{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:54:51Z","timestamp":1777737291903,"version":"3.51.4"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To test the hypothesis that the single use of fosaprepitant is not inferior to the use of palonosetron as antiemetic prophylaxis in the first 48\u00a0h after surgery in women undergoing laparoscopic cholecystectomy.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> Eighty-eight nonsmoking women (American Society of Anesthesiologists physical status I or II) aged between 18 and 60\u00a0years who underwent laparoscopic cholecystectomy received 150\u00a0mg of fosaprepitant or 75\u00a0\u03bcg of palonosetron, administered intravenously after the induction of general anesthesia.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In the fosaprepitant group and in the palonosetron group, 13.6 and 18.2% of the patients, respectively, vomited in the first 48\u00a0h after surgery (<jats:italic>p<\/jats:italic> = 0.560). There were no differences between groups in the total frequency and intensity of nausea, number of complete responders, need for rescue medication, time required for the first rescue medication dose or number of adverse events.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The administration of a single dose of fosaprepitant after the induction of anesthesia was as effective as the administration of a single dose of palonosetron for the prophylaxis of vomiting in the first 48\u00a0h after surgery in women undergoing laparoscopic cholecystectomy.<\/jats:p>","DOI":"10.3389\/fphar.2022.915347","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T05:04:00Z","timestamp":1652245440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Study Between Fosaprepitant and Palonosetron in the Prophylaxis of Postoperative Nausea and Vomiting in Women Undergoing Laparoscopic Cholecystectomy: Prospective, Randomized and Double-Blind Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Est\u00eav\u00e3o Luiz Carvalho","family":"Braga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nubia","family":"Ver\u00e7osa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismar Lima","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.2147\/cmar.s68102","article-title":"Palonosetron in the Management of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Multiple-Day Chemotherapy","volume":"6","author":"Affronti","year":"2014","journal-title":"Cancer Manag. 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