{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:33:33Z","timestamp":1793349213764,"version":"4.5.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate the efficacy of the fruits of the medicinal plant\n                    <jats:italic>Forsythia suspensa<\/jats:italic>\n                    (Thunb.) Vahl (FS), in treating inflammation-associated diseases through a meta-analysis of animal models, and also probe deeply into the signaling pathways underlying the progression of inflammation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    All data analyses were performed using Review Manager 5.3 and the results are presented as flow diagrams, risk-of-bias summaries, forest plots, and funnel plots. Summary estimates were calculated using a random- or fixed-effect model, depending on the value of I2.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Of the 710 records identified in the initial search, 11 were selected for the final meta-analysis. Each study extracted data from the model and treatment groups for analysis, and the results showed that FS alleviated the inflammatory cytokine levels in serum; oxidant indicator: reactive oxygen species; enzymes of liver function; endotoxin and regulatory cells in blood; and improved the antioxidant enzyme superoxide dismutase.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    FS effectively reversed the change in acute or chronic inflammation indicators in animal models, and the regulation of multiple channel proteins in inflammatory signaling pathways suggests that FS is a good potential drug for inflammatory disease drug therapy.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2024.1288584","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:42:12Z","timestamp":1709538132000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Forsythia suspensa (Thunb.) Vahl on mouse and rat models of inflammation-related diseases: a meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Chenyu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamizah Shahirah","family":"Hamezah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1142\/S0192415X16500580","article-title":"Forsythiae Fructus inhibits B16 melanoma growth involving MAPKs\/Nrf2\/HO-1 mediated anti-oxidation and anti-inflammation","volume":"44","author":"Bao","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"B2","volume-title":"Study on the Mechanism of Forsythiae Fructus in the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting Based on Nlrp3 Inflammasome","author":"Bi","year":"2021"},{"key":"B3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3390\/antiox11030475","article-title":"Polyphenol rich Forsythia suspensa extract alleviates DSS-Induced ulcerative colitis in mice through the Nrf2-NLRP3 pathway","volume":"11","author":"Chao","year":"2022","journal-title":"Antioxidants (Basel)."},{"key":"B4","volume-title":"Pharmacopoeia of the peoples Republic of China","year":"2020"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s13346-021-00977-8","article-title":"Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases","volume":"11","author":"Deng","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"B6","volume-title":"Effects of Forsythia Suspensa on Expression of Nf-\u039ab and Foxp3 During Liver Injury in Rats with Severe Acute Pancreatitis","author":"Fan","year":"2013"},{"key":"B7","doi-asserted-by":"publisher","first-page":"956218","DOI":"10.3389\/fnut.2022.956218","article-title":"Phillyrin restores metabolic disorders in mice fed with high-fat diet through inhibition of interleukin-6-mediated basal lipolysis","volume":"9","author":"Fang","year":"2022","journal-title":"Front. Nutr."},{"key":"B8","first-page":"60","article-title":"Study progress of","volume":"12","author":"Feng","year":"2018","journal-title":"Forsythia Suspensa. Mod. Agric. Sci. Technol."},{"key":"B9","volume-title":"Changes of Tlr4 and Treg in Severely Burnt Rats and Effects Of Forsythia Suspensa On Them","author":"Fu","year":"2007"},{"key":"B10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12974-020-01855-9","article-title":"Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses","volume":"17","author":"Gong","year":"2020","journal-title":"J. Neuroinflammation."},{"key":"B11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BST20190029","article-title":"Biomarkers of inflammation and the etiology of sepsis","volume":"48","author":"Grondman","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"B13","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.ccell.2020.05.004","article-title":"Multi-phenotype CRISPR-Cas9 screen identifies p38 kinase as a target for adoptive immunotherapies","volume":"37","author":"Gurusamy","year":"2020","journal-title":"Cancer Cell."},{"key":"B14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/imr.12625","article-title":"Changing the threshold-signals and mechanisms of mast cell priming","volume":"282","author":"Halova","year":"2018","journal-title":"Immunol. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"113275","DOI":"10.1016\/j.jep.2020.113275","article-title":"Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/smads signaling pathways","volume":"262","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.3390\/nu13082901","article-title":"Forsythia Fruit prevents fulminant hepatitis in mice and ameliorates inflammation in murine macrophages","volume":"13","author":"Jeong","year":"2021","journal-title":"Nutrients"},{"key":"B18","doi-asserted-by":"publisher","first-page":"8S-17S","DOI":"10.1177\/0148607115595974","article-title":"Clinically relevant mechanisms of lipid synthesis, transport, and storage","volume":"39","author":"Kalish","year":"2015","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/biomedicines6020044","article-title":"Subunit-specific role of NF-\u03baB in cancer","volume":"6","author":"Kaltschmidt","year":"2018","journal-title":"Biomedicines"},{"key":"B20","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3389\/fimmu.2020.00553","article-title":"Phagocytosis of apoptotic cells in resolution of inflammation","volume":"11","author":"Kourtzelis","year":"2020","journal-title":"Front. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3390\/ijms21031102","article-title":"Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"208","DOI":"10.13451\/j.sxu.ns.2021038","article-title":"Study on anti-inflammatory mechanism of Forsythiae Fructus based on network pharmacology","volume":"46","author":"Liu","year":"2021","journal-title":"J. Shanxi Univ."},{"key":"B23","volume-title":"Study on the Effective Component of Forsythiae Fructus to the Liver Injury","author":"Liu","year":"1988"},{"key":"B24","doi-asserted-by":"publisher","first-page":"112062","DOI":"10.1016\/j.jinorgbio.2022.112062","article-title":"ROS scavenging of SOD\/CAT mimics probed by EPR and reduction of lipid peroxidation in S. cerevisiae and mouse liver, under severe hydroxyl radical stress condition","volume":"239","author":"Menezes","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jhep.2013.06.023","article-title":"Cell-specific PPAR\u03b3 deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells","volume":"59","author":"Mor\u00e1n-Salvador","year":"2013","journal-title":"J. Hepatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10456-018-9658-x","article-title":"Interleukin-22 promotes tumor angiogenesis","volume":"22","author":"Protopsaltis","year":"2019","journal-title":"Angiogenesis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e12970","DOI":"10.1111\/sji.12970","article-title":"An inflammation classification system using cytokine parameters","volume":"93","author":"Roe","year":"2020","journal-title":"Scand. J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/imm.13423","article-title":"Neutrophil and remnant clearance in immunity and inflammation","volume":"165","author":"Singhal","year":"2022","journal-title":"Immunology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00280-020-04181-2","article-title":"Involvement of cytochrome P450 enzymes in inflammation and cancer: a review","volume":"87","author":"Stipp","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jep.2016.04.015","article-title":"Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model","volume":"187","author":"Sung","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114739119","article-title":"Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages","volume":"119","author":"van Dierendonck","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"115322","DOI":"10.1016\/j.jep.2022.115322","article-title":"Forsythiae Fructuse extracts alleviates LPS-induced acute lung injury in mice by regulating PPAR-\u03b3\/RXR-\u03b1 in lungs and colons","volume":"293","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jep.2017.08.040","article-title":"Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: a review","volume":"210","author":"Wang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.13313\/j.issn.1673-4890.2016.12.031","article-title":"Advances in chemical constituents and pharmacology of","volume":"18","author":"Xia","year":"2016","journal-title":"Forsythia Suspensa. Mod. Chin. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1159\/000484192","article-title":"Protective effect of phillyrin on lethal LPS-induced neutrophil inflammation in zebrafish","volume":"43","author":"Yang","year":"2017","journal-title":"Cell Physiol. biochem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"117275","DOI":"10.1016\/j.jep.2023.117275","article-title":"Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: active ingredients and mechanisms of action","volume":"319","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3969\/j.issn.1672-3511.2022.02.007","article-title":"Effect of Forsythia suspensa extract on the level of ICAM-1 and INF-\u03b3 in chronic pelvic inflammatory model rats","volume":"34","author":"Zhang","year":"2022","journal-title":"Med. J. West China"},{"key":"B38","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/asj.12717","article-title":"Forsythia suspensa extract attenuates lipopolysaccharide-induced inflammatory liver injury in rats via promoting antioxidant defense mechanisms","volume":"88","author":"Zhao","year":"2016","journal-title":"Anim. Sci. J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"704260","DOI":"10.3389\/fphar.2021.704260","article-title":"UPLC\/Q-TOF MS screening and identification of antibacterial compounds in Forsythia suspensa (thunb.) Vahl leaves","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1288584\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:42:22Z","timestamp":1709538142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1288584\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":39,"alternative-id":["10.3389\/fphar.2024.1288584"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1288584","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"article-number":"1288584"}}