{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:54:35Z","timestamp":1774324475291,"version":"3.50.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2018YFA0107500 2019YFC1709402"],"award-info":[{"award-number":["2018YFA0107500 2019YFC1709402"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173369 31771511"],"award-info":[{"award-number":["82173369 31771511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Focal segmental glomerulosclerosis (FSGS) is a common clinical condition with manifestations of nephrotic syndrome and fibrosis of the glomeruli and interstitium. Yi-Shen-Hua-Shi (YSHS) granule has been shown to have a good effect in alleviating nephrotic syndrome (NS) in clinical and in animal models of FSGS, but whether it can alleviate renal fibrosis in FSGS and its mechanism and targets are not clear. In this study, we explored the anti-fibrotic effect and the targets of the YSHS granule in an adriamycin (ADR)-induced FSGS model and found that the YSHS granule significantly improved the renal function of ADR-induced FSGS model mice and also significantly reduced the deposition of collagen fibers and the expression of mesenchymal cell markers FN, vimentin, and \u03b1-SMA in the glomeruli of ADR-induced FSGS mice, suggesting that the YSHS granule inhibited the fibrosis of sclerotic glomeruli. Subsequently, a network pharmacology-based approach was used to identify the potential targets of the YSHS granule for the alleviation of glomerulosclerosis in FSGS, and the results showed that the YSHS granule down-regulated the expressions of BMP2, GSTA1, GATS3, BST1, and S100A9 and up-regulated the expressions of TTR and GATM in ADR-induced FSGS model mice. We also proved that the YSHS granule inhibited the fibrosis in the glomeruli of ADR-induced FSGS model mice through the suppression of the BMP2\/Smad signaling pathway.<\/jats:p>","DOI":"10.3389\/fphar.2022.917428","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T05:09:35Z","timestamp":1655269775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2\/Smad Signaling Pathway"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhuojing","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yachen","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/jcp.30529","article-title":"TGF-\u03b2 Signaling: A Recap of SMAD-Independent and SMAD-Dependent Pathways","volume":"237","author":"Aashaq","year":"2022","journal-title":"J. Cell Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrneph.2017.15510.1038\/nrneph.2017.175","article-title":"Dyslipidaemia in Nephrotic Syndrome: Mechanisms and Treatment","volume":"14","author":"Agrawal","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e20191699","DOI":"10.1084\/jem.20191699","article-title":"Loss of Decay-Accelerating Factor Triggers Podocyte Injury and Glomerulosclerosis","volume":"217","author":"Angeletti","year":"2020","journal-title":"J. Exp. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41581-018-0017-3","article-title":"GATM Mutations Cause Mitochondrial Abnormalities and Kidney Failure","volume":"14","author":"Carney","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1934578X2110216","DOI":"10.1177\/1934578X211021691","article-title":"Chemical Profile Assessment and Potential Bioactive Component Screening of a Chinese Patent Herbal Drug Yi-Shen-Hua-Shi Granule","volume":"16","author":"Chan","year":"2021","journal-title":"Nat. Product. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12967-019-2027-8","article-title":"A Novel Role of Glutathione S-Transferase A3 in Inhibiting Hepatic Stellate Cell Activation and Rat Hepatic Fibrosis","volume":"17","author":"Chen","year":"2019","journal-title":"J. Transl. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/hmg\/dds407","article-title":"L-Arginine:Glycine Amidinotransferase Deficiency Protects from Metabolic Syndrome","volume":"22","author":"Choe","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1056\/NEJMra1106556","article-title":"Focal Segmental Glomerulosclerosis","volume":"365","author":"D'Agati","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1515\/cclm-2021-0912","article-title":"Prospective Urinary Albumin\/Creatinine Ratio for Diagnosis, Staging, and Organ Response Assessment in Renal AL Amyloidosis: Results From a Large Cohort of Patients","volume":"60","author":"Basset","year":"2022","journal-title":"Clin. Chem. Lab Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mam.2018.06.002","article-title":"Cellular and Molecular Mechanisms of Kidney Fibrosis","volume":"65","author":"Djudjaj","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New Insights into the Mechanisms of Epithelial-Mesenchymal Transition and Implications for Cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"108897","DOI":"10.1016\/j.cbi.2019.108897","article-title":"Renoprotective Effect of Calycosin in High Fat Diet-Fed\/STZ Injected Rats: Effect on IL-33\/ST2 Signaling, Oxidative Stress and Fibrosis Suppression","volume":"315","author":"Elsherbiny","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"B13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.rmed.2011.12.010","article-title":"S100A9 in BALF Is a Candidate Biomarker of Idiopathic Pulmonary Fibrosis","volume":"106","author":"Hara","year":"2012","journal-title":"Respir. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione Transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"CD003233","DOI":"10.1002\/14651858.CD003233.pub3","article-title":"Interventions for Focal Segmental Glomerulosclerosis in Adults","volume":"2","author":"Hodson","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3803\/EnM.2020.35.2.384","article-title":"Gemigliptin Inhibits Interleukin-1\u03b2-Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway","volume":"35","author":"Hong","year":"2020","journal-title":"Endocrinol. Metab. Seoul."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","article-title":"Network Pharmacology","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network Pharmacology: The Next Paradigm in Drug Discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/aps.2016.36","article-title":"Paeoniflorin Suppresses TGF-\u03b2 Mediated Epithelial-Mesenchymal Transition in Pulmonary Fibrosis through a Smad-Dependent Pathway","volume":"37","author":"Ji","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.kint.2018.01.020","article-title":"Global Glomerulosclerosis in Primary Nephrotic Syndrome: Including Age as a Variable to Predict Renal Outcomes","volume":"93","author":"Kopp","year":"2018","journal-title":"Kidney Int."},{"key":"B21","first-page":"24p","volume-title":"Nei-Wai-Shang-Han-Bian-Huo-Lun","author":"Li","year":"2018"},{"key":"B22","doi-asserted-by":"publisher","first-page":"9752","DOI":"10.1111\/jcmm.15539","article-title":"Nodakenin Alleviated Obstructive Nephropathy through Blunting Snail1 Induced Fibrosis","volume":"24","author":"Li","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"106222","DOI":"10.1016\/j.phrs.2022.106222","article-title":"Sinomenine Hydrochloride Suppresses the Stemness of Breast Cancer Stem Cells by Inhibiting Wnt Signaling Pathway through Down-Regulation of WNT10B","volume":"179","author":"Li","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"W609","DOI":"10.1093\/nar\/gkq300","article-title":"PharmMapper Server: A Web Server for Potential Drug Target Identification Using Pharmacophore Mapping Approach","volume":"38","author":"Liu","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and Molecular Mechanisms of Renal Fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal Fibrosis: New Insights into the Pathogenesis and Therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int."},{"key":"B27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of Myofibroblasts and Cellular Events Triggering Fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e13004","DOI":"10.1111\/acel.13004","article-title":"Wnt\/\u03b2-Catenin\/RAS Signaling Mediates Age-Related Renal Fibrosis and is Associated with Mitochondrial Dysfunction","volume":"18","author":"Miao","year":"2019","journal-title":"Aging Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"BSR20180519","DOI":"10.1042\/BSR20180519","article-title":"Network Pharmacology-Based Identification of Major Component of Angelica Sinensis and its Action Mechanism for the Treatment of Acute Myocardial Infarction","volume":"38","author":"Niu","year":"2018","journal-title":"Biosci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.carbpol.2018.06.109","article-title":"Preparation and Renoprotective Effects of Carboxymethyl Chitosan Oligosaccharide on Adriamycin Nephropathy","volume":"201","author":"Qiao","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1681\/ASN.2017111179","article-title":"Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure","volume":"29","author":"Reichold","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: A Database of Systems Pharmacology for Drug Discovery from Herbal Medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3389\/fphar.2019.01596","article-title":"ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6\/JAK\/STAT3 Signaling Pathway","volume":"10","author":"Shen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.2174\/1381612824666180829103355","article-title":"Chinese Herbal Formulas and Renal Fibrosis: An Overview","volume":"24","author":"Shen","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B36","doi-asserted-by":"publisher","first-page":"F23","DOI":"10.1152\/ajprenal.00328.2011","article-title":"BMP-2 Induces a Profibrotic Phenotype in Adult Renal Progenitor Cells through Nox4 Activation","volume":"303","author":"Simone","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"12476","DOI":"10.1111\/jcmm.15779","article-title":"Celastrol Attenuates Arterial and Valvular Calcification via Inhibiting BMP2\/Smad1\/5 Signalling","volume":"24","author":"Su","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1111\/j.1582-4934.2012.01538.x","article-title":"Up-Regulation of BMP-2 Antagonizes TGF-\u03b21\/ROCK-Enhanced Cardiac Fibrotic Signalling through Activation of Smurf1\/Smad6 Complex","volume":"16","author":"Wang","year":"2012","journal-title":"J. Cell Mol. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1046\/j.1523-1755.2000.00342.x","article-title":"Progressive Adriamycin Nephropathy in Mice: Sequence of Histologic and Immunohistochemical Events","volume":"58","author":"Wang","year":"2000","journal-title":"Kidney Int."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.3892\/ol.2018.8989","article-title":"SMOC1 Silencing Suppresses the Angiotensin II-Induced Myocardial Fibrosis of Mouse Myocardial Fibroblasts via Affecting the BMP2\/Smad Pathway","volume":"16","author":"Wang","year":"2018","journal-title":"Oncol. Lett."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1681\/ASN.2005010055","article-title":"Podocyte Depletion Causes Glomerulosclerosis: Diphtheria Toxin-Induced Podocyte Depletion in Rats Expressing Human Diphtheria Toxin Receptor Transgene","volume":"16","author":"Wharram","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1142\/S0192415X17500586","article-title":"Tongxinluo Inhibits Renal Fibrosis in Diabetic Nephropathy: Involvement of the Suppression of Intercellular Transfer of TGF-[Formula: See Text]1-Containing Exosomes from GECs to GMCs","volume":"45","author":"Wu","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e0160855","DOI":"10.1371\/journal.pone.0160855","article-title":"GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression","volume":"11","author":"Xiao","year":"2016","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1177\/0300060519876796","article-title":"GSTA3 Regulates TGF-\u03b21-Induced Renal Interstitial Fibrosis in NRK-52E Cells as a Component of the PI3K-Keap1\/Nrf2 Pathway","volume":"47","author":"Xiao","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"194","DOI":"10.22038\/IJBMS.2018.19987.5255","article-title":"S100A9 Aggravates Bleomycin-Induced Dermal Fibrosis in Mice via Activation of ERK1\/2 MAPK and NF-\u03baB Pathways","volume":"21","author":"Xu","year":"2018","journal-title":"Iran. J. Basic Med. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.3390\/ijms13066964","article-title":"A Novel Chemometric Method for the Prediction of Human Oral Bioavailability","volume":"13","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1152\/physiol.00029.2013","article-title":"Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease","volume":"28","author":"Yabluchanskiy","year":"2013","journal-title":"Physiol. (Bethesda)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"12135","DOI":"10.1038\/s41598-021-91407-9","article-title":"S100A9\/CD163 Expression Profiles in Classical Monocytes as Biomarkers to Discriminate Idiopathic Pulmonary Fibrosis from Idiopathic Nonspecific Interstitial Pneumonia","volume":"11","author":"Yamashita","year":"2021","journal-title":"Sci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.7150\/thno.35686","article-title":"Conditional Knockout of TGF-\u03b2RII\/Smad2 Signals Protects against Acute Renal Injury by Alleviating Cell Necroptosis, Apoptosis and Inflammation","volume":"9","author":"Yang","year":"2019","journal-title":"Theranostics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1002\/jcb.23180","article-title":"BMP-2 Suppresses Renal Interstitial Fibrosis by Regulating Epithelial-Mesenchymal Transition","volume":"112","author":"Yang","year":"2011","journal-title":"J. Cell Biochem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1210\/en.2008-0090","article-title":"Bone Morphogenetic Protein-2 Antagonizes Renal Interstitial Fibrosis by Promoting Catabolism of Type I Transforming Growth Factor-Beta Receptors","volume":"150","author":"Yang","year":"2009","journal-title":"Endocrinology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.yexcr.2016.06.005","article-title":"Berberine Attenuates High Glucose-Induced Fibrosis by Activating the G Protein-Coupled Bile Acid Receptor TGR5 and Repressing the S1P2\/MAPK Signaling Pathway in Glomerular Mesangial Cells","volume":"346","author":"Yang","year":"2016","journal-title":"Exp. Cell Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1042\/CS20200030","article-title":"Inhibition of ROCK2 Alleviates Renal Fibrosis and the Metabolic Disorders in the Proximal Tubular Epithelial Cells","volume":"134","author":"You","year":"2020","journal-title":"Clin. Sci. (Lond)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1111\/liv.14509","article-title":"Extensively Expanded Murine-Induced Hepatic Stem Cells Maintain High-Efficient Hepatic Differentiation Potential for Repopulation of Injured Livers","volume":"40","author":"Yu","year":"2020","journal-title":"Liver Int."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.7150\/thno.48679","article-title":"Histone Demethylase JMJD3 Protects against Renal Fibrosis by Suppressing TGF\u03b2 and Notch Signaling and Preserving PTEN Expression","volume":"11","author":"Yu","year":"2021","journal-title":"Theranostics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B57","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.phymed.2013.02.010","article-title":"Paeoniflorin of Paeonia Lactiflora Prevents Renal Interstitial Fibrosis Induced by Unilateral Ureteral Obstruction in Mice","volume":"20","author":"Zeng","year":"2013","journal-title":"Phytomedicine"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.biopha.2016.10.036","article-title":"The Protective Role of Liquiritin in High Fructose-Induced Myocardial Fibrosis via Inhibiting NF-\u03baB and MAPK Signaling Pathway","volume":"84","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"B59","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jep.2019.02.044","article-title":"A Patent Herbal Drug Yi-Shen-Hua-Shi Granule Ameliorates C-BSA-Induced Chronic Glomerulonephritis and Inhabits TGF\u03b2 Signaling in Rats","volume":"236","author":"Zhao","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"616378","DOI":"10.3389\/fphar.2020.616378","article-title":"Formononetin Activates the Nrf2\/ARE Signaling Pathway via Sirt1 to Improve Diabetic Renal Fibrosis","volume":"11","author":"Zhuang","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.917428\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T05:09:41Z","timestamp":1655269781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.917428\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":60,"alternative-id":["10.3389\/fphar.2022.917428"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.917428","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"article-number":"917428"}}