{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:59Z","timestamp":1753891979543,"version":"3.41.2"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2021ZD0202100 2021ZD0203500 2022ZD0214500"],"award-info":[{"award-number":["2021ZD0202100 2021ZD0203500 2022ZD0214500"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930046 82021002 31970543 32270660 32000671 32271064 31871021 32222033 32171041"],"award-info":[{"award-number":["31930046 82021002 31970543 32270660 32000671 32271064 31871021 32222033 32171041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> A growing body of evidence suggests that parental substance abuse, even prior to conception, may induce phenotypic changes in offspring. Parental opioid exposure has been shown to affect developmental processes, induce memory deficits, and lead to psycho-emotional disorders in offspring. However, how parental, especially paternal, chronic drug exposure affects offspring remains unexplored.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Adult male rats were subjected to 31\u00a0days of heroin self-administration followed by mating with na\u00efve females. Litter size and body weight of F1 offspring were recorded. Object-based attention tests, cocaine self-administration tests, and hot plate tests were used to test for potential effects of chronic paternal heroin seeking on cognition, reward, or analgesic sensitivity in the offspring.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Body weight and litter size of the heroin F1 generation were not altered compared to the saline F1 generation. Furthermore, paternal chronic heroin self-administration experience had no significant effect on object-based attention tests or cocaine self-administration behavior in either sex. However, in the hot plate test, although no difference in basal latency was found between the two groups in either sex, a significant increase in the analgesic effect of heroin was observed in the male heroin F1 generation.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Taken together, these data provide evidence that paternal chronic heroin self-administration experience could sex-dimorphically increase the analgesic effect of heroin in male offspring, but had no significant effect on response to cocaine reinforcement or attentional behavior.<\/jats:p>","DOI":"10.3389\/fphar.2023.1211897","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:10:51Z","timestamp":1686719451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhanced heroin analgesic effect in male offspring of sires who self-administered heroin"],"prefix":"10.3389","volume":"14","author":[{"given":"Wenjing","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiumin","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"113621","DOI":"10.1016\/j.expneurol.2021.113621","article-title":"Prenatal opioid exposure and vulnerability to future substance use disorders in offspring","volume":"339","author":"Abu","year":"2021","journal-title":"Exp. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.bbr.2011.01.039","article-title":"Evaluation of object-based attention in mice","volume":"220","author":"Alkam","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jpain.2017.12.268","article-title":"Is the nociception mechanism altered in offspring of morphine-abstinent rats?","volume":"19","author":"Ashabi","year":"2018","journal-title":"J. Pain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1007\/s00213-021-05962-0","article-title":"Preconception paternal morphine exposure leads to an impulsive phenotype in male rat progeny","volume":"238","author":"Azadi","year":"2021","journal-title":"Psychopharmacol. Berl."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e196405","DOI":"10.1001\/jamanetworkopen.2019.6405","article-title":"Prenatal risk factors and perinatal and postnatal outcomes associated with maternal opioid exposure in an urban, low-income, multiethnic US population","volume":"2","author":"Azuine","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"B6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrn3104","article-title":"Opiate versus psychostimulant addiction: The differences do matter","volume":"12","author":"Badiani","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2042-6410-3-14","article-title":"Sex differences in the neural mechanisms mediating addiction: A new synthesis and hypothesis","volume":"3","author":"Becker","year":"2012","journal-title":"Biol. Sex. Differ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.expneurol.2014.01.022","article-title":"Sex differences in the neurobiology of drug addiction","volume":"259","author":"Bobzean","year":"2014","journal-title":"Exp. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.biopsych.2019.06.027","article-title":"Epigenetic mechanisms of opioid addiction","volume":"87","author":"Browne","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.bbr.2010.11.059","article-title":"Adolescent opioid exposure in female rats: Transgenerational effects on morphine analgesia and anxiety-like behavior in adult offspring","volume":"218","author":"Byrnes","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.3390\/ijms24043920","article-title":"Maternal immune activation induced by prenatal lipopolysaccharide exposure leads to long-lasting autistic-like social, cognitive and immune alterations in male wistar rats","volume":"24","author":"Carbone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nrg.2016.106","article-title":"Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/(sici)1097-4695(20000605)43:3<234:aid-neu2>3.0.co;2-3","article-title":"Apoptosis during sexual differentiation of the bed nucleus of the stria terminalis in the rat brain","volume":"43","author":"Chung","year":"2000","journal-title":"J. Neurobiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/s0091-3057(02)01039-0","article-title":"Gender differences in the intravenous self-administration of mu opiate agonists","volume":"74","author":"Cicero","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e20190128","DOI":"10.1542\/peds.2019-0128","article-title":"Prenatal opioid exposure: Neurodevelopmental consequences and future research priorities","volume":"144","author":"Conradt","year":"2019","journal-title":"Pediatrics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.conb.2004.05.005","article-title":"Mu opioid receptor: A gateway to drug addiction","volume":"14","author":"Contet","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nn.3594","article-title":"Parental olfactory experience influences behavior and neural structure in subsequent generations","volume":"17","author":"Dias","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s00213-019-05450-6","article-title":"Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring","volume":"237","author":"Ellis","year":"2020","journal-title":"Psychopharmacol. Berl."},{"key":"B19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12993-016-0107-y","article-title":"Transgenerational effects of paternal heroin addiction on anxiety and aggression behavior in male offspring","volume":"12","author":"Farah Naquiah","year":"2016","journal-title":"Behav. Brain Funct."},{"key":"B20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/s0091-3057(97)00535-2","article-title":"Analgesia and abuse potential: An accidental association or a common substrate?","volume":"59","author":"Franklin","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0149-7634(89)80024-7","article-title":"Analgesia and the neural substrate of reward","volume":"13","author":"Franklin","year":"1989","journal-title":"Neurosci. Biobehav Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1038\/s41593-019-0512-2","article-title":"Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone","volume":"22","author":"Frau","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nn.3695","article-title":"Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice","volume":"17","author":"Gapp","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1038\/s41380-018-0271-6","article-title":"Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma","volume":"25","author":"Gapp","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/nu15051095","article-title":"Maternal over- and malnutrition and increased risk for addictive and eating disorders in the offspring","volume":"15","author":"Guillaumin","year":"2023","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","first-page":"107985","DOI":"10.1016\/j.drugalcdep.2020.107985","article-title":"Cross-generational THC exposure alters heroin reinforcement in adult male offspring","volume":"212","author":"Hempel","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"B27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.earlhumdev.2007.01.013","article-title":"Adverse neurodevelopmental outcome of infants exposed to opiate in-utero","volume":"84","author":"Hunt","year":"2008","journal-title":"Early Hum. Dev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: The role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fpsyt.2011.00029","article-title":"Adolescent opiate exposure in the female rat induces subtle alterations in maternal care and transgenerational effects on play behavior","volume":"2","author":"Johnson","year":"2011","journal-title":"Front. Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1080\/09297049.2014.967201","article-title":"Executive function in preschool children prenatally exposed to methadone or buprenorphine","volume":"21","author":"Konijnenberg","year":"2015","journal-title":"Child. Neuropsychol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fnbeh.2017.00184","article-title":"Binge-like sucrose self-administration experience inhibits cocaine and sucrose seeking behavior in offspring","volume":"11","author":"Le","year":"","journal-title":"Front. Behav. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"15527","DOI":"10.1038\/ncomms15527","article-title":"Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour","volume":"8","author":"Le","year":"","journal-title":"Nat. Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-neuro-092920-123905","article-title":"Consolidating the circuit model for addiction","volume":"44","author":"Luscher","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e437","DOI":"10.1371\/journal.pmed.0030437","article-title":"The mechanistic classification of addictive drugs","volume":"3","author":"Luscher","year":"2006","journal-title":"PLoS Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/sj.npp.1301277","article-title":"The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner","volume":"32","author":"McArthur","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e2006497","DOI":"10.1371\/journal.pbio.2006497","article-title":"Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants","volume":"16","author":"McCarthy","year":"2018","journal-title":"PLoS Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1007\/s00213-022-06257-8","article-title":"Perinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice","volume":"239","author":"Minakova","year":"2022","journal-title":"Psychopharmacol. Berl."},{"key":"B41","doi-asserted-by":"publisher","first-page":"615798","DOI":"10.3389\/fnbeh.2021.615798","article-title":"Ontogenetic oxycodone exposure affects early life communicative behaviors, sensorimotor reflexes, and weight trajectory in mice","volume":"15","author":"Minakova","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"dvaa020","DOI":"10.1093\/eep\/dvaa020","article-title":"Epigenome-wide association study (EWAS) for potential transgenerational disease epigenetic biomarkers in sperm following ancestral exposure to the pesticide methoxychlor","volume":"6","author":"Nilsson","year":"2020","journal-title":"Environ. Epigenet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1017\/s0012162201001219","article-title":"Developmental outcome of school-age children born to mothers with heroin dependency: Importance of environmental factors","volume":"43","author":"Ornoy","year":"2001","journal-title":"Dev. Med. Child. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1038\/s41386-018-0008-x","article-title":"Environmental, genetic and epigenetic contributions to cocaine addiction","volume":"43","author":"Pierce","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"13699","DOI":"10.1073\/pnas.1508347112","article-title":"Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress","volume":"112","author":"Rodgers","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/npp.2014.147","article-title":"Developmental consequences of fetal exposure to drugs: What we know and what we still must learn","volume":"40","author":"Ross","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s10803-018-3721-8","article-title":"Brief report: Maternal opioid prescription from preconception through pregnancy and the odds of autism spectrum disorder and autism features in children","volume":"49","author":"Rubenstein","year":"2019","journal-title":"J. Autism Dev. Disord."},{"key":"B49","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/children8020106","article-title":"Prenatal opioid exposure and adhd childhood symptoms: A meta-analysis","volume":"8","author":"Schwartz","year":"2021","journal-title":"Child. (Basel)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"114396","DOI":"10.1016\/j.bbr.2023.114396","article-title":"A maternal high-fat diet during pregnancy and lactation disrupts short-term memory functions via altered hippocampal glutamatergic signaling in female rat offspring","volume":"445","author":"Smaga","year":"2023","journal-title":"Behav. Brain Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00702-018-1957-2","article-title":"Dopamine and addiction: What have we learned from 40 years of research","volume":"126","author":"Solinas","year":"2019","journal-title":"J. Neural Transm. (Vienna)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/apa.12210","article-title":"Neurobehavioural development of preschool-age children born to addicted mothers given opiate maintenance treatment with buprenorphine during pregnancy","volume":"102","author":"Sundelin Wahlsten","year":"2013","journal-title":"Acta Paediatr."},{"key":"B53","doi-asserted-by":"publisher","first-page":"dvaa023","DOI":"10.1093\/eep\/dvaa023","article-title":"Ancestral plastics exposure induces transgenerational disease-specific sperm epigenome-wide association biomarkers","volume":"7","author":"Thorson","year":"2021","journal-title":"Environ. Epigenet"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1007\/s00213-018-5132-0","article-title":"Increased cocaine reward in offspring of females exposed to morphine during adolescence","volume":"236","author":"Vassoler","year":"2019","journal-title":"Psychopharmacol. Berl."},{"key":"B55","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nn.3280","article-title":"Epigenetic inheritance of a cocaine-resistance phenotype","volume":"16","author":"Vassoler","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuropharm.2015.11.026","article-title":"Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring","volume":"103","author":"Vassoler","year":"2016","journal-title":"Neuropharmacology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1177\/0963689718811060","article-title":"Historical review: Opiate addiction and opioid receptors","volume":"28","author":"Wang","year":"2019","journal-title":"Cell Transpl."},{"key":"B58","doi-asserted-by":"publisher","first-page":"eabd7605","DOI":"10.1126\/sciadv.abd7605","article-title":"Sperm microRNAs confer depression susceptibility to offspring","volume":"7","author":"Wang","year":"2021","journal-title":"Sci. Adv."},{"key":"B59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00213-010-1825-8","article-title":"The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse","volume":"210","author":"Wee","year":"2010","journal-title":"Psychopharmacol. Berl."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/ejn.14310","article-title":"Impaired cocaine-induced behavioral plasticity in the male offspring of cocaine-experienced sires","volume":"49","author":"Wimmer","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-psych-010418-103337","article-title":"Dopamine and addiction","volume":"71","author":"Wise","year":"2020","journal-title":"Annu. Rev. Psychol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.1038\/s41467-021-26909-1","article-title":"Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41556-018-0087-2","article-title":"Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.3390\/ijms24054460","article-title":"Effects of maternal high-fructose diet on long non-coding RNAs and anxiety-like behaviors in offspring","volume":"24","author":"Zou","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1211897\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:10:56Z","timestamp":1686719456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1211897\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,14]]},"references-count":60,"alternative-id":["10.3389\/fphar.2023.1211897"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1211897","relation":{},"ISSN":["1663-9812"],"issn-type":[{"type":"electronic","value":"1663-9812"}],"subject":[],"published":{"date-parts":[[2023,6,14]]},"article-number":"1211897"}}