{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:23:43Z","timestamp":1774581823051,"version":"3.50.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Sentrin-specific protease 1 (SENP1) is a protein whose main function is deSUMOylation. SENP1 inhibits apoptosis, and increases angiogenesis, estrogen and androgen receptor transcription and c-Jun transcription factor, proliferation, growth, cell migration, and invasion of cancer. The <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies also demonstrated which natural compounds, especially phytochemicals, minerals, and vitamins, prevent cancer. More than 3,000 plant species have been reported in modern medicine. Natural compounds have many anti-cancerous andanti-turmeric properties such as antioxidative, antiangiogenic, antiproliferative, and pro-apoptotic properties.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this study, we investigated the interaction of some natural compounds with SENP1 to inhibit its activity. We also screened the ZINC database including natural compounds. Molecular docking was performed, and toxicity of compounds was determined; then, molecular dynamics simulation (MDS) and essential dynamics (ED) were performed on natural compounds with higher free binding energies and minimal side effects. By searching in a large library, virtual screening of the ZINC database was performed using LibDock and CDOCKER, and the final top 20 compounds were allowed for docking against SENP1. According to the docking study, the top three leading molecules were selected and further analyzed by MDS and ED.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The results suggest that resveratrol (from the selected compounds) and ZINC33916875 (from the ZINC database) could be more promising SENP1 inhibitory ligands.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> Because these compounds can inhibit SENP1 activity, then they can be novel candidates for cancer treatment. However, wet laboratory experiments are needed to validate their efficacy as SENP1 inhibitors.<\/jats:p>","DOI":"10.3389\/fphar.2023.1144632","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:21:32Z","timestamp":1689168092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Computational study of SENP1 in cancer by novel natural compounds and ZINC database screening"],"prefix":"10.3389","volume":"14","author":[{"given":"Somayye","family":"Taghvaei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Taghvaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Saberi","family":"Anvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Sabouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarrin","family":"Minuchehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1126\/science.2300807","article-title":"Medicine from plants","volume":"247","author":"Abelson","year":"1990","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0233088","DOI":"10.1371\/journal.pone.0233088","article-title":"Betanin purification from red beetroots and evaluation of its anti-oxidant and anti-inflammatory activity on LPS-activated microglial cells","volume":"15","author":"Ahmadi","year":"2020","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1208\/s12249-012-9899-8","article-title":"Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content","volume":"14","author":"Alemi","year":"2013","journal-title":"Aaps Pharmscitech"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.3390\/molecules27092665","article-title":"Potential therapeutic targets of resveratrol, a plant polyphenol, and its role in the therapy of various types of cancer","volume":"27","author":"Almatroodi","year":"2022","journal-title":"Molecules"},{"key":"B5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/med.20067","article-title":"Combining docking and molecular dynamic simulations in drug design","volume":"26","author":"Alonso","year":"2006","journal-title":"Med. 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