{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:44:22Z","timestamp":1790631862376,"version":"4.1.0"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium. The reported use of <jats:italic>Bryophyllum pinnatum<\/jats:italic> preparations against inflammation and pain in ethnomedicine as well as current pharmacological data on their inhibition of myometrial contractility led us to hypothesize that this medicinal plant might be a new treatment option for dysmenorrhea. In the first part of the present work, clinical, <jats:italic>in vivo,<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies on the anti-nociceptive and anti-inflammatory, as well as on myometrium relaxing properties of <jats:italic>B. pinnatum<\/jats:italic> are reviewed. In the second part, cases of five women with dysmenorrhea who were tentatively treated with a <jats:italic>B. pinnatum<\/jats:italic> product are described. The review revealed thirty-three experimental <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies, but no clinical study, reporting anti-nociceptive and anti-inflammatory effects of <jats:italic>B. pinnatum<\/jats:italic> extracts and compounds in a wide range of conditions. Moreover, sixteen publications on smooth muscle contractility revealed relaxing effects. The latter consisted of clinical evidence, as well as of <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> data. The evidence reviewed therefore provided a rational basis for the use of <jats:italic>B. pinnatum<\/jats:italic> in the treatment of dysmenorrhea. We subsequently set out to tentatively treat patients with a well-tolerated <jats:italic>B. pinnatum<\/jats:italic> product that is registered (without indication) and commonly used in obstetrics and gynecology in Switzerland. All five treated patients reported a reduction in pain symptoms and 4 out of 5 indicated a reduced intake of painkillers during menstruation. Taken together, the reviewed information on the pharmacological properties and clinical evidence of <jats:italic>B. pinnatum<\/jats:italic> extracts and compounds as well as the outcomes of all five patients in the case series support our hypothesis in favor of <jats:italic>B. pinnatum<\/jats:italic> as a new, well-tolerated therapeutic approach for dysmenorrhea. Prospective clinical studies are urgently needed.<\/jats:p>","DOI":"10.3389\/fphar.2023.1292919","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T19:11:49Z","timestamp":1701457909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series"],"prefix":"10.3389","volume":"14","author":[{"given":"Leonie","family":"Zurfluh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuigia Giovannini","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Betschart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Sim\u00f5es-W\u00fcst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.fitote.2012.03.013","article-title":"Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum","volume":"83","author":"Afzal","year":"2012","journal-title":"Fitoterapia"},{"key":"B2","volume-title":"Medicinal plants of Nigeria","author":"Agoha","year":"1973"},{"key":"B3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/s0079-6123(02)39030-7","article-title":"Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea","volume":"139","author":"\u00c5kerlund","year":"2002","journal-title":"Cancer Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/j.1471-0528.1999.tb08112.x","article-title":"Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women","volume":"106","author":"\u00c5kerlund","year":"1999","journal-title":"BJOG"},{"key":"B5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1471-0528.1979.tb10794.x","article-title":"Primary dysmenorrhoea and vasopressin","volume":"86","author":"\u00c5kerlund","year":"1979","journal-title":"BJOG"},{"key":"B6","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3389\/fphar.2020.00998","article-title":"Anti-inflammatory and chemopreventive effects of Bryophyllum pinnatum (Lamarck) leaf extract in experimental colitis models in rodents","volume":"11","author":"Andrade","year":"2020","journal-title":"Front. 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