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The integrated intracellular signal cascade, namely the unfolded protein response, is induced to avoid ER stress. ER stress is involved in many pathological and physiological processes including myocardial diseases. For a long time, hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) has been considered as a toxic gas with the smell of rotten eggs. However, more and more evidences indicate that H<jats:sub>2<\/jats:sub>S is an important gas signal molecule after nitric oxide and carbon monoxide, and regulates a variety of physiological and pathological processes in mammals. In recent years, increasing studies have focused on the regulatory effects of H<jats:sub>2<\/jats:sub>S on ER stress in myocardial diseases, however, the mechanism is not very clear. Therefore, this review focuses on the role of H<jats:sub>2<\/jats:sub>S regulation of ER stress in myocardial diseases, and deeply analyzes the relevant mechanisms so as to lay the foundation for the future researches.<\/jats:p>","DOI":"10.3389\/fphar.2023.1172147","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T07:45:34Z","timestamp":1681458334000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogen sulfide plays an important role by regulating endoplasmic reticulum stress in myocardial diseases"],"prefix":"10.3389","volume":"14","author":[{"given":"Huijie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"Febs J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.plaphy.2020.11.045","article-title":"Hydrogen sulfide: A versatile gaseous molecule in plants","volume":"158","author":"Arif","year":"2021","journal-title":"Plant Physiol. 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