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A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment.<\/jats:p>","DOI":"10.3389\/fphar.2023.1287505","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:39:03Z","timestamp":1699871943000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer"],"prefix":"10.3389","volume":"14","author":[{"given":"Sandra","family":"Cotino-N\u00e1jera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Dom\u00ednguez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"D\u00edaz-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.oraloncology.2012.06.006","article-title":"Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma","volume":"48","author":"Adachi","year":"2012","journal-title":"Oral Oncol."},{"key":"B2","first-page":"2884","article-title":"Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas","volume":"5","author":"Akimoto","year":"1999","journal-title":"Clin. 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