{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:27:19Z","timestamp":1767907639007,"version":"3.49.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Ethnopharmacological relevance:<\/jats:bold> In the past, Ethiopian traditional medicine employed the leaves of the native <jats:italic>Commelina latifolia<\/jats:italic> Hochst. ex C.B. Clarke plant to treat wounds, pain, and malaria.<\/jats:p><jats:p><jats:bold>Aim of the study:<\/jats:bold> The crude extract and solvent fractions of <jats:italic>C. latifolia<\/jats:italic> Hochst. ex C.B. Clarke leaves were examined in the present investigation to determine their ability to have an antiinflammatory effect and provide an antinociceptive effect in animal models.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold> The leaves of <jats:italic>C. latifolia<\/jats:italic> were extracted with 80% methanol, and the CL crude extract was further fractionated with chloroform, pure methanol, and distilled water. The carrageenan-induced paw edema model was used to test the extracts\u2019 ability to reduce inflammation. The hotplate model and the acetic acid-induced writhing test on rodents were used to test the extracts\u2019 potential antinociceptive effect to reduce pain.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Inflammation was decreased by 64.59% with CL crude extract (400\u00a0mg\/kg); 56.34% (400\u00a0mg\/kg) of methanol fraction, 64.59% of aqueous fraction (400\u00a0mg\/kg), and 38.27% of chloroform fraction in the carrageenan-induced inflammatory model. All extracts demonstrated a considerable lengthening of the nociception reaction time in the hot plate test, with a maximum antinociceptive effect of 78.98% (crude extract) and 71.65% (solvent fractions). At a dosage of 400\u00a0mg\/kg, the natural <jats:italic>C. latifolia<\/jats:italic> crude extract and aqueous fraction demonstrated considerable antinociceptive effects against acetylsalicylic acid (ASA) during the writhing test (48.83% and 45.37than%, respectively). The current findings support Ethiopia\u2019s traditional user\u2019s assertions that the herb can alleviate inflammation and pain.<\/jats:p>","DOI":"10.3389\/fphar.2023.1284087","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T14:15:25Z","timestamp":1701958525000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model"],"prefix":"10.3389","volume":"14","author":[{"given":"Getnet","family":"Tadege","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betelhem","family":"Sirak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehnnet","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejen","family":"Nureye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.5897\/jpp2018.0532","article-title":"Ethnobotanical survey of plants traditionally used for malaria prevention and treatment in indigenous villages of Tepi Town South West Ethiopia","volume":"11","author":"Abebe","year":"2019","journal-title":"J. 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