{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:35:14Z","timestamp":1792697714934,"version":"4.5.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study constitutes a pioneering systematic review and meta analysis delving into the clinical efficacy and safety of the combined therapy involving Wuhu Decoction and azithromycin for treating <jats:italic>Mycoplasma<\/jats:italic> pneumoniae pneumonia in pediatric patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study conducted a comprehensive computerized search, covering 6 Chinese databases and 6 English databases, to collect randomized controlled trials related to the combined use of Wuhu Decoction and azithromycin for treating <jats:italic>Mycoplasma<\/jats:italic> pneumoniae pneumonia in pediatric patients. The search was extended until August 2023. Two independent researchers were involved in literature screening, data extraction, and bias risk assessment. Meta-analysis was performed using Stata 14.0 and RevMan 5.4 software. Additionally, meta-regression analysis and subgroup analysis were carried out on primary outcomes to identify potential sources of heterogeneity and confounding factors.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 22 randomized controlled trials involving 2,026 patients were included in this study. The combined therapy of Wuhu Decoction and azithromycin demonstrated superior efficacy compared to azithromycin alone (RR = 1.17, 95% CI [1.13, 1.21], <jats:italic>p<\/jats:italic> &amp;lt; 0.00001; low certainty of evidence). Additionally, patients receiving the combination therapy experienced significantly reduced the disappearance time of fever (MD = \u22121.42, 95% CI [\u22121.84, \u22121.00], <jats:italic>p<\/jats:italic> &amp;lt; 0.00001; very low certainty of evidence), disappearance time of cough (MD = \u22122.08, 95% CI [\u22122.44, \u22121.71], <jats:italic>p<\/jats:italic> &amp;lt; 0.00001; very low certainty of evidence), disappearance of pulmonary rales (MD = \u22121.97, 95% CI [\u22122.31, \u22121.63], <jats:italic>p<\/jats:italic> &amp;lt; 0.00001; very low certainty of evidence), and disappearance time of wheezing (MD = \u22121.47, 95% CI [\u22121.72, \u22121.22], <jats:italic>p<\/jats:italic> &amp;lt; 0.00001; very low certainty of evidence). Meta-regression analysis suggested that course of disease, sample size, and age might be sources of heterogeneity. Subgroup and sensitivity analyses reaffirmed the stability of these results. Furthermore, analyses of secondary outcomes such as T lymphocytes, serum inflammatory factors, and the incidence rate of adverse reactions consistently favored the combination therapy of WHD and azithromycin over azithromycin alone, with statistically significant differences.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Based on our meta-analysis findings, the combined therapy of Wuhu Decoction and azithromycin for treating pediatric <jats:italic>Mycoplasma<\/jats:italic> pneumoniae pneumonia exhibited superior overall efficacy in comparison to azithromycin monotherapy. However, in the included 22 studies, the majority of evaluated factors showed unclear bias risks, and a persistent bias risk was consistently present within one category. Moreover, due to the low quality of evidence, interpreting these results should be approached with caution. Hence, we emphasize the necessity for future high-quality, multicenter, and large-sample clinical randomized controlled trials. These trials are essential to provide more robust data for evidence-based research and to establish higher-quality evidence support.<\/jats:p><jats:p><jats:bold>Systematic Review Registration:<\/jats:bold><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>, identifier CRD42023465606<\/jats:p>","DOI":"10.3389\/fphar.2024.1329516","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:41:07Z","timestamp":1712119267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Wuhu decoction combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: a systematic review and meta analysis of randomized controlled trials"],"prefix":"10.3389","volume":"15","author":[{"given":"Shuo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.13422\/j.cnki.syfjx.2018020164","article-title":"Efficacy of modified wuhutang combined with azithromycin in treating children with phlegm heat closed lung type mycoplasma pneumonia and its effect on T lymphocyte subsets","volume":"24","author":"Bian","year":"2018","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1093\/cid\/cir531","article-title":"The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America","volume":"53","author":"Bradley","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1086\/653535","article-title":"High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China","volume":"51","author":"Cao","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3969\/j.issn.1673-7202.2023.19.026","article-title":"Progress in the pharmacological effect and clinical application of Wuhu Decoction","volume":"18","author":"Chen","year":"2023","journal-title":"World Chin. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.13457\/j.cnki.jncm.2019.10.022","article-title":"Clinical study on modified Wuhu tang combined with azithromycin for mycoplasma pneumonia in children with syndrome of phlegm-heat obstructing the lung","volume":"51","author":"Chen","year":"2019","journal-title":"Lung"},{"key":"B6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.13463\/j.cnki.jlzyy.2019.01.017","article-title":"Azithromycin combined with modified Wuhu decoction orally and xiaohuang san in the the treatment of mycoplasma pneumonia in children","volume":"39","author":"Chen","year":"2019","journal-title":"Jilin J. Chin. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.13200\/j.cnki.cjb.002990","article-title":"Progress in the epidemiology and drug resistance status of M. pneumoniae infection","volume":"33","author":"Cui","year":"2020","journal-title":"Chin. J. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/s0378-8741(96)01484-5","article-title":"Anti-allergic effect of an aqueous extract of Wu-hu-tang","volume":"55","author":"Dai","year":"1997","journal-title":"J. Ethnopharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.13935\/j.cnki.sjzx.210102","article-title":"Observation on the clinical efficacy of azithromycin sequential therapy combined with Wuhu decoction in the treatment of mycoplasma pneumonia in children","volume":"16","author":"Deng","year":"2021","journal-title":"World J. Integr. Traditional West. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.13638\/j.issn.1671-4040.2018.09.049","article-title":"Modified Wuhu tang combined with azithromycin for mycoplasma pneumonia in children with syndrome of phlegm-heat obstructing the lung","volume":"18","author":"Dong","year":"2018","journal-title":"Pract. Clin. J. Integr. Traditional Chin. West. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1099\/jmm.0.066191-0","article-title":"Clinical outcomes and macrolide resistance in Mycoplasma pneumoniae infection in Scotland, UK","volume":"62","author":"Ferguson","year":"2013","journal-title":"J. Med. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1017\/S0950268819000839","article-title":"The epidemiology of paediatric Mycoplasma pneumoniae pneumonia in North China: 2006 to 2016","volume":"147","author":"Gao","year":"2019","journal-title":"Epidemiol. Infect."},{"key":"B13","first-page":"76","article-title":"Clinical effect of azithromycin sequential treatment combined with Wuhu decoction in pediatric mycoplasma pneumonia","author":"Gong","year":"2023","journal-title":"Chin. Baby"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.3390\/molecules25143283","article-title":"A review of the Ephedra genus: distribution, ecology, ethnobotany, phytochemistry and pharmacological properties","volume":"25","author":"Gonz\u00e1lez-Ju\u00e1rez","year":"2020","journal-title":"Molecules"},{"key":"B15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.17305\/bjbms.2019.4053","article-title":"Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: a multicenter study","volume":"19","author":"Guo","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.5578\/mb.20239902","article-title":"\u00c7ocukluk \u00e7a\u011f\u0131nda mycoplasma pneumoniae\u2019nin etken olarak saptand\u0131\u011f\u0131 pn\u00f6moni olgular\u0131n\u0131n epidemiyolojik, klinik ve radyolojik \u00f6zelliklerinin de\u011ferlendirilmesi","volume":"57","author":"Han\u00e7erli Demirba\u015f","year":"2023","journal-title":"Mikrobiyol. Bul."},{"key":"B17","article-title":"Progress in traditional Chinese and western medicine in mycoplasma pneumonia in children","volume":"3","author":"Hao","year":"2022","journal-title":"MEDS Clin. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ Clin. researched."},{"key":"B19","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann. Intern Med."},{"key":"B20","first-page":"14","article-title":"Investigate the effectiveness of gastric gastric combined with plaster in a rat model of oral ulcer","volume":"51","author":"Jiang","year":"2022","journal-title":"Heilongjiang J. Traditional Chin. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1002\/ptr.7006","article-title":"Almond as a nutraceutical and therapeutic agent in Persian medicine and modern phytotherapy: a narrative review","volume":"35","author":"Karimi","year":"2021","journal-title":"Phytother. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/cid\/ciy419","article-title":"Mycoplasma pneumoniae among children hospitalized with community-acquired pneumonia","volume":"68","author":"Kutty","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.13935\/j.cnki.sjzx.201035","article-title":"Effects of Wuhu decoction on inflammatory factors and immune function in children with mycoplasma pneumonia with phlegm-heat obstructing the lung syndrome","volume":"15","author":"Li","year":"2020","journal-title":"World J. Integr. Traditional West. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.13241\/j.cnki.pmb.2022.01.030","article-title":"Effect of external application of xiaohuang powder combined with oral administration of jiawei Wuhu decoction on lung function and serum TNF-\u03b1,IFN-\u03b3,IL-4 in children with mycoplasma pneumoniae pneumonia of phlegm heat blocking lung type","volume":"22","author":"Li","year":"2022","journal-title":"Prog. Mod. Biomed."},{"key":"B25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3760\/cma.j.issn.0254-5101.2018.05.011","article-title":"Progress on global resistance and resistance mechanisms of M. pneumoniae macrolide antibiotics","volume":"38","author":"Li","year":"2018","journal-title":"Chin. J. Microbiol. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3969\/j.issn.1671-945X.2021.11.042","article-title":"Analysis of the factors influencing the adverse effects of intravenous azithromycin infusion","volume":"19","author":"Liao","year":"2021","journal-title":"J. China Prescr. Drug"},{"key":"B27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13020-019-0229-x","article-title":"Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine","volume":"14","author":"Lin","year":"2019","journal-title":"Chin. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"881","DOI":"10.19538\/j.ek2017120601","article-title":"Expert consensus on diagnosis and treatment of integrated traditional Chinese and western medicine of mycoplasma pneumoniae in children (formulated in 2017)","volume":"32","author":"Liu","year":"2017","journal-title":"Chin. J. Pract. Pediatr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3969\/j.issn.1000-7369.2016.10.017","article-title":"The curative effect of Modified Wuhu Decoction on mycoplasma pneumonia in children with Phlegm-Heat Obstructing Lung Syndrome and the regulation effect of T lymphocyte subsets and cytokines","volume":"37","author":"Liu","year":"2016","journal-title":"Shaanxi J. Traditional Chin. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"352","DOI":"10.16368\/j.issn.1674-8999.2017.03.091","article-title":"Modified Wuhu decoction combined with azithromycin in treatment of mycoplasma pneumonia in children with phlegm-heat obstructing lung syndrome","volume":"32","author":"Liu","year":"2017","journal-title":"Acta Chin. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.16458\/j.cnki.1007-0893.2022.03.013","article-title":"Efficacy of integrated traditional Chinese and Western medicine in treating 84 cases of pediatric mycoplasma pneumonia","volume":"32","author":"Ma","year":"2022","journal-title":"Shenzhen J. Integr. Traditional Chin. West. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.3389\/fmicb.2017.01916","article-title":"Editorial: mycoplasma pneumoniae clinical manifestations, microbiology, and immunology","volume":"8","author":"Nir-Paz","year":"2017","journal-title":"Front. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1002\/ptr.6178","article-title":"Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review","volume":"32","author":"Pastorino","year":"2018","journal-title":"Phytother. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.16040\/j.cnki.cn15-1101.2019.04.006","article-title":"Analysis of modified Wuhu tang in childrenwith mycoplasma pneumonia with phlegm-heat obstructing the lung syndrome.inner Mongolia","volume":"38","author":"Qi","year":"2019","journal-title":"J. Traditional Chin. Med."},{"key":"B35","first-page":"115","article-title":"The therapeutic value of Wuhu decoction and azithromycin in pediatric mycoplasma pneumonia","author":"Qi","year":"2021","journal-title":"Spec. Health"},{"key":"B36","doi-asserted-by":"publisher","first-page":"744624","DOI":"10.3389\/fphar.2021.744624","article-title":"Interactions between Ephedra sinica and Prunus armeniaca: from stereoselectivity to deamination as a metabolic detoxification mechanism of amygdalin","volume":"12","author":"Qin","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.13424\/j.cnki.mtcm.2020.02.022","article-title":"Effect of Modified Wuhu Tang combined with azithromycin in pediatric Mycoplasma pneumonia and its effect on SAA, CRP and PCT levels","volume":"40","author":"Ren","year":"2020","journal-title":"Mod. Chin. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3389\/fmicb.2014.00410","article-title":"Novel aspects on the pathogenesis of Mycoplasma pneumoniae pneumonia and therapeutic implications","volume":"5","author":"Saraya","year":"2014","journal-title":"Front. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"B40","doi-asserted-by":"publisher","first-page":"248","DOI":"10.16367\/j.issn.1003-5028.2022.02.0054","article-title":"Effect of modified Wuhu decoction combined with azithromycin in the treatment of mycoplasma pneumonia in children and its influence on the level of T cell subsets","volume":"42","author":"Shi","year":"2022","journal-title":"Henan Tradit. Chin. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3969\/j.issn.1674-1749.2016.12.036","article-title":"Modified Wuhu decoction combined with azithromycin sequential therapy to treat 57 cases of mycoplasma pneumoniae pneumonia in children phlegm heat blocking lung type","volume":"9","author":"Su","year":"2016","journal-title":"Glob. Tradit. Chin. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1007\/s10753-014-9821-5","article-title":"Antihepatotoxic effect of tadehaginoside, extracted from Tadehagi triquetrum (L.), against CCl4-lesioned rats through activating the Nrf2 signaling pathway and attenuating the inflammatory response","volume":"37","author":"Tang","year":"2014","journal-title":"Inflammation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3343\/alm.2013.33.6.410","article-title":"Macrolide resistance of Mycoplasma pneumoniae and its detection rate by real-time PCR in primary and tertiary care hospitals","volume":"33","author":"Uh","year":"2013","journal-title":"Ann. Lab. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1128\/CMR.00114-16","article-title":"Mycoplasma pneumoniae from the respiratory tract and beyond","volume":"30","author":"Waites","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.13422\/j.cnki.syfjx.20180620","article-title":"Clinical efficacy of modified wuhutang combined with azithromycin sequential therapy on anti-inflammatory, Proinflammatory cytokines and respiratory function of mycoplasmal pneumoniae pneumonia children with symptom of phlegm-heat obstructing lung","volume":"24","author":"Wang","year":"2018","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B46","doi-asserted-by":"publisher","first-page":"107151","DOI":"10.1016\/j.intimp.2020.107151","article-title":"Amygdalin inhibits TGF\u03b21-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo","volume":"90","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3969\/j.issn.1006-1959.2015.33.529","article-title":"Clinical analysis of mycoplasma pneumonia in children with phlegm-heat obstructing lung syndrome","author":"Wang","year":"2015","journal-title":"J. Med. Inf."},{"key":"B48","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/ptr.6274","article-title":"Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice","volume":"33","author":"Wang","year":"2019","journal-title":"Phytother. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.16368\/j.issn.1674-8999.2018.10.445","article-title":"Wuhu decoction combined with plaster therapy in treatment of children mycoplasma pneumonia with phlegm-heat obstructing lung syndrome","volume":"33","author":"Wu","year":"2018","journal-title":"Acta Chin. Med."},{"key":"B50","first-page":"106","article-title":"Efficacy of integrated traditional Chinese and Western medicine in treating 84 cases of pediatric mycoplasma pneumonia of Phlegm Heat Blocking Lung Type","author":"Xi","year":"2015","journal-title":"China Pharm."},{"key":"B51","doi-asserted-by":"publisher","first-page":"66","DOI":"10.13463\/j.cnki.jlzyy.2019.01.019","article-title":"Wuhu decoction in the treatment of mycoplasma pneumonia of phlegm fever","volume":"39","author":"Yan","year":"2019","journal-title":"Jilin J. Chin. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s11655-017-2409-9","article-title":"Effect of Qingfei Mixture on pediatric mycoplasma pneumoniae pneumonia with phlegm heat obstructing Fei (Lung) syndrome","volume":"23","author":"Yang","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3969\/j.issn.1008-049X.2016.10.046","article-title":"Progress on the heat-clearing effect of mineral traditional Chinese medicine gypsum","volume":"19","author":"Yang","year":"2016","journal-title":"China Pharm."},{"key":"B54","doi-asserted-by":"publisher","first-page":"885","DOI":"10.3969\/j.issn.1003-8914.2023.05.026","article-title":"The application of modified Wuhu decoction in the treatment of mycoplasma pneumonia in children","volume":"38","author":"Yang","year":"2023","journal-title":"Guangming J. Chin. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.13863\/j.issn1001-4454.2010.11.015","article-title":"Study of aboveground partial anti-IgE-mediated type I anaphylaxis in gourd tea","volume":"33","author":"Yu","year":"2010","journal-title":"J. Chin. Med. Mater."},{"key":"B56","doi-asserted-by":"publisher","first-page":"108","DOI":"10.13422\/j.cnki.syfjx.20231322","article-title":"Effects of Wuhu decoction on airway inflammation and protein expression of Muc5AC, STAT 3, NF- \u03ba B and NLRP 3 in RSV infected asthmatic mice","volume":"29","author":"Yu","year":"2023","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B57","doi-asserted-by":"publisher","first-page":"140146","DOI":"10.1016\/j.scitotenv.2020.140146","article-title":"Aqueous chlorination of ephedrine: kinetic, reaction mechanism and toxicity assessment","volume":"740","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B58","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1369\/0022155415610168","article-title":"Glycyrrhizic acid prevents sepsis-induced acute lung injury and mortality in rats","volume":"64","author":"Zhao","year":"2016","journal-title":"J. Histochem Cytochem"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3201\/eid2108.150273","article-title":"Macrolide-resistant mycoplasma pneumoniae, United States","volume":"21","author":"Zheng","year":"2015","journal-title":"Emerg. Infect. Dis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1329516\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:49:53Z","timestamp":1712119793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1329516\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":59,"alternative-id":["10.3389\/fphar.2024.1329516"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1329516","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"article-number":"1329516"}}