{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:42Z","timestamp":1787169522481,"version":"build-2736575974"},"reference-count":183,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as \u201cpodocyte disease.\u201d There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations. Primary podocytosis mostly manifests as nephrotic syndrome. At present, first-line treatment is based on glucocorticoid administration combined with immunosuppressive therapy, but some patients still progress to end-stage renal disease. In Asia, especially in China, traditional Chinese medicine (TCM) still plays an important role in the treatment of kidney diseases. This study summarizes the potential mechanism of TCM and its active components in protecting podocytes, such as repairing podocyte injury, inhibiting podocyte proliferation, reducing podocyte apoptosis and excretion, maintaining podocyte skeleton structure, and upregulating podocyte-related protein expression. At the same time, the clinical efficacy of TCM in the treatment of primary podocytosis (including idiopathic membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis) is summarized to support the development of new treatment strategies for primary podocytosis.<\/jats:p>","DOI":"10.3389\/fphar.2022.932739","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:31:56Z","timestamp":1659918716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research"],"prefix":"10.3389","volume":"13","author":[{"given":"Lirong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/infdis\/jix171","article-title":"Zika Virus Infection of the Human Glomerular Cells: Implications for Viral Reservoirs and Renal Pathogenesis","volume":"216","author":"Alcendor","year":"2017","journal-title":"J. Infect. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/ckj\/sfy104","article-title":"First Report of Collapsing Variant of Focal Segmental Glomerulosclerosis Triggered by Arbovirus: Dengue and Zika Virus Infection","volume":"12","author":"Ara\u00fajo","year":"2018","journal-title":"Clin. Kidney J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ki.2014.428","article-title":"Fine-Tuning of NF\u03baB by Glycogen Synthase Kinase 3\u03b2 Directs the Fate of Glomerular Podocytes upon Injury","volume":"87","author":"Bao","year":"2015","journal-title":"Kidney Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.5858\/133.2.20110.1043\/1543-2165-133.2.201","article-title":"Advances in the Biology and Genetics of the Podocytopathies: Implications for Diagnosis and Therapy","volume":"133","author":"Barisoni","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/j.1523-1755.2004.00426.x","article-title":"Podocyte Injury Associated Glomerulopathies Induced by Pamidronate","volume":"65","author":"Barri","year":"2004","journal-title":"Kidney Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01913123.2020.1850962","article-title":"Ultrastructure of the Kidney Filtration Barrier in Conditions of Distant Tumor Growth and Lithium Treatment","author":"Bgatova","year":"2020","journal-title":"Ultrastruct. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.mayocp.2020.11.028","article-title":"A Target Antigen-Based Approach to the Classification of Membranous Nephropathy","volume":"96","author":"Bobart","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jep.2010.06.004","article-title":"Zhen-Wu-tang, a Blended Traditional Chinese Herbal Medicine, Ameliorates Proteinuria and Renal Damage of Streptozotocin-Induced Diabetic Nephropathy in Rats","volume":"1","author":"Cai","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5301\/JN.2010.5817","article-title":"Sirolimus Damages Podocytes in Rats with Protein Overload Nephropathy","volume":"24","author":"Cai","year":"2011","journal-title":"J. Nephrol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1681\/ASN.2013050564","article-title":"The Kidney as a Reservoir for HIV-1 after Renal Transplantation","volume":"25","author":"Canaud","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12906-019-2598-1","article-title":"Wenshen Jianpi Recipe, a Blended Traditional Chinese Medicine, Ameliorates Proteinuria and Renal Injury in a Rat Model of Diabetic Nephropathy. BMC Complement","volume":"1","author":"Cao","year":"2019","journal-title":"Altern. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.kint.2020.09.016","article-title":"Neural Cell Adhesion Molecule 1 Is a Novel Autoantigen in Membranous Lupus Nephritis","volume":"100","author":"Caza","year":"2021","journal-title":"Kidney Int."},{"key":"B14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1681\/ASN.2015060707","article-title":"MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration","volume":"29","author":"Cechova","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ckj\/sft002","article-title":"Viruses and Collapsing Glomerulopathy: a Brief Critical Review","volume":"6","author":"Chandra","year":"2013","journal-title":"Clin. Kidney J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.ekir.2021.01.036","article-title":"Decreasing Incidence of Acute Kidney Injury in Patients with COVID-19 Critical Illness in New York City","volume":"6","author":"Charytan","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"B17","first-page":"255","article-title":"Effect of Jiajianxiayuxuetang on Mice Podocyte Secretion of Vascular Endothelial Growth Factor Induced by Low-Density-Lipoprotein and Oxidant-Low Density Lipoprotein","volume":"5","author":"Chen","year":"2007","journal-title":"Chin. J. Integr. Tradit. West Med. Nephrol."},{"key":"B18","first-page":"647","article-title":"Effect of Dahuang Zhethong Pill on the Expression of Skeleton Protein Desmin in Podocyte Lesion Induced by Adriamycin","volume":"5","author":"Chen","year":"2008","journal-title":"Chin. Tradit. Pat. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1053\/j.ajkd.2013.05.005","article-title":"Efficacy and Safety of Traditional Chinese Medicine (Shenqi Particle) for Patients with Idiopathic Membranous Nephropathy: a Multicenter Randomized Controlled Clinical Trial","volume":"6","author":"Chen","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"153643","DOI":"10.1016\/j.phymed.2021.153643","article-title":"Atractylodis Rhizoma Water Extract Attenuates Fructose-Induced Glomerular Injury in Rats through Anti-oxidation to Inhibit TRPC6\/p-CaMK4 Signaling","volume":"91","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12882-015-0090-9","article-title":"Focal Segmental Glomerulosclerosis: Molecular Genetics and Targeted Therapies","volume":"16","author":"Chen","year":"2015","journal-title":"BMC Nephrol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.2215\/CJN.04650420","article-title":"The Incidence, Risk Factors, and Prognosis of Acute Kidney Injury in Adult Patients with Coronavirus Disease 2019","volume":"15","author":"Cheng","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0136508","DOI":"10.1371\/journal.pone.0136508","article-title":"Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications - A National Population-Based Cohort Study","volume":"10","author":"Chiu","year":"2015","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"675406","DOI":"10.3389\/fphar.2021.675406","article-title":"Herbal Medicine \"Shulifenxiao\" Formula for Nephrotic Syndrome of Refractory Idiopathic Membranous Nephropathy","volume":"12","author":"Cui","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7809427","DOI":"10.1155\/2020\/7809427","article-title":"\u03b2Alleviation by Mahuang Fuzi and Shenzhuo Decoction in High Glucose-Induced Podocyte Injury by Inhibiting the Activation of Wnt\/-Catenin Signaling Pathway, Resulting in Activation of Podocyte Autophagy","volume":"3","author":"Dai","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2615286","article-title":"Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy","volume":"2017","author":"Dai","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMoa012895","article-title":"Antenatal Membranous Glomerulonephritis Due to Anti-neutral Endopeptidase Antibodies","volume":"346","author":"Debiec","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.kint.2021.09.022","article-title":"When Contactin Antibodies Hit the Podocyte: a New Neurorenal Syndrome","volume":"100","author":"Debiec","year":"2021","journal-title":"Kidney Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"256ra136","DOI":"10.1126\/scitranslmed.3008538","article-title":"A Circulating Antibody Panel for Pretransplant Prediction of FSGS Recurrence after Kidney Transplantation","volume":"6","author":"Delville","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7351964","article-title":"Infection-Related Focal Segmental Glomerulosclerosis in Children","volume":"2016","author":"Dettmar","year":"2016","journal-title":"BioMed Res. Int."},{"key":"B31","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/sj.ki.5001574","article-title":"Proliferating Cells in HIV and Pamidronate-Associated Collapsing Focal Segmental Glomerulosclerosis Are Parietal Epithelial Cells","volume":"70","author":"Dijkman","year":"2006","journal-title":"Kidney Int."},{"key":"B32","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fphar.2021.724744","article-title":"Effect of Mahuang Fuzi and Shenzhuo Decoction on Idiopathic Membranous Nephropathy: A Multicenter, Nonrandomized, Single-Arm Clinical Trial","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B33","first-page":"939","article-title":"Mechanism of Chinese Herbal Medicine Delaying Progression of Chronic Kidney Disease","volume":"34","author":"Dou","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B34","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/ki.2015.101","article-title":"Combined Use of Nonsteroidal Anti-inflammatory Drugs with Diuretics And\/or Renin-Angiotensin System Inhibitors in the Community Increases the Risk of Acute Kidney Injury","volume":"88","author":"Dreischulte","year":"2015","journal-title":"Kidney Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e00817","DOI":"10.1002\/prp2.817","article-title":"Kidney Damage from Nonsteroidal Anti-inflammatory Drugs-Myth or Truth? Review of Selected Literature","volume":"9","author":"Dro\u017cd\u017cal","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.3109\/13880209.2015.1129543","article-title":"Mechanism of Ginsenoside Rg1 Renal Protection in a Mouse Model of D-Galactose-Induced Subacute Damage","volume":"9","author":"Fan","year":"2016","journal-title":"Pharm. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"775745","DOI":"10.3389\/fphar.2021.775745","article-title":"Integrated UPLC-MS and Network Pharmacology Approach to Explore the Active Components and the Potential Mechanism of Yiqi Huoxue Decoction for Treating Nephrotic Syndrome","volume":"12","author":"Feng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3389\/fphar.2020.00994","article-title":"How Does Herbal Medicine Treat Idiopathic Membranous Nephropathy?","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6876","DOI":"10.1038\/s41598-017-07028-8","article-title":"PLA2R Binds to the Annexin A2-S100a10 Complex in Human Podocytes","volume":"7","author":"Fresquet","year":"2017","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2215\/CJN.15161219","article-title":"APOL1 Nephropathy: From Genetics to Clinical Applications","volume":"16","author":"Friedman","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1093\/ndt\/gfq245","article-title":"Treatment of Db\/db Diabetic Mice with Triptolide: a Novel Therapy for Diabetic Nephropathy","volume":"11","author":"Gao","year":"2010","journal-title":"Nephrol. Dial. Transpl."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e28157","DOI":"10.1097\/MD.0000000000028157","article-title":"Calcineurin Inhibitor Therapy in Combination with Tripterygium Wilfordii Polyglycoside Tablets for Idiopathic Membranous Nephropathy: A Retrospective Clinical Observation","volume":"51","author":"Gao","year":"2021","journal-title":"Med. Baltim."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000481633","article-title":"A Review of Podocyte Biology","volume":"47","author":"Garg","year":"2018","journal-title":"Am. J. Nephrol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1681\/ASN.2013090976","article-title":"Mutations in the Gene that Encodes the F-Actin Binding Protein Anillin Cause FSGS","volume":"25","author":"Gbadegesin","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00431-020-03792-4","article-title":"Prevalence of and Factors Associated to Chronic Kidney Disease and Hypertension in a Cohort of Children with Juvenile Idiopathic Arthritis","volume":"180","author":"Gicchino","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"B46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.xkme.2020.10.005","article-title":"Diabetic Kidney Disease, Endothelial Damage, and Podocyte-Endothelial Crosstalk","volume":"3","author":"Gil","year":"2021","journal-title":"Kidney Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"F1168","DOI":"10.1152\/ajprenal.00145.2016","article-title":"What We Need to Know about the Effect of Lithium on the Kidney","volume":"311","author":"Gong","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0175242","DOI":"10.1371\/journal.pone.0175242","article-title":"Cyclosporine A Alters Expression of Renal microRNAs: New Insights into Calcineurin Inhibitor Nephrotoxicity","volume":"12","author":"Gooch","year":"2017","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1097\/QAD.0b013e32835f1ea1","article-title":"Deletion of Podocyte STAT3 Mitigates the Entire Spectrum of HIV-1-Associated Nephropathy","volume":"27","author":"Gu","year":"2013","journal-title":"AIDS"},{"key":"B50","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/biom11040513","article-title":"Mechanisms of Primary Membranous Nephropathy","volume":"11","author":"Gu","year":"2021","journal-title":"Biomolecules"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.3892\/mmr.2016.5786","article-title":"Glycogen Synthase Kinase-3\u03b2 Is Required for Epithelial-Mesenchymal Transition and Barrier Dysfunction in Mouse Podocytes under High Glucose Conditions","volume":"14","author":"Guo","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1681\/ASN.2017121338","article-title":"ANLNThe Human -Causing R431C Mutation Induces Dysregulated PI3K\/AKT\/mTOR\/Rac1 Signaling in Podocytes","volume":"8","author":"Hall","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1681\/ASN.2017121338","article-title":"The Human FSGS-Causing R431C Mutation Induces Dysregulated PI3K\/AKT\/mTOR\/Rac1 Signaling in Podocytes","volume":"8","author":"Hall","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/cells9010044","article-title":"TRPC Channels in Proteinuric Kidney Diseases","volume":"9","author":"Hall","year":"2019","journal-title":"Cells"},{"key":"B55","first-page":"1496","article-title":"Clinical Observation of Shen No. 9 Recipe with Qingre Moshen Granule on the Treatment of Idiopathic Membranous Nephropathy after Treated by Multiple Western Drugs with No Efficacy","volume":"31","author":"Han","year":"2011","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B56","doi-asserted-by":"publisher","first-page":"bcr0720114531","DOI":"10.1136\/bcr.07.2011.4531","article-title":"The Development of Focal Segmental Glomerulosclerosis Secondary to Anabolic Steroid Abuse","volume":"2011","author":"Harrington","year":"2011","journal-title":"BMJ Case Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.2215\/CJN.04560421","article-title":"Evidence for and against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19","volume":"16","author":"Hassler","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000497325","article-title":"CD44-Positive Glomerular Parietal Epithelial Cells in a Mouse Model of Calcineurin Inhibitors-Induced Nephrotoxicity","volume":"142","author":"Hayashi","year":"2019","journal-title":"Nephron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.fct.2007.12.005","article-title":"Amelioration of Anti-cancer Agent Adriamycin-Induced Nephrotic Syndrome in Rats by Wulingsan (Gorei-San), a Blended Traditional Chinese Herbal Medicine","volume":"5","author":"He","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.2147\/DMSO.S253494","article-title":"Yu Nu Compound Regulates Autophagy and Apoptosis through mTOR In Vivo and Vitro","volume":"13","author":"He","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B61","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/s41401-021-00788-0","article-title":"Ginsenoside Rb1 Alleviates Diabetic Kidney Podocyte Injury by Inhibiting Aldose Reductase Activity","volume":"2","author":"He","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"B62","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1681\/ASN.2009040450","article-title":"Development of Focal Segmental Glomerulosclerosis after Anabolic Steroid Abuse","volume":"21","author":"Herlitz","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1681\/ASN.2018090941","article-title":"Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes","volume":"30","author":"Herwig","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/hep.29125","article-title":"Development of Proteinuria and Focal Segmental Glomerulosclerosis during Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection","volume":"66","author":"Hogan","year":"2017","journal-title":"Hepatology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.3390\/ph3072291","article-title":"Nonsteroidal Anti-inflammatory Drugs and the Kidney","volume":"3","author":"H\u00f6rl","year":"2010","journal-title":"Pharm. (Basel)"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4434504","DOI":"10.1155\/2021\/4434504","article-title":"Study of the Therapeutic Effects of Chinese Herbal Decoction Combined with Glucocorticoid in Treating Primary Nephrotic Syndrome in Children","volume":"19","author":"Hou","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1007\/s40620-021-01055-5","article-title":"FSGS in Chinese Twins with a De Novo PAX2 Mutation: a Case Report and Review of the Literature","volume":"6","author":"Hu","year":"2021","journal-title":"J. Nephrol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1111\/jcmm.14340","article-title":"Salidroside Ameliorates Adriamycin Nephropathy in Mice by Inhibiting \u03b2-catenin Activity","volume":"6","author":"Huang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"580178","DOI":"10.3389\/fped.2020.580178","article-title":"Case Report: CMV-Associated Congenital Nephrotic Syndrome","volume":"8","author":"Jacob","year":"2020","journal-title":"Front. Pediatr."},{"key":"B70","doi-asserted-by":"publisher","first-page":"115246","DOI":"10.1016\/j.jep.2022.115246","article-title":"Jiedu Tongluo Baoshen Formula Enhances Podocyte Autophagy and Reduces Proteinuria in Diabetic Kidney Disease by Inhibiting PI3K\/Akt\/mTOR Signaling Pathway","volume":"7","author":"Jin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1681\/ASN.2014050469","article-title":"APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans","volume":"26","author":"Kasembeli","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1007\/s00467-012-2111-2","article-title":"Increased Urinary Podocytes Following Indomethacin Suggests Drug-Induced Glomerular Injury","volume":"27","author":"Kent","year":"2012","journal-title":"Pediatr. Nephrol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1681\/ASN.2020081229","article-title":"Does SARS-CoV-2 Infect the Kidney?","volume":"31","author":"Khan","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases","volume":"100","year":"2021","journal-title":"Kidney Int."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.transproceed.2017.03.021","article-title":"Reduction of Slit Diaphragm-Associated Molecules by Sirolimus: Is it Enough to Induce Proteinuria?","volume":"49","author":"Kim","year":"2017","journal-title":"Transpl. Proc."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1681\/ASN.2011040388","article-title":"APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy","volume":"22","author":"Kopp","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.kint.2017.02.032","article-title":"Potential Relevance of Shear Stress for Slit Diaphragm and Podocyte Function","volume":"91","author":"Kriz","year":"2017","journal-title":"Kidney Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"F333","DOI":"10.1152\/ajprenal.00478.2012","article-title":"The Podocyte's Response to Stress: the Enigma of Foot Process Effacement","volume":"304","author":"Kriz","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1681\/ASN.2020060802","article-title":"Kidney Biopsy Findings in Patients with COVID-19","volume":"31","author":"Kudose","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.kint.2021.08.014","article-title":"Contactin-1 Is a Novel Target Antigen in Membranous Nephropathy Associated with Chronic Inflammatory Demyelinating Polyneuropathy","volume":"100","author":"Le Quintrec","year":"2021","journal-title":"Kidney Int."},{"key":"B81","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2215\/CJN.03751106","article-title":"High Sirolimus Levels May Induce Focal Segmental Glomerulosclerosis De Novo","volume":"2","author":"Letavernier","year":"2007","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.trre.2007.12.001","article-title":"mToR Inhibitors-Induced Proteinuria: Mechanisms, Significance, and Management","volume":"22","author":"Letavernier","year":"2008","journal-title":"Transpl. Rev. Orl."},{"key":"B83","doi-asserted-by":"publisher","first-page":"193","DOI":"10.17305\/bjbms.2016.887","article-title":"Huaiqihuang May Protect from Proteinuria by Resisting MPC5 Podocyte Damage via Targeting P-ERK\/CHOP Pathway","volume":"3","author":"Li","year":"2016","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1177\/0022034519882000","article-title":"Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and beyond","volume":"98","author":"Li","year":"2019","journal-title":"J. Dent. Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"BSR20192920","DOI":"10.1042\/BSR20192920","article-title":"Anti-apoptosis Mechanism of Triptolide Based on Network Pharmacology in Focal Segmental Glomerulosclerosis Rats","volume":"4","author":"Li","year":"2020","journal-title":"Biosci. Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"114351","DOI":"10.1016\/j.jep.2021.114351","article-title":"Salvianolic Acid A Attenuates Steroid Resistant Nephrotic Syndrome through suPAR\/uPAR-\u0391v\u03b23 Signaling Inhibition","volume":"279","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/ptr.6818","article-title":"Chemical Constituents, Clinical Efficacy and Molecular Mechanisms of the Ethanol Extract of Abelmoschus Manihot Flowers in Treatment of Kidney Diseases","volume":"1","author":"Li","year":"2021","journal-title":"Phytother. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e042573","DOI":"10.1136\/bmjopen-2020-042573","article-title":"Risk Factors and Prognosis for COVID-19-Induced Acute Kidney Injury: a Meta-Analysis","volume":"10","author":"Lin","year":"2020","journal-title":"BMJ Open"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3390\/jcm10061184","article-title":"Podocyte Autophagy in Homeostasis and Disease","volume":"10","author":"Lin","year":"2021","journal-title":"J. Clin. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/ki.2012.263","article-title":"Apolipoprotein L1 Gene Variants Associate with Hypertension-Attributed Nephropathy and the Rate of Kidney Function Decline in African Americans","volume":"83","author":"Lipkowitz","year":"2013","journal-title":"Kidney Int."},{"key":"B91","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12882-015-0199-x","article-title":"Comparison of Tripterygium Wilfordii Multiglycosides and Tacrolimus in the Treatment of Idiopathic Membranous Nephropathy: a Prospective Cohort Study","volume":"16","author":"Liu","year":"2015","journal-title":"BMC Nephrol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.3389\/fimmu.2020.01846","article-title":"Idiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"687455","DOI":"10.3389\/fped.2021.687455","article-title":"Case Report: A Novel Heterozygous Mutation of CD2AP in a Chinese Family with Proteinuria Leads to Focal Segmental Glomerulosclerosis","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Pediatr."},{"key":"B94","doi-asserted-by":"publisher","first-page":"111907","DOI":"10.1016\/j.biopha.2021.111907","article-title":"Huangqi Guizhi Wuwu Decoction Attenuates Podocyte Cytoskeletal Protein Damage in IgA Nephropathy Rats by Regulating AT1R\/Nephrin\/c-Abl Pathway","volume":"142","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B95","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-981-13-8871-2_10","article-title":"Role of Podocyte Injury in Glomerulosclerosis","volume":"1165","author":"Lu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e0251131","DOI":"10.1371\/journal.pone.0251131","article-title":"Traditional Chinese Medicine as an Adjunct Therapy in the Treatment of Idiopathic Membranous Nephropathy: A Systematic Review and Meta-Analysis","volume":"5","author":"Lu","year":"2021","journal-title":"PLoS One"},{"key":"B97","doi-asserted-by":"publisher","first-page":"e0145130","DOI":"10.1371\/journal.pone.0145130","article-title":"Tongxinluo Protects against Hypertensive Kidney Injury in Spontaneously-Hypertensive Rats by Inhibiting Oxidative Stress and Activating Forkhead Box O1 Signaling","volume":"12","author":"Luo","year":"2015","journal-title":"PLoS One"},{"key":"B98","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.xkme.2020.05.004","article-title":"COVID-19-Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis","volume":"2","author":"Magoon","year":"2020","journal-title":"Kidney Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/cells10061509","article-title":"A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome and Extramedullary Hematopoiesis","volume":"10","author":"Maier","year":"2021","journal-title":"Cells"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1681\/ASN.V1261164","article-title":"Collapsing Focal Segmental Glomerulosclerosis Following Treatment with High-Dose Pamidronate","volume":"12","author":"Markowitz","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"607","DOI":"10.2215\/CJN.07311009","article-title":"Treatment with IFN-{alpha}, -{beta}, or -{gamma} Is Associated with Collapsing Focal Segmental Glomerulosclerosis","volume":"4","author":"Markowitz","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"987","DOI":"10.2169\/internalmedicine.9576-17","article-title":"Pazopanib-induced Endothelial Injury with Podocyte Changes","volume":"57","author":"Maruyama","year":"2018","journal-title":"Intern Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"983","DOI":"10.2215\/CJN.13371019","article-title":"Response to First Course of Intensified Immunosuppression in Genetically Stratified Steroid Resistant Nephrotic Syndrome","volume":"7","author":"Mason","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.kint.2019.10.022","article-title":"A Novel Mouse Model of Phospholipase A2 Receptor 1-associated Membranous Nephropathy Mimics Podocyte Injury in Patients","volume":"97","author":"Meyer-Schwesinger","year":"2020","journal-title":"Kidney Int."},{"key":"B105","doi-asserted-by":"publisher","first-page":"8580","DOI":"10.1038\/s41598-020-65352-y","article-title":"Inhibition of mTOR Delayed but Could Not Prevent Experimental Collapsing Focal Segmental Glomerulosclerosis","volume":"10","author":"Miesen","year":"2020","journal-title":"Sci. Rep."},{"key":"B106","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ajpath.2013.04.017","article-title":"The Antiviral Cytokines IFN-\u03b1 and IFN-\u03b2 Modulate Parietal Epithelial Cells and Promote Podocyte Loss: Implications for IFN Toxicity, Viral Glomerulonephritis, and Glomerular Regeneration","volume":"183","author":"Migliorini","year":"2013","journal-title":"Am. J. Pathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"800074","DOI":"10.3389\/fimmu.2021.800074","article-title":"Collapsing Focal Segmental Glomerulosclerosis in Viral Infections","volume":"12","author":"Muehlig","year":"2022","journal-title":"Front. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3389\/fimmu.2020.01833","article-title":"Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H","volume":"11","author":"M\u00fchlig","year":"2020","journal-title":"Front. Immunol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"189","DOI":"10.14670\/HH-25.189","article-title":"Tubular Epithelial Cell and Podocyte Apoptosis with De Novo Sirolimus Based Immunosuppression in Renal Allograft Recipients with DGF","volume":"25","author":"Munivenkatappa","year":"2010","journal-title":"Histol. Histopathol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e12959","DOI":"10.1111\/tid.12959","article-title":"Recurrent Membranous Nephropathy and Acute Cellular Rejection in a Patient Treated with Direct Anti-HCV Therapy (Ledipasvir\/sofosbuvir)","volume":"20","author":"Murakami","year":"2018","journal-title":"Transpl. Infect. Dis."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","article-title":"Podocyte Injury and its Consequences","volume":"89","author":"Nagata","year":"2016","journal-title":"Kidney Int."},{"key":"B112","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1042\/CS20120543","article-title":"Celecoxib Modifies Glomerular Basement Membrane, Mesangium and Podocytes in OVE26 Mice, but Ibuprofen Is More Detrimental","volume":"124","author":"Nasrallah","year":"2013","journal-title":"Clin. Sci. (Lond)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1017\/cjn.2020.46","article-title":"Chronic Inflammatory Demyelinating Polyneuropathy and Concurrent Membranous Nephropathy","volume":"47","author":"Nazarali","year":"2020","journal-title":"Can. J. Neurol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s00467-006-0208-1","article-title":"WT1 and Glomerular Diseases","volume":"11","author":"Niaudet","year":"2006","journal-title":"Pediatr. Nephrol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"108976","DOI":"10.1016\/j.clim.2022.108976","article-title":"Revisiting Immunological and Clinical Aspects of Membranous Nephropathy","volume":"237","author":"Nieto-Ga\u00f1\u00e1n","year":"2022","journal-title":"Clin. Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/v10020063","article-title":"All-Round Manipulation of the Actin Cytoskeleton by HIV","volume":"10","author":"Ospina Stella","year":"2018","journal-title":"Viruses"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.2215\/CJN.00360114","article-title":"Nephrotoxic Effects of Common and Emerging Drugs of Abuse","volume":"9","author":"Pendergraft","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"761600","DOI":"10.3389\/fmed.2021.761600","article-title":"Molecular Mechanisms of Proteinuria in Minimal Change Disease","volume":"8","author":"Purohit","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1111\/bph.14935","article-title":"Berberine Protects against Diabetic Kidney Disease via Promoting PGC-1\u03b1-Regulated Mitochondrial Energy Homeostasis","volume":"16","author":"Qin","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"e41391","DOI":"10.1371\/journal.pone.0041391","article-title":"Genipin Inhibits Mitochondrial Uncoupling Protein 2 Expression and Ameliorates Podocyte Injury in Diabetic Mice","volume":"7","author":"Qiu","year":"2012","journal-title":"PLoS One"},{"key":"B121","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fmed.2018.00177","article-title":"Molecular Mechanisms of Injury in HIV-Associated Nephropathy","volume":"5","author":"Rednor","year":"2018","journal-title":"Front. Med. (Lausanne)"},{"key":"B122","doi-asserted-by":"publisher","first-page":"9419","DOI":"10.1038\/s41598-020-64907-3","article-title":"Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease","volume":"10","author":"Refaeli","year":"2020","journal-title":"Sci. Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/MOP.0000000000000603","article-title":"Genetic Risk of APOL1 and Kidney Disease in Children and Young Adults of African Ancestry","volume":"30","author":"Reidy","year":"2018","journal-title":"Curr. Opin. Pediatr."},{"key":"B124","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ncpneph0198","article-title":"Mechanisms of Disease: Alloimmunization in Renal Diseases","volume":"2","author":"Ronco","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"502","DOI":"10.2215\/CJN.05960616","article-title":"Focal Segmental Glomerulosclerosis","volume":"3","author":"Rosenberg","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3389\/fimmu.2020.01229","article-title":"Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?","volume":"11","author":"Sallenave","year":"2020","journal-title":"Front. Immunol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s00467-021-05196-4","article-title":"How Immunosuppressive Drugs May Directly Target Podocytes in Glomerular Diseases","volume":"37","author":"Salvadori","year":"2021","journal-title":"Pediatr. Nephrol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.kint.2019.09.014","article-title":"Neural Epidermal Growth Factor-like 1 Protein (NELL-1) Associated Membranous Nephropathy","volume":"97","author":"Sethi","year":"2020","journal-title":"Kidney Int."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1093\/ckj\/sfab069","article-title":"Membranous Nephropathy: a Single Disease or a Pattern of Injury Resulting from Different Diseases","volume":"14","author":"Sethi","year":"2021","journal-title":"Clin. Kidney J."},{"key":"B130","doi-asserted-by":"publisher","first-page":"15517","DOI":"10.1038\/s41598-019-51825-2","article-title":"Focal Segmental Glomerulosclerosis ACTN4 Mutants Binding to Actin: Regulation by Phosphomimetic Mutations","volume":"9","author":"Shao","year":"2019","journal-title":"Sci. Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1681\/ASN.2020060804","article-title":"COVID-19-Associated Glomerular Disease","volume":"32","author":"Shetty","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"5854710","DOI":"10.1155\/2018\/5854710","article-title":"Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study","volume":"24","author":"Shi","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ekir.2016.06.006","article-title":"Lupus-like Immune Complex-Mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-Acting Antiviral Therapy","volume":"1","author":"Sise","year":"2016","journal-title":"Kidney Int. Rep."},{"key":"B134","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1097\/TP.0b013e318211d342","article-title":"Sirolimus and Proteinuria in Renal Transplant Patients: Evidence for a Dose-dependent Effect on Slit Diaphragm-Associated Proteins","volume":"91","author":"Stallone","year":"2011","journal-title":"Transplantation"},{"key":"B135","doi-asserted-by":"publisher","first-page":"4057","DOI":"10.3390\/jcm9124057","article-title":"SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure","volume":"9","author":"Stasi","year":"2020","journal-title":"J. Clin. Med."},{"key":"B136","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1681\/ASN.2019050443","article-title":"FSGS-causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes","volume":"31","author":"Subramanian","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3736\/jcim20110513","article-title":"Effects of Chinese Herbal Medicine Huaiqihuang Granule on Nephrin and Podocin Expressions in Renal Tissues of Rats with Adriamycin-Induced Nephrosis","volume":"5","author":"Sun","year":"2011","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"B138","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1159\/000518132","article-title":"The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease","volume":"7","author":"Sun","year":"2021","journal-title":"Kidney Dis. (Basel)"},{"key":"B139","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.yexmp.2012.06.001","article-title":"Nef Interaction with Actin Compromises Human Podocyte Actin Cytoskeletal Integrity","volume":"94","author":"Tan","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"328","DOI":"10.4103\/1947-2714.161252","article-title":"Lithium-Induced Minimal Change Disease and Acute Kidney Injury","volume":"7","author":"Tandon","year":"2015","journal-title":"N. Am. J. Med. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3892\/mmr.2021.12231","article-title":"Tripterygium Glycoside Suppresses Epithelial-To-Mesenchymal Transition of Diabetic Kidney Disease Podocytes by Targeting Autophagy through the mTOR\/Twist1 Pathway","volume":"2","author":"Tao","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B142","doi-asserted-by":"publisher","first-page":"5859102","DOI":"10.1155\/2019\/5859102","article-title":"Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome","volume":"2019","author":"Tojo","year":"2019","journal-title":"Int. J. Nephrol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1056\/NEJMoa1409354","article-title":"Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy","volume":"371","author":"Tomas","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1172\/JCI85265","article-title":"Autoantibodies against Thrombospondin Type 1 Domain-Containing 7A Induce Membranous Nephropathy","volume":"126","author":"Tomas","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B145","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.kint.2019.05.015","article-title":"From Podocyte Biology to Novel Cures for Glomerular Disease","volume":"96","author":"Torban","year":"2019","journal-title":"Kidney Int."},{"key":"B146","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ki.2010.64","article-title":"Overexpression of VEGF-A in Podocytes of Adult Mice Causes Glomerular Disease","volume":"77","author":"Veron","year":"2010","journal-title":"Kidney Int."},{"key":"B147","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ki.2014.381","article-title":"Genetic Homogeneity but IgG Subclass-dependent Clinical Variability of Alloimmune Membranous Nephropathy with Anti-neutral Endopeptidase Antibodies","volume":"87","author":"Vivarelli","year":"2015","journal-title":"Kidney Int."},{"key":"B148","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal Change Disease","volume":"2","author":"Vivarelli","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.jep.2013.12.005","article-title":"Low-dose of Multi-Glycoside of Tripterygium Wilfordii Hook. f., a Natural Regulator of TGF-\u03b21\/Smad Signaling Activity Improves Adriamycin-Induced Glomerulosclerosis In Vivo","volume":"3","author":"Wan","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1681\/ASN.2013090985","article-title":"GIV\/girdin Links Vascular Endothelial Growth Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin","volume":"26","author":"Wang","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12882-015-0031-7","article-title":"Astragaloside IV Attenuates Proteinuria in Streptozotocin-Induced Diabetic Nephropathy via the Inhibition of Endoplasmic Reticulum Stress","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Nephrol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"8746349","DOI":"10.1155\/2018\/8746349","article-title":"Traditional Chinese Medicine for Refractory Nephrotic Syndrome: Strategies and Promising Treatments","volume":"4","author":"Wang","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"587663","DOI":"10.3389\/fphar.2020.587663","article-title":"Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1\/PAK1\/p38MAPK Signaling Pathway in High-Fat Diet\/Streptozotocin-Induced Diabetic Mice","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"779652","DOI":"10.3389\/fphar.2021.779652","article-title":"Inhibition of Podocytes DPP4 Activity Is a Potential Mechanism of Lobeliae Chinensis Herba in Treating Diabetic Kidney Disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s00467-021-04960-w","article-title":"APOL1 in an Ethnically Diverse Pediatric Population with Nephrotic Syndrome: Implications in Focal Segmental Glomerulosclerosis and Other Diagnoses","volume":"36","author":"Watanabe","year":"2021","journal-title":"Pediatr. Nephrol."},{"key":"B156","first-page":"452","article-title":"Treatment of 100 Children with Infantile Nephrotic Syndrome by Integrated Traditional Chinese Medicine and Western Medicine","volume":"12","author":"Wei","year":"1992","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.jep.2013.12.028","article-title":"Qi-Dan Fang Ameliorates Adriamycin-Induced Nephrotic Syndrome Rat Model by Enhancing Renal Function and Inhibiting Podocyte Injury","volume":"3","author":"Wu","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"B158","first-page":"1137","article-title":"Experience of Professor Yang Nizhi in Treating Minimal Change Disease","volume":"4","author":"Wu","year":"2020","journal-title":"Mod. Traditional Chin. Med. Materia Medica-World Sci. Technol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"e930097","DOI":"10.12659\/MSM.930097","article-title":"A Review of the Current Practice of Diagnosis and Treatment of Idiopathic Membranous Nephropathy in China","volume":"27","author":"Wu","year":"2021","journal-title":"Med. Sci. Monit."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1516633","DOI":"10.1155\/2022\/1516633","article-title":"Clinical Efficacy of Adjuvant Treatment of Primary Nephrotic Syndrome in Pediatric Patients with Chinese Medicine","volume":"25","author":"Wu","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"B161","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1016\/j.ajpath.2014.06.027","article-title":"Glycogen Synthase Kinase 3\u03b2 Dictates Podocyte Motility and Focal Adhesion Turnover by Modulating Paxillin Activity: Implications for the Protective Effect of Low-Dose Lithium in Podocytopathy","volume":"184","author":"Xu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000437288","article-title":"Management of Membranous Nephropathy in Asia","volume":"2","author":"Xu","year":"2015","journal-title":"Kidney Dis. (Basel)"},{"key":"B163","doi-asserted-by":"publisher","first-page":"624404","DOI":"10.3389\/fphar.2021.624404","article-title":"Yiqi Jiedu Huayu Decoction Alleviates Renal Injury in Rats with Diabetic Nephropathy by Promoting Autophagy","volume":"12","author":"Xuan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.phymed.2018.10.031","article-title":"Salidroside Stimulates the Sirt1\/PGC-1\u03b1 axis and Ameliorates Diabetic Nephropathy in Mice","volume":"54","author":"Xue","year":"2019","journal-title":"Phytomedicine"},{"key":"B165","first-page":"3125","article-title":"Regulative Mechanisms of Mammalian Target of Rapamycin Signaling Pathway in Glomerular Hypertrophy in Diabetic Nephropathy and Interventional Effects of Chinese Herbal Medicine","volume":"40","author":"Yang","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B166","doi-asserted-by":"publisher","first-page":"110479","DOI":"10.1016\/j.biopha.2020.110479","article-title":"Paecilomyces Cicadae-Fermented Radix Astragali Activates Podocyte Autophagy by Attenuating PI3K\/AKT\/mTOR Pathways to Protect against Diabetic Nephropathy in Mice","volume":"129","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1016\/j.ekir.2021.05.001","article-title":"Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children","volume":"8","author":"Ying","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"B168","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1080\/0886022X.2017.1313164","article-title":"Molecular Mechanisms Involved in Podocyte EMT and Concomitant Diabetic Kidney Diseases: an Update","volume":"39","author":"Ying","year":"2017","journal-title":"Ren. Fail"},{"key":"B169","doi-asserted-by":"publisher","first-page":"9742754","DOI":"10.1155\/2020\/9742754","article-title":"Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study","volume":"2020","author":"Yu","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B170","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3892\/etm.2018.6492","article-title":"Modified Huangqi Chifeng Decoction Inhibits Excessive Autophagy to Protect against Doxorubicin-Induced Nephrotic Syndrome in Rats via the PI3K\/mTOR Signaling Pathway","volume":"3","author":"Yu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B171","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fcimb.2016.00112","article-title":"Respiratory Syncytial Virus Aggravates Renal Injury through Cytokines and Direct Renal Injury","volume":"6","author":"Zhai","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B172","first-page":"252","article-title":"A Case of Focal Segmental Glomerulosclerosis Treated with Modified Fangji Huangqi Decoction","volume":"2","author":"Zhang","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B173","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1177\/0022034510376401","article-title":"The Role of NELL-1, a Growth Factor Associated with Craniosynostosis, in Promoting Bone Regeneration","volume":"89","author":"Zhang","year":"2010","journal-title":"J. Dent. Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1053\/j.ajkd.2014.01.431","article-title":"Efficacy and Safety of Abelmoschus Manihot for Primary Glomerular Disease: a Prospective, Multicenter Randomized Controlled Clinical Trial","volume":"1","author":"Zhang","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"B175","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s11418-016-1007-z","article-title":"Hyperoside Reduces Albuminuria in Diabetic Nephropathy at the Early Stage through Ameliorating Renal Damage and Podocyte Injury","volume":"4","author":"Zhang","year":"2016","journal-title":"J. Nat. Med."},{"key":"B176","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12882-017-0673-8","article-title":"Non-steroidal Anti-inflammatory Drug Induced Acute Kidney Injury in the Community Dwelling General Population and People with Chronic Kidney Disease: Systematic Review and Meta-Analysis","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Nephrol."},{"key":"B177","first-page":"387","article-title":"Meta-analysis of Yiqi Huoxue Method in Treating Focal Segmental Glomerulosclerosis","volume":"5","author":"Zhang","year":"2019","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B178","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1038\/s41598-020-58781-2","article-title":"Renoprotective Effects of Gushen Jiedu Capsule on Diabetic Nephropathy in Rats","volume":"1","author":"Zhang","year":"2020","journal-title":"Sci. Rep."},{"key":"B179","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00467-019-04225-7","article-title":"Treatment of Nephrotic Syndrome: Going beyond Immunosuppressive Therapy","volume":"4","author":"Zhao","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.19540\/j.cnki.cjcmm.20170623.009","article-title":"Meta-analysis of Yiqi Huoxue Method in Treating Idiopathic Membranous Nephropathy","volume":"18","author":"Zheng","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B181","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3389\/fendo.2018.00624","article-title":"SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease","volume":"9","author":"Zhong","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B182","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1080\/15548627.2019.1580512","article-title":"Podocytes and Autophagy: a Potential Therapeutic Target in Lupus Nephritis","volume":"15","author":"Zhou","year":"2019","journal-title":"Autophagy"},{"key":"B183","doi-asserted-by":"publisher","first-page":"110082","DOI":"10.1016\/j.cellsig.2021.110082","article-title":"IL-6\/STAT3 Signaling Activation Exacerbates High Fructose-Induced Podocyte Hypertrophy by Ketohexokinase-A-Mediated Tristetraprolin Down-Regulation","volume":"86","author":"Zhou","year":"2021","journal-title":"Cell. Signal."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.932739\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:32:10Z","timestamp":1659918730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.932739\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":183,"alternative-id":["10.3389\/fphar.2022.932739"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.932739","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"article-number":"932739"}}