{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:08:46Z","timestamp":1767204526894,"version":"build-2238731810"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"\n Context:<\/jats:bold>\n Hepatic fibrosis is a progressive condition, often attributed to metabolic disorders, which may promote cirrhosis and liver cancer.\n Ganlong capsules<\/jats:italic>\n derived from\n Periplaneta Americana<\/jats:italic>\n have been shown to have a therapeutic effect on liver fibrosis but little is known about the molecular mechanisms involved.\n <\/jats:p>\n \n Objective:<\/jats:bold>\n To investigate the metabolic modulations produced by\n Ganlong capsules<\/jats:italic>\n in liver fibrosis.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n A carbon tetrachloride- (CCl\n 4<\/jats:sub>\n ) treated rat model of liver fibrosis was constructed and\n Ganlong capsules<\/jats:italic>\n administered. Levels of serum liver enzymes and pathological changes to the liver were evaluated. Non-targeted metabolomics of liver, serum and urine were used to investigate metabolic regulatory mechanisms.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Ganlong capsules<\/jats:italic>\n reduced serum levels of liver enzymes and improved pathological changes in the rat model of fibrosis. Non-targeted metabolomics showed that\n Ganlong capsules<\/jats:italic>\n ameliorated pathways of glycerophospholipid, linoleic acid, pyrimidine, glycine, butyric acid, valine, serine, threonine and arachidonic acid metabolism and biosynthesis of leucine and isoleucine. Such pathways influence the development of CCl\n 4<\/jats:sub>\n -induced liver fibrosis.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n Ganlong capsules<\/jats:italic>\n had an anti-fibrotic hepatoprotective effect and regulated lipid, butyric acid, amino acid and arachidonic acid metabolism.\n <\/jats:p>","DOI":"10.3389\/fphar.2023.1122118","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T02:05:02Z","timestamp":1679537102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabonomic analysis of the anti-hepatic fibrosis effect of Ganlong capsules"],"prefix":"10.3389","volume":"14","author":[{"given":"ChangLing","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YinRui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DingYu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/metabo10020050","article-title":"Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy","volume":"10","author":"Beyoglu","year":"2020","journal-title":"Metabolites"},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s40265-018-1017-0","article-title":"Hepatic encephalopathy in cirrhosis: Pathology and pathophysiology","volume":"79","author":"Butterworth","year":"2019","journal-title":"Drugs"},{"key":"B3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fphar.2018.00187","article-title":"Exploring the mechanism of dangguiliuhuang decoction against hepatic fibrosis by network Pharmacology and experimental validation","volume":"9","author":"Cao","year":"2018","journal-title":"Front. 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