{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:20:07Z","timestamp":1780503607066,"version":"3.54.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Colonoscopy plays an important role in the diagnosis, prognosis prediction, assessment of disease activity and severity, and treatment of inflammatory bowel disease (IBD)-related complications. However, some patients refuse to undergo colonoscopy due to perceived pain and other discomfort, their diagnosis and treatment are affected. Therefore, we conducted a prospective study to explore the efficacy and safety of midazolam combined with dezocine for sedation in IBD patients undergoing colonoscopy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> 224 patients were divided into sedative-colonoscopy-group (SCG, n = 93), anesthesia-colonoscopy-group (ACG, n = 90) and ordinary-colonoscopy-group (OCG, n = 41). The vital signs (blood pressure, pulse, respiration and blood oxygen saturation), pain degree during colonoscopy, satisfaction and complication rates of the three groups were compared.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Before colonoscopy, there was no significant difference among the vital signs of the three groups. The vital signs of the ACG were significantly lower than those of the SEG and the OCG (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), and the difference was not significant between the SCG and OCG during colonoscopy. The colonoscopy pain score in the SCG was lower than that in the OCG (0.79 \u00b1 1.09 vs. 2.98 \u00b1 1.27, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The satisfaction score of the SCG (9.26 \u00b1 1.16) was not significantly different from that of the ACG (9.42 \u00b1 1.41) but was higher than that of the OCG (6.63 \u00b1 1.13) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). The total complication rate of the ACG was 45.56% (41\/90), which was significantly higher than that of the SCG [20.43% (19\/93)] and the OCG [19.51% (8\/41)]. Colon perforation, abnormal blood pressure fluctuation and hypoxemia were significantly more common in the ACG than in the SCG and the OCG (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). However, there was no significant difference in the incidence of complications between the SCG and OCG.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Compared with ordinary-colonoscopy, colonoscopy performed under midazolam and dezocine sedation is more comfortable for patients, thereby increasing satisfaction and compliance. Colonoscopy that is performed under midazolam and dezocine is similar to colonoscopy that is anesthesia with propofol in terms of comfort, satisfaction and compliance and similar to ordinary-colonoscopy in terms of safety. Considering the shortage of anesthesiologists, the application of midazolam combined with dezocine for digestive endoscopy is worthy of clinical promotion.<\/jats:p>","DOI":"10.3389\/fphar.2023.1150045","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T09:39:51Z","timestamp":1688981991000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety analysis of midazolam combined with dezocine sedation and analgesia colonoscopy in patients with inflammatory bowel disease: a prospective single-center open study"],"prefix":"10.3389","volume":"14","author":[{"given":"Yongpeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chujun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1001\/jamainternmed.2016.8566","article-title":"National trends in use of monitored anesthesia care for outpatient gastrointestinal endoscopy in the veterans health administration","volume":"177","author":"Adams","year":"2017","journal-title":"JAMA Intern Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.gie.2008.09.008","article-title":"Risk of perforation from a colonoscopy in adults: A large population-based study","volume":"69","author":"Arora","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/s0399-8320(05)82174-8","article-title":"Intestinal perforation in Crohn's disease. Factors predictive of surgical resection","volume":"29","author":"Brihier","year":"2005","journal-title":"Gastroent\u00e9rologie Clin. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1155\/2008\/268320","article-title":"Clinical affairs committee of the Canadian association of Gastroenterology. Propofol use for sedation during endoscopy in adults: A Canadian association of Gastroenterology position statement","volume":"22","author":"Byrne","year":"2008","journal-title":"Can. J. Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"945597","DOI":"10.3389\/fphar.2022.945597","article-title":"Efficacy and safety of midazolam combined with dezocine for sedation and analgesia in digestive endoscopy: A prospective open single-center study","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/j.1532-5415.2000.tb02628.x","article-title":"Midazolam sedation for upper gastrointestinal endoscopy in older persons: A randomized, double-blind, placebo-controlled study","volume":"48","author":"Christe","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.bjane.2014.09.014","article-title":"Colonoscopy sedation: Clinical trial comparing propofol and fentanyl with or without midazolam","volume":"66","author":"das Neves","year":"2016","journal-title":"Braz J. Anesth."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13017-018-0162-9","article-title":"2017 WSES guidelines for the management of iatrogenic colonoscopy perforation","volume":"13","author":"de\u2019Angelis","year":"2018","journal-title":"World J. Emerg. Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s00384-018-3112-9","article-title":"Management of iatrogenic perforation during colonoscopy in ulcerative colitis patients: A survey of gastroenterologists and colorectal surgeons","volume":"33","author":"DiCaprio","year":"2018","journal-title":"Int. J. Colorectal Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12876-015-0262-x","article-title":"The clinical characteristics of patients with free perforation in Korean crohn\u2019s disease: Results from the CONNECT study","volume":"15","author":"Doh","year":"2015","journal-title":"BMC Gastroenterol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12876-020-01561-z","article-title":"Sedation practices for routine gastrointestinal endoscopy: A systematic review of recommendations","volume":"21","author":"Dossa","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1055\/s-0034-1393414","article-title":"Non-anesthesiologist administration of propofol for gastrointestinal endoscopy: European society of gastrointestinal endoscopy, European society of Gastroenterology and endoscopy nurses and associates guideline-updated june 2015","volume":"47","author":"Dumonceau","year":"2015","journal-title":"Endoscopy"},{"key":"B13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.gie.2017.07.018","article-title":"Guidelines for sedation and anesthesia in GI endoscopy","volume":"87","author":"Early","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"B14","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.jnma.2019.09.001","article-title":"The influence of adding diphenhydramine before initiation of moderate sedation with midazolam and pethidine for improving quality of colonoscopy","volume":"111","author":"El Shahawy","year":"2019","journal-title":"J. Natl. Med. Assoc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.disamonth.2017.07.001","article-title":"A comprehensive review and update on Crohn\u2019s disease","volume":"64","author":"Gajendran","year":"2018","journal-title":"Dis. Mon."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.suc.2019.08.007","article-title":"Abdominal emergencies in inflammatory bowel disease","volume":"99","author":"Goldstone","year":"2019","journal-title":"Surg. Clin. North Am."},{"key":"B17","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.gie.2015.08.034","article-title":"Propofol sedation with a target-controlled infusion pump and bispectral index monitoring system in elderly patients during a complex upper endoscopy procedure","volume":"83","author":"Gotoda","year":"2016","journal-title":"Gastrointest. Endosc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1111\/j.1365-2036.2007.03532.x","article-title":"Systematic review: Endoscopic dilatation in Crohn's disease","volume":"26","author":"Hassan","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B19","first-page":"195","article-title":"Sedation for gastrointestinal endoscopy. Clinical practice guidelines of the Sociedad Espa\u00f1ola de Endoscopia Digestiva","volume":"106","author":"Igea","year":"2014","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3748\/wjg.v23.i6.1098","article-title":"How to improve patient satisfaction during midazolam sedation for gastrointestinal endoscopy?","volume":"23","author":"Jin","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000363567","article-title":"Prospective long-term assessment of sedation-related adverse events and patient satisfaction for upper endoscopy and colonoscopy","volume":"90","author":"Kilgert","year":"2014","journal-title":"Digestion"},{"key":"B22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.gie.2020.03.3864","article-title":"Impacts of age and sedation on cardiocerebrovascular adverse events after diagnostic GI endoscopy: A nationwide population-based study","volume":"92","author":"Kim","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12871-021-01275-z","article-title":"A prospective observational cohort pilot study of the association between midazolam use and delirium in elderly endoscopy patients","volume":"21","author":"Lee","year":"2021","journal-title":"BMC Anesth."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.12998\/wjcc.v7.i20.3237","article-title":"Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial","volume":"7","author":"Li","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"B25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1155\/2013\/615206","article-title":"Patient satisfaction with the endoscopy experience and willingness to return in a central Canadian health region","volume":"27","author":"Loftus","year":"2013","journal-title":"Can. J. Gastroenterol."},{"key":"B26","first-page":"573","article-title":"Colonoscopic perforation in inflammatory bowel disease","volume":"9","author":"Makkar","year":"2013","journal-title":"Gastroenterol. Hepatol. (N Y)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4321\/s1130-01082011000200005","article-title":"Safety of continuous propofol sedation for endoscopic procedures in elderly patients","volume":"103","author":"Mart\u00ednez","year":"2011","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"B28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.crohns.2010.12.005","article-title":"Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized inflammatory bowel disease patients","volume":"5","author":"Navaneethan","year":"2011","journal-title":"J. Crohns Colitis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1055\/s-0041-109680","article-title":"Update S3-guideline: \u201csedation for gastrointestinal endoscopy\u201d 2014 (AWMF-register-no 021\/014)","volume":"54","author":"Riphaus","year":"2016","journal-title":"Z Gastroenterol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/s0016-5085(99)70279-9","article-title":"Colonoscopic polypectomy in chronic colitis: Conservative management after endoscopic resection of dysplastic polyps","volume":"117","author":"Rubin","year":"1999","journal-title":"Gastroenterology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000353373","article-title":"Perforating crohn\u2019s disease: Conservative and surgical treatment","volume":"31","author":"Sampietro","year":"2013","journal-title":"Dig. Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1055\/s-2008-1077445","article-title":"Safety, feasibility, and tolerability of ileocolonoscopy in inflammatory bowel disease","volume":"40","author":"Terheggen","year":"2008","journal-title":"Endoscopy"},{"key":"B33","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1177\/0300060513515437","article-title":"Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy","volume":"42","author":"Wu","year":"2014","journal-title":"J. Int. Med. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2641257","DOI":"10.1155\/2016\/2641257","article-title":"Comparison of nasopharyngeal airway device and nasal oxygen tube in obese patients undergoing intravenous anesthesia for gastroscopy: A prospective and randomized study","volume":"2016","author":"Xiao","year":"2016","journal-title":"Gastroenterol. Res. P. R."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.3748\/wjg.v22.i24.5609","article-title":"Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy","volume":"22","author":"Xu","year":"2016","journal-title":"World J. Gastroenterol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1150045\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T09:39:55Z","timestamp":1688981995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1150045\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":35,"alternative-id":["10.3389\/fphar.2023.1150045"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1150045","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,10]]},"article-number":"1150045"}}