{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:15:48Z","timestamp":1778814948049,"version":"3.51.4"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Podoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in different cell types including choroid plexus epithelial cells, glial cells, as well as periphery infiltrated immune cells during brain development and neurological disorders. As a transmembrane protein, podoplanin interacts with other molecules in the same or neighboring cells. In the past, a lot of studies reported a pleiotropic role of podoplanin in the modulation of thrombosis, inflammation, lymphangiogenesis, angiogenesis, immune surveillance, epithelial mesenchymal transition, as well as extracellular matrix remodeling in periphery, which have been well summarized and discussed. Recently, mounting evidence demonstrates the distribution and function of this molecule in brain development and neurological disorders. In this review, we summarize the research progresses in understanding the roles and mechanisms of podoplanin in the development and disorders of the nervous system. The challenges of podoplanin-targeted approaches for disease prognosis and preventions are also discussed.<\/jats:p>","DOI":"10.3389\/fphar.2022.964973","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T09:39:36Z","timestamp":1663061976000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Podoplanin: Its roles and functions in neurological diseases and brain cancers"],"prefix":"10.3389","volume":"13","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"28621","DOI":"10.18632\/oncotarget.5765","article-title":"PDGF upregulates CLEC-2 to induce T regulatory cells","volume":"6","author":"Agrawal","year":"2015","journal-title":"Oncotarget"},{"key":"B2","first-page":"1141","article-title":"Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis","volume":"151","author":"Breiteneder-Geleff","year":"1997","journal-title":"Am. J. pathology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0002-9440(10)65285-6","article-title":"Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium","volume":"154","author":"Breiteneder-Geleff","year":"1999","journal-title":"Am. J. pathology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1002\/ijc.27919","article-title":"Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors","volume":"132","author":"Chandramohan","year":"2013","journal-title":"Int. J. cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"11302","DOI":"10.1038\/ncomms11302","article-title":"Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3","volume":"7","author":"Chen","year":"2016","journal-title":"Nat. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuroscience.2013.05.019","article-title":"Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival","volume":"247","author":"Christie","year":"2013","journal-title":"Neuroscience"},{"key":"B7","first-page":"12757","article-title":"Phosphorylated mTOR expression correlates with podoplanin expression and high tumor grade in esophageal squamous cell carcinoma","volume":"8","author":"Chuang","year":"2015","journal-title":"Int. J. Clin. Exp. pathology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3389\/fncel.2019.00561","article-title":"Podoplanin gene disruption in mice promotes in vivo neural progenitor cells proliferation, selectively impairs dentate gyrus synaptic depression and induces anxiety-like behaviors","volume":"13","author":"Cicvaric","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1080\/07853890.2016.1219455","article-title":"The brain-tumor related protein podoplanin regulates synaptic plasticity and hippocampus-dependent learning and memory","volume":"48","author":"Cicvaric","year":"2016","journal-title":"Ann. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1161\/STROKEAHA.115.011238","article-title":"Thromboinflammation in stroke brain damage","volume":"47","author":"De Meyer","year":"2016","journal-title":"Stroke"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3390\/jcm8071000","article-title":"Increased lymphangiogenesis and lymphangiogenic growth factor expression in perivascular adipose tissue of patients with coronary artery disease","volume":"8","author":"Drosos","year":"2019","journal-title":"J. Clin. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/neuonc\/noy18410.1093\/neuonc\/noy184","article-title":"Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma","volume":"21","author":"Eisemann","year":"2019","journal-title":"Neuro-oncology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6541","DOI":"10.1158\/1078-0432.CCR-09-0695","article-title":"Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival","volume":"15","author":"Ernst","year":"2009","journal-title":"Clin. cancer Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bbrc.2019.12.003","article-title":"Podoplanin influences the inflammatory phenotypes and mobility of microglia in traumatic brain injury","volume":"523","author":"Fei","year":"2020","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1182\/blood-2011-09-38070910.1182\/blood-2011-09-380709","article-title":"CLEC-2 and Syk in the megakaryocytic\/platelet lineage are essential for development","volume":"119","author":"Finney","year":"2012","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.thromres.2019.10.015","article-title":"Podoplanin expression on endothelial cells promotes superficial erosive injury and thrombus formation in rat carotid artery: Implications for plaque erosion","volume":"183","author":"Furukoji","year":"2019","journal-title":"Thrombosis Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/(sici)1098-2744(199709)20:1<10::aid-mc3>3.0.co;2-m","article-title":"Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis","volume":"20","author":"Gandarillas","year":"1997","journal-title":"Mol. Carcinog."},{"key":"B18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/jnc.1498310.1111\/jnc.14983","article-title":"Platelet regulates neuroinflammation and restores blood-brain barrier integrity in a mouse model of traumatic brain injury","volume":"154","author":"Gao","year":"2020","journal-title":"J. Neurochem."},{"key":"B19","first-page":"8663","article-title":"Podoplanin increases migration and angiogenesis in malignant glioma","volume":"8","author":"Grau","year":"2015","journal-title":"Int. J. Clin. Exp. pathology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.4049\/jimmunol.173.12.7161","article-title":"IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells","volume":"173","author":"Gr\u00f6ger","year":"2004","journal-title":"J. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neurol.2019.07.025","article-title":"Melatonin: A review of its potential functions and effects on neurological diseases","volume":"176","author":"Gunata","year":"2020","journal-title":"Rev. Neurol. Paris."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cca.2019.06.014","article-title":"Higher plasma C-type lectin-like receptor 2 concentrations for prediction of higher risk of 30-day mortality in isolated severe blunt traumatic brain injury","volume":"496","author":"Guo","year":"2019","journal-title":"Clin. chimica acta; Int. J. Clin. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1016\/j.thromres.2012.01.003","article-title":"Podoplanin expression in advanced atherosclerotic lesions of human aortas","volume":"129","author":"Hatakeyama","year":"2012","journal-title":"Thrombosis Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1182\/blood.2020010310","article-title":"Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin","volume":"137","author":"Hoover","year":"2021","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1158\/0008-5472.CAN-10-3228","article-title":"Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: Podoplanin in fibroblast functions for tumor progression","volume":"71","author":"Hoshino","year":"2011","journal-title":"Cancer Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.nbd.2017.08.019","article-title":"Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease","volume":"108","author":"Iulita","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7169","DOI":"10.4049\/jimmunol.0901906","article-title":"Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes","volume":"183","author":"J\u00e4ger","year":"2009","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1469-7580.2012.01484.x","article-title":"The expression of podoplanin and classic cadherins in the mouse brain","volume":"220","author":"Kaji","year":"2012","journal-title":"J. Anat."},{"key":"B29","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.1038\/srep05924","article-title":"A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin","volume":"4","author":"Kato","year":"2014","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1349-7006.2007.00634.x","article-title":"Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2","volume":"99","author":"Kato","year":"2008","journal-title":"Cancer Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.2174\/1570159X15666170613083606","article-title":"Recent advances in pathophysiology of traumatic brain injury","volume":"16","author":"Kaur","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/ijc.23611","article-title":"Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma","volume":"123","author":"Kawase","year":"2008","journal-title":"Int. J. cancer"},{"key":"B33","first-page":"4284","article-title":"Bridge between neuroimmunity and traumatic brain injury","volume":"20","author":"Kelso","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"B34","doi-asserted-by":"publisher","first-page":"506","DOI":"10.2174\/187152712801661248","article-title":"Pathology of multiple sclerosis","volume":"11","author":"Kipp","year":"2012","journal-title":"CNS neurological Disord. drug targets"},{"key":"B35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/NEN.0000000000000150","article-title":"Podoplanin: A marker for reactive gliosis in gliomas and brain injury","volume":"74","author":"Kolar","year":"2015","journal-title":"J. neuropathology Exp. neurology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"12215","DOI":"10.1074\/jbc.C112.446823","article-title":"Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility","volume":"288","author":"Krishnan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.yexcr.2015.04.019","article-title":"PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility","volume":"335","author":"Krishnan","year":"2015","journal-title":"Exp. Cell Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00401-012-1023-3","article-title":"Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response","volume":"124","author":"Kuerten","year":"2012","journal-title":"Acta neuropathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.2353\/ajpath.2007.060790","article-title":"The platelet aggregation-inducing factor aggrus\/podoplanin promotes pulmonary metastasis","volume":"170","author":"Kunita","year":"2007","journal-title":"Am. J. pathology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3892\/mmr.2017.6830","article-title":"Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1182\/blood-2014-09-603803","article-title":"Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development","volume":"125","author":"Lowe","year":"2015","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1165\/ajrcmb.19.1.2953","article-title":"Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels","volume":"19","author":"Ma","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/brain\/awm038","article-title":"Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology","volume":"130","author":"Magliozzi","year":"2007","journal-title":"Brain a J. neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.0105-2896.2009.00861.x","article-title":"Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: From inflammation to autoimmunity and tissue damage\/remodeling","volume":"233","author":"Manzo","year":"2010","journal-title":"Immunol. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.autrev.2007.03.006","article-title":"Lymphoid tissue reactions in rheumatoid arthritis","volume":"7","author":"Manzo","year":"2007","journal-title":"Autoimmun. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1038\/onc.2014.388","article-title":"Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability","volume":"34","author":"Mart\u00edn-Villar","year":"2015","journal-title":"Oncogene"},{"key":"B47","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1091\/mbc.E10-06-0489","article-title":"Podoplanin associates with CD44 to promote directional cell migration","volume":"21","author":"Mart\u00edn-Villar","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/ijc.20656","article-title":"Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas","volume":"113","author":"Mart\u00edn-Villar","year":"2005","journal-title":"Int. J. cancer"},{"key":"B49","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s12640-020-00295-w","article-title":"A role of the podoplanin-CLEC-2 axis in promoting inflammatory response after ischemic stroke in mice","volume":"39","author":"Meng","year":"2021","journal-title":"Neurotox. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/jth.14129","article-title":"Combination of isocitrate dehydrogenase 1 (IDH1) mutation and podoplanin expression in brain tumors identifies patients at high or low risk of venous thromboembolism","volume":"16","author":"Mir Seyed Nazari","year":"2018","journal-title":"J. thrombosis haemostasis:JTH"},{"key":"B51","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00401-006-0063-y","article-title":"Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression","volume":"111","author":"Mishima","year":"2006","journal-title":"Acta neuropathol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.molimm.2012.11.013","article-title":"Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints","volume":"54","author":"Miyamoto","year":"2013","journal-title":"Mol. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1182\/blood-2007-11-124693","article-title":"Tetraspanin family member CD9 inhibits Aggrus\/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis","volume":"112","author":"Nakazawa","year":"2008","journal-title":"Blood"},{"key":"B54","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13075-016-1046-6","article-title":"Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion","volume":"18","author":"Noack","year":"","journal-title":"Arthritis Res. Ther."},{"key":"B55","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/cei.12830","article-title":"Role of podoplanin in the high interleukin-17A secretion resulting from interactions between activated lymphocytes and psoriatic skin-derived mesenchymal cells","volume":"186","author":"Noack","year":"","journal-title":"Clin. Exp. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e92321","DOI":"10.1172\/jci.insight.92321","article-title":"Podoplanin is a negative regulator of Th17 inflammation","volume":"2","author":"Nylander","year":"2017","journal-title":"JCI insight"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-2567.2004.02075.x","article-title":"How do follicular dendritic cells interact intimately with B cells in the germinal centre?","volume":"114","author":"Park","year":"2005","journal-title":"Immunology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.immuni.2011.10.015","article-title":"Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation","volume":"35","author":"Peters","year":"2011","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1093\/neuonc\/nos055","article-title":"Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation","volume":"14","author":"Peterziel","year":"2012","journal-title":"Neuro-oncology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"20640","DOI":"10.18632\/oncotarget.25045","article-title":"Functional invadopodia formed in glioblastoma stem cells are important regulators of tumor angiogenesis","volume":"9","author":"Petropoulos","year":"2018","journal-title":"Oncotarget"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1182\/blood-2016-06-720714","article-title":"Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism","volume":"129","author":"Riedl","year":"2017","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1242\/jcs.112.24.4601","article-title":"Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes","volume":"112","author":"Scholl","year":"1999","journal-title":"J. Cell Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1750-3639.2004.tb00049.x","article-title":"Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis","volume":"14","author":"Serafini","year":"2004","journal-title":"Brain pathol. (Zurich, Switz."},{"key":"B64","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00428-005-0133-x","article-title":"Podoplanin is expressed in subsets of tumors of the central nervous system","volume":"448","author":"Shibahara","year":"2006","journal-title":"Virchows Archiv Int. J. pathology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s10571-014-0060-y","article-title":"Up-regulation of podoplanin involves in neuronal apoptosis in LPS-induced neuroinflammation","volume":"34","author":"Song","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"100758","DOI":"10.1016\/j.tranon.2020.100758","article-title":"Wild-type IDH1 and mutant IDH1 opposingly regulate podoplanin expression in glioma","volume":"13","author":"Sun","year":"2020","journal-title":"Transl. Oncol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.febslet.2007.12.028","article-title":"Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma","volume":"582","author":"Suzuki","year":"2008","journal-title":"FEBS Lett."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1182\/blood-2017-02-764670","article-title":"CLEC-2\/podoplanin and thromboinflammation","volume":"129","author":"Suzuki-Inoue","year":"2017","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1538-7836.2011.04335.x","article-title":"Novel platelet activation receptor CLEC-2: From discovery to prospects","volume":"9","author":"Suzuki-Inoue","year":"2011","journal-title":"J. thrombosis haemostasis:JTH"},{"key":"B70","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/jth.13590","article-title":"Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: Partners from in utero to adulthood","volume":"15","author":"Suzuki-Inoue","year":"2017","journal-title":"J. thrombosis haemostasis:JTH"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1182\/blood.2019001388","article-title":"Platelets and cancer-associated thrombosis: Focusing on the platelet activation receptor CLEC-2 and podoplanin","volume":"134","author":"Suzuki-Inoue","year":"2019","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","first-page":"9791","DOI":"10.7150\/thno.64601","article-title":"CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice","volume":"11","author":"Tang","year":"2021","journal-title":"Theranostics"},{"key":"B73","doi-asserted-by":"publisher","first-page":"31876","DOI":"10.18632\/oncotarget.16311","article-title":"Tumor hypoxia modulates podoplanin\/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization","volume":"8","author":"Tejchman","year":"2017","journal-title":"Oncotarget"},{"key":"B74","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1267\/ahc.13035","article-title":"Distribution of podoplanin-expressing cells in the mouse nervous systems","volume":"46","author":"Tomooka","year":"2013","journal-title":"Acta Histochem. Cytochem."},{"key":"B75","first-page":"767","article-title":"Purification and characterization of the platelet-aggregating sialoglycoprotein gp44 expressed by highly metastatic variant cells of mouse colon adenocarcinoma 26","volume":"55","author":"Toyoshima","year":"1995","journal-title":"Cancer Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbrc.2013.03.057","article-title":"Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells","volume":"434","author":"Tsuneki","year":"2013","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.drudis.2011.01.005","article-title":"The VEGF\/Rho GTPase signalling pathway: A promising target for anti-angiogenic\/anti-invasion therapy","volume":"16","author":"van der Meel","year":"2011","journal-title":"Drug Discov. today"},{"key":"B78","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2174\/187152712801661293","article-title":"Mechanisms in the development of multiple sclerosis lesions: Reconciling autoimmune and neurodegenerative factors","volume":"11","author":"van Noort","year":"2012","journal-title":"CNS neurological Disord. drug targets"},{"key":"B79","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jaut.2018.11.005","article-title":"Il-23\/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis","volume":"98","author":"Villegas","year":"2019","journal-title":"J. Autoimmun."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1093\/ndt\/gfr012","article-title":"Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis","volume":"26","author":"Washida","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"B81","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/8756-3282(95)00457-2","article-title":"Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes","volume":"18","author":"Wetterwald","year":"1996","journal-title":"Bone"},{"key":"B82","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ccr.2006.03.010","article-title":"Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton","volume":"9","author":"Wicki","year":"2006","journal-title":"Cancer Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1111\/ene.13984","article-title":"Plasma C-type lectin-like receptor 2 as a predictor of death and vascular events in patients with acute ischemic stroke","volume":"26","author":"Wu","year":"2019","journal-title":"Eur. J. neurology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1083\/jcb.200311112","article-title":"Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans","volume":"164","author":"Xia","year":"2004","journal-title":"J. Cell Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1161\/STROKEAHA.118.022563","article-title":"Prognostic significance of plasma CLEC-2 (C-type lectin-like receptor 2) in patients with acute ischemic stroke","volume":"50","author":"Zhang","year":"","journal-title":"Stroke"},{"key":"B86","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1089\/lrb.2018.0023","article-title":"Functions and regeneration of mature cardiac lymphatic vessels in atherosclerosis, myocardial infarction, and heart failure","volume":"16","author":"Zhang","year":"","journal-title":"Lymphatic Res. Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"e21975","DOI":"10.1096\/fj.202101050RR","article-title":"Cardiac ectopic lymphoid follicle formation in viral myocarditis involving the regulation of podoplanin in Th17 cell differentiation","volume":"35","author":"Zhu","year":"2021","journal-title":"FASEB"},{"key":"B88","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1042\/bj3410277","article-title":"Cloning and characterization of gp36, a human mucintype glycoprotein preferentially expressed in vascular endothelium","volume":"341","author":"Zimmer","year":"1999","journal-title":"Biochem. J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.964973\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T09:39:49Z","timestamp":1663061989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.964973\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":88,"alternative-id":["10.3389\/fphar.2022.964973"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.964973","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]},"article-number":"964973"}}