{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:47:40Z","timestamp":1788536860069,"version":"build-2803163510"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Stroke is one of the leading causes of mortality and permanent disability worldwide. However, the current stroke treatment has a limited effect. Therefore, a new treatment is urgently needed. Stem cell therapy is a cutting-edge treatment for stroke patients. This study aimed to gain better understanding of global stem cell trends in stroke <jats:italic>via<\/jats:italic> a bibliometric analysis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We used the Web of Science Core Collection to search pertinent articles about stem cells in stroke published between 2004 and 2022. Analysis was conducted using CiteSpace, VOSviewer, and the R package \u201cbibliometrix\u201d to identify publication outputs, countries\/regions, institutions, authors\/co-cited authors, journals\/co-cited journals, co-cited references, and keywords.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 6,703 publications were included in the bibliometric analysis. The total number of citations significantly and rapidly increased between 2004 and 2022, with the most pronounced growth pattern observed in the period of 2008\u20132009. In terms of authoritarian countries, the USA had the most publications among the countries. As for institutions and authors, the most prolific institution was the University of South Florida, followed by Oakland University and then Shanghai Jiao Tong University, and Chopp, M. and Borlongan, Cesario V, had the most output among the authors. Regarding the journals, <jats:italic>Cell Transplantation<\/jats:italic> had the highest publication, followed by <jats:italic>Brain Research<\/jats:italic>. As for references, \u201cMesenchymal stem cells as trophic mediators\u201d was the most frequently cited (2,082), and the article entitled <jats:italic>Neuronal replacement from endogenous precursors in the adult brain after stroke<\/jats:italic> had the strongest burstiness (strength = 81.35). Emerging hot words in the past decade included \u201cadhesion molecule,\u201d \u201cmesenchymal stromal cell,\u201d \u201cextracellular vesicle,\u201d \u201cpluripotent stem cells,\u201d \u201csignaling pathway,\u201d \u201cplasticity,\u201d and \u201cexosomes.\u201d<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Between 2004 and 2022, the terms \u201cneurogenesis,\u201d \u201cangiogenesis,\u201d \u201cmesenchymal stem cells,\u201d \u201cextracellular vesicle,\u201d \u201cexosomes,\u201d \u201cinflammation,\u201d and \u201coxidative stress\u201d have emerged as the hot research areas for research on stem cells in stroke. Although stem cells exert a number of positive effects, the main mechanisms for mitigating the damage caused by stroke are still unknown. Clinical challenges may include complicating factors that can affect the efficacy of stem cell therapy, which are worth a deep exploration.<\/jats:p>","DOI":"10.3389\/fphar.2023.1111815","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T05:16:45Z","timestamp":1677820605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022"],"prefix":"10.3389","volume":"14","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s13287-015-0175-1","article-title":"Pre-Differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke","volume":"6","author":"Abeysinghe","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1152\/physrev.00055.2003","article-title":"Adult neurogenesis: From precursors to network and physiology","volume":"85","author":"Abrous","year":"2005","journal-title":"Physiol. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3390\/cells7120250","article-title":"Mesenchymal stem cells (MSCs) coculture protects [Ca2+]i orchestrated oxidant mediated damage in differentiated neurons in vitro","volume":"7","author":"Alhazzani","year":"2018","journal-title":"Cells"},{"key":"B4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/sctm.19-0114","article-title":"Mesenchymal stromal cell-derived extracellular vesicles for regenerative therapy and immune modulation: Progress and challenges toward clinical application","volume":"9","author":"Allan","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Inf."},{"key":"B6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.15283\/ijsc.2012.5.1.31","article-title":"The levels of pro-inflammatory factors are significantly decreased in cerebral palsy patients following an allogeneic umbilical cord blood cell transplant","volume":"5","author":"Bae","year":"2012","journal-title":"Int. J. Stem Cells"},{"key":"B8","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann. Neurology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.2174\/0929867325666180111101410","article-title":"Mesenchymal stem cell therapy in intracerebral haemorrhagic stroke","volume":"25","author":"Bedini","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1002\/glia.22406","article-title":"Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation","volume":"60","author":"Buller","year":"2012","journal-title":"Glia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.biochi.2020.09.025","article-title":"Stroke treatment: Is exosome therapy superior to stem cell therapy?","volume":"179","author":"Cai","year":"2020","journal-title":"Biochimie"},{"key":"B12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/jcp.21200","article-title":"Adult mesenchymal stem cells for tissue engineering versus regenerative medicine","volume":"213","author":"Caplan","year":"2007","journal-title":"J. Cell. Physiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"104877","DOI":"10.1016\/j.phrs.2020.104877","article-title":"Therapeutic targets of oxidative\/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology","volume":"158","author":"Chen","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1517\/14712598.2012.674507","article-title":"Emerging trends in regenerative medicine: A scientometric analysis in CiteSpace","volume":"12","author":"Chen","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1161\/STROKEAHA.107.490946","article-title":"Atorvastatin promotes presenilin-1 expression and Notch1 activity and increases neural progenitor cell proliferation after stroke","volume":"39","author":"Chen","year":"2008","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","first-page":"74537","DOI":"10.18632\/oncotarget.12902","article-title":"Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"B18","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3389\/fphys.2020.00433","article-title":"Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: Potential application of natural compounds","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Physiology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"133932","DOI":"10.1016\/j.chemosphere.2022.133932","article-title":"Wastewater treatment and emerging contaminants: Bibliometric analysis","volume":"297","author":"Chen","year":"2022","journal-title":"Chemosphere"},{"key":"B20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000477122","article-title":"Bone marrow mesenchymal stem cell transplantation increases GAP-43 expression via ERK1\/2 and PI3K\/akt pathways in intracerebral hemorrhage","volume":"42","author":"Cui","year":"2017","journal-title":"Cell. Physiology Biochem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/mt.2009.104","article-title":"Molecular and magnetic resonance imaging of human embryonic stem cell\u2013derived neural stem cell grafts in ischemic rat brain","volume":"17","author":"Daadi","year":"2009","journal-title":"Mol. Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/ijpvm.ijpvm_441_21","article-title":"Safety of intraparenchymal injection of allogenic placenta mesenchymal stem cells derived exosome in patients undergoing decompressive craniectomy following malignant middle cerebral artery infarct, A pilot randomized clinical trial","volume":"13","author":"Dehghani","year":"2022","journal-title":"Int. J. Prev. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/jcbfm.2013.50","article-title":"The sonic hedgehog pathway mediates brain plasticity and subsequent functional recovery after bone marrow stromal cell treatment of stroke in mice","volume":"33","author":"Ding","year":"2013","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1182\/blood-2003-04-1193","article-title":"Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals","volume":"102","author":"Djouad","year":"2003","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","first-page":"876954","DOI":"10.3389\/fnagi.2022.876954","article-title":"Exercise for stroke rehabilitation: A bibliometric analysis of global research from 2001 to 2021","volume":"14","author":"Dong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"628663","DOI":"10.3389\/fnins.2021.628663","article-title":"Induced pluripotent stem cells for ischemic stroke treatment","volume":"15","author":"Duan","year":"2021","journal-title":"Front. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nature11260","article-title":"Myocardial infarction accelerates atherosclerosis","volume":"487","author":"Dutta","year":"2012","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpsychires.2018.08.015","article-title":"Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis","volume":"105","author":"Godfrey","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"641157","DOI":"10.3389\/fnins.2021.641157","article-title":"Oxidative stress, inflammation, and autophagy: Potential targets of mesenchymal stem cells-based therapies in ischemic stroke","volume":"15","author":"He","year":"","journal-title":"Front. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"120448","DOI":"10.1016\/j.biomaterials.2020.120448","article-title":"MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway","volume":"265","author":"He","year":"","journal-title":"Biomaterials"},{"key":"B32","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1177\/0963689718816990","article-title":"Potential of exosomes for the treatment of stroke","volume":"28","author":"Hong","year":"2019","journal-title":"Cell Transplant."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/brain\/awr063","article-title":"Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke","volume":"134","author":"Honmou","year":"2011","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/stem.584","article-title":"Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair","volume":"29","author":"Horie","year":"2011","journal-title":"Stem Cells"},{"key":"B35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2176\/nmc.ra.2014-0271","article-title":"Stem cell transplantation enhances endogenous brain repair after experimental stroke","volume":"55","author":"Horie","year":"2015","journal-title":"Neurol. Medico-Chirurgica"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1007\/s12035-016-9740-6","article-title":"Exogenous neural stem cells transplantation as a potential therapy for photothrombotic ischemia stroke in kunming mice model","volume":"54","author":"Hou","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/jcbfm.2008.47","article-title":"Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1","volume":"28","author":"Iosif","year":"2008","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5930244","article-title":"Ischemic brain stroke and mesenchymal stem cells: An overview of molecular mechanisms and therapeutic potential","volume":"2022","author":"Jingli","year":"2022","journal-title":"Stem Cells Int."},{"key":"B39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/sctm.19-0202","article-title":"Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range?","volume":"9","author":"Kabat","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0140-6736(16)30513-X","article-title":"Human neural stem cells in patients with chronic ischaemic stroke (PISCES): A phase 1, first-in-man study","volume":"388","author":"Kalladka","year":"2016","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/hir.12295","article-title":"Application of bibliometrics in medicine: A historical bibliometrics analysis","volume":"38","author":"Kokol","year":"2021","journal-title":"Health info. Libr. J."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0115","article-title":"Placental mesenchymal stromal cells derived from blood vessels or avascular tissues: What is the better choice to support endothelial cell function?","volume":"24","author":"K\u00f6nig","year":"2015","journal-title":"Stem Cells Dev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"E7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: Present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"891514","DOI":"10.3389\/fneur.2022.891514","article-title":"Safety and clinical efficacy of mesenchymal stem cell treatment in traumatic spinal cord injury, multiple sclerosis and ischemic stroke - a systematic review and meta-analysis","volume":"13","author":"Kvistad","year":"2022","journal-title":"Front. Neurology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1530\/JOE-15-0201","article-title":"Microvesicles and exosomes: New players in metabolic and cardiovascular disease","volume":"228","author":"Lawson","year":"2016","journal-title":"J. Endocrinol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7795","DOI":"10.3390\/ijms21207795","article-title":"Enhancing the therapeutic potential of CCL2-overexpressing mesenchymal stem cells in acute stroke","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1021\/acschemneuro.1c00599","article-title":"SRC3 promotes the protective effects of bone marrow mesenchymal stem cell transplantation on cerebral ischemia in a mouse model","volume":"13","author":"Lei","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1161\/STROKEAHA.119.026318","article-title":"Phase I\/II study of safety and preliminary efficacy of intravenous allogeneic mesenchymal stem cells in chronic stroke","volume":"50","author":"Levy","year":"2019","journal-title":"Stroke"},{"key":"B49","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.brainresbull.2019.10.001","article-title":"Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke","volume":"153","author":"Li","year":"2019","journal-title":"Brain Res. Bull."},{"key":"B50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1108\/ijicc-06-2020-0067","article-title":"Bibliometric analysis on Pythagorean fuzzy sets during 2013\u20132020","volume":"14","author":"Lin","year":"2020","journal-title":"Int. J. Intelligent Comput. Cybern."},{"key":"B51","doi-asserted-by":"publisher","first-page":"12478","DOI":"10.1074\/jbc.M112.449025","article-title":"MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"22680","DOI":"10.1074\/jbc.M109.006551","article-title":"Angiopoietin 2 mediates the differentiation and migration of neural progenitor cells in the subventricular zone after stroke","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mvr.2019.01.001","article-title":"Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke","volume":"123","author":"Liu","year":"2019","journal-title":"Microvasc. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","article-title":"Cell based therapies for ischemic stroke: From basic science to bedside","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"9628536","DOI":"10.1155\/2019\/9628536","article-title":"Challenges and controversies in human mesenchymal stem cell therapy","volume":"2019","author":"Lukomska","year":"2019","journal-title":"Stem Cells Int."},{"key":"B56","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1108\/ijicc-02-2021-0034","article-title":"Flash translation layer: A review and bibliometric analysis","volume":"14","author":"Luo","year":"2021","journal-title":"Int. J. Intelligent Comput. Cybern."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3145\/epi.2020.ene.03","article-title":"\u201cSoftware tools for conducting bibliometric analysis in science: An up-to-Date review.\u201d","volume":"29","author":"Moral-Mu\u00f1oz","year":"2020","journal-title":"Prof. La Inf."},{"key":"B58","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/jnnp-2019-322515","article-title":"Intracerebral implantation of human neural stem cells and motor recovery after stroke: Multicentre prospective single-arm study (PISCES-2)","volume":"91","author":"Muir","year":"2020","journal-title":"J. Neurology, Neurosurg. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e0144218","DOI":"10.1371\/journal.pone.0144218","article-title":"Effects of mesenchymal stem cell treatment on the expression of matrix metalloproteinases and angiogenesis during ischemic stroke recovery","volume":"10","author":"Nam","year":"2015","journal-title":"PloS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s40037-021-00695-4","article-title":"Bibliometrics: Methods for studying academic publishing","volume":"11","author":"Ninkov","year":"2022","journal-title":"Perspect. Med. Educ."},{"key":"B61","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3390\/bioengineering9110717","article-title":"Stem cell- and cell-based therapies for ischemic stroke","volume":"9","author":"Nistor-Cseppent\u00f6","year":"2022","journal-title":"Bioengineering"},{"key":"B62","doi-asserted-by":"publisher","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2018.0055","article-title":"Metformin preconditioning of human induced pluripotent stem cell-derived neural stem cells promotes their engraftment and improves post-stroke regeneration and recovery","volume":"27","author":"Ould-Brahim","year":"2018","journal-title":"Stem Cells Dev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1016\/S2468-2667(21)00230-9","article-title":"Primary stroke prevention worldwide: Translating evidence into action","volume":"7","author":"Owolabi","year":"2022","journal-title":"Lancet Public Health"},{"key":"B65","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.joi.2018.03.005","article-title":"Examining the usage, citation, and diffusion patterns of bibliometric mapping software: A comparative study of three tools","volume":"12","author":"Pan","year":"2018","journal-title":"J. Inf."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1093\/brain\/awt330","article-title":"Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons","volume":"136","author":"Pluchino","year":"2013","journal-title":"Brain A J. Neurology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"219","DOI":"10.5114\/fn.2012.30522","article-title":"Oxidative stress \u2013 assassin behind the ischemic stroke","volume":"3","author":"Pradeep","year":"2012","journal-title":"Folia Neuropathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuropharm.2018.07.006","article-title":"Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management","volume":"139","author":"Rana","year":"2018","journal-title":"Neuropharmacology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/CIRCULATIONAHA.104.504340","article-title":"Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair","volume":"111","author":"Schmidt-Lucke","year":"2005","journal-title":"Circulation"},{"key":"B71","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12964-022-00919-y","article-title":"Exosomes-based therapy of stroke, an emerging approach toward recovery","volume":"20","author":"Seyedaghamiri","year":"2022","journal-title":"Cell Commun. Signal. CCS"},{"key":"B72","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3171\/jns.2006.104.2.313","article-title":"Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats","volume":"104","author":"Seyfried","year":"2006","journal-title":"J. Neurosurg."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e54083","DOI":"10.1371\/journal.pone.0054083","article-title":"Efficacy of single and multiple injections of human umbilical tissue-derived cells following experimental stroke in rats","volume":"8","author":"Shehadah","year":"2013","journal-title":"PloS One"},{"key":"B74","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ejphar.2018.06.028","article-title":"Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches","volume":"833","author":"Shekhar","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1161\/STROKEAHA.106.481218","article-title":"One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke","volume":"38","author":"Shen","year":"","journal-title":"Stroke"},{"key":"B76","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/sj.jcbfm.9600311","article-title":"Therapeutic benefit of bone marrow stromal cells administered 1 Month after stroke","volume":"27","author":"Shen","year":"","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B77","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuroscience.2005.08.092","article-title":"Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke","volume":"137","author":"Shen","year":"2006","journal-title":"Neuroscience"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/glia.20988","article-title":"Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats","volume":"58","author":"Shen","year":"2010","journal-title":"Glia"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: What is known and where we go from here","volume":"34","author":"Tobin","year":"2014","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B80","doi-asserted-by":"publisher","first-page":"e013583","DOI":"10.1161\/JAHA.119.013583","article-title":"Activated mesenchymal stem cells induce recovery following stroke via regulation of inflammation and oligodendrogenesis","volume":"9","author":"Tobin","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20928147","article-title":"Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1","volume":"41","author":"Tseng","year":"2021","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B82","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/sctm.18-0014","article-title":"Cell-based and exosome therapy in diabetic stroke","volume":"7","author":"Venkat","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/jcbfm.2008.32","article-title":"Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF","volume":"28","author":"Wang","year":"2008","journal-title":"J. Cereb. Blood Flow Metabolism"},{"key":"B84","doi-asserted-by":"publisher","first-page":"102660","DOI":"10.1016\/j.ebiom.2020.102660","article-title":"Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke","volume":"52","author":"Wang","year":"2020","journal-title":"EBioMedicine"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1161\/STROKEAHA.117.018290","article-title":"Cell therapy for chronic stroke","volume":"49","author":"Wechsler","year":"2018","journal-title":"Stroke"},{"key":"B86","doi-asserted-by":"publisher","first-page":"7370","DOI":"10.1021\/acsnano.1c00672","article-title":"Embryonic stem cell derived small extracellular vesicles modulate regulatory T cells to protect against ischemic stroke","volume":"15","author":"Xia","year":"2021","journal-title":"ACS Nano"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e9027","DOI":"10.1371\/journal.pone.0009027","article-title":"Increasing TPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse","volume":"5","author":"Xin","year":"2010","journal-title":"PLoS ONE"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e84116","DOI":"10.1371\/journal.pone.0084116","article-title":"Bone marrow-derived mesenchymal stem cells maintain the resting phenotype of microglia and inhibit microglial activation","volume":"8","author":"Yan","year":"2013","journal-title":"PloS One"},{"key":"B89","doi-asserted-by":"publisher","first-page":"633","DOI":"10.4252\/wjsc.v12.i7.633","article-title":"Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA\/MANF signaling","volume":"12","author":"Yang","year":"2020","journal-title":"World J. Stem Cells"},{"key":"B90","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fneur.2019.00082","article-title":"Feasibility of human neural stem cell transplantation for the treatment of acute subdural hematoma in a rat model: A pilot study","volume":"10","author":"Yokobori","year":"2019","journal-title":"Front. Neurology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1161\/hh0302.104460","article-title":"Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse","volume":"90","author":"Zhang","year":"2002","journal-title":"Circulation Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"e48141","DOI":"10.1371\/journal.pone.0048141","article-title":"Sildenafil enhances neurogenesis and oligodendrogenesis in ischemic brain of middle-aged mouse","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS ONE"},{"key":"B93","doi-asserted-by":"publisher","first-page":"14072","DOI":"10.1016\/j.egyr.2022.10.347","article-title":"Artificial intelligence in renewable energy: A comprehensive bibliometric analysis","volume":"8","author":"Zhang","year":"2022","journal-title":"Energy Rep."},{"key":"B94","doi-asserted-by":"publisher","first-page":"817","DOI":"10.4252\/wjsc.v11.i10.817","article-title":"Neural stem cell transplantation therapy for brain ischemic stroke: Review and perspectives","volume":"11","author":"Zhang","year":"2019","journal-title":"World J. Stem Cells"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1108\/IJICC-01-2022-0004","article-title":"A comprehensive bibliometric analysis of Apache hadoop from 2008 to 2020","author":"Zhang","year":"2022","journal-title":"Int. J. Intelligent Comput. Cybern"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2412890","DOI":"10.1155\/2017\/2412890","article-title":"Transcriptional and genomic targets of neural stem cells for functional recovery after hemorrhagic stroke","volume":"2017","author":"Zhang","year":"2017","journal-title":"Stem Cells Int."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1161\/STROKEAHA.110.593129","article-title":"Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia","volume":"42","author":"Zhang","year":"2011","journal-title":"Stroke"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.3390\/ijms23052550","article-title":"Mesenchymal stem cells: Therapeutic mechanisms for stroke","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12975-022-00984-y","article-title":"Neural stem cells therapy for ischemic stroke: Progress and challenges","volume":"13","author":"Zhao","year":"2022","journal-title":"Transl. Stroke Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"e10757","DOI":"10.1016\/j.heliyon.2022.e10757","article-title":"\u201cBibliometric analysis for economy in COVID-19 pandemic.\u201d","volume":"8","author":"Zhong","year":"2022","journal-title":"Heliyon"},{"key":"B101","doi-asserted-by":"publisher","first-page":"101610","DOI":"10.1016\/j.pneurobio.2019.03.003","article-title":"Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage","volume":"178","author":"Zhu","year":"2019","journal-title":"Prog. Neurobiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1111815\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T05:16:49Z","timestamp":1677820609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1111815\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":101,"alternative-id":["10.3389\/fphar.2023.1111815"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1111815","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"article-number":"1111815"}}