{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:50:37Z","timestamp":1783097437623,"version":"3.54.6"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The objective of this study is to access the effect of purple sweet potato leaf (PSPL) extract on diabetic retinopathy (DR) of streptozotocin (STZ)-induced male Sprague\u2013Dawley (SD) rats. In this study, rats were injected intraperitoneally with a single dose of 60\u00a0mg\/kg STZ, and diabetes was confirmed on day 7. Rats were further divided into a few groups, which were then orally administered with one of the following treatments: 25\u00a0mg\/kg of gliclazide (D25G), 200\u00a0mg\/kg of PSPL extract (DT 200), and 400\u00a0mg\/kg of PSPL extract (DT 400). However, the normal control (NS) and control group for diabetic (DNS) were given normal saline (NS) for 12\u00a0weeks. The results show that the treated group demonstrated a reduction in serum oral glucose tolerance test (OGTT) levels of DT 200 and DT 400, and an increase in the serum and retinal insulin levels, and restored oxidative stress markers in serum and retina on week 12. The PSPL extract exhibited protective effects in maintaining the kidney, liver, retina, and pancreas architecture in 400\u00a0mg\/kg compared to the 200\u00a0mg\/kg treated group and D25G, thereby restoring fully transparent lenses in diabetes-induced rats. In conclusion, 400\u00a0mg\/kg PSPL is the most effective dose for the amelioration of STZ-induced DR pathology in male SD rats.<\/jats:p>","DOI":"10.3389\/fphar.2023.1175907","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T04:58:21Z","timestamp":1684385901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague\u2013Dawley rats"],"prefix":"10.3389","volume":"14","author":[{"given":"Ahmad Safiyyu'd-din Bin","family":"Hisamuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Naomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairul Aiman Bin","family":"Manan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnah","family":"Bahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fezah","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Embong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamar Uddin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Hadizah","family":"Jumidil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Khairi","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainul Amiruddin","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1515\/jbcpp-2020-0053","article-title":"Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring","volume":"32","author":"Abidin","year":"2021","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1016\/J.FCT.2012.05.057","article-title":"Prevention and management of diabetic retinopathy in STZ diabetic rats by Tinospora cordifolia and its molecular mechanisms","volume":"50","author":"Agrawal","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s00125-016-3984-6","article-title":"Morphology of the pancreas in type 2 diabetes: Effect of weight loss with or without normalisation of insulin secretory capacity","volume":"59","author":"Al-Mrabeh","year":"2016","journal-title":"Diabetologia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/J.TIFS.2021.07.001","article-title":"A comprehensive review of sweet potato (Ipomoea batatas [L] Lam): Revisiting the associated health benefits","volume":"115","author":"Alam","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/J.SJOPT.2011.01.009","article-title":"Diabetic retinopathy \u2013 an update","volume":"25","author":"Alghadyan","year":"2011","journal-title":"Saudi J. Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4103\/0253-7613.40484","article-title":"Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats","volume":"40","author":"Barik","year":"2008","journal-title":"Indian J. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11892-017-0909-9","article-title":"Diameter changes of retinal vessels in diabetic retinopathy","volume":"17","author":"Bek","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/J.1365-2362.2010.02372.X","article-title":"Liver fat in obesity: Role of type 2 diabetes mellitus and adipose tissue distribution","volume":"41","author":"Bozzetto","year":"2010","journal-title":"Eur. J. Clin. Invest."},{"key":"B9","first-page":"31","article-title":"Vitrectomy surgery of diabetic retinopathy complications","volume":"60","author":"Br\u0103ni\u015fteanuonstanti","year":"2016","journal-title":"Rom. J. Ophthalmol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/NU10091321","article-title":"The effect of lutein on eye and extra-eye health","volume":"10","author":"Buscemi","year":"2018","journal-title":"Nutrients"},{"key":"B11","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3390\/BIOMEDICINES9070831","article-title":"IL-17A damages the blood\u2013retinal barrier through activating the janus kinase 1 pathway","volume":"9","author":"Byrne","year":"2021","journal-title":"Biomedicines"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1027C","DOI":"10.21273\/HORTSCI.41.4.1027C","article-title":"(268) lutein content in sweetpotato leaves","volume":"41","author":"Cavalier","year":"2019","journal-title":"Hortic. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"9341","DOI":"10.1038\/S41598-018-27516-9","article-title":"Rosmarinic acid restores complete transparency of sonicated human cataract ex vivo and delays cataract formation in vivo","volume":"8","author":"Chemerovski-Glikman","year":"2018","journal-title":"Sci. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3390\/JCM10050981","article-title":"Inflammatory complications of intravitreal anti-VEGF injections","volume":"10","author":"Cox","year":"2021","journal-title":"J. Clin. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9711176","DOI":"10.1155\/2021\/9711176","article-title":"The antioxidative role of natural compounds from a green coconut mesocarp undeniably contributes to control diabetic complications as evidenced by the associated genes and biochemical indexes","volume":"2021","author":"Das","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3109\/08820538.2014.959198","article-title":"Side-effects and complications of laser treatment in diabetic retinal disease","volume":"29","author":"Deschler","year":"2014","journal-title":"Semin. Ophthalmol."},{"key":"B17","first-page":"1258","article-title":"Measurement of retinal blood vessel width using computerized image analysis","volume":"29","author":"Eaton","year":"1988","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3390\/foods11071058","article-title":"Sweet potato (Ipomoea batatas L) phenotypes: From agroindustry to health effects","volume":"11","author":"Escobar-Puentes","year":"2022","journal-title":"Foods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e26498","DOI":"10.1371\/journal.pone.0026498","article-title":"Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: Evidence for retinal insulin resistance","volume":"6","author":"Fort","year":"2011","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fbio.2016.04.004","article-title":"Antioxidant activities and polyphenols of sweet potato (Ipomoea batatas L) leaves extracted with solvents of various polarities","volume":"15","author":"Fu","year":"2016","journal-title":"Food Biosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S12652-020-01963-7","article-title":"Deep neural networks to predict diabetic retinopathy","volume":"2020","author":"Gadekallu","year":"2020","journal-title":"J. Ambient. Intell. Humaniz. Comput."},{"key":"B22","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.3390\/IJMS21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1017\/S0007114520004997","article-title":"Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: Effects on anthropometric indices, body composition and metabolic parameters","volume":"126","author":"Hajizadeh-Sharafabad","year":"2020","journal-title":"Br. J. Nutr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1132087","DOI":"10.3389\/FPHAR.2023.1132087","article-title":"Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague Dawley rats","volume":"14","author":"Hisamuddin","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1167\/iovs.03-1081","article-title":"Downregulation of ATP synthase subunit-6, cytochrome c oxidase-III, and NADH dehydrogenase-3 by bright cyclic light in the rat retina","volume":"45","author":"Huang","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e12495","DOI":"10.1111\/JFBC.12495","article-title":"Lutein suppresses hyperglycemia-induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1","volume":"42","author":"Hwang","year":"2018","journal-title":"J. Food Biochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fendo.2020.00069","article-title":"Thinning of macular neuroretinal layers contributes to sleep disorder in patients with type 2 diabetes without clinical evidences of neuropathy and retinopathy","volume":"11","author":"Ishibashi","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/S13098-020-0515-X","article-title":"Enhancement of the serum chloride concentration by administration of sodium\u2013glucose cotransporter-2 inhibitor and its mechanisms and clinical significance in type 2 diabetic patients: A pilot study","volume":"12","author":"Kataoka","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.7860\/JCDR\/2012\/4856.2626","article-title":"The oxidative stress in cataract patients","volume":"6","author":"Kaur","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1001\/ARCHOPHTHALMOL.2011.2560","article-title":"Changes in retinal vessel diameter and incidence and progression of diabetic retinopathy","volume":"130","author":"Klein","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e01373","DOI":"10.1016\/J.HELIYON.2019.E01373","article-title":"In vivo antihyperglycemic, antihyperlipidemic, antioxidative stress and antioxidant potential activities of Syzygium paniculatum Gaertn. in Streptozotocin-induced diabetic rats","volume":"5","author":"Konda","year":"2019","journal-title":"Heliyon"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.7150\/IJMS.46395","article-title":"Pancreatic fat is not significantly correlated with \u03b2-cell dysfunction in patients with new-onset type 2 diabetes mellitus using quantitative computed tomography","volume":"17","author":"Li","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"488","DOI":"10.12998\/WJCC.V2.I10.488","article-title":"Diabetes mellitus and electrolyte disorders","volume":"2","author":"Liamis","year":"2014","journal-title":"World J. Clin. Cases WJCC"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.3892\/mmr.2014.2982","article-title":"Lutein protects against ischemia\/reperfusion injury in rat kidneys","volume":"11","author":"Liu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"B35","volume-title":"LiverTox: Clinical and research information on drug-induced liver injury","year":"2018"},{"key":"B36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/S13749-015-0014-0","article-title":"The beneficial role of lutein and zeaxanthin in cataracts","volume":"14","author":"Maci","year":"2015","journal-title":"Nutrafoods"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1104\/PP.18.01065","article-title":"Osmotic stress activates two reactive oxygen species pathways with distinct effects on protein nanodomains and diffusion","volume":"179","author":"Martini\u00e8re","year":"2019","journal-title":"Plant Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/J.1469-7580.2006.00620.X","article-title":"Morphological changes of isolated rat pancreatic islets: A structural, ultrastructural and morphometric study","volume":"209","author":"Morini","year":"2006","journal-title":"J. Anat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/NU14040827","article-title":"Lutein and zeaxanthin and their roles in age-related macular degeneration - neurodegenerative disease","volume":"14","author":"Mrowicka","year":"2022","journal-title":"Nutrients"},{"key":"B40","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.foodchem.2011.04.045","article-title":"Comparative antioxidant activities of carotenoids measured by ferric reducing antioxidant power (FRAP), ABTS bleaching assay (\u03b1TEAC), DPPH assay and peroxyl radical scavenging assay","volume":"129","author":"M\u00fcller","year":"2011","journal-title":"Food Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"608751","DOI":"10.1155\/2010\/608751","article-title":"Diabetic cataract - pathogenesis, epidemiology and treatment","volume":"2010","author":"Pollreisz","year":"2010","journal-title":"J. Ophthalmol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/DATA3030025","article-title":"Indian diabetic retinopathy image dataset (IDRiD): A database for diabetic retinopathy screening research","volume":"3","author":"Porwal","year":"2018","journal-title":"Data"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e280","DOI":"10.1038\/EMM.2016.117","article-title":"IL-17A exacerbates diabetic retinopathy by impairing M\u00fcller cell function via Act1 signaling","volume":"48","author":"Qiu","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S2221-1691(12)60020-3","article-title":"Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats","volume":"2","author":"Ramachandran","year":"2012","journal-title":"Asian pac. J. Trop. Biomed."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.3390\/METABO12111133","article-title":"Anti-diabetic and cytotoxic evaluation of phlomis stewartii plant phytochemicals on cigarette smoke inhalation and alloxan-induced diabetes in wistar rats","volume":"12","author":"Rasheed","year":"2022","journal-title":"Metabolites"},{"key":"B46","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3390\/IJMS19040942","article-title":"Role of inflammation in diabetic retinopathy","volume":"19","author":"R\u00fcbsam","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"105115","DOI":"10.1016\/J.PHRS.2020.105115","article-title":"Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy","volume":"161","author":"Rudraraju","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3109\/09286586.2015.1129426","article-title":"Dietary intake of lutein and diabetic retinopathy in the atherosclerosis risk in communities study (ARIC)","volume":"23","author":"Sahli","year":"2015","journal-title":"Ophthalmic Epidemiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/J.JAIM.2021.04.010","article-title":"Antidiabetic effect of bio-enhanced preparation of turmeric in streptozotocin-nicotinamide induced type 2 diabetic Wistar rats","volume":"12","author":"Sayeli","year":"2021","journal-title":"J. Ayurveda Integr. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1007\/s00394-016-1283-0","article-title":"Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model","volume":"56","author":"Sharavana","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"B51","doi-asserted-by":"publisher","first-page":"103921","DOI":"10.1016\/J.CELLIMM.2019.04.009","article-title":"Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability","volume":"341","author":"Sigurdardottir","year":"2019","journal-title":"Cell. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1615\/JENVIRONPATHOLTOXICOLONCOL.2013004933","article-title":"Carotenoid lutein protects the kidney against cisplatin-induced acute renal failure","volume":"32","author":"Sindhu","year":"2013","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"B53","first-page":"843","article-title":"Antioxidant activity of carotenoid lutein in vitro and in vivo","volume":"48","author":"Sindhu","year":"2010","journal-title":"Indian J. Exp. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/jdi.12235","article-title":"Modeling type 2 diabetes in rats using high fat diet and streptozotocin","volume":"5","author":"Skovs\u00f8","year":"2014","journal-title":"J. Diabetes Investig."},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-401717-7.00042-3","article-title":"Polyphenols in vision and eye health","volume-title":"Handbook of nutrition, diet and the eye","author":"Srinivasan","year":"2014"},{"key":"B56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12906-016-1118-9","article-title":"Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats","volume":"16","author":"Taher","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1038\/S41374-019-0264-3","article-title":"Vascular changes in diabetic retinopathy \u2013 a longitudinal study in the Nile rat","volume":"99","author":"Toh","year":"2019","journal-title":"Lab. Invest."},{"key":"B58","doi-asserted-by":"publisher","first-page":"7092140","DOI":"10.1155\/2018\/7092140","article-title":"Effects of modified sanzi yangqin decoction on tyrosine phosphorylation of IRS-1 in skeletal muscle of type 2 diabetic rats","volume":"2018","author":"Wang","year":"2018","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4161\/ISL.27494","article-title":"\u03b2-cell dedifferentiation in diabetes is important, but what is it?","volume":"5","author":"Weir","year":"2013","journal-title":"Islets"},{"key":"B60","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1590\/fst.28619","article-title":"Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats","volume":"40","author":"Wu","year":"2020","journal-title":"Food Sci. Technol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/JDI.12424","article-title":"Dynamic pathology of islet endocrine cells in type 2 diabetes: \u03b2\u2010Cell growth, death, regeneration and their clinical implications","volume":"7","author":"Yagihashi","year":"2016","journal-title":"J. Diabetes Investig."},{"key":"B62","doi-asserted-by":"publisher","first-page":"636580","DOI":"10.1155\/2013\/636580","article-title":"Hepatoprotective activity of methanolic extract of Bauhinia purpurea leaves against paracetamol-induced hepatic damage in rats","volume":"2013","author":"Yahya","year":"2013","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/jdi.12665","article-title":"Impact of non-alcoholic fatty pancreas disease on glucose metabolism","volume":"8","author":"Yu","year":"2017","journal-title":"J. Diabetes Investig."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.3390\/NU11122945","article-title":"Aqueous partition of methanolic extract of dicranopteris linearis leaves protects against liver damage induced by paracetamol","volume":"11","author":"Zakaria","year":"2019","journal-title":"Nutrients"},{"key":"B65","doi-asserted-by":"publisher","first-page":"6772","DOI":"10.1021\/acs.jafc.8b01831","article-title":"Improvement of lipid and glucose metabolism by capsiate in palmitic acid-treated HepG2 cells via activation of the AMPK\/SIRT1 signaling pathway","volume":"66","author":"Zang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"CD007939","DOI":"10.1002\/14651858.CD007939.PUB2","article-title":"Single herbal medicine for diabetic retinopathy","volume":"2018","author":"Zhang","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"847937","DOI":"10.3389\/FIMMU.2022.847937","article-title":"Contribution of interleukin-17a to retinal degenerative diseases","volume":"13","author":"Zhong","year":"2022","journal-title":"Front. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"14175","DOI":"10.1080\/21655979.2022.2084241","article-title":"Interleukin-17A attenuates photoreceptor cell apoptosis in streptozotocin-induced diabetic mouse model","volume":"13","author":"Zhu","year":"2022","journal-title":"Bioengineered"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1175907\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T04:58:28Z","timestamp":1684385908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1175907\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":68,"alternative-id":["10.3389\/fphar.2023.1175907"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1175907","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"article-number":"1175907"}}