{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:25:09Z","timestamp":1787027109443,"version":"build-2736575974"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Supine hypotensive syndrome is a common complication in late pregnancy. This study aims to explore the effects of ondansetron on the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 80 women undergoing elective cesarean delivery were randomly assigned to two groups (the ondansetron group and the control group), with 40 cases in each group. The ondansetron group received 0.075\u00a0mg\/kg of ondansetron intravenously 5\u00a0min before the induction of spinal anesthesia; the control group was given the same volume of saline solution. The blood pressure and heart rate were measured. Umbilical artery pH was analyzed, and the incidence of nausea and vomiting and vasoconstrictor drug usage were noted.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The incidence of supine hypotensive syndrome, nausea and vomiting, and vasoconstrictor drug use were significantly lower in the ondansetron group than the control group (2.5% vs. 20%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029; 2.5% vs. 22.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007; and 5% vs. 22.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.012, respectively). Umbilical artery pH was higher in the ondansetron group than the control group, and statistical significance was observed (7.31 \u00b1 0.03 vs. 7.28 \u00b1 0.04,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). The maternal hemodynamic parameters and the neonatal Apgar score were similar between the two groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Ondansetron can effectively prevent supine hypotensive syndrome, reduce the incidence of nausea, vomiting, and vasoconstrictor drug use, and improve neonatal umbilical arterial pH during spinal anesthesia for cesarean section.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                    <jats:ext-link>https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                    , identifier ChiCTR180018756.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2024.1194196","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:17:16Z","timestamp":1705533436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous ondansetron for the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section: a randomized controlled trial"],"prefix":"10.3389","volume":"15","author":[{"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1111\/j.1556-4029.2012.02165.x","article-title":"Supine hypotensive syndrome as the probable cause of both maternal and fetal death","volume":"57","author":"De-Giorgio","year":"2012","journal-title":"J. Forensic Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1111\/j.1471-0528.2004.00236.x","article-title":"The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study","volume":"111","author":"Einarson","year":"2004","journal-title":"BJOG"},{"key":"B3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.npep.2011.03.004","article-title":"Multiple opioid receptors mediate the hypotensive response induced by central 5-HT (3) receptor stimulation","volume":"45","author":"Fregoneze","year":"2011","journal-title":"Neuropeptides"},{"key":"B4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/aogs.13789","article-title":"Hemodynamic changes in women with symptoms of supine hypotensive syndrome","volume":"99","author":"Humphries","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"B5","first-page":"774","article-title":"Supine hypotensive syndrome","volume":"83","author":"Kinsella","year":"1994","journal-title":"Obstet. Gynecol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"461","DOI":"10.17772\/gp\/2405","article-title":"The influence of intravenous ondansetron on maternal blood haemodynamics after spinal anaesthesia for caesarean section: a double-blind, placebo-controlled study","volume":"86","author":"Marciniak","year":"2015","journal-title":"Ginekol. Pol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/EJA.0000000000001554","article-title":"Supine hypotensive syndrome of pregnancy: a review of current knowledge","volume":"39","author":"Massoth","year":"2022","journal-title":"Eur. J. Anaesthesiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijoa.2014.01.005","article-title":"The effect of intravenous ondansetron on maternal haemodynamics during elective caesarean delivery under spinal anaesthesia: a double-blind, randomised, placebo-controlled trial","volume":"23","author":"Ortiz-G\u00f3mez","year":"2014","journal-title":"Int. J. Obstet. Anesth."},{"key":"B9","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4103\/sja.SJA_237_17","article-title":"Reducing by 50% the incidence of maternal hypotension during elective caesarean delivery under spinal anesthesia: effect of prophylactic ondansetron and\/or continuous infusion of phenylephrine - a double-blind, randomized, placebo-controlled trial","volume":"11","author":"Ortiz-G\u00f3mez","year":"2017","journal-title":"Saudi J. Anaesth."},{"key":"B10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.rapm.2008.01.010","article-title":"Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study","volume":"33","author":"Owczuk","year":"2008","journal-title":"Reg. Anesth. Pain Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1056\/NEJMoa1211035","article-title":"Ondansetron in pregnancy and risk of adverse fetal outcomes","volume":"368","author":"Pasternak","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.autneu.2010.07.028","article-title":"Blockade of 5-HT3 receptors at septal area increase blood pressure in unanaesthetized rats","volume":"159","author":"Urzedo-Rodrigues","year":"2011","journal-title":"Auton. Neurosci."},{"key":"B13","first-page":"5210","article-title":"Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study","volume":"7","author":"Wang","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"103175","DOI":"10.1016\/j.ijoa.2021.103175","article-title":"Prediction of spinal anesthesia-induced hypotension during elective cesarean section: a systematic review of prospective observational studies","volume":"47","author":"Yu","year":"2021","journal-title":"Int. J. Obstet. Anesth."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1194196\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:17:24Z","timestamp":1705533444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1194196\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":14,"alternative-id":["10.3389\/fphar.2024.1194196"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1194196","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]},"article-number":"1194196"}}