{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:55:07Z","timestamp":1788965707643,"version":"build-2803163510"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2314-B-182A-104 -MY3 110-2320-B-182A-014-MY3 110-2326-B-182A-003-"],"award-info":[{"award-number":["MOST 108-2314-B-182A-104 -MY3 110-2320-B-182A-014-MY3 110-2326-B-182A-003-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3K0561-2 CLRPG3L0041-2"],"award-info":[{"award-number":["CMRPG3K0561-2 CLRPG3L0041-2"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS). A previous study has reported a strong association between <jats:italic>HLA-A*32:01<\/jats:italic> and vancomycin-induced DRESS in European ethnicity. Herein, we aim to investigate the genetic predisposition of vancomycin-induced DRESS in the Han-Chinese population. In this study, we enrolled a total of 26 patients with vancomycin-induced DRESS, 1,616 general population controls, and 51 subjects tolerant to vancomycin. <jats:italic>In vitro<\/jats:italic> granulysin-based lymphocyte activation tests (LAT) were conducted among 6 vancomycin-induced DRESS patients who were concomitantly receiving other medicines. <jats:italic>HLA-A<\/jats:italic> and <jats:italic>HLA-B<\/jats:italic> genotypes were determined by sequencing-based typing. Our results found that vancomycin-induced DRESS was associated with <jats:italic>HLA-A*32:01<\/jats:italic> [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 1.7\u201335.8; <jats:italic>p<\/jats:italic>-value = 0.035], <jats:italic>HLA-B*07:05<\/jats:italic> (OR = 32.3, 95% CI = 2.8\u2013367.7; <jats:italic>p<\/jats:italic>-value = 0.047), <jats:italic>HLA-B*40:06<\/jats:italic> (OR = 4.7, 95% CI = 1.3\u201316.1; <jats:italic>p<\/jats:italic>-value = 0.036) and <jats:italic>HLA-B*67:01<\/jats:italic> (OR = 44.8, 95% CI = 7.2\u2013280.4; <jats:italic>p<\/jats:italic>-value = 0.002) when comparing the vancomycin-induced DRESS patients with the general population controls. LAT results showed that granulysin significantly increased in the vancomycin-induced DRESS patients upon vancomycin stimulation (4.7 \u00b1 3.7 fold increased), but not upon other co-medicines. This study identified that, in addition to <jats:italic>HLA-A*32:01<\/jats:italic>, <jats:italic>HLA-B*07:05<\/jats:italic>, <jats:italic>HLA-B*40:06<\/jats:italic>, and <jats:italic>HLA-B*67:01<\/jats:italic> were also genetic markers for vancomycin-induced DRESS in the Han-Chinese population. Associations of ethnic variances in <jats:italic>HLA<\/jats:italic> with vancomycin-DRESS were observed.<\/jats:p>","DOI":"10.3389\/fphar.2022.954596","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T05:36:12Z","timestamp":1669354572000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population"],"prefix":"10.3389","volume":"13","author":[{"given":"Chuang-Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ti","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Han","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaline Chung-Yee","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Jung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ching","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Taiwan Severe Cutaneous Adverse Reaction Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1001\/archderm.129.1.92","article-title":"Clinical classification of cases of toxic epidermal necrolysis, stevens-johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Archives Dermatology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2500\/aap.2012.33.3498","article-title":"The importance of vancomycin in drug rash with eosinophilia and systemic symptoms (DRESS) syndrome","volume":"33","author":"Blumenthal","year":"2012","journal-title":"Allergy Asthma Proc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: A literature review","volume":"124","author":"Cacoub","year":"2011","journal-title":"Am. 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