{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:20:40Z","timestamp":1790266840845,"version":"4.1.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:italic>Dendrobium nobile<\/jats:italic> Lindl. belongs to the genus <jats:italic>Dendrobium<\/jats:italic> of the orchid family and is a valuable herbal medicinal material. The information in this paper has been collected from the scientific literature databases including PubMed, Google Scholar, Web of Science, SciFinder, China National Knowledge Infrastructure, published books, Ph.D., and M.S. dissertations systematically in recent 20 years. \u201c<jats:italic>Dendrobium nobile<\/jats:italic> Lindl.,\u201d \u201cchemical composition,\u201d \u201cpharmacological activities,\u201d and \u201cdiseases\u201d were used as search terms to screen the literature. The collected chemical compositions are classified and summarized according to their different chemical structures, and the clinical disease treatment effects of <jats:italic>Dendrobium nobile<\/jats:italic> Lindl. are classified and summarized based on their pharmacological activities and different experimental disease models. Recent studies have revealed that <jats:italic>Dendrobium nobile<\/jats:italic> Lindl. contains chemical components such as alkaloids, bibenzyls, sesquiterpenes, phenanthrenes, and polysaccharides, and that its pharmacological activities are closely related to the chemical components, with pharmacological activities such as anti-tumor, anti-aging, immune enhancement, hypoglycemic, and anti-cataract. Currently, researchers are conducting extensive and detailed studies on <jats:italic>Dendrobium nobile<\/jats:italic> Lindl. and research experiments on its chemical constituents in the treatment of various clinical diseases. Therefore, the purpose of this paper is to review the chemical composition of <jats:italic>Dendrobium nobile<\/jats:italic> Lindl. and its experimental studies in the treatment of diseases and to provide a scientific reference for the future application of <jats:italic>Dendrobium nobile<\/jats:italic> Lindl. in the treatment of diseases.<\/jats:p>","DOI":"10.3389\/fphar.2023.1163830","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T09:24:21Z","timestamp":1689067461000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Therapeutic potential of the chemical composition of Dendrobium nobile Lindl."],"prefix":"10.3389","volume":"14","author":[{"given":"Chenxi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.14109\/j.cnki.xyylc.2017.06.008","article-title":"Dendrobium nobile Lindl. alkaloids ameliorates streptozotocin - 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