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A comprehensive examination of OS biomarkers was carried out, encompassing measurements of total oxidative capacity (TOC) and total antioxidant capacity (TAC). Our analysis results reveal noteworthy connections between OS levels and the severity of IR in overweight and obese patients. Moreover, in the study, we demonstrated the diagnostic utility of serum concentrations of TAC and TOC as indicators of the risk of RH, the occurrence of which, even at the stage of overweight, may be associated with increased OS and further development of obesity. Our findings imply that the evaluation of oxidative status could serve as a crucial diagnostic and prognostic tool for patients observed with IR and overweight and obesity. In conclusion, our study underscores the potential utility of assessing oxidative status in the context of IR and highlights the possibility of identifying novel therapeutic targets for the treatment of overweight and obese patients.<\/jats:p>","DOI":"10.3389\/fphar.2024.1329802","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T04:32:48Z","timestamp":1712637168000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessing the impact of body composition, metabolic and oxidative stress parameters on insulin resistance as a prognostic marker for reactive hypoglycemia: a cross-sectional study in overweight, obese, and normal weight individuals"],"prefix":"10.3389","volume":"15","author":[{"given":"Maria","family":"Ko\u015bciuszko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Buczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"\u0141uka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Duraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"\u017buk-Czerniawska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Siewko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Wiatr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam Jacek","family":"Kr\u0119towski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pop\u0142awska-Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1007\/s10753-016-0329-z","article-title":"Does inflammation mediate the association between obesity and insulin resistance?","volume":"39","author":"Adabimohazab","year":"2016","journal-title":"Inflammation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.metabol.2018.11.001","article-title":"Obesity and cancer risk: emerging biological mechanisms and perspectives","volume":"92","author":"Avgerinos","year":"2019","journal-title":"Metabolism"},{"key":"B3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.atherosclerosis.2010.12.035","article-title":"Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation","volume":"215","author":"Codo\u00f1er-Franch","year":"2011","journal-title":"Atherosclerosis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.cjca.2020.02.066","article-title":"Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited","volume":"36","author":"da Silva","year":"2020","journal-title":"Can. 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