{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:06:16Z","timestamp":1787594776670,"version":"build-2736575974"},"reference-count":257,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression. Despite promising efficacy observed in some clinical trials, the full range of biological effects and mechanism(s) of action of these compounds have yet to be fully established. Indeed, most studies to date have focused on assessing the psychological mechanisms of psychedelics, often neglecting the non-psychological modes of action. However, it is important to understand that psychedelics may mediate their therapeutic effects through multi-faceted mechanisms, such as the modulation of brain network activity, neuronal plasticity, neuroendocrine function, glial cell regulation, epigenetic processes, and the gut-brain axis. This review provides a framework supporting the implementation of a multi-faceted approach, incorporating <jats:italic>in silico<\/jats:italic>, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> modeling, to aid in the comprehensive understanding of the physiological effects of psychedelics and their potential for clinical application beyond the treatment of psychiatric disorders. We also provide an overview of the literature supporting the potential utility of psychedelics for the treatment of brain injury (e.g., stroke and traumatic brain injury), neurodegenerative diseases (e.g., Parkinson\u2019s and Alzheimer\u2019s diseases), and gut-brain axis dysfunction associated with psychiatric disorders (e.g., generalized anxiety disorder and major depressive disorder). To move the field forward, we outline advantageous experimental frameworks to explore these and other novel applications for psychedelics.<\/jats:p>","DOI":"10.3389\/fphar.2023.1240295","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:38:31Z","timestamp":1696264711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Bedside to bench: the outlook for psychedelic research"],"prefix":"10.3389","volume":"14","author":[{"given":"Victor P.","family":"Acero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Cribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Rivellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Burrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suradip","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Kacy","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s41465-019-00151-6","article-title":"Can psychedelic drugs attenuate age-related changes in cognition and affect?","volume":"4","author":"Aday","year":"2020","journal-title":"J. Cogn. Enhanc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.cell.2021.03.022","article-title":"SnapShot: the microbiota-gut-brain axis","volume":"184","author":"Agirman","year":"2021","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","author":"Alatab","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3389\/fmed.2019.00334","article-title":"Intestinal organoids as a tool for inflammatory bowel disease research","volume":"6","author":"Angus","year":"2020","journal-title":"Front. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/bph.13714","article-title":"Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus","volume":"174","author":"Ardalan","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/03344355.2020.1732046","article-title":"Cannabis and frankincense at the judahite shrine of arad","volume":"47","author":"Arie","year":"2020","journal-title":"Tel Aviv"},{"key":"B7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1746-4269-10-26","article-title":"Traditional medicine applied by the saraguro yachakkuna: A preliminary approach to the use of sacred and psychoactive plant species in the southern region of Ecuador","volume":"10","author":"Armijos","year":"2014","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"B8","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00109-011-0752-4","article-title":"Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo","volume":"89","author":"Aviello","year":"2011","journal-title":"J. Mol. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1080\/02791072.2019.1593560","article-title":"Effects of the psychedelic amphetamine MDA (3,4-methylenedioxyamphetamine) in healthy volunteers","volume":"51","author":"Baggott","year":"2019","journal-title":"J. Psychoact. Drugs"},{"key":"B10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/jnnp-2019-320912","article-title":"Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: A systematic review and meta-analysis of randomised controlled trials","volume":"91","author":"Bai","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"30550","DOI":"10.1038\/srep30550","article-title":"Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury","volume":"6","author":"Bar-Kochba","year":"2016","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00213-007-0963-0","article-title":"Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers","volume":"196","author":"Barbanoj","year":"2008","journal-title":"Psychopharmacol. Berl."},{"key":"B13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.4103\/0253-7176.183086","article-title":"Cognitive impairment and rehabilitation strategies after traumatic brain injury","volume":"38","author":"Barman","year":"2016","journal-title":"Indian J. Psychol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.paid.2017.06.004","article-title":"The challenging experience questionnaire: characterization of challenging experiences with psilocybin mushrooms frederick","volume":"117","author":"Barrett","year":"2017","journal-title":"Pers. Individ. Dif."},{"key":"B15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.5152\/eurjrheum.2017.17025","article-title":"The endocannabinoid system in pain and inflammation: its relevance to rheumatic disease","volume":"4","author":"Barrie","year":"2017","journal-title":"Eur. J. Rheumatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e826","DOI":"10.1038\/tp.2016.71","article-title":"Ibogaine and addiction in the animal model, a systematic review and meta-analysis","volume":"6","author":"Belgers","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1101\/2020.07.14.202325","article-title":"A tropane-based ibogaine analog rescues folding-deficient SERT and DAT","volume":"40","author":"Bhat","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/S41575-022-00634-6","article-title":"Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment","volume":"19","author":"Bisgaard","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.3390\/ijms23052514","article-title":"Impact of two neuronal sigma\u20101 receptor modulators, PRE084 and DMT, on neurogenesis and neuroinflammation in an a\u03b21\u201042\u2010injected, wild\u2010type mouse model of AD","volume":"23","author":"Borb\u00e9ly","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/npp.2015.247","article-title":"Intergenerational transmission of stress in humans","volume":"41","author":"Bowers","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00213-006-0639-1","article-title":"Hallucinatory and rewarding effect of salvinorin A in zebrafish: \u03ba-Opioid and CB1-cannabinoid receptor involvement","volume":"190","author":"Braida","year":"2007","journal-title":"Psychopharmacol. Berl."},{"key":"B22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1126\/science.aat4104","article-title":"Cell-autonomous clock of astrocytes drives circadian behavior in mammals","volume":"363","author":"Brancaccio","year":"2019","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1126\/science.1215990","article-title":"Lysergic acid diethylamide: effect on histone acetylation in rabbit brain","volume":"188","author":"Brown","year":"1975","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/00952990.2017.1320802","article-title":"Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes","volume":"44","author":"Brown","year":"2018","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41531-019-0104-6","article-title":"Potential of animal models for advancing the understanding and treatment of pain in Parkinson\u2019s disease","volume":"6","author":"Buhidma","year":"2020","journal-title":"npj Park. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.psychres.2017.04.033","article-title":"Transgenerational trauma in a post-conflict setting: Effects on offspring PTSS\/PTSD and offspring vulnerability in Cambodian families","volume":"254","author":"Burchert","year":"2017","journal-title":"Psychiatry Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41586-020-3008-z","article-title":"A non-hallucinogenic psychedelic analogue with therapeutic potential","volume":"589","author":"Cameron","year":"2021","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B31","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00213-017-4701-y","article-title":"Psychedelics and connectedness","volume":"235","author":"Carhart-Harris","year":"2018","journal-title":"Psychopharmacol. Berl."},{"key":"B32","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/pr.118.017160","article-title":"REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics","volume":"71","author":"Carhart-Harris","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fnhum.2014.00020","article-title":"The entropic brain: A theory of conscious states informed by neuroimaging research with psychedelic drugs","volume":"8","author":"Carhart-Harris","year":"","journal-title":"Front. Hum. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1017\/S1461145713001405","article-title":"The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories","volume":"17","author":"Carhart-Harris","year":"","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00213-017-4771-x","article-title":"Psilocybin with psychological support for treatment-resistant depression: six-month follow-up","volume":"235","author":"Carhart-Harris1","year":"2018","journal-title":"Psychopharmacol. Berl."},{"key":"B36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.nrl.2011.07.003","article-title":"Hallucinogenic drugs in pre-Columbian Mesoamerican cultures","volume":"30","author":"Carod-Artal","year":"2015","journal-title":"Neurol"},{"key":"B37","first-page":"9","article-title":"Salvinorin A decreases mortality and improves neurological outcome in a neonatal mouse hypoxia model","volume":"1","author":"Chen","year":"2014","journal-title":"Transl. Perioper. Pain"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/s0963180123000270","article-title":"Psychedelics, meaningfulness, and the \u201cproper scope\u201d of medicine: continuing the conversation","volume":"23","author":"Cheung","year":"2023","journal-title":"Camb. Q. Healthc. Ethics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.bbrc.2017.05.157","article-title":"Ketamine induces brain-derived neurotrophic factor expression via phosphorylation of histone deacetylase 5 in rats","volume":"489","author":"Choi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"15755","DOI":"10.1073\/pnas.1513913112","article-title":"Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats","volume":"112","author":"Choi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/WNP.0000000000000275","article-title":"Spreading depolarizations: A therapeutic target against delayed cerebral ischemia after subarachnoid hemorrhage","volume":"33","author":"Chung","year":"2016","journal-title":"J. Clin. Neurophysiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cobme.2020.07.004","article-title":"Engineered microtissue as an anatomically inspired model of Parkinson\u2019s disease","volume":"14","author":"Clark","year":"2020","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"B43","doi-asserted-by":"publisher","first-page":"698","DOI":"10.2139\/ssrn.3155698","article-title":"Three-dimensional human axon tracts derived from cerebral organoids","volume":"18","author":"Cullen","year":"2018","journal-title":"SSRN"},{"key":"B44","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-1-4939-3816-2_17","article-title":"A porcine model of traumatic brain injury via head rotational acceleration","volume":"1462","author":"Cullen","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1089\/neu.2006.23.1304","article-title":"Neuronal response to high rate shear deformation depends on heterogeneity of the local strain field","volume":"23","author":"Cullen","year":"2006","journal-title":"J. Neurotrauma"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1002\/jnr.21434","article-title":"In vitro neural injury model for optimization of tissue-engineered constructs","volume":"3253","author":"Cullen","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"110 1","DOI":"10.1016\/j.jad.2008.02.012","article-title":"Safety and efficacy of Vagus Nerve Stimulation in treatment-resistant depression. A systematic review","volume":"110","author":"Daban","year":"2008","journal-title":"J. Affect. Disord."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e2727","DOI":"10.7717\/peerj.2727","article-title":"Harmine stimulates proliferation of human neural progenitors","volume":"4","author":"Dakic","year":"2016","journal-title":"PeerJ"},{"key":"B49","doi-asserted-by":"publisher","first-page":"12863","DOI":"10.1038\/s41598-017-12779-5","article-title":"Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT","volume":"7","author":"Dakic","year":"2017","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.drugalcdep.2013.12.019","article-title":"Therapeutic infusions of ketamine: do the psychoactive effects matter?","volume":"136","author":"Dakwar","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"B51","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1007\/s00213-018-5010-9","article-title":"Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study","volume":"235","author":"Danforth","year":"2018","journal-title":"Psychopharmacol. Berl."},{"key":"B52","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ecl.2013.05.004","article-title":"Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment","volume":"42","author":"Daskalakis","year":"2013","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2470547020939564","DOI":"10.1177\/2470547020939564","article-title":"Psychedelic treatment for trauma-related psychological and cognitive impairment among US special Operations forces veterans","volume":"4","author":"Davis","year":"2020","journal-title":"Chronic Stress"},{"key":"B54","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jcbs.2019.11.004","article-title":"Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety","volume":"15","author":"Davis","year":"2015","journal-title":"Cancer Cell J. Contextu"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/s41386-022-01301-9","article-title":"Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline","volume":"47","author":"De Gregorio","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e2020705118","DOI":"10.1073\/pnas.2020705118","article-title":"Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission","volume":"118","author":"de Gregorio","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"109836","DOI":"10.1016\/j.celrep.2021.109836","article-title":"Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice","volume":"37","author":"de la Fuente Revenga","year":"2021","journal-title":"Cell Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s13181-013-0295-x","article-title":"2C or not 2C: phenethylamine designer drug review","volume":"9","author":"Dean","year":"2013","journal-title":"J. Med. Toxicol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s10571-015-0244-0","article-title":"Sigma-1 receptor modulates neuroinflammation after traumatic brain injury","volume":"36","author":"Dong","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"109714","DOI":"10.1016\/j.celrep.2021.109714","article-title":"LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions","volume":"36","author":"Domenico","year":"2021","journal-title":"Cell Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.euroneuro.2020.11.013","article-title":"Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig","volume":"42","author":"Donovan","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"492842","DOI":"10.1101\/2022.05.20.492842","article-title":"Unique effects of sedatives, dissociatives, psychedelics, stimulants, and cannabinoids on episodic memory: A review and reanalysis of acute drug effects on recollection","author":"Doss","year":"2022","journal-title":"Fam. Metamemory"},{"key":"B63","doi-asserted-by":"publisher","first-page":"157","DOI":"10.31887\/DCNS.2004.6.2\/rduman","article-title":"Neural plasticity: Consequences of stress and actions of antidepressant treatment","volume":"6","author":"Duman","year":"2004","journal-title":"Dialogues Clin. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/shm\/hkl039","article-title":"\u201cHitting highs at rock bottom\u201d: LSD treatment for alcoholism, 1950-1970","volume":"19","author":"Dyck","year":"2006","journal-title":"Soc. Hist. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/00152192-199211000-00013","article-title":"Bowel disease","volume":"19","author":"Ehrmann","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/acps.12904","article-title":"Effects of psilocybin therapy on personality structure","volume":"138","author":"Erritzoe","year":"2018","journal-title":"Acta Psychiatr. Scand."},{"key":"B67","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00213-019-05417-7","article-title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers","volume":"237","author":"Family","year":"2020","journal-title":"Psychopharmacol. Berl."},{"key":"B68","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neuroscience.2018.05.050","article-title":"At the origin of the history of glia","volume":"385","author":"Fan","year":"2018","journal-title":"Neuroscience"},{"key":"B69","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3389\/fpsyt.2019.00650","article-title":"Breakthrough for trauma treatment: Safety and efficacy of MDMA-assisted psychotherapy compared to paroxetine and sertraline","volume":"10","author":"Feduccia","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"108741","DOI":"10.1016\/j.jneumeth.2020.108741","article-title":"From cell lines to pluripotent stem cells for modelling Parkinson\u2019s Disease","volume":"340","author":"Ferrari","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/ibd.21873","article-title":"Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors","volume":"18","author":"Fichna","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/j.1365-2982.2009.01369.x","article-title":"Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating \u03ba-opioid and cannabinoid receptors","volume":"21","author":"Fichna","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"B73","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/ptr.6017","article-title":"The effect of Banisteriopsis caapi (B. caapi) on the motor deficits in the MPTP-treated common marmoset model of Parkinson\u2019s disease","volume":"32","author":"Fisher","year":"2017","journal-title":"Phyther. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1021\/acsptsci.0c00063","article-title":"Structure-activity relationship analysis of psychedelics in a rat model of asthma reveals the anti-inflammatory pharmacophore","volume":"4","author":"Flanagan","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/7854_2022_367","article-title":"Psychedelics and anti-inflammatory activity in animal models","volume":"56","author":"Flanagan","year":"2022","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/09540261.2018.1481827","article-title":"Psychedelics as anti-inflammatory agents","volume":"30","author":"Flanagan","year":"2018","journal-title":"Int. Rev. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fphar.2016.00035","article-title":"The therapeutic potentials of ayahuasca: possible effects against various diseases of civilization","volume":"7","author":"Frecska","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"173954","DOI":"10.1016\/j.ejphar.2021.173954","article-title":"Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (R)-ketamine, but not (S)-ketamine: A role of TrkB signaling","volume":"897","author":"Fujita","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/s41564-019-0540-4","article-title":"Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut","volume":"4","author":"Fung","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1073\/pnas.1012531108","article-title":"Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway","volume":"108","author":"Furrer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B81","doi-asserted-by":"publisher","first-page":"e24566","DOI":"10.1371\/journal.pone.0024566","article-title":"Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus","volume":"6","author":"Gao","year":"2011","journal-title":"PLoS One"},{"key":"B82","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1037\/pha0000084","article-title":"Clinical applications of hallucinogens: A review","volume":"24","author":"Garcia-Romeu","year":"2016","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/NMD.0000000000000113","article-title":"Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases","volume":"202","author":"Gasser","year":"2014","journal-title":"J. Nerv. Ment. Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12866-018-1373-7","article-title":"Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties","volume":"18","author":"Getachew","year":"2018","journal-title":"BMC Microbiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"116726","DOI":"10.1016\/j.neuroimage.2020.116726","article-title":"Updating the dynamic framework of thought: Creativity and psychedelics","volume":"213","author":"Girn","year":"2020","journal-title":"Neuroimage"},{"key":"B86","doi-asserted-by":"publisher","first-page":"8523","DOI":"10.1523\/JNEUROSCI.21-21-08523.2001","article-title":"Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury","volume":"21","author":"Golarai","year":"2001","journal-title":"J. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1056\/NEJMoa2206443","article-title":"Single-dose psilocybin for a treatment-resistant episode of major depression","volume":"387","author":"Goodwin","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"451006","DOI":"10.1101\/2021.07.03.451006","article-title":"Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway","volume":"21","author":"Gordi\u00e1n-V\u00e9lez","year":"2021","journal-title":"bioRxiv"},{"key":"B89","first-page":"3","article-title":"The intersection of the microbiome-gut-brain Axis, PTSD, and ayahuasca in veterans","volume":"30","author":"Gould","year":"2020","journal-title":"MAPS Bulliten Autumn"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1177\/0269881116675513","article-title":"Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial","volume":"30","author":"Griffiths","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"115","DOI":"10.31480\/2330-4871\/098","article-title":"Salvinorin A as a potential medication for stroke","volume":"6","author":"Grothusen","year":"2019","journal-title":"Transl. Perioper. Pain Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12974-023-02730-z","article-title":"Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research","volume":"20","author":"Grovola","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B93","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1744-8069-8-60","article-title":"Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection","volume":"8","author":"Guida","year":"2012","journal-title":"Mol. Pain"},{"key":"B94","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1272\/jnms.82.4","article-title":"Brain plasticity and rehabilitation in stroke patients","volume":"82","author":"Hara","year":"2015","journal-title":"J. Nippon. Med. Sch."},{"key":"B95","doi-asserted-by":"publisher","first-page":"0055","DOI":"10.1038\/s41562-017-0055","article-title":"Viewing addiction as a brain disease promotes social injustice","volume":"1","author":"Hart","year":"2017","journal-title":"Nat. Hum. Behav."},{"key":"B96","volume-title":"The fascinating connection of psychedelic medicine and the gut-brain Axis","author":"Hasty","year":"2022"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1042\/CS20170004","article-title":"Vascular basement membrane alterations and \u03b2-amyloid accumulations in an animal model of cerebral small vessel disease","volume":"131","author":"Held","year":"2017","journal-title":"Clin. Sci. (Lond)."},{"key":"B98","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1021\/acschemneuro.9b00493","article-title":"Psychedelics, but not ketamine, produce persistent antidepressant-like effects in a rodent experimental system for the study of depression","volume":"11","author":"Hibicke","year":"2020","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"B99","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/tgr.0b013e31821e588e","article-title":"Plasticity in early Alzheimer\u2019s disease: an opportunity for intervention","volume":"4","author":"Hill","year":"2011","journal-title":"Bone"},{"key":"B100","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.neubiorev.2019.12.006","article-title":"Neuropharmacological modulation of the aberrant bodily self through psychedelics","volume":"108","author":"Ho","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B101","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/STROKEAHA.115.011932","article-title":"Modeling ischemic stroke in vitro: the status quo and future perspectives","volume":"176","author":"Holloway","year":"2017","journal-title":"Physiol. Behav."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1093\/cercor\/bhu321","article-title":"Prefrontal cortical inactivations decrease willingness to expend cognitive effort on a rodent cost\/benefit decision-making task","volume":"26","author":"Hosking","year":"2016","journal-title":"Cereb. Cortex"},{"key":"B103","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/08923979409029898","article-title":"Immunological consequences of in vitro exposure to lysergic acid diethylamide (LSD)","volume":"16","author":"House","year":"1994","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12929-018-0404-x","article-title":"Impact of social relationships on Alzheimer\u2019s memory impairment: Mechanistic studies","volume":"25","author":"Hsiao","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1021\/acsptsci.0c00099","article-title":"Low doses of LSD acutely increase BDNF blood plasma levels in healthy volunteers","volume":"4","author":"Hutten","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1177\/2040622315579059","article-title":"Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: A perspective review","volume":"6","author":"Iadarola","year":"2015","journal-title":"Ther. Adv. Chronic Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"110594","DOI":"10.1016\/j.pnpbp.2022.110594","article-title":"Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): impact on neurotropic, neurotrophic, and neuroplasticity signaling","volume":"119","author":"Inserra","year":"2022","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"B108","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41551-019-0397-0","article-title":"A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip","volume":"3","author":"Jalili-Firoozinezhad","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"B109","volume-title":"Mescaline: A global history of the first psychedelic","author":"Jay","year":"2019"},{"key":"B110","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/0269881109102787","article-title":"How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale","volume":"23","author":"Johansen","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"686425","DOI":"10.5402\/2012\/686425","article-title":"Mental fatigue and cognitive impairment after an almost neurological recovered stroke","volume":"2012","author":"Johansson","year":"2012","journal-title":"ISRN Psychiatry"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1210\/js.2019-00053","article-title":"Neuroendocrine regulation of brain cytokines after psychological stress","volume":"3","author":"Johnson","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"B113","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/0269881108093587","article-title":"Human hallucinogen research: guidelines for safety","volume":"22","author":"Johnson","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fpsyt.2018.00277","article-title":"Efficacy of ketamine in the treatment of substance use disorders: A systematic review","volume":"9","author":"Jones","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B115","doi-asserted-by":"publisher","first-page":"46427","DOI":"10.1038\/srep46427","article-title":"Early neurovascular dysfunction in a transgenic rat model of Alzheimer\u2019s disease","volume":"7","author":"Joo","year":"2017","journal-title":"Sci. Rep."},{"key":"B116","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1089\/neu.2016.4953","article-title":"Pathophysiological bases of comorbidity: Traumatic brain injury and post-traumatic stress disorder","volume":"35","author":"Kaplan","year":"2018","journal-title":"J. Neurotrauma"},{"key":"B117","doi-asserted-by":"publisher","first-page":"20876","DOI":"10.1074\/jbc.M116.737551","article-title":"Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones","volume":"291","author":"Kasture","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B118","doi-asserted-by":"publisher","first-page":"112743","DOI":"10.1016\/j.jep.2020.112743","article-title":"Neuroprotective potential of ayahuasca and untargeted metabolomics analyses: applicability to Parkinson\u2019s disease","volume":"255","author":"Katchborian-Neto","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/BF00427383","article-title":"LSD and tryptamine effects on sleep\/wakefulness and electrocorticogram patterns in intact cats","volume":"58","author":"Kay","year":"1978","journal-title":"Psychopharmacology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1053\/j.gastro.2021.09.015","article-title":"A Rome Working team report on brain-gut behavior therapies for disorders of gut-brain interaction","volume":"162","author":"Keefer","year":"2022","journal-title":"Gastroenterology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1039\/c2lc40074j","article-title":"Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow","volume":"12","author":"Kim","year":"2012","journal-title":"Lab. Chip"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1039\/c3ib40126j","article-title":"Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation","volume":"5","author":"Kim","year":"2013","journal-title":"Integr. Biol. (United Kingdom)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.1073\/pnas.1522193112","article-title":"Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B124","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/acps.12675","article-title":"Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder","volume":"135","author":"Kim","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"B125","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/npp.2015.249","article-title":"Models of intergenerational and transgenerational transmission of risk for psychopathology in mice","volume":"41","author":"Klengel","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B126","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fimmu.2018.00672","article-title":"The inflammatory continuum of traumatic brain injury and Alzheimer\u2019s disease","volume":"9","author":"Kokiko-Cochran","year":"2018","journal-title":"Front. Immunol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"434103","DOI":"10.1101\/2021.03.07.434103","article-title":"The DMT and psilocin treatment changes CD11b+ activated microglia immunological phenotype","volume":"6","author":"Koz\u0142owska","year":"2021","journal-title":"bioRxiv"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.bbadis.2017.03.007","article-title":"7,8-dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: implications for early brain trauma recovery","volume":"1863","author":"Krishna","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B129","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0740-5472(02)00275-1","article-title":"Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up","volume":"23","author":"Krupitsky","year":"2002","journal-title":"J. Subst. Abuse Treat."},{"key":"B130","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11920-017-0829-z","article-title":"Synaptic loss and the pathophysiology of PTSD: implications for ketamine as a prototype novel therapeutic","volume":"19","author":"Krystal","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nm0704-678","article-title":"Cannabinoids cool the intestine","volume":"23","author":"Kunos","year":"2004","journal-title":"Nat. Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mehy.2019.02.029","article-title":"Psychedelic medicine: the biology underlying the persisting psychedelic effects","volume":"125","author":"Kuypers","year":"2019","journal-title":"Med. Hypotheses"},{"key":"B133","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.tips.2017.08.003","article-title":"Psychedelic drugs in biomedicine","volume":"38","author":"Kyzar","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.jbiomech.2004.05.032","article-title":"High rate shear strain of three-dimensional neural cell cultures: A new in vitro traumatic brain injury model","volume":"38","author":"LaPlaca","year":"2005","journal-title":"J. Biomech."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.neuropharm.2010.12.033","article-title":"Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond","volume":"61","author":"Lee","year":"2011","journal-title":"Neuropharmacology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.3389\/fimmu.2019.01696","article-title":"The role of inflammation in depression and fatigue","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Immunol."},{"key":"B137","volume-title":"Acid dreams: A complete social history of the 1960s","author":"Lee","year":"1992"},{"key":"B138","doi-asserted-by":"publisher","first-page":"959590","DOI":"10.3389\/fpsyt.2023.959590","article-title":"Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD","volume":"14","author":"Lewis","year":"","journal-title":"Front. Psychiatry"},{"key":"B139","doi-asserted-by":"publisher","first-page":"112203","DOI":"10.1016\/j.celrep.2023.112203","article-title":"A non-hallucinogenic LSD analog with therapeutic potential for mood disorders","volume":"42","author":"Lewis","year":"","journal-title":"Cell Rep."},{"key":"B140","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3389\/fphar.2018.00346","article-title":"Analogous \u03b2-carboline alkaloids harmaline and harmine ameliorate scopolamine-induced cognition dysfunction by attenuating acetylcholinesterase activity, oxidative stress, and inflammation in mice","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.bbrc.2017.05.126","article-title":"Harmine is an inflammatory inhibitor through the suppression of NF-\u03baB signaling","volume":"489","author":"Liu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B142","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1016\/j.celrep.2018.05.022","article-title":"Psychedelics promote structural and functional neural plasticity","volume":"23","author":"Ly","year":"2018","journal-title":"Cell Rep."},{"key":"B143","doi-asserted-by":"publisher","first-page":"WE01","DOI":"10.7860\/JCDR\/2014\/10077.4828","article-title":"Relationship between loneliness, psychiatric disorders and physical health? A review on the psychological aspects of loneliness","volume":"8","author":"Mushtaq","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"B144","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1526-4610.2012.02241.x","article-title":"Migraine: maladaptive brain responses to stress","volume":"52","author":"Maleki","year":"2012","journal-title":"Headache J. Head. Face Pain"},{"key":"B145","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41586-022-04492-9","article-title":"Reproducible brain-wide association studies require thousands of individuals","volume":"603","author":"Marek","year":"2022","journal-title":"Nature"},{"key":"B146","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ebiom.2016.08.049","article-title":"Psychedelics recruit multiple cellular types and produce complex transcriptional responses within the brain","volume":"11","author":"Martin","year":"2016","journal-title":"EBioMedicine"},{"key":"B147","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fphar.2019.00193","article-title":"Ibogaine administration modifies GDNF and BDNF expression in brain regions involved in mesocorticolimbic and nigral dopaminergic circuits","volume":"10","author":"Marton","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/02791072.2019.1580804","article-title":"Sub-acute effects of psilocybin on empathy, creative thinking, and subjective well-being","volume":"51","author":"Mason","year":"2019","journal-title":"J. Psychoact. Drugs"},{"key":"B149","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3389\/fnins.2019.00384","article-title":"The interplay between stress, inflammation, and emotional attention: relevance for depression","volume":"13","author":"Maydych","year":"2019","journal-title":"Front. Neurosci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"19250","DOI":"10.1074\/jbc.M117.797092","article-title":"Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile\/juvenile parkinsonism","volume":"292","author":"Mazhar Asjad","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B152","doi-asserted-by":"publisher","first-page":"104689","DOI":"10.1016\/j.neubiorev.2022.104689","article-title":"Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses","volume":"138","author":"McCulloch","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/j.1471-4159.2008.05745.x","article-title":"Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways","volume":"107","author":"Mclennan","year":"2008","journal-title":"Animals"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41598-017-01284-4","article-title":"Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain","volume":"7","author":"Menyh\u00e1rt","year":"2017","journal-title":"Sci. Rep."},{"key":"B155","doi-asserted-by":"publisher","first-page":"105495","DOI":"10.1016\/j.bandc.2019.105495","article-title":"Embodying addiction: A predictive processing account","volume":"138","author":"Miller","year":"2020","journal-title":"Brain Cogn."},{"key":"B156","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s12276-020-0386-0","article-title":"Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches","volume":"52","author":"Min","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41591-021-01336-3","article-title":"MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study","volume":"27","author":"Mitchell","year":"2021","journal-title":"Nat. Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1007\/s00213-019-05249-5","article-title":"MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials","volume":"236","author":"Mithoefer","year":"2019","journal-title":"Psychopharmacol. Berl."},{"key":"B159","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/0269881112456611","article-title":"Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4- methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study","volume":"27","author":"Mithoefer","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4103\/0973-7847.120524","article-title":"Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids","volume":"7","author":"Moloudizargari","year":"2013","journal-title":"Pharmacogn. Rev."},{"key":"B161","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota\u2013brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41398-020-01011-0","article-title":"N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo","volume":"10","author":"Morales-Garcia","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"B163","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/s0014-2999(00)00749-4","article-title":"(+\/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') increases social interaction in rats","volume":"408","author":"Morley","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"106566","DOI":"10.1590\/1414-431X202010656","article-title":"Modeling of post-traumatic epilepsy and experimental research aimed at its prevention","volume":"54","author":"Mosini","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.nicl.2018.03.005","article-title":"Altered network hub connectivity after acute LSD administration","volume":"18","author":"M\u00fcller","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B166","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/schbul\/sby024","article-title":"Inflammation in schizophrenia: Pathogenetic aspects and therapeutic considerations","volume":"44","author":"M\u00fcller","year":"2018","journal-title":"Schizophr. Bull."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2","DOI":"10.33015\/dominican.edu\/2013.hum.02","article-title":"Demeter\u2019s daughters: how the myth of the captured bride helped spur feminine consciousness in ancient Greece","volume":"64","author":"Naples","year":"2013","journal-title":"Grad. Master\u2019s Theses, Capst. Culminating Proj."},{"key":"B168","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41586-019-1075-9","article-title":"Oxytocin-dependent reopening of a social reward learning critical period with MDMA","volume":"569","author":"Nardou","year":"2019","journal-title":"Nature"},{"key":"B169","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-023-06204-3","article-title":"Psychedelics reopen the social reward learning critical period","volume":"618","author":"Nardou","year":"2023","journal-title":"Nature"},{"key":"B170","doi-asserted-by":"publisher","first-page":"L191","DOI":"10.1152\/ajplung.00138.2013","article-title":"Serotonin 5-HT\u2082 receptor activation prevents allergic asthma in a mouse model","volume":"308","author":"Nau","year":"2015","journal-title":"Am. J. Physiol. - Lung Cell. Mol. Physiol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"e75426","DOI":"10.1371\/journal.pone.0075426","article-title":"Serotonin 5-HT2A receptor activation blocks TNF-\u03b1 mediated inflammation in vivo","volume":"8","author":"Nau","year":"2013","journal-title":"PLoS One"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1021\/cn400090q","article-title":"Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds","volume":"4","author":"Neelkantan","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"109232","DOI":"10.1016\/j.neuropharm.2022.109232","article-title":"Psychedelics as potent anti-inflammatory therapeutics","volume":"219","author":"Nichols","year":"2022","journal-title":"Neuropharmacology"},{"key":"B174","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/S0893-133X(01)00405-5","article-title":"A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain","volume":"26","author":"Nichols","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"B175","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/biom8030093","article-title":"The biology of glial cells and their complex roles in Alzheimer\u2019s disease: new opportunities in therapy","volume":"8","author":"Nirzhor","year":"2018","journal-title":"Biomolecules"},{"key":"B176","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1177\/0269881118780612","article-title":"Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts","volume":"32","author":"Noorani","year":"2018","journal-title":"J. Psychopharmacol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3389\/fnhum.2013.00887","article-title":"Recovery after brain injury: Mechanisms and principles","volume":"7","author":"Nudo","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1179069518800508","DOI":"10.1177\/1179069518800508","article-title":"Psychoplastogens: A promising class of plasticity-promoting neurotherapeutics","volume":"12","author":"Olson","year":"2018","journal-title":"J. Exp. Neurosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1021\/acsptsci.0c00192","article-title":"The subjective effects of psychedelics may not Be necessary for their enduring therapeutic effects","volume":"4","author":"Olson","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"114148","DOI":"10.1016\/j.expneurol.2022.114148","article-title":"Nootropic effects of LSD: behavioral, molecular and computational evidence","volume":"356","author":"Ornelas","year":"2022","journal-title":"Exp. Neurol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"B182","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1017\/S0033291718001356","article-title":"Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: A randomized placebo-controlled trial","volume":"49","author":"Palhano-Fontes","year":"2019","journal-title":"Psychol. Med."},{"key":"B183","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13148-018-0569-x","article-title":"DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder","volume":"10","author":"Pape","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"B184","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41593-018-0175-4","article-title":"A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer\u2019s disease","volume":"21","author":"Park","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1755-5949.2008.00059.x","article-title":"The pharmacology of lysergic acid diethylamide: A review","volume":"14","author":"Passie","year":"2008","journal-title":"CNS Neurosci. Ther."},{"key":"B186","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3389\/fneur.2016.00176","article-title":"Exposure to a predator scent induces chronic behavioral changes in rats previously exposed to low-level blast: implications for the relationship of blast-related TBI to PTSD","volume":"7","author":"Perez-Garcia","year":"2016","journal-title":"Front. Neurol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.neuropharm.2018.09.023","article-title":"Blast-induced \u201cPTSD\u201d: evidence from an animal model","volume":"145","author":"Perez-Garcia","year":"2019","journal-title":"Neuropharmacology"},{"key":"B188","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1097\/ALN.0000000000002197","article-title":"Ketamine alters hippocampal cell proliferation and improves learning in mice after traumatic brain injury","volume":"129","author":"Peters","year":"2018","journal-title":"Anesthesiology"},{"key":"B189","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1176\/appi.neuropsych.18040093","article-title":"Epidemiology and natural history of psychiatric disorders after TBI","volume":"30","author":"Ponsford","year":"2018","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B190","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cub.2016.12.030","article-title":"The fabric of meaning and subjective effects in LSD-induced states depend on serotonin 2A receptor activation","volume":"27","author":"Preller","year":"2017","journal-title":"Curr. Biol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3389\/fpsyt.2019.00881","article-title":"Modulation of social cognition via hallucinogens and \u201centactogens\u201d","volume":"10","author":"Preller","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B192","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1007\/s00213-018-5049-7","article-title":"Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting","volume":"235","author":"Prochazkova","year":"2018","journal-title":"Psychopharmacol. Berl."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psc.2013.11.004","article-title":"Cognitive sequelae of traumatic brain injury","volume":"37","author":"Rabinowitz","year":"2014","journal-title":"Psychiatric Clin. N. Am."},{"key":"B194","doi-asserted-by":"publisher","first-page":"146","DOI":"10.4103\/2394-8108.172892","article-title":"Control of the brain microcirculation following traumatic brain injury and stroke","volume":"1","author":"Rafols","year":"2015","journal-title":"Brain Circ."},{"key":"B195","volume-title":"Nova Mentis launches autism microbiome study in the United States","author":"Rascan","year":"2021"},{"key":"B196","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1038\/s41598-020-59252-4","article-title":"Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse","volume":"10","author":"Ratliff","year":"2020","journal-title":"Sci. Rep."},{"key":"B197","first-page":"237","article-title":"Transcultural perspective on consciousness: traditional use of ayahuasca in psychotherapy in the 21st century in western world","volume":"12","author":"Re","year":"2016","journal-title":"Cosm. Hist."},{"key":"B198","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1038\/s41598-019-40803-3","article-title":"The influence of the host microbiome o n 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa","volume":"9","author":"Ridge","year":"2019","journal-title":"Sci. Rep."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.mehy.2013.09.021","article-title":"Astrocyte domains and the three-dimensional and seamless expression of consciousness and explicit memories","volume":"81","author":"Robertson","year":"2013","journal-title":"Med. Hypotheses"},{"key":"B200","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.euroneuro.2011.08.002","article-title":"Evaluation of sigma (\u03c3) receptors in the antidepressant-like effects of ketamine in vitro and in vivo","volume":"22","author":"Robson","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1021\/acschemneuro.0c00152","article-title":"A single administration of the atypical psychedelic ibogaine or its metabolite noribogaine induces an antidepressant-like effect in rats","volume":"11","author":"Rodr\u00edguez","year":"2020","journal-title":"ChemRxiv"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1177\/0269881119855974","article-title":"Emotional breakthrough and psychedelics: validation of the emotional breakthrough inventory","volume":"33","author":"Roseman","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3389\/fphar.2017.00974","article-title":"Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression","volume":"8","author":"Roseman","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1177\/0269881116675512","article-title":"Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial","volume":"30","author":"Ross","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"1","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"B206","doi-asserted-by":"publisher","first-page":"384875","DOI":"10.1155\/2012\/384875","article-title":"Use of physical and intellectual activities and socialization in the management of cognitive decline of aging and in dementia: A review","volume":"2012","author":"Ruthirakuhan","year":"2012","journal-title":"J. Aging Res."},{"key":"B207","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/0041-008x(66)90128-1","article-title":"Endocrine and metabolic effects of lysergic acid diethylamide on female rats","volume":"9","author":"Sackler","year":"1966","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1124\/jpet.114.214239","article-title":"Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome","volume":"350","author":"Sa\u0142aga","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B209","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jep.2009.10.030","article-title":"Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson\u2019s disease","volume":"127","author":"Samoylenko","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/npp.2016.224","article-title":"Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and history of inadequate response to antidepressants: A randomized, placebo-controlled study","volume":"42","author":"Sanacora","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"B211","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","article-title":"Unexpected roles for the second brain: enteric nervous system as master regulator of bowel function","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"0061899","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B213","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3389\/fpsyt.2019.00138","article-title":"A review of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy","volume":"10","author":"Sessa","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B214","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2021.680301","article-title":"Astrocyte-neuron signaling in synaptogenesis","volume":"9","author":"Shan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0024-3205(71)90066-x","article-title":"Stimulation of [14 C] serotonin synthesis from [14 C] tryptophan by mescaline in rat pineal organ cultures","volume":"10","author":"Shein","year":"1971","journal-title":"Life Sci."},{"key":"B216","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1017\/S0033291715001555","article-title":"Early life trauma, depression and the glucocorticoid receptor gene-an epigenetic perspective","volume":"45","author":"Smart","year":"2015","journal-title":"Psychol. Med."},{"key":"B217","first-page":"133","article-title":"Sigma receptors: their role in disease and as therapeutic targets","volume-title":"Advances in experimental medicine and biology","author":"Smith","year":"2017"},{"key":"B218","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3390\/molecules25051204","article-title":"Salvinorin a does not affect seizure threshold in mice","volume":"25","author":"Soca\u0142a","year":"2020","journal-title":"Molecules"},{"key":"B219","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2147\/JIR.S155903","article-title":"Systemic low-grade inflammation in post-traumatic stress disorder: A systematic review","volume":"11","author":"Speer","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"B220","first-page":"266","article-title":"Serotonergic modulation of rat pineal gland activity: in vivo evidence for a 5-hydroxytryptamine(2c) receptor involvement","volume":"295","author":"Steardo","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnint.2014.00020","article-title":"The claustrum\u2019s proposed role in consciousness is supported by the effect and target localization of Salvia divinorum","volume":"8","author":"Stiefel","year":"2014","journal-title":"Front. Integr. Neurosci."},{"key":"B222","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/0006-3223(95)00200-6","article-title":"Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-Dimethyltryptamine in humans","volume":"39","author":"Strassman","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1002\/term.2698","article-title":"Tissue engineered nigrostriatal pathway for treatment of Parkinson\u2019s disease","volume":"12","author":"Struzyna","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B224","doi-asserted-by":"publisher","first-page":"13985","DOI":"10.3390\/ijms232213985","article-title":"Axonal tract reconstruction using a tissue-engineered nigrostriatal pathway in a rat model of Parkinson\u2019s disease","volume":"23","author":"Struzyna","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B225","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/ALN.0b013e318204e029","article-title":"Salvinorin a produces cerebrovasodilation through activation of nitric oxide synthase, \u03ba receptor, and adenosine triphosphate-sensitive potassium channel","volume":"114","author":"Su","year":"2011","journal-title":"Anesthesiology"},{"key":"B226","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1213\/ANE.0b013e31823a5d36","article-title":"Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic\/ischemic injury via extracellular signal-regulated kinase\/mitogen-activated protein kinase in piglets","volume":"114","author":"Su","year":"2012","journal-title":"Anesth. Analg."},{"key":"B227","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4103\/1673-5374.177710","article-title":"Neurotrophic factor therapy for Parkinson\u2019s disease: past, present and future","volume":"11","author":"Sullivan","year":"2016","journal-title":"Neural Regen. Res."},{"key":"B228","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fphar.2018.00172","article-title":"Unifying theories of psychedelic drug effects","volume":"9","author":"Swanson","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"1065333","DOI":"10.1371\/journal.pone.0106533","article-title":"Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells","volume":"9","author":"Szabo","year":"2014","journal-title":"PLoS One"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2016.00423","article-title":"The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells","volume":"10","author":"Szabo","year":"2016","journal-title":"Front. Neurosci."},{"key":"B231","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3389\/fimmu.2015.00358","article-title":"Psychedelics and immunomodulation: novel approaches and therapeutic opportunities","volume":"6","author":"Szabo","year":"2015","journal-title":"Front. Immunol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"108612","DOI":"10.1016\/j.neuropharm.2021.108612","article-title":"N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain","volume":"192","author":"Szab\u00f3","year":"2021","journal-title":"Neuropharmacology"},{"key":"B233","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.imlet.2020.10.001","article-title":"Psychedelics as a novel approach to treating autoimmune conditions","volume":"228","author":"Thompson","year":"2020","journal-title":"Immunol. Lett."},{"key":"B234","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1526-4610.2009.01557.x","article-title":"Childhood maltreatment and migraine (part II). Emotional abuse as a risk factor for headache chronification","volume":"50","author":"Tietjen","year":"2010","journal-title":"Headache"},{"key":"B235","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/molecules24050918","article-title":"Cannabinoid signaling in the skin: therapeutic potential of the \u2018c(ut)annabinoid\u2019 system","volume":"24","author":"T\u00f3th","year":"2019","journal-title":"Molecules"},{"key":"B236","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1523\/JNEUROSCI.21-10-03572.2001","article-title":"5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells","volume":"21","author":"Van De Kar","year":"2001","journal-title":"J. Neurosci."},{"key":"B237","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1126\/science.adf0435","article-title":"Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors","volume":"379","author":"Vargas","year":"2023","journal-title":"Science"},{"key":"B238","doi-asserted-by":"publisher","first-page":"727117","DOI":"10.3389\/fpsyt.2021.727117","article-title":"Psychedelics and other psychoplastogens for treating mental illness","volume":"12","author":"Vargas","year":"2021","journal-title":"Front. Psychiatry"},{"key":"B239","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1038\/s41598-021-90343-y","article-title":"Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis","volume":"11","author":"Vizeli","year":"2021","journal-title":"Sci. Rep."},{"key":"B240","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.cell.2016.12.033","article-title":"Crystal structure of an LSD-bound human serotonin receptor","volume":"168","author":"Wacker","year":"2017","journal-title":"Cell"},{"key":"B241","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jep.2010.02.013","article-title":"Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson\u2019s disease","volume":"128","author":"Wang","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B242","doi-asserted-by":"publisher","first-page":"e41724","DOI":"10.1371\/journal.pone.0041724","article-title":"Salvinorin a administration after global cerebral hypoxia\/ischemia preserves cerebrovascular autoregulation via Kappa opioid receptor in piglets","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"B243","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.euroneuro.2022.01.114","article-title":"LSD, afterglow and hangover: increased episodic memory and verbal fluency, decreased cognitive flexibility","volume":"58","author":"Wie\u00dfner","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B244","doi-asserted-by":"publisher","first-page":"fcab268","DOI":"10.1093\/braincomms\/fcab268","article-title":"Relationships between injury kinematics, neurological recovery, and pathology following concussion","volume":"3","author":"Wofford","year":"2021","journal-title":"Brain Commun."},{"key":"B245","doi-asserted-by":"publisher","first-page":"271678X20938137","DOI":"10.1177\/0271678X20938137","article-title":"Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot","volume":"20","author":"Wu","year":"2020","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B246","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jad.2012.12.025","article-title":"Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression","volume":"148","author":"Wu","year":"2013","journal-title":"J. Affect. Disord."},{"key":"B247","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/1673-5374.198964","article-title":"Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury","volume":"12","author":"Wurzelmann","year":"2017","journal-title":"Neural Regen. Res."},{"key":"B248","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jmgm.2016.08.001","article-title":"Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification\u2014salvinorin A as a case study","volume":"70","author":"Xu","year":"2016","journal-title":"J. Mol. Graph. Model."},{"key":"B249","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1021\/acsptsci.0c00194","article-title":"The subjective effects of psychedelics are necessary for their enduring therapeutic effects","volume":"4","author":"Yaden","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"B250","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780190665678.001.0001","volume-title":"The varieties of spiritual experience: 21st century research and perspectives","author":"Yaden","year":"2022"},{"key":"B251","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fpsyt.2013.00118","article-title":"Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD","volume":"4","author":"Yehuda","year":"2013","journal-title":"Front. Psychiatry"},{"key":"B252","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/jpet.108.143461","article-title":"Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency","volume":"327","author":"Yu","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B253","doi-asserted-by":"publisher","first-page":"e00993","DOI":"10.1002\/brb3.993","article-title":"Nest-building activity as a reproducible and long-term stroke deficit test in a mouse model of stroke","volume":"8","author":"Yuan","year":"2018","journal-title":"Brain Behav."},{"key":"B254","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fnint.2018.00054","article-title":"The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines","volume":"12","author":"Zamberlan","year":"2018","journal-title":"Front. Integr. Neurosci."},{"key":"B255","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"B256","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13140\/RG.2.2.13846.98881","article-title":"Potential non-covalent SARS-CoV-2 3C-like protease inhibitors designed using generative deep learning approaches and reviewed by human medicinal chemist in virtual reality","volume":"20","author":"Zhavoronkov","year":"2020","journal-title":"ChemRxiv"},{"key":"B257","doi-asserted-by":"publisher","first-page":"7985","DOI":"10.3892\/mmr.2015.4437","article-title":"Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury","volume":"12","author":"Zhong","year":"2015","journal-title":"Mol. Med. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1240295\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:50:26Z","timestamp":1696593026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1240295\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":257,"alternative-id":["10.3389\/fphar.2023.1240295"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1240295","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"article-number":"1240295"}}