{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:54:41Z","timestamp":1790823281902,"version":"4.1.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda Ministerio de la Producci\u00f3n, Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Ethnopharmacological relevance:<\/jats:bold><jats:italic>Serpylli herba<\/jats:italic> extract (SHE), composed of the aerial parts of wild thyme (<jats:italic>Thymus serpyllum<\/jats:italic> L.) (<jats:italic>Lamiaceae<\/jats:italic> family), is traditionally used in Europe and North Africa to treat diarrhea, gastric ulcers, intestinal parasites and upper respiratory tract infections. Recently, SHE has generated a great interest for irritable bowel syndrome (IBS) management, probably due to its intestinal anti-inflammatory properties shown in experimental colitis and the fact that its active components could preserve the intestinal barrier integrity, which is altered in patients with IBS.<\/jats:p><jats:p><jats:bold>Aim of study:<\/jats:bold> We aimed to test the effects of a SHE in a rat experimental model resembling human IBS.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold> IBS was provoked by deoxycholic acid (DCA). Rats were then treated with SHE (100\u00a0mg\/kg) or gabapentin (70\u00a0mg\/kg) and different inflammatory and gut barrier integrity markers were evaluated. Moreover, several gut hypersensitivity and hyperalgesia determinations were performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> SHE improved referred pain and visceral hypersensitivity. Additionally, SHE enhanced immune status by downregulating of the expression of the pro-inflammatory mediators Il-1\u03b2, Il-6, Ifn-\u03b3, Tlr-4, and the inducible enzyme <jats:italic>Cox-2<\/jats:italic>, thus inducing visceral analgesia, and promoting the restore of the gut barrier function by upregulating the mucins <jats:italic>Muc-2<\/jats:italic> and <jats:italic>Muc-3<\/jats:italic>. These anti-inflammatory effects could be related to its action on mast cells since it significantly inhibited the <jats:italic>\u03b2<\/jats:italic>-Hexosaminidase production in RBL-2H3 cells. Lastly, SHE also seems to modulate the serotonin pathway by restoring the altered expression of the 5-HT receptors <jats:italic>Htr-3<\/jats:italic> and <jats:italic>Htr-4<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> SHE could be considered a potential new treatment for IBS, since it ameliorates hypersensitivity, visceral hyperalgesia, and inflammation. These beneficial effects may be due to the inhibition of mast cells degranulation and serotonin pathway.<\/jats:p>","DOI":"10.3389\/fphar.2022.967644","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:46:16Z","timestamp":1662111976000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats"],"prefix":"10.3389","volume":"13","author":[{"given":"Antonio Jes\u00fas","family":"Ruiz-Malag\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Rodr\u00edguez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Rodr\u00edguez-Sojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Vezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Pischel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Algieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Rodr\u00edguez-Cabezas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Rodr\u00edguez-Nogales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.crohns.2013.12.012","article-title":"Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis","volume":"8","author":"Algieri","year":"2014","journal-title":"J. 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