{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:44:54Z","timestamp":1790196294717,"version":"4.1.0"},"reference-count":223,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004433","name":"Chinese Pharmaceutical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Second-generation antipsychotics (SGAs) are the mainstay of treatment for schizophrenia and other neuropsychiatric diseases but cause a high risk of disruption to lipid metabolism, which is an intractable therapeutic challenge worldwide. Although the exact mechanisms underlying this lipid disturbance are complex, an increasing body of evidence has suggested the involvement of the gut microbiota in SGA-induced lipid dysregulation since SGA treatment may alter the abundance and composition of the intestinal microflora. The subsequent effects involve the generation of different categories of signaling molecules by gut microbes such as endogenous cannabinoids, cholesterol, short-chain fatty acids (SCFAs), bile acids (BAs), and gut hormones that regulate lipid metabolism. On the one hand, these signaling molecules can directly activate the vagus nerve or be transported into the brain to influence appetite <jats:italic>via<\/jats:italic> the gut\u2013brain axis. On the other hand, these molecules can also regulate related lipid metabolism <jats:italic>via<\/jats:italic> peripheral signaling pathways. Interestingly, therapeutic strategies directly targeting the gut microbiota and related metabolites seem to have promising efficacy in the treatment of SGA-induced lipid disturbances. Thus, this review provides a comprehensive understanding of how SGAs can induce disturbances in lipid metabolism by altering the gut microbiota.<\/jats:p>","DOI":"10.3389\/fphar.2023.1097284","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:30:49Z","timestamp":1674624649000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications"],"prefix":"10.3389","volume":"14","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12361","DOI":"10.3390\/ijms222212361","article-title":"Assessment of the effects of dietary vitamin D levels on olanzapine-induced metabolic side effects: Focus on the endocannabinoidome-gut microbiome Axis","volume":"22","author":"Abolghasemi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"17878","DOI":"10.1038\/s41598-020-74934-9","article-title":"Unravelling the antimicrobial action of antidepressants on gut commensal microbes","volume":"10","author":"Ait Chait","year":"2020","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1128\/MCB.00858-12","article-title":"Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor \u03b3","volume":"33","author":"Alex","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1476-511X-10-116","article-title":"Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats","volume":"10","author":"An","year":"2011","journal-title":"Lipids health Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/hep.26160","article-title":"Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells","volume":"57","author":"Anth\u00e9rieu","year":"2013","journal-title":"Hepatol. Baltim. Md"},{"key":"B6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.psychres.2018.09.014","article-title":"Antipsychotics and cardiovascular risk: A case\/non-case study","volume":"270","author":"Arias","year":"2018","journal-title":"Psychiatry Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e652","DOI":"10.1038\/tp.2015.135","article-title":"Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children","volume":"5","author":"Bahr","year":"","journal-title":"Transl. psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.ebiom.2015.10.018","article-title":"Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure","volume":"2","author":"Bahr","year":"","journal-title":"EBioMedicine"},{"key":"B9","doi-asserted-by":"publisher","first-page":"R1-R33","DOI":"10.1530\/JOE-18-0596","article-title":"The melanocortin pathway and control of appetite-progress and therapeutic implications","volume":"241","author":"Baldini","year":"2019","journal-title":"J. Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"S498","DOI":"10.1086\/432005","article-title":"Triglyceride-rich lipoproteins as agents of innate immunity","volume":"41","author":"Barcia","year":"2005","journal-title":"Clin. Infect. Dis. official Publ. Infect. Dis. Soc. Am."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1093\/emboj\/18.17.4722","article-title":"PKA-Mediated phosphorylation of the human K(ATP) channel: Separate roles of Kir6.2 and SUR1 subunit phosphorylation","volume":"18","author":"B\u00e9guin","year":"1999","journal-title":"EMBO J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/s0021-9258(20)89957-8","article-title":"Acyl adenylates; an enzymatic mechanism of acetate activation","volume":"222","author":"Berg","year":"1956","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-chain fatty acids protect against high-fat diet-induced obesity via a ppar\u03b3-dependent switch from lipogenesis to fat oxidation","volume":"64","author":"Besten","year":"2015","journal-title":"Diabetes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"G900","DOI":"10.1152\/ajpgi.00265.2013","article-title":"Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids","volume":"305","author":"Besten","year":"2013","journal-title":"Am. J. physiology. Gastrointest. liver physiology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7356","DOI":"10.3748\/wjg.v20.i23.7356","article-title":"Incretin based therapies: A novel treatment approach for non-alcoholic fatty liver disease","volume":"20","author":"Blaslov","year":"2014","journal-title":"World J. gastroenterology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00429-012-0406-5","article-title":"Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei","volume":"218","author":"Bonn","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"B17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/BF02236073","article-title":"Chlorpromazine hepatotoxicity manifested by A selective and sustained rise of serum alkaline phosphatase activity; report of A case","volume":"10","author":"Breuer","year":"1965","journal-title":"Am. J. Dig. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.chom.2019.04.002","article-title":"Bacteroides-derived sphingolipids are critical for maintaining intestinal homeostasis and symbiosis","volume":"25","author":"Brown","year":"2019","journal-title":"Cell. host microbe"},{"key":"B19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s40261-019-00751-2","article-title":"Association of first-vs. Second-generation antipsychotics with lipid abnormalities in individuals with severe mental illness: A systematic review and meta-analysis","volume":"39","author":"Buhagiar","year":"2019","journal-title":"Clin. drug Investig."},{"key":"B20","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell. metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1007\/s00018-010-0454-z","article-title":"AMP-activated protein kinase and its downstream transcriptional pathways","volume":"67","author":"Cant\u00f3","year":"2010","journal-title":"Cell. Mol. life Sci. CMLS"},{"key":"B22","first-page":"203","article-title":"The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1128\/MCB.01004-12","article-title":"Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes","volume":"33","author":"Caron","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3389\/fnins.2016.00488","article-title":"From molecules to the clinic: Linking schizophrenia and metabolic syndrome through sphingolipids metabolism","volume":"10","author":"Castillo","year":"2016","journal-title":"Front. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.1074\/jbc.M111.310342","article-title":"Regulation of adipocyte formation by GLP-1\/GLP-1R signaling","volume":"287","author":"Challa","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"159054","DOI":"10.1016\/j.scitotenv.2022.159054","article-title":"The antipsychotic drug olanzapine altered lipid metabolism in the common carp (Cyprinus carpio L.): Insight from the gut microbiota-SCFAs-liver axis","volume":"856","author":"Chang","year":"2022","journal-title":"Sci. total Environ."},{"key":"B27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/YCO.0000000000000594","article-title":"Antipsychotics and the microbiota","volume":"33","author":"Chen","year":"2020","journal-title":"Curr. Opin. psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1159\/000478872","article-title":"GLP-1\/GLP-1R signaling in regulation of adipocyte differentiation and lipogenesis","volume":"42","author":"Chen","year":"2017","journal-title":"Cell. physiology Biochem. Int. J. Exp. Cell. physiology, Biochem. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"G554-G573","DOI":"10.1152\/ajpgi.00223.2019","article-title":"Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy","volume":"318","author":"Chiang","year":"2020","journal-title":"Am. J. physiology. Gastrointest. liver physiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annu. Rev. Nutr."},{"key":"B31","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/s0016-5085(03)00896-5","article-title":"Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression","volume":"125","author":"Claudel","year":"2003","journal-title":"Gastroenterology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"E4825","DOI":"10.1073\/pnas.1508737112","article-title":"Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A\/132 agonist","volume":"112","author":"Cohen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"Cotillard","year":"2013","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"146385","DOI":"10.1016\/j.brainres.2019.146385","article-title":"The sex-specific interaction of the microbiome in neurodegenerative diseases","volume":"1724","author":"Cox","year":"2019","journal-title":"Brain Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1039\/d0fo02748k","article-title":"Modulation of the gut microbiota by probiotics and symbiotics is associated with changes in serum metabolite profile related to a decrease in inflammation and overall benefits to metabolic health: A double-blind randomized controlled clinical trial in women with obesity","volume":"12","author":"Crovesy","year":"2021","journal-title":"Food. Funct."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00213-018-5006-5","article-title":"Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function","volume":"236","author":"Cussotto","year":"2019","journal-title":"Psychopharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterology hepatology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.yfrne.2010.06.002","article-title":"Leptin in human physiology and therapeutics","volume":"31","author":"Dardeno","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e309","DOI":"10.1038\/tp.2013.83","article-title":"Antipsychotics and the gut microbiome: Olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat","volume":"3","author":"Davey","year":"2013","journal-title":"Transl. psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00213-011-2555-2","article-title":"Gender-dependent consequences of chronic olanzapine in the rat: Effects on body weight, inflammatory, metabolic and microbiota parameters","volume":"221","author":"Davey","year":"2012","journal-title":"Psychopharmacology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1530\/JOE-20-0018","article-title":"SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD","volume":"245","author":"Deng","year":"2020","journal-title":"J. Endocrinol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/cells10010185","article-title":"Beneficial effects of Akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new PPAR\u03b1 agonists","volume":"10","author":"Depommier","year":"2021","journal-title":"Cells"},{"key":"B44","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/978-1-4939-9554-7_31","article-title":"The probiotic mixture VSL#3 reverses olanzapine-induced metabolic dysfunction in mice","volume":"2011","author":"Dhaliwal","year":"2019","journal-title":"Methods Mol. Biol. Clift. N.J.)"},{"key":"B45","first-page":"178","volume-title":"Microbes, immunity, and behavior: Psychoneuroimmunology meets the microbiome. Neuropsychopharmacology","author":"Dinan","year":"2017"},{"key":"B46","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jff.2017.03.021","article-title":"Screening for lactic acid bacteria in traditional fermented Tibetan yak milk and evaluating their probiotic and cholesterol-lowering potentials in rats fed a high-cholesterol diet","volume":"32","author":"Ding","year":"2017","journal-title":"J. Funct. Foods"},{"key":"B47","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.pharmthera.2006.11.007","article-title":"Mechanisms of action of glucagon-like peptide 1 in the pancreas","volume":"113","author":"Doyle","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12944-020-01203-z","article-title":"Leptin and psychiatric illnesses: Does leptin play a role in antipsychotic-induced weight gain?","volume":"19","author":"Endomba","year":"2020","journal-title":"Lipids health Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nn1214","article-title":"Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system","volume":"7","author":"Fan","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.jpsychires.2013.07.011","article-title":"Schizophrenia and the risk of cardiovascular diseases: A meta-analysis of thirteen cohort studies","volume":"47","author":"Fan","year":"2013","journal-title":"J. psychiatric Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nat. Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1462-2920.2012.02845.x","article-title":"Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure","volume":"15","author":"Ferrer","year":"2013","journal-title":"Environ. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/phar.2214","article-title":"Effects of atypical antipsychotic treatment and resistant starch supplementation on gut microbiome composition in a cohort of patients with bipolar disorder or schizophrenia","volume":"39","author":"Flowers","year":"2019","journal-title":"Pharmacotherapy"},{"key":"B55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/phar.1890","article-title":"Interaction between atypical antipsychotics and the gut microbiome in a bipolar disease cohort","volume":"37","author":"Flowers","year":"2017","journal-title":"Pharmacotherapy"},{"key":"B56","first-page":"515","article-title":"Haloperidol-induced liver disease","volume":"127","author":"Fuller","year":"1977","journal-title":"West. J. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.psychres.2014.06.039","article-title":"Lovastatin for the adjunctive treatment of schizophrenia: A preliminary randomized double-blind placebo-controlled trial","volume":"219","author":"Ghanizadeh","year":"2014","journal-title":"Psychiatry Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.euroneuro.2014.11.008","article-title":"Antipsychotics-induced metabolic alterations: Focus on adipose tissue and molecular mechanisms","volume":"25","author":"Gon\u00e7alves","year":"2015","journal-title":"Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3390\/nu13041206","article-title":"A combination of lactoplantibacillus plantarum strains CECT7527, CECT7528, and CECT7529 plus monacolin K reduces blood cholesterol: Results from a randomized, double-blind, placebo-controlled study","volume":"13","author":"Guerrero-Bonmatty","year":"2021","journal-title":"Nutrients"},{"key":"B60","doi-asserted-by":"publisher","first-page":"5664","DOI":"10.1039\/d0fo00594k","article-title":"S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway","volume":"11","author":"Guo","year":"2020","journal-title":"Food & Funct."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-1286-1_1","article-title":"Functional interrogation of the AgRP neural circuits in control of appetite, body weight, and behaviors","volume":"1090","author":"Han","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00213-002-1368-8","article-title":"Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat","volume":"167","author":"Hartfield","year":"2003","journal-title":"Psychopharmacology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbrc.2016.05.086","article-title":"GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK\/mTOR pathway","volume":"476","author":"He","year":"2016","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.ahj.2005.02.007","article-title":"Schizophrenia and increased risks of cardiovascular disease","volume":"150","author":"Hennekens","year":"2005","journal-title":"Am. heart J."},{"key":"B66","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nrendo.2011.156","article-title":"Metabolic and cardiovascular adverse effects associated with antipsychotic drugs","volume":"8","author":"Hert","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.4088\/jcp.v67n1208","article-title":"Treatment with rosuvastatin for severe dyslipidemia in patients with schizophrenia and schizoaffective disorder","volume":"67","author":"Hert","year":"2006","journal-title":"J. Clin. psychiatry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"447","DOI":"10.18388\/abp.2020_5404","article-title":"Dietary Lactobacillus plantarum LS\/07 and inulin in the management of chronic disease risk factors","volume":"67","author":"Hijova","year":"2020","journal-title":"Acta biochim. Pol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ecl.2008.08.006","article-title":"The microbes of the intestine: An introduction to their metabolic and signaling capabilities","volume":"37","author":"Hsiao","year":"2008","journal-title":"Endocrinol. metabolism Clin. N. Am."},{"key":"B70","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1476-511X-12-67","article-title":"Effects of NS Lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet","volume":"12","author":"Hu","year":"2013","journal-title":"Lipids health Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1007\/s00213-021-05878-9","article-title":"A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: Mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice","volume":"238","author":"Huang","year":"2021","journal-title":"Psychopharmacology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3389\/fphar.2020.00739","article-title":"Increased appetite plays a key role in olanzapine-induced weight gain in first-episode schizophrenia patients","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/schbul\/sbac044","article-title":"Probiotics plus dietary fiber supplements attenuate olanzapine-induced weight gain in drug-na\u00efve first-episode schizophrenia patients: Two randomized clinical trials","volume":"48","author":"Huang","year":"","journal-title":"Schizophr. Bull."},{"key":"B74","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41398-022-01958-2","article-title":"The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: A randomized clinical trial","volume":"12","author":"Huang","year":"","journal-title":"Transl. psychiatry"},{"key":"B75","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1017\/S0007114510001285","article-title":"The hypocholesterolaemic effects of Lactobacillus acidophilus American type culture collection 4356 in rats are mediated by the down-regulation of Niemann-Pick C1-like 1","volume":"104","author":"Huang","year":"2010","journal-title":"Br. J. Nutr."},{"key":"B76","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","first-page":"587189","DOI":"10.3389\/fendo.2020.587189","article-title":"ChREBP-mediated regulation of lipid metabolism: Involvement of the gut microbiota, liver, and adipose tissue","volume":"11","author":"Iizuka","year":"2020","journal-title":"Front. Endocrinol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s00405-016-4058-6","article-title":"The possible mechanisms of the human microbiome in allergic diseases","volume":"274","author":"Ipci","year":"2017","journal-title":"Eur. archives oto-rhino-laryngology official J. Eur. Fed. Oto-Rhino-Laryngological Soc. (EUFOS) Affil. Ger. Soc. Oto-Rhino-Laryngology - Head Neck Surg."},{"key":"B79","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1176\/appi.ajp.2013.12101344","article-title":"Sustained weight loss after treatment with a glucagon-like peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes","volume":"170","author":"Ish\u00f8y","year":"2013","journal-title":"Am. J. psychiatry"},{"key":"B80","doi-asserted-by":"publisher","first-page":"310","DOI":"10.22088\/cjim.11.3.310","article-title":"Prevalence of metabolic syndrome in schizophrenia patients treated with antipsychotic medications","volume":"11","author":"Jaberi","year":"2020","journal-title":"Casp. J. Intern. Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41398-020-0785-y","article-title":"Adjunctive metformin for antipsychotic-induced dyslipidemia: A meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"10","author":"Jiang","year":"2020","journal-title":"Transl. psychiatry"},{"key":"B82","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fendo.2017.00372","article-title":"Short-chain fatty acids differentially affect intracellular lipolysis in a human white adipocyte model","volume":"8","author":"Jocken","year":"2017","journal-title":"Front. Endocrinol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11912-016-0528-7","article-title":"The gut microbiome and obesity","volume":"18","author":"John","year":"2016","journal-title":"Curr. Oncol. Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1038\/s41467-020-16274-w","article-title":"Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels","volume":"11","author":"Johnson","year":"2020","journal-title":"Nat. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jff.2015.10.006","article-title":"Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA (2) activity in overweight subjects","volume":"19","author":"Jung","year":"2015","journal-title":"J. Funct. FOODS"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1113\/jphysiol.2007.143818","article-title":"Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells","volume":"586","author":"Kang","year":"2008","journal-title":"J. physiology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00406-017-0820-z","article-title":"The microbiome-gut-brain axis: Implications for schizophrenia and antipsychotic induced weight gain","volume":"268","author":"Kanji","year":"2018","journal-title":"Eur. archives psychiatry Clin. Neurosci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuropharm.2019.02.014","article-title":"Prebiotic reduction of brain histone deacetylase (HDAC) activity and olanzapine-mediated weight gain in rats, are acetate independent","volume":"150","author":"Kao","year":"","journal-title":"Neuropharmacology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.schres.2019.03.003","article-title":"Pro-cognitive effect of a prebiotic in psychosis: A double blind placebo controlled cross-over study","volume":"208","author":"Kao","year":"","journal-title":"Schizophrenia Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41398-018-0116-8","article-title":"Prebiotic attenuation of olanzapine-induced weight gain in rats: Analysis of central and peripheral biomarkers and gut microbiota","volume":"8","author":"Kao","year":"2018","journal-title":"Transl. psychiatry"},{"key":"B91","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"B92","doi-asserted-by":"publisher","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3389\/fmicb.2019.01947","article-title":"Alterations in gut microbiota by statin therapy and possible intermediate effects on hyperglycemia and hyperlipidemia","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Microbiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbrc.2012.12.121","article-title":"Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production","volume":"431","author":"Kim","year":"2013","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B95","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1159\/000490615","article-title":"The gut microbiota and healthy aging: A mini-review","volume":"64","author":"Kim","year":"2018","journal-title":"Gerontology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1038\/s41467-018-05767-4","article-title":"The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice","volume":"9","author":"Kindt","year":"2018","journal-title":"Nat. Commun."},{"key":"B99","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12866-021-02198-y","article-title":"Sex differences in the phylum-level human gut microbiota composition","volume":"21","author":"Koliada","year":"2021","journal-title":"BMC Microbiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell."},{"key":"B101","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.schres.2018.09.019","article-title":"GLP-1 agonists for metabolic disorders in schizophrenia","volume":"204","author":"Kouidrat","year":"2019","journal-title":"Schizophrenia Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41579-020-0438-4","article-title":"Gut microbial metabolites as multi-kingdom intermediates","volume":"19","author":"Krautkramer","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1699-0463.1979.tb02445.x","article-title":"Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall","volume":"87","author":"Kristiansen","year":"1979","journal-title":"Acta pathologica Microbiol. Scand. Sect. B, Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4274\/jcrpe.3682","article-title":"The relationship between serum zonulin level and clinical and laboratory parameters of childhood obesity","volume":"9","author":"K\u00fcme","year":"2017","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1096\/fj.09-150672","article-title":"Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender","volume":"24","author":"Lage","year":"2010","journal-title":"FASEB J. official Publ. Fed. Am. Soc. Exp. Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/14656566.2017.1288722","article-title":"How gender affects the pharmacotherapeutic approach to treating psychosis - a systematic review","volume":"18","author":"Lange","year":"2017","journal-title":"Expert Opin. Pharmacother."},{"key":"B107","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41598-017-18259-0","article-title":"SCFAs strongly stimulate PYY production in human enteroendocrine cells","volume":"8","author":"Larraufie","year":"2018","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00010.2008","article-title":"Role of bile acids and bile acid receptors in metabolic regulation","volume":"89","author":"Lefebvre","year":"2009","journal-title":"Physiol. Rev."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/s41401-021-00680-x","article-title":"Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1\/GLP1R signaling in rats","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.3390\/ijms17111865","article-title":"Berberine alleviates olanzapine-induced adipogenesis via the ampk\u03b1-SREBP pathway in 3T3-L1 cells","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell. metab."},{"key":"B112","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13063-021-05123-w","article-title":"Dietary fiber and probiotics for the treatment of atypical antipsychotic-induced metabolic side effects: Study protocol for a randomized, double-blind, placebo-controlled trial","volume":"22","author":"Liu","year":"2021","journal-title":"Trials"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/s41401-019-0212-1","article-title":"Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway","volume":"40","author":"Liu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"B114","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40360-020-00427-0","article-title":"Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Pharmacol. Toxicol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tem.2015.01.003","article-title":"Regulation of energy homeostasis by the NPY system","volume":"26","author":"Loh","year":"2015","journal-title":"Trends Endocrinol. metabolism TEM"},{"key":"B116","first-page":"394","article-title":"Possible olanzapine-induced hepatotoxicity in a young Chinese patient","volume":"15","author":"Lui","year":"2009","journal-title":"Hong Kong Med. J. = Xianggang yi xue za zhi"},{"key":"B117","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00213-020-05677-8","article-title":"Coadministration of metformin prevents olanzapine-induced metabolic dysfunction and regulates the gut-liver axis in rats","volume":"238","author":"Luo","year":"2021","journal-title":"Psychopharmacology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"13270","DOI":"10.1038\/s41598-017-13774-6","article-title":"The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity","volume":"7","author":"Lynch","year":"2017","journal-title":"Sci. Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jpsychires.2020.02.005","article-title":"Alteration of the gut microbiome in first-episode drug-na\u00efve and chronic medicated schizophrenia correlate with regional brain volumes","volume":"123","author":"Ma","year":"2020","journal-title":"J. psychiatric Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1192\/bjp.bp.106.031716","article-title":"Metabolic disease and cardiovascular risk in people treated with antipsychotics in the community","volume":"191","author":"Mackin","year":"2007","journal-title":"Br. J. psychiatry J. Ment. Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"B122","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fphys.2019.00428","article-title":"The influence of the gut microbiome on host metabolism through the regulation of gut hormone release","volume":"10","author":"Martin","year":"2019","journal-title":"Front. physiology"},{"key":"B123","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.chom.2018.03.011","article-title":"Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids","volume":"23","author":"Martinez-Guryn","year":"2018","journal-title":"Cell. host microbe"},{"key":"B124","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/s0006-291x(02)02550-0","article-title":"Identification of membrane-type receptor for bile acids (M-BAR)","volume":"298","author":"Maruyama","year":"2002","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.4161\/cc.7.12.6157","article-title":"Leptin and mTOR: Partners in metabolism and inflammation","volume":"7","author":"Maya-Monteiro","year":"2008","journal-title":"Cell. cycleGeorget. Tex.)"},{"key":"B126","first-page":"22","article-title":"Lipid profile in schizophrenia: Case control study","volume":"96","author":"Mhalla","year":"2018","journal-title":"La Tunis. medicale"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1128\/aem.62.5.1589-1592.1996","article-title":"Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora","volume":"62","author":"Miller","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/415339a","article-title":"Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase","volume":"415","author":"Minokoshi","year":"2002","journal-title":"Nature"},{"key":"B129","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrmicro.2017.30","article-title":"M\u00e9nage \u00e0 trois in the human gut: Interactions between host, bacteria and phages","volume":"15","author":"Mirzaei","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"e115225","DOI":"10.1371\/journal.pone.0115225","article-title":"The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse","volume":"9","author":"Morgan","year":"2014","journal-title":"PloS one"},{"key":"B131","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut microbes"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.jhep.2014.12.034","article-title":"Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity","volume":"62","author":"Mueller","year":"2015","journal-title":"J. hepatology"},{"key":"B133","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2337\/diabetes.51.4.901","article-title":"Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells","volume":"51","author":"Muoio","year":"2002","journal-title":"Diabetes"},{"key":"B134","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.lwt.2019.05.057","article-title":"Hypocholesterolaemic activity of a novel autochthonous potential probiotic Lactobacillus plantarum YS5 isolated from yogurt","volume":"111","author":"Nami","year":"2019","journal-title":"LWT-FOOD Sci. Technol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"e0189950","DOI":"10.1371\/journal.pone.0189950","article-title":"Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity","volume":"13","author":"Nehme","year":"2018","journal-title":"PloS one"},{"key":"B136","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1146\/annurev-pharmtox-011613-135945","article-title":"Free fatty acid (FFA) and hydroxy carboxylic acid (HCA) receptors","volume":"54","author":"Offermanns","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"E624","DOI":"10.1152\/ajpendo.00502.2010","article-title":"Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism","volume":"300","author":"Oh","year":"2011","journal-title":"Am. J. physiology. Endocrinol. metabolism"},{"key":"B138","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/0269881107077815","article-title":"Statins are effective in treating dyslipidemia among psychiatric patients using second-generation antipsychotic agents","volume":"22","author":"Ojala","year":"2008","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"B139","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","article-title":"Macronutrient metabolism by the human gut microbiome: Major fermentation by-products and their impact on host health","volume":"7","author":"Oliphant","year":"2019","journal-title":"Microbiome"},{"key":"B140","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e59470","DOI":"10.1371\/journal.pone.0059470","article-title":"Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity","volume":"8","author":"Park","year":"2013","journal-title":"PloS one"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.3390\/jcm8101605","article-title":"Analysis of gut microbiota and their metabolic potential in patients with schizophrenia treated with olanzapine: Results from a six-week observational prospective cohort study","volume":"8","author":"Pe\u0142ka-Wysiecka","year":"2019","journal-title":"J. Clin. Med."},{"key":"B143","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s42255-021-00398-4","article-title":"Central anorexigenic actions of bile acids are mediated by TGR5","volume":"3","author":"Perino","year":"2021","journal-title":"Nat. Metab."},{"key":"B144","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate mediates a microbiome-brain-\u03b2-cell axis to promote metabolic syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature"},{"key":"B145","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41380-018-0275-2","article-title":"Correction to: Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models","volume":"24","author":"Pillinger","year":"2019","journal-title":"Mol. psychiatry"},{"key":"B146","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1210\/me.2002-0120","article-title":"Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor","volume":"17","author":"Pineda Torra","year":"2003","journal-title":"Mol. Endocrinol. Baltim. Md"},{"key":"B147","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s42255-021-00345-3","article-title":"POMC neuronal heterogeneity in energy balance and beyond: An integrated view","volume":"3","author":"Quarta","year":"2021","journal-title":"Nat. Metab."},{"key":"B148","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1096\/fj.10-164921","article-title":"Germ-free C57BL\/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism","volume":"24","author":"Rabot","year":"2010","journal-title":"FASEB J. official Publ. Fed. Am. Soc. Exp. Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/1471-0307.12154","article-title":"Anti-obesity effect of feeding probiotic dahi containing Lactobacillus casei NCDC 19 in high fat diet-induced obese mice","volume":"67","author":"Rather","year":"2014","journal-title":"Int. J. DAIRY Technol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s0303-7207(03)00146-1","article-title":"Cell signalling of the GLP-1 action in rat liver","volume":"204","author":"Redondo","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"90","DOI":"10.5217\/ir.2014.12.2.90","article-title":"Lipopolysaccharide: Basic biochemistry, intracellular signaling, and physiological impacts in the gut","volume":"12","author":"Rhee","year":"2014","journal-title":"Intestinal Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Sci. (New York, N.Y.)"},{"key":"B153","doi-asserted-by":"publisher","first-page":"zqab019","DOI":"10.1093\/function\/zqab019","article-title":"Gut microbiota represent a major thermogenic biomass","volume":"2","author":"Riedl","year":"2021","journal-title":"Funct. Oxf. Engl."},{"key":"B154","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/mp.2016.50","article-title":"From gut dysbiosis to altered brain function and mental illness: Mechanisms and pathways","volume":"21","author":"Rogers","year":"2016","journal-title":"Mol. psychiatry"},{"key":"B155","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fendo.2018.00672","article-title":"Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function","volume":"9","author":"Rowlands","year":"2018","journal-title":"Front. Endocrinol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3109\/09637486.2013.775224","article-title":"The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: A randomized triple-masked controlled trial","volume":"64","author":"Safavi","year":"2013","journal-title":"Int. J. food Sci. Nutr."},{"key":"B157","doi-asserted-by":"publisher","first-page":"135142","DOI":"10.1155\/2013\/135142","article-title":"The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet","volume":"2013","author":"Salaj","year":"2013","journal-title":"TheScientificWorldJournal"},{"key":"B158","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"Samuel","year":"2008","journal-title":"Gpr41. Proc. Natl. Acad. Sci. U. S. A."},{"key":"B159","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell. metab."},{"key":"B160","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1124\/jpet.113.207621","article-title":"Olanzapine activates hepatic mammalian target of rapamycin: New mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs","volume":"347","author":"Schmidt","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B161","doi-asserted-by":"publisher","first-page":"16643","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci. Rep."},{"key":"B162","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/oby.2009.167","article-title":"Microbiota and SCFA in lean and overweight healthy subjects","volume":"18","author":"Schwiertz","year":"2010","journal-title":"Obes. (Silver Spring, Md"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/schbul\/sbm141","article-title":"Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: A review","volume":"34","author":"Sentissi","year":"2008","journal-title":"Schizophr. Bull."},{"key":"B164","doi-asserted-by":"publisher","first-page":"110258","DOI":"10.1016\/j.pnpbp.2021.110258","article-title":"Gut microbiota alteration and modulation in psychiatric disorders: Current evidence on fecal microbiota transplantation","volume":"109","author":"Settanni","year":"2021","journal-title":"Prog. neuro-psychopharmacology Biol. psychiatry"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1097\/MEG.0b013e3282f8e3a0","article-title":"Drug-induced liver injury: Hepatotoxicity of quetiapine revisited","volume":"20","author":"Shpaner","year":"2008","journal-title":"Eur. J. gastroenterology hepatology"},{"key":"B166","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/s0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell."},{"key":"B167","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/09637486.2014.953450","article-title":"Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet","volume":"66","author":"Singh","year":"2015","journal-title":"Int. J. food Sci. Nutr."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00213-018-5102-6","article-title":"Second-generation antipsychotics and metabolism alterations: A systematic review of the role of the gut microbiome","volume":"236","author":"Skonieczna-\u017bydecka","year":"2019","journal-title":"Psychopharmacology"},{"key":"B169","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.neuron.2011.06.012","article-title":"Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels","volume":"71","author":"Sohn","year":"2011","journal-title":"Neuron"},{"key":"B170","doi-asserted-by":"publisher","first-page":"790046","DOI":"10.3389\/fendo.2021.790046","article-title":"Efficacy and safety of Lactobacillus plantarum K50 on lipids in Koreans with obesity: A randomized, double-blind controlled clinical trial","volume":"12","author":"Sohn","year":"2021","journal-title":"Front. Endocrinol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1053\/j.gastro.2010.11.049","article-title":"Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency","volume":"140","author":"Spencer","year":"2011","journal-title":"Gastroenterology"},{"key":"B172","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1096\/fj.12-225136","article-title":"Differential regulation of AMPK activation in leptin- and creatine-deficient mice","volume":"27","author":"Stockebrand","year":"2013","journal-title":"FASEB J. official Publ. Fed. Am. Soc. Exp. Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1755-8794-6-39","article-title":"Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes","volume":"6","author":"Szalowska","year":"2013","journal-title":"BMC Med. genomics"},{"key":"B174","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/YIC.0000000000000159","article-title":"Simvastatin adjunct therapy for negative symptoms of schizophrenia: A randomized double-blind placebo-controlled trial","volume":"32","author":"Tajik-Esmaeeli","year":"2017","journal-title":"Int. Clin. Psychopharmacol."},{"key":"B175","first-page":"E45","article-title":"Regulation of SREBP1c expression by mTOR signaling in hepatocytes","volume":"55","author":"Takashima","year":"2009","journal-title":"Kobe J. Med. Sci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"116398","DOI":"10.1016\/j.carbpol.2020.116398","article-title":"A synbiotic consisting of Lactobacillus plantarum S58 and hull-less barley \u03b2-glucan ameliorates lipid accumulation in mice fed with a high-fat diet by activating AMPK signaling and modulating the gut microbiota","volume":"243","author":"Tang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"B177","doi-asserted-by":"publisher","first-page":"E960","DOI":"10.1152\/ajpendo.00237.2005","article-title":"Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: Effects of time and intensity","volume":"289","author":"Taylor","year":"2005","journal-title":"Am. J. physiology Endocrinol. metabolism"},{"key":"B178","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.2337\/db13-0430","article-title":"Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease","volume":"62","author":"Teff","year":"2013","journal-title":"Diabetes"},{"key":"B179","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.tem.2011.07.002","article-title":"Hepatic FXR: Key regulator of whole-body energy metabolism","volume":"22","author":"Teodoro","year":"2011","journal-title":"Trends Endocrinol. metabolism TEM"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1007\/s12602-019-09622-w","article-title":"Hypocholesterolemic effect of potential probiotic Lactobacillus fermentum strains isolated from traditional fermented foods in wistar rats","volume":"12","author":"Thakkar","year":"2020","journal-title":"Probiotics Antimicrob. proteins"},{"key":"B181","doi-asserted-by":"publisher","first-page":"e64518","DOI":"10.1371\/journal.pone.0064518","article-title":"Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300","volume":"8","author":"Thorsing","year":"2013","journal-title":"PloS one"},{"key":"B182","doi-asserted-by":"publisher","first-page":"11102","DOI":"10.1038\/s41598-017-10734-y","article-title":"Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients","volume":"7","author":"Ticinesi","year":"2017","journal-title":"Sci. Rep."},{"key":"B183","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41577-019-0198-4","article-title":"The intestinal microbiota fuelling metabolic inflammation","volume":"20","author":"Tilg","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4137\/BMI.S22007","article-title":"Immunomodulatory effects of probiotic supplementation in schizophrenia patients: A randomized, placebo-controlled trial","volume":"10","author":"Tomasik","year":"2015","journal-title":"Biomark. insights"},{"key":"B185","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1159\/000282091","article-title":"Bile acids as regulators of hepatic lipid and glucose metabolism","volume":"28","author":"Trauner","year":"2010","journal-title":"Dig. Dis. (Basel, Switz."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"B187","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1073\/pnas.96.5.2327","article-title":"Regulation of fatty acid homeostasis in cells: Novel role of leptin","volume":"96","author":"Unger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B188","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/wps.20614","article-title":"The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: A meta-review of meta-analyses of randomized controlled trials","volume":"18","author":"Vancampfort","year":"2019","journal-title":"World psychiatry official J. World Psychiatric Assoc. (WPA)"},{"key":"B189","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/wps.20252","article-title":"Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta-analysis","volume":"14","author":"Vancampfort","year":"2015","journal-title":"World psychiatry official J. World Psychiatric Assoc. (WPA)"},{"key":"B190","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1677\/JME-10-0068","article-title":"Ghrelin and lipid metabolism: Key partners in energy balance","volume":"46","author":"Varela","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/s41586-020-2269-x","article-title":"Statin therapy is associated with lower prevalence of gut microbiota dysbiosis","volume":"581","author":"Vieira-Silva","year":"2020","journal-title":"Nature"},{"key":"B192","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.schres.2014.08.021","article-title":"A randomized placebo-controlled pilot study of pravastatin as an adjunctive therapy in schizophrenia patients: Effect on inflammation, psychopathology, cognition and lipid metabolism","volume":"159","author":"Vincenzi","year":"2014","journal-title":"Schizophrenia Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell. metab."},{"key":"B194","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"B195","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/oby.20605","article-title":"Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue","volume":"22","author":"Wan","year":"2014","journal-title":"Obes. (Silver Spring, Md.)"},{"key":"B196","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/s1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell."},{"key":"B197","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.3168\/jds.2011-4768","article-title":"Selection of potential probiotic lactobacilli for cholesterol-lowering properties and their effect on cholesterol metabolism in rats fed a high-lipid diet","volume":"95","author":"Wang","year":"2012","journal-title":"J. dairy Sci."},{"key":"B198","doi-asserted-by":"publisher","first-page":"321","DOI":"10.5582\/bst.2021.01317","article-title":"Metformin acts on the gut-brain axis to ameliorate antipsychotic-induced metabolic dysfunction","volume":"15","author":"Wang","year":"2021","journal-title":"Biosci. trends"},{"key":"B199","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00253-009-2012-x","article-title":"Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet","volume":"84","author":"Wang","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2015.08.092","article-title":"GLP-1 contributes to increases in PGC-1\u03b1 expression by downregulating miR-23a to reduce apoptosis","volume":"466","author":"Wang, C","year":"2015","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ismej.2014.99","article-title":"Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice","volume":"9","author":"Wang, J","year":"2015","journal-title":"ISME J."},{"key":"B202","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J. Clin. investigation"},{"key":"B204","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12929-018-0437-1","article-title":"Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration","volume":"25","author":"Weston-Green","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"B205","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1186\/s13063-019-3689-5","article-title":"Liraglutide and the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first-episode psychosis: Protocol for a pilot trial","volume":"20","author":"Whicher","year":"2019","journal-title":"Trials"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1345\/aph.1K145","article-title":"Risperidone- and quetiapine-induced cholestasis","volume":"41","author":"Wright","year":"2007","journal-title":"Ann. Pharmacother."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/mp.2015.221","article-title":"Metformin treatment of antipsychotic-induced dyslipidemia: An analysis of two randomized, placebo-controlled trials","volume":"21","author":"Wu","year":"2016","journal-title":"Mol. psychiatry"},{"key":"B208","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/JCP.0b013e3180cac8db","article-title":"Sex difference in effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia","volume":"27","author":"Wu","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1472-6882-11-53","article-title":"Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet","volume":"11","author":"Xie","year":"2011","journal-title":"BMC complementary Altern. Med."},{"key":"B210","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1590\/S1517-838246220131278","article-title":"Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat","volume":"46","author":"Xie","year":"2015","journal-title":"Braz. J. Microbiol. Publ. Braz. Soc. Microbiol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gad.281410.116","article-title":"Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1\u03b1\/ERR\u03b1","volume":"30","author":"Yan","year":"2016","journal-title":"Genes. Dev."},{"key":"B212","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1007\/s00213-021-05866-z","article-title":"Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis","volume":"238","author":"Yang","year":"2021","journal-title":"Psychopharmacology"},{"key":"B213","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12888-022-03853-y","article-title":"Previous exposure to antipsychotic drug treatment is an effective predictor of metabolic disturbances experienced with current antipsychotic drug treatments","volume":"22","author":"Yang","year":"2022","journal-title":"BMC psychiatry"},{"key":"B214","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"B215","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.3748\/wjg.v16.i27.3394","article-title":"Effects of four Bifidobacteria on obesity in high-fat diet induced rats","volume":"16","author":"Yin","year":"2010","journal-title":"World J. gastroenterology"},{"key":"B216","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1002\/oby.20428","article-title":"Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity","volume":"21","author":"Yoo","year":"2013","journal-title":"Obes. (Silver Spring, Md.)"},{"key":"B217","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41398-021-01531-3","article-title":"Gut microbial biomarkers for the treatment response in first-episode, drug-na\u00efve schizophrenia: A 24-week follow-up study","volume":"11","author":"Yuan","year":"2021","journal-title":"Transl. psychiatry"},{"key":"B218","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.schres.2018.05.017","article-title":"Changes in metabolism and microbiota after 24-week risperidone treatment in drug na\u00efve, normal weight patients with first episode schizophrenia","volume":"201","author":"Yuan","year":"2018","journal-title":"Schizophrenia Res."},{"key":"B219","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1093\/jn\/133.11.3509","article-title":"Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells","volume":"133","author":"Zambell","year":"2003","journal-title":"J. Nutr."},{"key":"B220","doi-asserted-by":"publisher","first-page":"4262094","DOI":"10.1155\/2022\/4262094","article-title":"Analysis of gut microbiota in patients with exacerbated symptoms of schizophrenia following therapy with amisulpride: A pilot study","volume":"2022","author":"Zheng","year":"2022","journal-title":"Behav. Neurol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1038\/s41598-022-09610-1","article-title":"Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXR\u03b1\/PCSK9 pathway","volume":"12","author":"Zhu, W","year":"2022","journal-title":"Sci. Rep."},{"key":"B222","doi-asserted-by":"publisher","first-page":"897926","DOI":"10.3389\/fphar.2022.897926","article-title":"Olanzapine-induced lipid disturbances: A potential mechanism through the gut microbiota-brain axis","volume":"13","author":"Zhu, Z","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41398-021-01778-w","article-title":"Mechanistic\/mammalian target of rapamycin and side effects of antipsychotics: Insights into mechanisms and implications for therapy","volume":"12","author":"Zhuo","year":"2022","journal-title":"Transl. psychiatry"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1097284\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:31:00Z","timestamp":1674624660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1097284\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":223,"alternative-id":["10.3389\/fphar.2023.1097284"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1097284","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"article-number":"1097284"}}