journal-title":"Front. Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"998","DOI":"10.13430\/j.cnki.jpgr.2011.06.001","article-title":"Survey of Agro-Bio-Resources and Their Traditional Knowledge in Dulong Community","volume":"12","author":"Zhou","year":"2011","journal-title":"J. Plant Genet. Resour."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.914951\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T04:40:59Z","timestamp":1655095259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.914951\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,13]]},"references-count":76,"alternative-id":["10.3389\/fphar.2022.914951"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.914951","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,13]]},"article-number":"914951"}}