{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:38:21Z","timestamp":1790969901770,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Thyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the gastrointestinal system, to its unique skin-related activities, the investigation of the medicinal properties of thyme has always been an alluring topic for researchers aiming to develop conventional medications from this traditional herb. With an incentive to contribute to the extensive thyme research, three<jats:italic>Thymus<\/jats:italic>L. species namely<jats:italic>Thymus cariensis<\/jats:italic>Hub-Mor. &amp;amp; Jalas (endemic),<jats:italic>Thymus praceox<\/jats:italic>subsp.<jats:italic>grossheimii<\/jats:italic>(Ronniger) Jalas, and<jats:italic>Thymus pubescens<\/jats:italic>Boiss. et Kotschy ex Celak from Turkey were deeply investigated within this study. The analysis of the phytochemical constituents of the extracts was conducted by LC-MS\/MS. 12 biologically important secondary metabolites (<jats:italic>p<\/jats:italic>-coumaric acid, caffeic acid, salicylic acid, quinic acid, fumaric acid, vanillin, malic acid, rutin, apigenin, naringenin, and nicotiflorin) were detected in all extracts. Their total phenolic and flavonoid contents were calculated (11.15 \u00b1 0.17\u201461.12 \u00b1 2.59\u00a0\u03bcg PEs\/mg extract, 2.53 \u00b1 0.04\u201440.28 \u00b1 0.92\u00a0\u03bcg QEs\/mg extract, respectively), and the antioxidant potential of the extracts was evaluated by DPPH and ABTS radical scavenging and CUPRAC activity methods, accordingly, the extracts were shown to possess significant antioxidant activity. Among them,<jats:italic>Thymus cariensis<\/jats:italic>Hub-Mor. &amp;amp; Jalas was the most active with IC<jats:sub>50<\/jats:sub>values of 34.97 \u00b1 1.00\u00a0\u03bcg\/ml and 9.98 \u00b1 0.04\u00a0\u03bcg\/ml regarding the DPPH and ABTS radical scavenging assays, respectively, and an A<jats:sub>0.5<\/jats:sub>value of 5.80 \u00b1 0.02\u00a0\u03bcg\/ml according to CUPRAC activity method. Their anticholinesterase, antityrosinase, and antiurease activities were also tested,<jats:italic>Thymus cariensis<\/jats:italic>Hub-Mor. &amp;amp; Jalas (35.61 \u00b1 1.20%) and<jats:italic>Thymus pubescens<\/jats:italic>Boiss. et Kotschy ex Celak aerial part extract (33.49 \u00b1 1.39%) exhibited moderate antibutyrylcholinesterase activity at 200\u00a0\u03bcg\/ml concentration. The results of the cell viability assay indicated that the extracts demonstrated moderate-to-low cytotoxicity on A498 human renal cell lines. Furthermore, all studied extracts exerted noteworthy antimicrobial activity, especially against<jats:italic>Candida tropicalis<\/jats:italic>(MIC values: 19.53\u201478.12\u00a0\u03bcg\/ml). The presented data substantiates the use of thyme extracts as therapeutic agents in both ethnomedicine and conventional therapies.<\/jats:p>","DOI":"10.3389\/fphar.2022.923063","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T05:57:05Z","timestamp":1654754225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Therapeutic Potential of Ethnomedicinally Important Anatolian Thyme Species: A Phytochemical and Biological Assessment"],"prefix":"10.3389","volume":"13","author":[{"given":"Esra","family":"Eroglu Ozkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeter","family":"Yesil Canturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Mataraci Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Cinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Karahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Karaca Sancaktepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Boga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"B64","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.1021\/jf048741x","article-title":"Novel Total Antioxidant Capacity Index for Dietary Polyphenols and Vitamins C and E, Using Their Cupric Ion Reducing Capability in the Presence of Neocuproine: CUPRAC Method","volume":"52","author":"Apak","year":"2004","journal-title":"J. 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