{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:09:19Z","timestamp":1791986959033,"version":"4.4.0"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Kr\u00fcppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly during fasting, and contributes to the regulation of gluconeogenesis, lipid, amino acid catabolism, bile acids, endobiotic and xenobiotic metabolism. This review summarizes the latest advances of KLF15 in metabolic reprogramming, and explore the function of KLF15 in acute liver injury, hepatitis B virus, and autoimmune hepatitis. which aims to evaluate the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases.<\/jats:p>","DOI":"10.3389\/fphar.2023.1115226","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T04:43:31Z","timestamp":1677732211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Kr\u00fcppel-like factor 15 in liver diseases: Insights into metabolic reprogramming"],"prefix":"10.3389","volume":"14","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17677","DOI":"10.1016\/s0021-9258(17)32494-8","article-title":"Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney","volume":"269","author":"Adachi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"18551","DOI":"10.1038\/s41598-021-97937-6","article-title":"Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts","volume":"11","author":"Anzai","year":"2021","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"34355","DOI":"10.1074\/jbc.R100043200","article-title":"Kruppel-like factors: Three fingers in many pies","volume":"276","author":"Bieker","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/jcp.1111","article-title":"Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer","volume":"188","author":"Black","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12013-008-9008-5","article-title":"Keep your fingers off my DNA: Protein-protein interactions mediated by C2H2 zinc finger domains","volume":"50","author":"Brayer","year":"2008","journal-title":"Cell. Biochem. Biophys."},{"key":"B6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/s0014-4827(03)00393-8","article-title":"Cell differentiation and proliferation-simultaneous but independent?","volume":"291","author":"Brown","year":"2003","journal-title":"Exp. Cell. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1194\/jlr.P020867","article-title":"The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men","volume":"53","author":"Browning","year":"2012","journal-title":"J. Lipid Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"dev.199814","DOI":"10.1242\/dev.199814","article-title":"Signalling pathways and transcriptional regulators orchestrating liver development and cancer","volume":"148","author":"Campbell","year":"2021","journal-title":"Development"},{"key":"B9","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/MOH.0000000000000337","article-title":"Kruppel-like factors in endothelial cell biology","volume":"24","author":"Chang","year":"2017","journal-title":"Curr. Opin. Hematol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e141024","DOI":"10.1172\/jci.insight.141024","article-title":"Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration","volume":"5","author":"Chen","year":"2020","journal-title":"JCI Insight"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: Metabolic interactions and impacts on disease","author":"Collins","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/s1357-2725(00)00059-5","article-title":"The biology of the mammalian Kruppel-like family of transcription factors","volume":"32","author":"Dang","year":"2000","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.phrs.2017.12.018","article-title":"Kruppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity","volume":"130","author":"Fan","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"105292","DOI":"10.1016\/j.isci.2022.105292","article-title":"KLF15 controls Brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands","volume":"25","author":"Fan","year":"2022","journal-title":"iScience"},{"key":"B16","doi-asserted-by":"publisher","first-page":"109952","DOI":"10.18632\/oncotarget.21972","article-title":"KLF15 promotes the proliferation and metastasis of lung adenocarcinoma cells and has potential as a cancer prognostic marker","volume":"8","author":"Gao","year":"2017","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3389\/fphys.2020.00208","article-title":"Differential proteomic analysis of Chinese giant salamander liver in response to fasting","volume":"11","author":"Geng","year":"2020","journal-title":"Front. Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"34322","DOI":"10.1074\/jbc.M201304200","article-title":"The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4","volume":"277","author":"Gray","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.cmet.2007.03.002","article-title":"Regulation of gluconeogenesis by Kruppel-like factor 15","volume":"5","author":"Gray","year":"2007","journal-title":"Cell. Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/cphy.c120020","article-title":"Apoptosis and necrosis in the liver","volume":"3","author":"Guicciardi","year":"2013","journal-title":"Compr. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1681\/ASN.2018030324","article-title":"Podocyte-specific induction of kruppel-like factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease","volume":"29","author":"Guo","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2007.04.005","article-title":"Kruppel-like Factors (KLFs) in muscle biology","volume":"43","author":"Haldar","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.1038\/ncomms8231","article-title":"Circadian control of bile acid synthesis by a KLF15-Fgf15 axis","volume":"6","author":"Han","year":"2015","journal-title":"Nat. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1038\/emm.2015.122","article-title":"Regulation of glucose metabolism from a liver-centric perspective","volume":"48","author":"Han","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s42255-019-0054-7","article-title":"KLF15 regulates endobiotic and xenobiotic metabolism","volume":"1","author":"Han","year":"2019","journal-title":"Nat. Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e2200173","DOI":"10.1002\/mnfr.202200173","article-title":"Diallyl trisulfide prevents adipogenesis and lipogenesis by regulating the transcriptional activation function of KLF15 on PPAR\u03b3 to ameliorate obesity","volume":"66","author":"Hu","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cmet.2012.01.020","article-title":"Klf15 orchestrates circadian nitrogen homeostasis","volume":"15","author":"Jeyaraj","year":"2012","journal-title":"Cell. Metab."},{"key":"B28","doi-asserted-by":"publisher","first-page":"eabj2917","DOI":"10.1126\/sciadv.abj2917","article-title":"KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation","volume":"8","author":"Jiang","year":"2022","journal-title":"Sci. Adv."},{"key":"B29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.5483\/BMBRep.2021.54.4.215","article-title":"Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis","volume":"54","author":"Jo","year":"2021","journal-title":"BMB Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e77851","DOI":"10.1371\/journal.pone.0077851","article-title":"KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance","volume":"8","author":"Jung","year":"2013","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/gb-2003-4-2-206","article-title":"Sp1-and Kruppel-like transcription factors","volume":"4","author":"Kaczynski","year":"2003","journal-title":"Genome Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/0092-8674(87)90594-0","article-title":"Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain","volume":"51","author":"Kadonaga","year":"1987","journal-title":"Cell."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1093\/emboj\/18.8.2127","article-title":"Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer","volume":"18","author":"Kamiya","year":"1999","journal-title":"EMBO J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1053\/jhep.2002.33331","article-title":"Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: Induction of tryptophan oxygenase","volume":"35","author":"Kamiya","year":"2002","journal-title":"Hepatology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s13318-020-00656-y","article-title":"The impact of fasting on major metabolic pathways of macronutrients and pharmacokinetics steps of drugs","volume":"46","author":"Karimi","year":"2021","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1053\/j.gastro.2017.03.035","article-title":"SP and KLF transcription factors in digestive physiology and diseases","volume":"152","author":"Kim","year":"2017","journal-title":"Gastroenterology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1038\/s41598-019-40359-2","article-title":"B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3350\/cmh.2020.0189","article-title":"Recent updates on the management of autoimmune hepatitis","volume":"27","author":"Komori","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s12072-019-09986-9","article-title":"Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: A randomized controlled trial","volume":"13","author":"Kumar","year":"2019","journal-title":"Hepatol. Int."},{"key":"B40","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.copbio.2009.09.004","article-title":"Stem cells and liver repair","volume":"20","author":"Kung","year":"2009","journal-title":"Curr. Opin. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.bbrc.2015.12.035","article-title":"c-Jun regulates adipocyte differentiation via the KLF15-mediated mode","volume":"469","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"144782","DOI":"10.1016\/j.gene.2020.144782","article-title":"Impact of short-term starvation and refeeding on the expression of KLF15 and regulatory mechanism of branched-chain amino acids metabolism in muscle of Chinese soft-shelled turtle (Pelodiscus sinensis)","volume":"752","author":"Li","year":"2020","journal-title":"Gene"},{"key":"B43","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1681\/ASN.2015060672","article-title":"Kruppel-like factor 15 mediates glucocorticoid-induced restoration of podocyte differentiation markers","volume":"28","author":"Mallipattu","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrn.2017.156","article-title":"Intermittent metabolic switching, neuroplasticity and brain health","volume":"19","author":"Mattson","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1136\/bjsm.2010.072181","article-title":"The effects of fasting on metabolism and performance","volume":"44","author":"Maughan","year":"2010","journal-title":"Br. J. Sports Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kruppel-like factors in health and diseases","volume":"90","author":"Mcconnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/0004563218817798","article-title":"Bile acids and the metabolic syndrome","volume":"56","author":"Mcglone","year":"2019","journal-title":"Ann. Clin. Biochem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbrc.2021.10.027","article-title":"High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways","volume":"582","author":"Mehrazad Saber","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","volume-title":"Physiology, gluconeogenesis","author":"Melkonian","year":"2022"},{"key":"B50","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.3390\/cancers14205084","article-title":"Is fasting good when one is at risk of liver cancer?","volume":"14","author":"Minciuna","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B51","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/00008480-200208000-00021","article-title":"Multiple trauma: Liver and spleen injury","volume":"14","author":"Mooney","year":"2002","journal-title":"Curr. Opin. Pediatr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.jhep.2018.01.005","article-title":"Development of the liver: Insights into organ and tissue morphogenesis","volume":"68","author":"Ober","year":"2018","journal-title":"J. Hepatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s12272-013-0018-5","article-title":"Transcriptional regulators of hepatic gluconeogenesis","volume":"36","author":"Oh","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fcvm.2018.00069","article-title":"Kruppel-like factors in metabolic homeostasis and cardiometabolic disease","volume":"5","author":"Oishi","year":"2018","journal-title":"Front. Cardiovasc Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1080\/00498250802309492","article-title":"Editorial overview. Xenobiotic and endobiotic transporters: Structure, function and regulation","volume":"38","author":"Plant","year":"2008","journal-title":"Xenobiotica"},{"key":"B56","doi-asserted-by":"publisher","first-page":"101178","DOI":"10.11131\/2015\/101178","article-title":"Nuclear receptors in drug metabolism, drug response and drug interactions","volume":"2","author":"Prakash","year":"2015","journal-title":"Nucl. Recept. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1093\/gbe\/evv141","article-title":"KLF\/SP transcription factor family evolution: Expansion, diversification, and innovation in eukaryotes","volume":"7","author":"Presnell","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/dmrr.217","article-title":"Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis","volume":"17","author":"Radziuk","year":"2001","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ebiom.2019.01.021","article-title":"Kr\u03cbppel-like factors (KLFs) in renal physiology and disease","volume":"40","author":"Rane","year":"2019","journal-title":"EBioMedicine"},{"key":"B60","doi-asserted-by":"publisher","first-page":"E1334","DOI":"10.1073\/pnas.1118515109","article-title":"KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing","volume":"109","author":"Ray","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"101850","DOI":"10.1016\/j.mcp.2022.101850","article-title":"Kruppel-like factors family regulation of adipogenic markers genes in bovine cattle adipogenesis","volume":"65","author":"Raza","year":"2022","journal-title":"Mol. Cell. Probes"},{"key":"B62","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jbt.20178","article-title":"Human carboxylesterases and their role in xenobiotic and endobiotic metabolism","volume":"21","author":"Ross","year":"2007","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: A matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nature10263","article-title":"Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors","volume":"475","author":"Sekiya","year":"2011","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s13105-016-0528-y","article-title":"PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 (del\/del) mice, unmasking role in non-gluconeogenic tissues","volume":"73","author":"Semakova","year":"2017","journal-title":"J. Physiol. Biochem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1073\/pnas.0607837103","article-title":"PGC-1alpha controls Hepatitis B virus through nutritional signals","volume":"103","author":"Shlomai","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.2337\/db09-1679","article-title":"Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action","volume":"59","author":"Takashima","year":"2010","journal-title":"Diabetes"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1016\/j.celrep.2016.07.069","article-title":"KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting","volume":"16","author":"Takeuchi","year":"2016","journal-title":"Cell. Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"103446","DOI":"10.1016\/j.isci.2021.103446","article-title":"FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin","volume":"24","author":"Takeuchi","year":"2021","journal-title":"iScience"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.3748\/wjg.v28.i24.2654","article-title":"Drug-induced autoimmune hepatitis: A minireview","volume":"28","author":"Tan","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.bbrc.2004.12.096","article-title":"Role of Kruppel-like factor 15 in PEPCK gene expression in the liver","volume":"327","author":"Teshigawara","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"B73","doi-asserted-by":"publisher","first-page":"10819","DOI":"10.26355\/eurrev_202010_23444","article-title":"KLF15 reduces the level of apoptosis in mouse liver induced by sepsis by inhibiting p38MAPK\/ERK1\/2 signaling pathway","volume":"24","author":"Tian","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"E215","DOI":"10.1152\/ajpendo.00026.2022","article-title":"Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice","volume":"323","author":"Tice","year":"2022","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B75","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1159\/000282091","article-title":"Bile acids as regulators of hepatic lipid and glucose metabolism","volume":"28","author":"Trauner","year":"2010","journal-title":"Dig. Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tim.2017.07.006","article-title":"Mechanisms of hepatitis B virus persistence","volume":"26","author":"Tsai","year":"2018","journal-title":"Trends Microbiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"119698","DOI":"10.1016\/j.lfs.2021.119698","article-title":"Inhibition of miR-431-5p attenuated liver apoptosis through KLF15\/p53 signal pathway in S100 induced autoimmune hepatitis mice","volume":"280","author":"Tu","year":"2021","journal-title":"Life Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/s0968-0004(99)01406-1","article-title":"Mammalian kruppel-like transcription factors: More than just a pretty finger","volume":"24","author":"Turner","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"7319","DOI":"10.1128\/MCB.20.19.7319-7331.2000","article-title":"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor","volume":"20","author":"Uchida","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1046\/j.1523-1755.2001.060002416.x","article-title":"Isolation of a novel zinc finger repressor that regulates the kidney-specific CLC-K1 promoter","volume":"60","author":"Uchida","year":"2001","journal-title":"Kidney Int."},{"key":"B82","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1081\/dmr-120034001","article-title":"Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism","volume":"36","author":"Vasiliou","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/cld.1080","article-title":"Diagnosis and management of autoimmune hepatitis in adults and children: A patient-friendly summary of the 2019 aasld guidelines","volume":"17","author":"Volk","year":"2021","journal-title":"Clin. Liver Dis. Hob."},{"key":"B84","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jconrel.2019.08.011","article-title":"Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury","volume":"310","author":"Vong","year":"2019","journal-title":"J. Control Release"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1021\/acs.chemrestox.0c00192","article-title":"Teneligliptin promotes bile acid synthesis and attenuates lipid accumulation in obese mice by targeting the KLF15-fgf15 pathway","volume":"33","author":"Wang","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"e1010229","DOI":"10.1371\/journal.pgen.1010229","article-title":"Kruppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation","volume":"18","author":"Wang","year":"2022","journal-title":"PLoS Genet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.trecan.2018.11.003","article-title":"Gluconeogenesis in cancer: Function and regulation of PEPCK, FBPase, and G6Pase","volume":"5","author":"Wang","year":"2019","journal-title":"Trends Cancer"},{"key":"B88","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/bs.apha.2015.04.001","article-title":"Xenobiotic and endobiotic mediated interactions between the cytochrome P450 system and the inflammatory response in the liver","volume":"74","author":"Woolbright","year":"2015","journal-title":"Adv. Pharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"16954","DOI":"10.1074\/jbc.M312079200","article-title":"A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2","volume":"279","author":"Yamamoto","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1007\/s12275-022-2371-x","article-title":"Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: An evolutionary explanation for HBV's oncogenic role","volume":"60","author":"Yu","year":"2022","journal-title":"J. Microbiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3389\/fendo.2018.00802","article-title":"Unraveling the regulation of hepatic gluconeogenesis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B92","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/hep.24362","article-title":"Kruppel-like factor 15 activates Hepatitis B virus gene expression and replication","volume":"54","author":"Zhou","year":"2011","journal-title":"Hepatology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0959-437x(00)00162-3","article-title":"Coordinating cell proliferation and differentiation","volume":"11","author":"Zhu","year":"2001","journal-title":"Curr. Opin. Genet. Dev."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1115226\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T04:43:35Z","timestamp":1677732215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1115226\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":93,"alternative-id":["10.3389\/fphar.2023.1115226"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1115226","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"article-number":"1115226"}}