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During the pathogenesis of this degenerative joint lesion, several local inflammatory responses are activated, resulting in synovial proliferation and pannus formation that facilitates the destruction of the bone and the articular cartilage. The commonly used drugs for the clinical diagnosis and treatment of OA have limitations such as low bioavailability, short half-life, poor targeting, and high systemic toxicity. With the application of nanomaterials and intelligent nanomedicines, novel nanotherapeutic strategies have shown more specific targeting, prolonged half-life, refined bioavailability, and reduced systemic toxicity, compared to the existing medications. In this review, we summarized the recent advancements in new nanotherapeutic strategies for OA and provided suggestions for improving the treatment of OA.<\/jats:p>","DOI":"10.3389\/fphar.2022.924387","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T05:05:04Z","timestamp":1655787904000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Recent Advances in Nano-Therapeutic Strategies for Osteoarthritis"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinjing","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s10787-021-00833-8","article-title":"Biosynthesis of Gold Nanoparticles for the Treatment of Osteoarthritis Alone or in Combination with Diacerein\u00ae in a Rat Model","volume":"29","author":"Abdel-Aziz","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.actbio.2018.04.015","article-title":"Protective Therapeutic Effects of Peptide Nanofiber and Hyaluronic Acid Hybrid Membrane in In Vivo Osteoarthritis Model","volume":"73","author":"Arslan","year":"2018","journal-title":"Acta Biomater."},{"key":"B3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.joca.2015.07.010","article-title":"Charge Based Intra-cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-Carriers Suppresses Cytokine-Induced Catabolism Long Term","volume":"24","author":"Bajpayee","year":"2016","journal-title":"Osteoarthr. 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