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By binding to their corresponding receptors, they are involved in the development and progression of several systemic diseases, including digestive, cardiovascular, and central nervous system diseases. The HPT axis-related receptors include thyrotropin receptor (TSHR), thyroid hormone receptor (TR), and thyrotropin-releasing hormone receptor (TRHR). Recently, research on regulators has become popular in the field of biology. Several HPT axis-related receptor modulators have been used for clinical treatment. This study reviews the developments and recent findings on HPT axis-related receptor modulators. This will provide a theoretical basis for the development and utilisation of new modulators of the HPT axis receptors.<\/jats:p>","DOI":"10.3389\/fphar.2023.1291856","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T04:47:40Z","timestamp":1701665260000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Receptor modulators associated with the hypothalamus -pituitary-thyroid axis"],"prefix":"10.3389","volume":"14","author":[{"given":"Xianbin","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cell.2012.09.003","article-title":"Restructuring G-protein- coupled receptor activation","volume":"151","author":"Audet","year":"2012","journal-title":"Cell."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4724","DOI":"10.1074\/jbc.RA117.001101","article-title":"B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77\/Nor-1 orphan steroid receptors","volume":"293","author":"Banta","year":"2018","journal-title":"J. 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