{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:24:41Z","timestamp":1790015081892,"version":"4.0.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other studies reject such effects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Therefore, in this umbrella meta-analysis, we performed a comprehensive systematic search in such databases as Web of Science, PubMed, Scopus, Embase, and Google Scholar up to January 2023.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Based on standardized mean difference analysis, CoQ10 supplementation significantly decreased serum C-reactive protein (CRP) (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = \u22120.39; 95% CI: 0.77, \u22120.01,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.042) and malondialdehyde (MDA) (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = \u22121.17; 95% CI: 1.55, \u22120.79,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001), while it increased the total antioxidant capacity (TAC) (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = 1.21; 95% CI: 0.61, 1.81,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001) and serum superoxide dismutase (SOD) activity (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = 1.08; 95% CI: 0.37, 1.79,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003). However, CoQ10 supplementation had no significant reducing effect on tumor-necrosis factor-alpha (TNF- \u03b1) (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = \u22120.70; 95% CI: 2.09, 0.68,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.320) and interleukin-6 (IL-6) levels (ES\n                    <jats:sub>SMD<\/jats:sub>\n                    = \u22120.85; 95% CI: 1.71, 0.01,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.053). Based on weighted mean difference analysis, CoQ10 supplementation considerably decreased TNF-\u03b1 (ES\n                    <jats:sub>WMD<\/jats:sub>\n                    = \u22120.46, 95% CI: 0.65, \u22120.27;\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001), IL-6 (ES\n                    <jats:sub>WMD<\/jats:sub>\n                    = \u22120.92, 95% CI: 1.40, \u22120.45;\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001), and CRP levels (effect sizes\n                    <jats:sub>WMD<\/jats:sub>\n                    = \u22120.28, 95% CI: 0.47, \u22120.09;\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    The results of our meta-analysis supported the alleviating effects of CoQ10 on markers of inflammation cautiously. However, CoQ10 had antioxidant effects regarding the improvement of all the studied antioxidant and oxidative stress biomarkers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Systematic Review Registration:<\/jats:bold>\n                    <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=323861<\/jats:ext-link>\n                    , identifier CRD42022323861\n                  <\/jats:p>","DOI":"10.3389\/fphar.2023.1191290","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T04:08:10Z","timestamp":1691467690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Sara","family":"Dabbaghi Varnousfaderani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vali","family":"Musazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Ghalichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Kavyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Razmjouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Faghfouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Sedgh","family":"Ahrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Morteza","family":"Seyyed Shoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"110627","DOI":"10.1016\/j.biopha.2020.110627","article-title":"Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney","volume":"130","author":"Abdeen","year":"2020","journal-title":"Biomed. 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