{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:11:35Z","timestamp":1793146295376,"version":"4.5.0"},"reference-count":148,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Abstract Background:<\/jats:bold> Diabetic cardiomyopathy (DCM) is one of the serious microvascular complications of diabetes mellitus. It is often associated with clinical manifestations such as arrhythmias and heart failure, and significantly reduces the quality of life and years of survival of patients. Endoplasmic reticulum stress (ERS) is the removal of unfolded and misfolded proteins and is an important mechanism for the maintenance of cellular homeostasis. ERS plays an important role in the pathogenesis of DCM by causing cardiomyocyte apoptosis, insulin resistance, calcium imbalance, myocardial hypertrophy and fibrosis. Targeting ERS is a new direction in the treatment of DCM. A large number of studies have shown that Chinese herbal medicine and active ingredients can significantly improve the clinical outcome of DCM patients through intervention in ERS and effects on myocardial structure and function, which has become one of the hot research directions.<\/jats:p><jats:p><jats:bold>Purpose:<\/jats:bold> The aim of this review is to elucidate and summarize the roles and mechanisms of Chinese herbal medicine and active ingredients that have the potential to modulate endoplasmic reticulum stress, thereby contributing to better management of DCM.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Databases such as PubMed, Web of Science, China National Knowledge Internet, and Wanfang Data Knowledge Service Platform were used to search, analyze, and collect literature, in order to review the mechanisms by which phytochemicals inhibit the progression of DCM by targeting the ERS and its key signaling pathways. Keywords used included \u201cdiabetic cardiomyopathy\u201d and \u201cendoplasmic reticulum stress.\u201d<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> This review found that Chinese herbs and their active ingredients can regulate ERS through IRE1, ATF6, and PERK pathways to reduce cardiomyocyte apoptosis, ameliorate myocardial fibrosis, and attenuate myocardial hypertrophy for the treatment of DCM.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> A comprehensive source of information on potential ERS inhibitors is provided in this review. The analysis of the literature suggests that Chinese herbal medicine and its active ingredients can be used as potential drug candidates for the treatment of DCM. In short, we cannot ignore the role of traditional Chinese medicine in regulating ERS and treating DCM, and look forward to more research and new drugs to come.<\/jats:p>","DOI":"10.3389\/fphar.2023.1290023","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:54:15Z","timestamp":1699350855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress"],"prefix":"10.3389","volume":"14","author":[{"given":"Lianjun","family":"Ao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1166653","DOI":"10.3389\/fphar.2023.1166653","article-title":"Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1","volume":"14","author":"Abo-Saif","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"111410","DOI":"10.1016\/j.biopha.2021.111410","article-title":"Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats","volume":"138","author":"Abukhalil","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/pharmaceutics15051562","article-title":"Ginkgo biloba and long COVID: in vivo and in vitro models for the evaluation of nanotherapeutic efficacy","volume":"15","author":"Akanchise","year":"2023","journal-title":"Pharmaceutics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.jacc.2005.09.050","article-title":"The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy","volume":"47","author":"Asbun","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"113411","DOI":"10.1016\/j.biopha.2022.113411","article-title":"Interval training and Crataegus persica ameliorate diabetic nephropathy via miR-126\/Nrf-2 mediated inhibition of stress oxidative in rats with diabetes after myocardial ischemia-reperfusion injury","volume":"153","author":"Asgari","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.niox.2014.12.013","article-title":"Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress","volume":"46","author":"Barr","year":"2015","journal-title":"Nitric Oxide"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3390\/ijms23031288","article-title":"LCZ696 protects against diabetic cardiomyopathy-induced myocardial inflammation, ER stress, and apoptosis through inhibiting AGEs\/NF-\u03baB and PERK\/CHOP signaling pathways","volume":"23","author":"Belali","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"111404","DOI":"10.1016\/j.biopha.2021.111404","article-title":"A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment","volume":"137","author":"Bi","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3724\/SP.J.1009.2016.00017","article-title":"Phytochemistry, pharmacology, and clinical trials of Morus alba","volume":"14","author":"Chan","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fphar.2020.00042","article-title":"Distinct types of cell death and the implication in diabetic cardiomyopathy","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"453","DOI":"10.11847\/zgggws2015-31-04-21","article-title":"Effect of mangiferin on myocardial apoptosis in diabetic rats","volume":"31","author":"Chen","year":"2015","journal-title":"Chin. J. Public Health"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1002\/jcp.27038","article-title":"Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats","volume":"234","author":"Chengji","year":"2019","journal-title":"J. Cell Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bcp.2016.07.013","article-title":"Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK\/PPAR\u03b4 signaling pathway","volume":"116","author":"Choy","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1066244","DOI":"10.3389\/fphar.2022.1066244","article-title":"Fuzheng Nizeng Decoction regulated ferroptosis and endoplasmic reticulum stress in the treatment of gastric precancerous lesions: a mechanistic study based on metabolomics coupled with transcriptomics","volume":"13","author":"Chu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/s41374-022-00819-2","article-title":"Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db\/db mice","volume":"102","author":"Deng","year":"2022","journal-title":"Lab. Invest."},{"key":"B16","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12974-020-01981-4","article-title":"Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE\/NF-\u03baB signaling pathway in vivo and in vitro","volume":"17","author":"Ding","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.13863\/j.issn1001-4454.2018.08.050","article-title":"Clinical observation and related mechanism study of HuangQi-BaoXin Decoction in the treatment of diabetic cardiomyopathy","volume":"41","author":"Du","year":"2018","journal-title":"J. Chin. Med. Mater."},{"key":"B18","doi-asserted-by":"publisher","first-page":"E294","DOI":"10.1161\/CIR.0000000000000691","article-title":"Type 2 diabetes mellitus and heart failure: a scientific statement from the American heart association and the heart failure society of America: this statement does not represent an update of the 2017 ACC\/AHA\/HFSA heart failure guideline update","volume":"140","author":"Dunlay","year":"2019","journal-title":"Circulation"},{"key":"B19","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2147\/DDDT.S400249","article-title":"Glucagon-like peptide-1 receptor agonist protects against diabetic cardiomyopathy by modulating microRNA-29b-3p\/SLMAP","volume":"17","author":"Fang","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"175342","DOI":"10.1016\/j.ejphar.2022.175342","article-title":"Resveratrol improves diabetic cardiomyopathy by preventing asymmetric dimethylarginine-caused peroxisome proliferator-activated receptor-\u03b3 coactivator-1\u03b1 acetylation","volume":"936","author":"Fang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"611087","DOI":"10.3389\/fphar.2020.611087","article-title":"Tanshinone IIA: a review of its anticancer effects","volume":"11","author":"Fang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3892\/ijmm.2021.4996","article-title":"Astragaloside IV ameliorates diabetic nephropathy in db\/db mice by inhibiting NLRP3 inflammasome-mediated inflammation","volume":"48","author":"Feng","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1177\/1535370216660634","article-title":"Tanshinone IIA ameliorates apoptosis of cardiomyocytes induced by endoplasmic reticulum stress","volume":"241","author":"Feng","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.molcel.2017.05.031","article-title":"The UPR(ER): sensor and coordinator of organismal homeostasis","volume":"66","author":"Frakes","year":"2017","journal-title":"Mol. Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/nu8070396","article-title":"Mangiferin and cancer: mechanisms of action","volume":"8","author":"Gold-Smith","year":"2016","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","first-page":"114382","DOI":"10.1016\/j.biopha.2023.114382","article-title":"Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy","volume":"160","author":"Gong","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12933-023-01811-w","article-title":"Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation","volume":"22","author":"Gopal","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5973","DOI":"10.3390\/ijms22115973","article-title":"The mystery of diabetic cardiomyopathy: from early concepts and underlying mechanisms to novel therapeutic possibilities","volume":"22","author":"Grubic Rotkvic","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1177\/0960327119836222","article-title":"Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes","volume":"38","author":"Guan","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijcard.2015.04.245","article-title":"SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism","volume":"191","author":"Guo","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3390\/ijms18040792","article-title":"Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology","volume":"18","author":"Guzel","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/s41419-018-0593-y","article-title":"Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12929-018-0453-1","article-title":"A lifetime of stress: ATF6 in development and homeostasis","volume":"25","author":"Hillary","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/ijms23010266","article-title":"Changes in polar metabolites content during natural and methyl-jasmonate-promoted senescence of Ginkgo biloba leaves","volume":"23","author":"Horbowicz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3390\/ijms20030535","article-title":"The effects of resveratrol in the treatment of metabolic syndrome","volume":"20","author":"Hou","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"13573","DOI":"10.1002\/jcb.28632","article-title":"Matrine improves diabetic cardiomyopathy through TGF-\u03b2-induced protein kinase RNA-like endoplasmic reticulum kinase signaling pathway","volume":"120","author":"Hou","year":"","journal-title":"J. Cell Biochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1139\/cjpp-2015-0073","article-title":"Mangiferin suppressed advanced glycation end products (AGEs) through NF-\u03baB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats","volume":"94","author":"Hou","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1139\/cjpp-2013-0090","article-title":"Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats","volume":"91","author":"Hou","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1002\/cbin.11360","article-title":"Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway","volume":"44","author":"Hu","year":"2020","journal-title":"Cell Biol. Int."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e00904","DOI":"10.1002\/prp2.904","article-title":"New insights into the role of melatonin in diabetic cardiomyopathy","volume":"10","author":"Huang","year":"2022","journal-title":"Pharmacol. Res. Perspe"},{"key":"B41","doi-asserted-by":"publisher","first-page":"114634","DOI":"10.1016\/j.jep.2021.114634","article-title":"Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction","volume":"283","author":"Hui","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ahj.2022.11.003","article-title":"Rationale and design of the aldose reductase inhibition for stabilization of exercise capacity in heart failure trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy","volume":"256","author":"Januzzi","year":"2023","journal-title":"Am. Heart J."},{"key":"B43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"7847","DOI":"10.1039\/d2fo00912a","article-title":"Quercetin ameliorated cardiac injury via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in a diabetic cardiomyopathy mouse model","volume":"13","author":"Jiang","year":"2022","journal-title":"Food Funct."},{"key":"B46","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1080\/13813455.2018.1440409","article-title":"The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K(ATP) channel","volume":"125","author":"Kaya","year":"2019","journal-title":"Arch. Physiol. Biochem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/eurjhf\/hfq110","article-title":"Pre-clinical diabetic cardiomyopathy: prevalence, screening, and outcome","volume":"12","author":"Kiencke","year":"2010","journal-title":"Eur. J. Heart Fail"},{"key":"B48","doi-asserted-by":"publisher","first-page":"111712","DOI":"10.1016\/j.biopha.2021.111712","article-title":"Ginkgo biloba leaf extract suppresses intestinal human breast cancer resistance protein expression in mice: correlation with gut microbiota","volume":"140","author":"Kim","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.3390\/ijerph15102093","article-title":"Curcumin, cardiometabolic health and dementia","volume":"15","author":"Kim","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s40200-021-00948-3","article-title":"Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model","volume":"21","author":"Kumar","year":"2022","journal-title":"J. Diabetes Metab. Disord."},{"key":"B51","doi-asserted-by":"publisher","first-page":"119664","DOI":"10.1016\/j.lfs.2021.119664","article-title":"Daidzein mitigates myocardial injury in streptozotocin-induced diabetes in rats","volume":"284","author":"Laddha","year":"2021","journal-title":"Life Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.biocel.2012.09.017","article-title":"The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins","volume":"45","author":"Lakshmanan","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"110817","DOI":"10.1016\/j.biopha.2020.110817","article-title":"Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC\/AMPK\/NF-\u03baB and GLC\/PPAR\u03b1\/PGC-1\u03b1 pathways in diabetic mice","volume":"132","author":"Li","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B54","doi-asserted-by":"publisher","first-page":"152774","DOI":"10.1016\/j.phymed.2018.11.034","article-title":"Luteolin protects against diabetic cardiomyopathy by inhibiting NF-\u03baB-mediated inflammation and activating the Nrf2-mediated antioxidant responses","volume":"59","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"B55","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jb\/mvaa056","article-title":"Mangiferin alleviates endoplasmic reticulum stress in acute liver injury by regulating the miR-20a\/miR-101a-Nrf2 axis","volume":"168","author":"Li","year":"","journal-title":"J. Biochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"170774","DOI":"10.1016\/j.peptides.2022.170774","article-title":"Irisin alleviates high glucose-induced hypertrophy in H9c2 cardiomyoblasts by inhibiting endoplasmic reticulum stress","volume":"152","author":"Li","year":"2022","journal-title":"Peptides"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1002\/ptr.7175","article-title":"Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3","volume":"35","author":"Li","year":"2021","journal-title":"Phytother. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.biopha.2017.03.097","article-title":"Cortex Mori Radicis extract attenuates myocardial damages in diabetic rats by regulating ERS","volume":"90","author":"Lian","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B59","doi-asserted-by":"publisher","first-page":"6629729","DOI":"10.1155\/2021\/6629729","article-title":"Dahuang danshen decoction inhibits pancreatic fibrosis by regulating oxidative stress and endoplasmic reticulum stress","volume":"2021","author":"Liang","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"882198","DOI":"10.3389\/fphar.2022.882198","article-title":"Rhynchophylline regulates calcium homeostasis by antagonizing ryanodine receptor 2 phosphorylation to improve diabetic cardiomyopathy","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3892\/ijmm.2018.3419","article-title":"Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK\/STAT signaling pathway","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e147836","DOI":"10.1172\/JCI147836","article-title":"Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction","volume":"131","author":"Liu","year":"2021","journal-title":"J. Clin. Investigation"},{"key":"B63","doi-asserted-by":"publisher","first-page":"108900","DOI":"10.1016\/j.biopha.2019.108900","article-title":"Antidepressant-like effects of ginseng fruit saponin in myocardial infarction mice","volume":"115","author":"Liu","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B64","doi-asserted-by":"publisher","first-page":"680","DOI":"10.14336\/AD.2016.0729","article-title":"Pretreatment with ginseng fruit saponins affects serotonin expression in an experimental comorbidity model of myocardial infarction and depression","volume":"7","author":"Liu","year":"2016","journal-title":"Aging Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3892\/etm.2019.7612","article-title":"Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-\u03baB activation in streptozotocin-induced diabetic rats","volume":"18","author":"Liu","year":"","journal-title":"Exp. Ther. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.phrs.2015.01.001","article-title":"Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model","volume":"93","author":"Liu","year":"2015","journal-title":"Pharmacol. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1016\/j.cellsig.2014.08.015","article-title":"Protein kinase RNA-like endoplasmic reticulum kinase (PERK)\/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy","volume":"26","author":"Liu","year":"2014","journal-title":"Cell Signal"},{"key":"B68","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ejphar.2017.03.061","article-title":"Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy","volume":"804","author":"Liu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2811789","DOI":"10.1155\/2022\/2811789","article-title":"Targeting oxidative stress and endothelial dysfunction using tanshinone IIA for the treatment of tissue inflammation and fibrosis","volume":"2022","author":"Lu","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B70","first-page":"33","article-title":"Observation on the curative effect of 38 cases of diabetic cardiomyopathy treated with Benefiting qi-nourishing yin-activating blood circulation formula combined with western medicine","volume":"42","author":"Lu","year":"2010","journal-title":"Benefiting qi-nourishing yin-activating blood Circ. formula"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1080\/13880209.2022.2107019","article-title":"Jiedutongluotiaogan formula restores pancreatic function by suppressing excessive autophagy and endoplasmic reticulum stress","volume":"60","author":"Luo","year":"2022","journal-title":"Pharm. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3736\/jcim20050611","article-title":"Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats","volume":"3","author":"Luo","year":"2005","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"B73","volume-title":"The expression of endoplasmic reticulum stress protein CHOP in myocardium of diabetic cardiomyopathy rats and the intervention effect of puerarin","author":"W. B.","year":"2013"},{"key":"B74","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3877\/cma.j.issn.1674-6880.2012.01.002","article-title":"Research on the expression of Caspase 12 in rats with diabeticcardiomyopathy and the intervention of puerarin","volume":"5","author":"Ma","year":"","journal-title":"Chin. J. Crit. Care Med. Ed."},{"key":"B75","volume-title":"Effect of puerarin on endoplasmic reticulum stress in diabetic cardiomyopathy ratsTen-year review and prospect of critical care medicine-2012 zhejiang academic annual meeting of critical care medicine","author":"W. B.","year":""},{"key":"B76","doi-asserted-by":"publisher","first-page":"1124613","DOI":"10.3389\/fendo.2023.1124613","article-title":"Diabetic cardiomyopathy: the role of microRNAs and long non-coding RNAs","volume":"14","author":"Macvanin","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B77","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1002\/ptr.7544","article-title":"Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: a systematic review and meta-analysis of the clinical trials","volume":"36","author":"Mousavi","year":"2022","journal-title":"Phytother. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.3390\/ijms23073587","article-title":"Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus","volume":"23","author":"Nakamura","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.yjmcc.2015.05.016","article-title":"CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction","volume":"85","author":"Nam","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3969\/j.issn.1005-9202.2022.06.011","article-title":"Clinical observation on the treatment of early senile diabetic cardiomyopathy with the prescription of yiqiyangyinhuoxuetongluofang","volume":"42","author":"Niu","year":"2022","journal-title":"Chin. J. Gerontology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1182\/blood-2010-08-303099","article-title":"Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma","volume":"117","author":"Papandreou","year":"2011","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1507\/endocrj.EJ21-0016","article-title":"Granulocyte colony-stimulating factor reduces the endoplasmic reticulum stress in a rat model of diabetic cardiomyopathy","volume":"68","author":"Park","year":"2021","journal-title":"Endocr. J."},{"key":"B84","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.bbrc.2018.06.070","article-title":"Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation","volume":"503","author":"Pei","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.toxlet.2017.11.018","article-title":"Inhibition of advanced glycation endproduct (AGE) rescues against streptozotocin-induced diabetic cardiomyopathy: role of autophagy and ER stress","volume":"284","author":"Pei","year":"","journal-title":"Toxicol. Lett."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3919161","DOI":"10.1155\/2022\/3919161","article-title":"Fufang Xueshuantong improves diabetic cardiomyopathy by regulating the wnt\/\u03b2-catenin pathway","volume":"2022","author":"Peng","year":"2022","journal-title":"Int. J. Endocrinol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"H840","DOI":"10.1152\/ajpheart.00632.2019","article-title":"Gene therapy targeting cardiac phosphoinositide 3-kinase (p110\u03b1) attenuates cardiac remodeling in type 2 diabetes","volume":"318","author":"Prakoso","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3390\/pharmaceutics15030863","article-title":"Naringin: nanotechnological strategies for potential pharmaceutical applications","volume":"15","author":"Ravetti","year":"2023","journal-title":"Pharmaceutics"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1093\/jpp\/rgac066","article-title":"The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy","volume":"74","author":"Rhman","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am. J. Cardiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"695792","DOI":"10.3389\/fmed.2021.695792","article-title":"The diabetic cardiomyopathy: the contributing pathophysiological mechanisms","volume":"8","author":"Salvatore","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B92","article-title":"Histology, rough endoplasmic reticulum","author":"Sanvictores","year":"2022","journal-title":"StatPearls. Treasure Isl. (FL)"},{"key":"B93","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/ejhf.1170","article-title":"Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology","volume":"20","author":"Seferovic","year":"2018","journal-title":"Eur. J. Heart Fail"},{"key":"B94","first-page":"1877","article-title":"Clinical study on intervention of early diabetic cardiomyopathy by huotan jiedu Tongluo method guided by collateral disease theory","volume":"29","author":"Shi","year":"2020","journal-title":"Mod. J. Integr. Traditional Chin. West. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.3390\/nu14102022","article-title":"Ginkgo biloba leaf extract improves an innate immune response of peripheral blood leukocytes of Alzheimer's disease patients","volume":"14","author":"Sochocka","year":"2022","journal-title":"Nutrients"},{"key":"B96","doi-asserted-by":"publisher","first-page":"14414","DOI":"10.1021\/acs.jafc.2c06650","article-title":"Lycopene alleviates chronic stress-induced liver injury by inhibiting oxidative stress-mediated endoplasmic reticulum stress pathway apoptosis in rats","volume":"70","author":"Sun","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"B97","doi-asserted-by":"publisher","first-page":"111857","DOI":"10.1016\/j.jep.2019.111857","article-title":"Astragalus polysaccharides inhibits cardiomyocyte apoptosis during diabetic cardiomyopathy via the endoplasmic reticulum stress pathway","volume":"238","author":"Sun","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3969\/j.issn.1000-7369.2022.06.009","article-title":"Clinical study treatment of diabetic cardiomyopathy with Zicui Tongmai recipe","volume":"43","author":"Tan","year":"2022","journal-title":"Shaanxi J. Traditional Chin. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3892\/etm.2019.7580","article-title":"Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats","volume":"18","author":"Tao","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2370617","DOI":"10.1155\/2018\/2370617","article-title":"Ginkgo biloba leaf extract protects against myocardial injury via attenuation of endoplasmic reticulum stress in streptozotocin-induced diabetic ApoE(-\/-) mice","volume":"2018","author":"Tian","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B101","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41401-020-0461-z","article-title":"Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress","volume":"42","author":"Tian","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.2337\/diabetes.51.4.1166","article-title":"Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy","volume":"51","author":"Trost","year":"2002","journal-title":"Diabetes"},{"key":"B103","doi-asserted-by":"publisher","first-page":"719268","DOI":"10.3389\/fphar.2021.719268","article-title":"Effects of naringin on cardiomyocytes from a rodent model of type 2 diabetes","volume":"12","author":"Uryash","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1142\/S0192415X17500793","article-title":"Endoplasmic reticulum stress and NF-[Formula: see text]B pathway in Salidroside mediated neuroprotection: potential of Salidroside in neurodegenerative diseases","volume":"45","author":"Wang","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"109729","DOI":"10.1016\/j.biopha.2019.109729","article-title":"Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-\/-) mice by activating PI3K\/AKT signaling and suppressing TRL4\/NF-\u03baB signaling","volume":"123","author":"Wang","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B106","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3892\/etm.2018.6533","article-title":"Resveratrol ameliorates sepsis-induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway","volume":"16","author":"Wang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1080\/09168451.2020.1815170","article-title":"Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax\/Bcl2, and caspase-3 pathways","volume":"84","author":"Wang","year":"","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"E1239","DOI":"10.1152\/ajpendo.00629.2013","article-title":"Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression","volume":"306","author":"Wang","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B109","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13020-022-00574-y","article-title":"Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3\/TGF-\u03b21 and Smad3\/p38 MAPK pathways","volume":"17","author":"Wei","year":"2022","journal-title":"Chin. Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1002\/ptr.7831","article-title":"Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1","volume":"37","author":"Wu","year":"2023","journal-title":"Phytotherapy Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"696135","DOI":"10.3389\/fphar.2021.696135","article-title":"Naringin ameliorates monocrotaline-induced pulmonary arterial hypertension through endothelial-to-mesenchymal transition inhibition","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"9925561","DOI":"10.1155\/2021\/9925561","article-title":"Astragaloside IV alleviates cerebral ischemia-reperfusion injury through NLRP3 inflammasome-mediated pyroptosis inhibition via activating Nrf2","volume":"2021","author":"Xiao","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B113","doi-asserted-by":"publisher","first-page":"119068","DOI":"10.1016\/j.lfs.2021.119068","article-title":"Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPAR\u03b3-Klotho-FoxO1 axis in diabetic nephropathy","volume":"269","author":"Xing","year":"2021","journal-title":"Life Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1039\/d0fo02761h","article-title":"Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway","volume":"12","author":"Xu","year":"","journal-title":"Food Funct."},{"key":"B115","doi-asserted-by":"publisher","first-page":"35475","DOI":"10.1038\/srep35475","article-title":"The effects of puerarin on rat ventricular myocytes and the potential mechanism","volume":"6","author":"Xu","year":"","journal-title":"Sci. Rep."},{"key":"B116","doi-asserted-by":"publisher","first-page":"827971","DOI":"10.1155\/2012\/827971","article-title":"Endoplasmic reticulum stress and diabetic cardiomyopathy","volume":"2012","author":"Xu","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.21037\/apm-19-516","article-title":"Scutellarin protects against diabetic cardiomyopathy via inhibiting oxidative stress and inflammatory response in mice","volume":"10","author":"Xu","year":"","journal-title":"Ann. Palliat. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"7296092","DOI":"10.1155\/2016\/7296092","article-title":"SIRT1\/3 activation by resveratrol attenuates acute kidney injury in a septic rat model","volume":"2016","author":"Xu","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B119","doi-asserted-by":"publisher","first-page":"112709","DOI":"10.1016\/j.biopha.2022.112709","article-title":"The Chinese herbal medicine Fufang Zhenzhu Tiaozhi protects against diabetic cardiomyopathy by alleviating cardiac lipotoxicity-induced oxidative stress and NLRP3-dependent inflammasome activation","volume":"148","author":"Yan","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B120","doi-asserted-by":"publisher","first-page":"114919","DOI":"10.1016\/j.biopha.2023.114919","article-title":"The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice","volume":"164","author":"Yan","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B121","doi-asserted-by":"publisher","first-page":"E190","DOI":"10.1152\/ajpendo.00196.2016","article-title":"Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes","volume":"312","author":"Yang","year":"","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B122","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3892\/ijmm.2023.5252","article-title":"Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR-18a-3p\/Gsdmd pathway","volume":"51","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbadis.2014.05.006","article-title":"Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy","volume":"1852","author":"Yang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B124","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3945\/an.116.014852","article-title":"Effects of anthocyanins on cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials","volume":"8","author":"Yang","year":"","journal-title":"Adv. Nutr."},{"key":"B125","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3389\/fimmu.2020.00285","article-title":"Mangiferin attenuates LPS\/D-GalN-Induced acute liver injury by promoting HO-1 in kupffer cells","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"C508","DOI":"10.1152\/ajpcell.00248.2012","article-title":"Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a","volume":"304","author":"Younce","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/jcmm.12739","article-title":"Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model","volume":"20","author":"Yu","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"115535","DOI":"10.1016\/j.jep.2022.115535","article-title":"A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1\/GSK-3\u03b2 pathway","volume":"297","author":"Yu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"9668","DOI":"10.3390\/ijms22189668","article-title":"Ginsenoside prolongs the lifespan of C. elegans via lipid metabolism and activating the stress response signaling pathway","volume":"22","author":"Yu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"117959","DOI":"10.1016\/j.lfs.2020.117959","article-title":"Resveratrol regulates the recovery of rat sciatic nerve crush injury by promoting the autophagy of Schwann cells","volume":"256","author":"Zhang","year":"","journal-title":"Life Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3969\/j.issn.1674-4616.2022.02.003","article-title":"Effect of Tongluo yangyin recipe and ventricular remodeling in patients with diabetic cardiomyopathy","volume":"14","author":"Zhang","year":"","journal-title":"Res. Integr. Traditional Chin. West. Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"154350","DOI":"10.1016\/j.phymed.2022.154350","article-title":"Tong-Xie-Yao-Fang alleviates diarrhea-predominant irritable bowel syndrome in rats via the GCN2\/PERK-eIF2\u03b1-ATF4 signaling pathway","volume":"107","author":"Zhang","year":"","journal-title":"Phytomedicine"},{"key":"B133","doi-asserted-by":"publisher","first-page":"112573","DOI":"10.1016\/j.jep.2020.112573","article-title":"Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia","volume":"252","author":"Zhang","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41419-022-04653-8","article-title":"Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog","volume":"37","author":"Zhang","year":"","journal-title":"West China J. Pharm. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.7150\/ijbs.63593","article-title":"Pharmacologic IRE1\u03b1 kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis","volume":"18","author":"Zhang","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"108599","DOI":"10.1016\/j.biopha.2019.108599","article-title":"Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs\/mTOR-dependent autophagy pathway","volume":"112","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B137","doi-asserted-by":"publisher","first-page":"957829","DOI":"10.3389\/fphar.2022.957829","article-title":"Integrating pharmacological evaluation and computational identification for deciphering the action mechanism of Yunpi-Huoxue-Sanjie formula alleviates diabetic cardiomyopathy","volume":"13","author":"Zhang","year":"","journal-title":"Front. Pharmacol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3969\/j.issn.1000-4718.2022.05.005","article-title":"Effect of astragaloside IV combined with puerarin on high glucose-inducedendoplasmic reticulum stress in H9c2 cells","volume":"38","author":"Zhang","year":"2022","journal-title":"Chin. J. Pathophysiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"596","DOI":"10.19540\/j.cnki.cjcmm.2018.0013","article-title":"Effect of naringin on oxidative stress and endoplasmic reticulum stress indiabetic cardiomyopathy","volume":"43","author":"Zhang","year":"2018","journal-title":"China J. Chin. Materia Medica"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.11842\/wst.20201229002","article-title":"Discussion on primary research direction of modernization of traditinal Chinese medicine in the period of the \"14th five-year plan","volume":"24","author":"Zhang","year":"2022","journal-title":"Mod. Traditional Chin. Med. Materia Medica-World Sci. Technol."},{"key":"B141","first-page":"1744","article-title":"Myocardial protection of Ginseng fruit saponins in streptozotocin-induced diabetic rats","volume":"18","author":"Zhao","year":"2014","journal-title":"Chin. J. Laboratory Diagnosis"},{"key":"B142","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fphar.2020.00349","article-title":"A review of the pharmacological action of Astragalus polysaccharide","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"778847","DOI":"10.3389\/fphar.2021.778847","article-title":"Recent research progress (2015-2021) and perspectives on the pharmacological effects and mechanisms of tanshinone IIA","volume":"12","author":"Zhong","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13046-023-02702-4","article-title":"Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer","volume":"42","author":"Zhou","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B145","doi-asserted-by":"publisher","first-page":"956688","DOI":"10.3389\/fimmu.2022.956688","article-title":"Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.3390\/molecules26144210","article-title":"Coptisine attenuates diabetes-associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress","volume":"26","author":"Zhou","year":"2021","journal-title":"Molecules"},{"key":"B147","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phytother. Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3182931","DOI":"10.1155\/2022\/3182931","article-title":"miR-340-5p mediates cardiomyocyte oxidative stress in diabetes-induced cardiac dysfunction by targeting mcl-1","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1290023\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:54:39Z","timestamp":1699350879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2023.1290023\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":148,"alternative-id":["10.3389\/fphar.2023.1290023"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2023.1290023","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"article-number":"1290023"}}