{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:51:18Z","timestamp":1787316678749,"version":"build-2736575974"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1C1C1004937 2022M3A9E4082682"],"award-info":[{"award-number":["2022R1C1C1004937 2022M3A9E4082682"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The demand for complementary and alternative medicine for the management of functional dyspepsia (FD) is increasing due to the insufficient efficacy of conventional treatment options. In Asia, the Chinese herbal medicine formula\n                    <jats:italic>Banxia-xiexin tang<\/jats:italic>\n                    (BXT) has been used to treat FD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We searched 11 digital medical databases on 1 September 2021. Randomized controlled trials (RCTs) that investigated the efficacy of BXT or combination therapy (BXT plus Western medicines) for FD were selected. The outcome parameters were total clinical efficacy rate (TCE), motilin level, symptom checklist-90-revised (SCL-90-R), and visual analog scale (VAS) for dyspepsia and adverse events. Cochrane risk of bias tool 2.0 (RoB 2) was used for the quality assessment of included studies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The meta-analysis comprised 57 RCTs with 5,525 participants. BXT was more efficacious, with a higher TCE than Western medicine. Combination therapy (BXT plus Western medicine) also resulted in a higher TCE than Western medicine. Combination therapy improved motilin levels and psychological symptoms to a greater extent than Western medicine, evidenced by a higher SCL-90-R score. However, no significant difference in VAS scores was observed between the BXT and placebo groups. BXT and combination therapy were associated with fewer adverse events than Western medicine or placebo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our findings suggest that BXT and its combination therapy may be an effective and safe alternative treatment for FD. More RCTs with better methodologies are required to strengthen this evidence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Systematic Review Registration:<\/jats:bold>\n                    [\n                    <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42019123285<\/jats:ext-link>\n                    ], identifier [CRD42019123285].\n                  <\/jats:p>","DOI":"10.3389\/fphar.2023.1130257","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:34:47Z","timestamp":1684456487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Herbal medicine, Banxia-xiexin tang, for functional dyspepsia: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Keumji","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Jae","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Ho","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.14740\/gr1219","article-title":"Functional, diagnostic and therapeutic aspects of gastrointestinal hormones","volume":"12","author":"Ahmed","year":"2019","journal-title":"Gastroenterol. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.19613\/j.cnki.1671-3141.2018.40.136","article-title":"Investigation of the clinical effect of Banxia Xiexin decoction on functional dyspepsia","volume":"18","author":"Cai","year":"2018","journal-title":"World Latest Med. Inf."},{"key":"B3","volume-title":"The clinical observation of functional dyspepsia of mixed cold and heat syndrome with the treatment of Banxiaxiexin decoction","author":"Cai","year":"2016"},{"key":"B4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.13194\/j.issn.1673-842x.2014.11.017","article-title":"Effectiveness of Banxia xiexin decoction combined with Western medicine in treating peptic ulcer: A systematic review","volume":"16","author":"Chen","year":"2014","journal-title":"J. Liaoning Univ. TCM"},{"key":"B5","first-page":"451","article-title":"Clinical analysis of Banxia Xiexin decoction in treating Pperimenopausal depression","volume":"23","author":"Chen","year":"2019","journal-title":"Heal. Everyone"},{"key":"B6","first-page":"39","article-title":"Clinical observation on treatment of 56 cases of functional dyspepsia with Banxia Xiexin decoction","volume":"42","author":"Chen","year":"2010","journal-title":"Jiangsu J. Tradit. Chin. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.phymed.2004.07.0099","article-title":"Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles","volume":"12","author":"Chrubasik","year":"2005","journal-title":"Phytomedicine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/9591319","article-title":"Efficacy and safety of modified Banxia xiexin decoction (Pinellia decoction for draining the heart) for gastroesophageal reflux disease in adults: A systematic review and meta-analysis","volume":"2017","author":"Dai","year":"2017","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B9","first-page":"167","article-title":"Analysis of the effect of Banxia Xiexin decoction in the treatment of dyspepsia in children","volume":"1","author":"Dang","year":"2019","journal-title":"Cap. Food Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.19347\/j.cnki.2096-1413.2016.03.050","article-title":"Observation on the efficacy of Banxia Xiexin decoction in treating functional dyspepsia","volume":"1","author":"Deng","year":"2016","journal-title":"Clin. Res. Pract."},{"key":"B11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.19613\/j.cnki.1671-3141.2018.19.104","article-title":"Observation on the clinical efficacy and safety of Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"18","author":"Ding","year":"2018","journal-title":"World Latest Med. Inf."},{"key":"B12","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3969\/j.issn.1003-6350.2017.04.015","article-title":"Clinical effect of Pinelliae Decoction for purging stomach-fire on gastric mucosal mast cells and plasma motilin in patients with functional dyspepsia","volume":"28","author":"Dong","year":"2017","journal-title":"Hainan Med. J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.16662\/j.cnki.1674-0742.2009.19.018","article-title":"Clinical observation on treatment of 63 cases of functional dyspepsia with Banxia Xiexin decoction","volume":"19","author":"Dong","year":"2009","journal-title":"China Foreign Med. Treat."},{"key":"B14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.15912\/j.cnki.gocm.2018.29.068","article-title":"Clinical efficacy and safety of Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"16","author":"Dong","year":"2018","journal-title":"Guid. China Med."},{"key":"B15","first-page":"71","article-title":"Psychological factors in patients with peptic ulcer and functional dyspepsia","volume":"5","author":"Faramarzi","year":"2014","journal-title":"Casp. J. Intern. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.14148\/j.issn.1672-0482.2015.0310","article-title":"Influence of Banxia Xiexin decoction on substance P (SP) in the blood serum and calcitonin gene-related peptide (CGRP) in the gastric antrum mucosa of patients with functional dyspepsia","volume":"31","author":"Feng","year":"2015","journal-title":"J. Nanjing Univ. TCM"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","article-title":"Functional dyspepsia","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"B18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.13862\/j.cnki.cn43-1446\/r.2010.08.030","article-title":"Treatment of 50 cases of functional dyspepsia with Banxia Xiexin decoction. Guid. J. Tradit","volume":"16","author":"Fu","year":"2010","journal-title":"Chin. Med. Pharm."},{"key":"B19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3969\/j.issn.1671-3141.2017.52.103","article-title":"Clinical analysis of Banxia Xiexin decoction for functional dyspepsia","volume":"17","author":"Fu","year":"2017","journal-title":"World Latest Med. Inf."},{"key":"B20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/s0254-6272(14)60067-4","article-title":"Effect of Banxiaxiexin tang on treatment of functional dyspepsia: A meta-analysis of randomized controlled trials","volume":"34","author":"Gan","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"B21","first-page":"487","article-title":"Treatment of functional dyspepsia with Banxia Xiexin decoction","volume":"7","author":"He","year":"2007","journal-title":"China Trop. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.13457\/j.cnki.jncm.2012.04.077","article-title":"Observation on the efficacy of Mosapride combined with Banxia Xiexin decoction in the treatment of functional dyspepsia and its effect on plasma motilin","volume":"44","author":"He","year":"2012","journal-title":"J. New Chin. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3969\/j.issn.1671-038X.2020.12.06","article-title":"Banxia xiexin decoction in the treatment of functional dyspepsia: A meta-analysis of randomized controlled trials","volume":"28","author":"Hu","year":"2020","journal-title":"Chin. J. Integr. Tradit. West. Med. Dig."},{"key":"B24","first-page":"40","article-title":"Clinical study of Banxia Xiexin decoction in treating functional dyspepsia due to combination of cold and heat","volume":"26","author":"Hu","year":"2006","journal-title":"J. TCM Univ. Hunan"},{"key":"B25","first-page":"559","article-title":"Clinical observation of Banxia Xiexin decoction combined with Western medicine for functional dyspepsia","volume":"17","author":"Huang","year":"2004","journal-title":"Acta Med. Sin."},{"key":"B26","first-page":"34","article-title":"The effect of Chaizhi Banxia Xiexin decoction on clinical effect of treating patients with functional indigestion","volume":"3","author":"Huang","year":"2011","journal-title":"Clin. J. Chin. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"156","DOI":"10.11656\/j.issn.1673-9043.2017.02.20","article-title":"Current status of clinical and experimental research on the treatment of digestive system diseases with Banxia Xiexin decoction","volume":"36","author":"Ji","year":"2017","journal-title":"J. Tianjin Univ. Tradit. Chin. Med."},{"key":"B28","first-page":"50","article-title":"Clinical observation on treatment of functional dyspepsia due to combination of cold and heat by Banxia Xiexin granule","volume":"21","author":"Jin","year":"2004","journal-title":"Inf. Tradit. Chin. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.cgh.2016.12.032","article-title":"Mood and anxiety disorders precede development of functional gastrointestinal disorders in patients but not in the population","volume":"15","author":"Jones","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"B30","volume-title":"Effects and safety of Banhasasim-tang Depending on pattern identification and Subtypes of functional dyspepsia: A randomized, double-blind, placebo-controlled","author":"Kim","year":"2017"},{"key":"B31","doi-asserted-by":"publisher","first-page":"636752","DOI":"10.3389\/fphar.2021.636752","article-title":"Beneficial potential of Banha-sasim-tang for stress-sensitive functional dyspepsia via modulation of ghrelin: A randomized controlled trial","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1186\/s13063-017-2282-z","article-title":"Efficacy of Banha-sasim-tang on functional dyspepsia classified as excess pattern: Study protocol for a randomized controlled trial","volume":"18","author":"Kim","year":"2017","journal-title":"Trials"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e15760","DOI":"10.1097\/MD.0000000000015760","article-title":"Herbal medicine Banha-sasim-tang for the treatment of functional dyspepsia protocol for a systematic review of randomized controlled trials","volume":"98","author":"Ko","year":"2019","journal-title":"Med. Baltim."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain-gut pathway in functional gastrointestinal disorders is bidirectional: A 12-year prospective population-based study","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"key":"B35","first-page":"90","article-title":"Clinical observation of using Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"33","author":"Lang","year":"2015","journal-title":"J. Sichuan Tradit. Chin. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/bdd.771","article-title":"Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones","volume":"32","author":"Li","year":"2011","journal-title":"Drug Dispos."},{"key":"B37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.13422\/j.cnki.syfjx.2014220203","article-title":"Clinical observation on effect of Banxia Xiexin decoction combined with Domperidone in treating patients with functional dyspepsia","volume":"20","author":"Li","year":"2014","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"B38","doi-asserted-by":"publisher","first-page":"54","DOI":"10.16808\/j.cnki.issn1003-7705.2016.07.026","article-title":"Clinical observation on the treatment of 44 cases of functional dyspepsia with Banxia Xiexin decoction","volume":"32","author":"Li","year":"2016","journal-title":"Hunan J. Tradit. Chin. Med."},{"key":"B39","first-page":"21","article-title":"50 cases of functional dyspepsia treated by Banxia Xiexin decoction","volume":"25","author":"Li","year":"2004","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"456","DOI":"10.16025\/j.1674-1307.2016.05.012","article-title":"Systematic review of Banxia Xiexin decoction for the treatment of functional dyspepsia","volume":"35","author":"Li","year":"2016","journal-title":"Beijing J. Tradit. Chin. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.cyto.2012.12.017","article-title":"Stage specific effect of leptin on the expressions of estrogen receptor and extracellular matrix in a model of chondrocyte differentiation","volume":"28","author":"Li","year":"2013","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"key":"B42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.16440\/j.cnki.1674-8166.2016.01.020","article-title":"Clinical study on modification of Banxia Xiexin decoction for functional dyspepsia","volume":"17","author":"Li","year":"2016","journal-title":"Chronic Pathematology J."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.3969\/j.issn.1008-8849.2015.14.009","article-title":"Therapeutic observation of Banxia Xiexin decoction for functional dyspepsia","volume":"24","author":"Li","year":"2015","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"B44","first-page":"442","article-title":"Effect of Chaiqin Banxia Xiexin decoction on clinical efficacy and gastric acid in patients with ulcer-like functional dyspepsia","volume":"21","author":"Liang","year":"2010","journal-title":"Lishizhen Med. Mater. Medica Res."},{"key":"B45","first-page":"42","article-title":"Clinical observation on 30 cases of functional dyspepsia treated with Chaizhi Banxia Xiexin decoction","volume":"40","author":"Liang","year":"2008","journal-title":"Jiangsu J. Tradit. Chin. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA Statement for reporting systematic reviews and meta-analyses of studies that evaluate Health Care interventions: Explanation and Elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med."},{"key":"B47","first-page":"482","article-title":"Clinical observation of Banxia Xiexin decoction in treating cold-heat complex type FD","volume":"35","author":"Liu","year":"2020","journal-title":"Guangming J. Chin. Med."},{"key":"B48","first-page":"2211","article-title":"Effect of Banxia Xiexin decoction on functional dyspepsia","volume":"29","author":"Lu","year":"2018","journal-title":"Mod. Diagn. Treat."},{"key":"B49","first-page":"33","article-title":"Application experience of Banxia Xiexin decoction in patients with functional dyspepsia","volume":"10","author":"Luo","year":"2016","journal-title":"all Heal"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.3748\/wjg.v12.i17.2661","article-title":"Epidemiology of functional dyspepsia: A global perspective","volume":"12","author":"Mahadeva","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"113252","DOI":"10.1016\/j.jep.2020.113252","article-title":"Pinellia ternata (Thunb) Breit: A review of its germplasm resources, genetic diversity and active components","volume":"263","author":"Mao","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B52","first-page":"30","article-title":"Observation on the efficacy of Banxia Xiexin decoction in the treatment of functional dyspepsia due to mixed cold and heat syndrome","volume":"32","author":"Min","year":"2009","journal-title":"Guangxi J. Tradit. Chin. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/ajg.2017.154","article-title":"ACG and CAG clinical guideline: Management of dyspepsia","volume":"112","author":"Moayyedi","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1248\/bpb.26.101","article-title":"Some gastrointestinal function regulatory Kampo medicines have modulatory effects on human plasma adrenocorticotropic hormone and cortisol levels with continual stress exposure","volume":"26","author":"Naito","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"B55","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1248\/bpb.25.327","article-title":"Hange-shashin-to raises levels of somatostatin, motilin, and gastrin in the plasma of healthy subjects","volume":"25","author":"Naito","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"B56","doi-asserted-by":"publisher","first-page":"14","DOI":"10.16662\/j.cnki.1674-0742.2017.25.014","article-title":"Observation of clinical effect of Banxia Xiexin decoction in the treatment of functional dyspepsia and its influence on the plasma motilin","volume":"25","author":"Nong","year":"2017","journal-title":"China Foreign Med. Treat."},{"key":"B57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5056\/jnm19209","article-title":"Clinical practice guidelines for functional dyspepsia in Korea","volume":"26","author":"Oh","year":"2020","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B58","doi-asserted-by":"publisher","first-page":"265035","DOI":"10.1155\/2013\/265035","article-title":"The effects of Banha-sasim-tang on dyspeptic symptoms and gastric motility in cases of functional dyspepsia: A randomized, double-blind, placebo-controlled, and two-center trial","volume":"2013","author":"Park","year":"2013","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1745-6215-11-83","article-title":"Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled, two-center trial","volume":"11","author":"Park","year":"2010","journal-title":"Trials"},{"key":"B60","first-page":"54","article-title":"Therapeutic effect of Banxia Xiexin decoction in treating functional dyspepsia with cold and heat syndromes","volume":"49","author":"Qiu","year":"2011","journal-title":"China Mod. Dr."},{"key":"B61","first-page":"10","article-title":"Clinical effect of Banxia Xiexin decoction in the treatment of elderly patients with functional dyspepsia","volume":"13","author":"Ren","year":"2015","journal-title":"J. Community Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.phymed.2006.03.022","article-title":"Phytotherapy for functional dyspepsia: A review of the clinical evidence for the herbal preparation STW 5","volume":"13","author":"R\u00f6sch","year":"2006","journal-title":"Phytomedicine"},{"key":"B63","doi-asserted-by":"publisher","first-page":"198","DOI":"10.13194\/j.issn.1673-842x.2014.10.071","article-title":"Clinical observation on functional dyspepsia treated with Pinelliae decoction for purging stomach-fire","volume":"16","author":"Shi","year":"2014","journal-title":"J. Liaoning Univ. TCM"},{"key":"B64","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber","year":"2020","journal-title":"Gastroenterology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"B66","first-page":"10","article-title":"Observation on the efficacy of Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"1","author":"Su","year":"2014","journal-title":"Nei Mong. J. Tradit. Chin. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3969\/j.issn.1009-7201.2014.02.015","article-title":"A comparative study of Banxia-xiexin decoction combined with paroxetine in treatment of female patients with somatoform disorder","volume":"27","author":"Sun","year":"2014","journal-title":"J. Psychiatry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/j.1365-2982.2009.01290.x","article-title":"Japanese herbal medicine in functional gastrointestinal disorders","volume":"21","author":"Suzuki","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3969\/j.issn.1007-614x.2015.7.64","article-title":"Curative effect and recurrence prevention of Banxiaxiexin decoction in the treatment of the patients with functional dyspepsia","volume":"31","author":"Tang","year":"2015","journal-title":"Chin. Community Dr."},{"key":"B71","doi-asserted-by":"publisher","first-page":"80","DOI":"10.13799\/j.cnki.mdjyxyxb.2014.03.042","article-title":"Therapeutic effect of Banxia Xiexin decoction on functional dyspepsia","volume":"35","author":"Tang","year":"2014","journal-title":"J. Mudanjang Med. Univ."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/749495","article-title":"Chinese herbal medicine Banxiaxiexin decoction treating diabetic gastroparesis: A systematic review of randomized controlled trials","volume":"2013","author":"Tian","year":"2013","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.19604\/j.cnki.dys.2018.10.022","article-title":"Clinical effect of modified Banxia Xiexin decoction in treatment of patients with functional dyspepsia","volume":"10","author":"Tian","year":"2018","journal-title":"Doctor"},{"key":"B74","volume-title":"Study on the effects of Banxia Xiexin decoction on visceral sensitivity and psychology of patients with functional dyspepsia","author":"Tian","year":"2017"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2020.00172","article-title":"The role of GI peptides in functional dyspepsia and gastroparesis: A systematic review","volume":"11","author":"Van den Houte","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B76","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/nrgastro.2013.10","article-title":"The role of psychosocial factors and psychiatric disorders in functional dyspepsia","volume":"10","author":"Van Oudenhove","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nrgastro.2012.255","article-title":"Changes in gastrointestinal tract function and structure in functional dyspepsia","volume":"10","author":"Vanheel","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B78","first-page":"239","article-title":"60 cases of functional dyspepsia treated with Banxia Xiexin decoction","volume":"4","author":"Wang","year":"2001","journal-title":"Zhejiang J. Tradit. Chin. Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.isatra.2018.10.024","article-title":"Modeling and control of mine main fan switchover system","volume":"19","author":"Wang","year":"2019","journal-title":"World Latest Med. Inf."},{"key":"B80","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1746-1596-7-69","article-title":"Oncogenic reg IV is a novel prognostic marker for glioma patient survival","volume":"4","author":"Wang","year":"2012","journal-title":"Clin. J. Chin. Med."},{"key":"B81","first-page":"660","article-title":"Observation on the efficacy of Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"34","author":"Wang","year":"2018","journal-title":"J. Pract. Tradit. Chin. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.13192\/j.ljtcm.2007.09.94.wangxp.041","article-title":"Effect of modified Banxia Xiexin decoction on functional dyspepsia","volume":"34","author":"Wang","year":"2007","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/gutjnl-2019-318536","article-title":"Novel concepts in the pathophysiology and treatment of functional dyspepsia","volume":"69","author":"Wauters","year":"2020","journal-title":"Gut"},{"key":"B84","first-page":"19","article-title":"Treatment of 50 cases of functional dyspepsia with Banxia Xiexin decoction","volume":"28","author":"Wu","year":"2008","journal-title":"Henan Tradit. Chin. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"30","DOI":"10.16194\/j.cnki.31-1059\/g4.2011.07.016","article-title":"Banxia Xiexin decoction in the treatment of 42 cases of functional dyspepsia","volume":"30","author":"Xie","year":"2011","journal-title":"J. Anhui Tradit. Chin. Med. Coll."},{"key":"B86","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12944-019-1054-z","article-title":"Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats","volume":"11","author":"Yang","year":"","journal-title":"Clin. J. Chin. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/mrd.23085","article-title":"Expression profiles of interferon-stimulated gene 15 and prostaglandin synthases in the ovine lymph nodes during early pregnancy","volume":"40","author":"Yang","year":"","journal-title":"Yunnan J. Tradit. Chin. Med. Mater. Medica"},{"key":"B88","volume-title":"The clinical observation of functional dyspepsia of mixed cold and heat syndrome with the treatment of Banxiaxiexin decoction","author":"Yi","year":"2015"},{"key":"B89","volume-title":"Clinical research on the therapy of Banxiaxiexin soup joint Mosapride to FD with cold and heat","author":"Yin","year":"2011"},{"key":"B90","doi-asserted-by":"publisher","first-page":"14","DOI":"10.19335\/j.cnki.2096-1219.2017.21.007","article-title":"Investigating clinical effect and safety of modified Pinelliae decoction for purging stomach-fire in treatment of functional dyspepsia","volume":"21","author":"Yu","year":"2017","journal-title":"Smart Healthc."},{"key":"B91","volume-title":"Clinical research of Banxiaxiexin decoction in treating functional dyspepsia-epigastric pain syndrome of cold-heat complicated type","author":"Yu","year":"2016"},{"key":"B92","first-page":"34","article-title":"Clinical observation on BanXia XieXin decoction in treating 90 cases of functional indigestion","volume":"23","author":"Yu","year":"2010","journal-title":"Gansu J. TCM"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-020-02988-3","article-title":"Analysis of the pharmacological mechanism of Banxia Xiexin decoction in treating depression and ulcerative colitis based on a biological network module","volume":"20","author":"Yu","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"59","DOI":"10.13457\/j.cnki.jncm.2019.06.017","article-title":"Clinical study on modified Banxia Xiexin tang combined with Domperidone for functional dyspepsia","volume":"51","author":"Zhang","year":"2019","journal-title":"J. New Chin. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s12272-010-0809-x","article-title":"Preparation, characterization, and in vivo evaluation of mitoxantrone-loaded, folate-conjugated albumin nanoparticles","volume":"19","author":"Zhang","year":"2010","journal-title":"J. Integr. Tradit. Chin. West. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jphys.2014.11.013","article-title":"The use of a modified, oscillating positive expiratory pressure device reduced fever and length of hospital stay in patients after thoracic and upper abdominal surgery: A randomised trial","volume":"38","author":"Zhang","year":"2015","journal-title":"J. Shaanxi Coll. Tradit. Chin. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"73","DOI":"10.13729\/j.issn.1671-7813.2017.10.27","article-title":"Banxia Xiexin decoction combined with mosapride in the treatment of functional dyspepsia randomized controlled study","volume":"31","author":"Zhang","year":"2017","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.3969\/j.issn.1003-8914.2017.10.025","article-title":"Clinical observation of Banxia Xiexin decoction in treating functional dyspepsia","volume":"32","author":"Zhao","year":"2017","journal-title":"Guangming J. Chin. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"812143","DOI":"10.1155\/2013\/812143","article-title":"Efficacy of modified ban Xia Xie Xin decoction on functional dyspepsia of cold and heat in complexity syndrome: A randomized controlled trial","volume":"2013","author":"Zhao","year":"2013","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.16194\/j.cnki.31-1059\/g4.2011.07.016","article-title":"Banxia Xiexin decoction for 48 cases of functional dyspepsia with cold and heat syndrome","volume":"32","author":"Zhao","year":"2011","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3969\/j.issn.1004-6763.2019.03.080","article-title":"Clinical observation of Banxia Xiexin decoction in the treatment of functional dyspepsia","volume":"33","author":"Zheng","year":"2019","journal-title":"Contin. Med. Educ."},{"key":"B102","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3389\/fphar.2016.00201","article-title":"Synergistic effects of Chinese herbal medicine: A comprehensive review of methodology and current research","volume":"7","author":"Zhou","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"104","DOI":"10.13194\/j.issn.1673-842x.2016.12.030","article-title":"Meta-analysis on random-control experiment of treatment of ulcerative colitis with Banxia Xiexin decoction and its decomposed recipe","volume":"18","author":"Zhu","year":"2016","journal-title":"J. Liaoning Univ. TCM"},{"key":"B104","first-page":"36","article-title":"Influence of Banxia Xiexin decoction on functional dyspepsia and motilin concentration","volume":"42","author":"Zhu","year":"2008","journal-title":"Shanghai J. Tradit. Chin. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3969\/j.issn.1009-4393.2015.2.109","article-title":"Clinical effect of Banxia Xiexin decoction on functional dyspepsia","volume":"21","author":"Zou","year":"2015","journal-title":"Contemp. Med."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1130257\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:35:57Z","timestamp":1684456557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1130257\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":105,"alternative-id":["10.3389\/fphar.2023.1130257"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1130257","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"article-number":"1130257"}}