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Berberine is a natural quaternary alkaloid which has been shown to have a variety of pharmacological effects, such as hypoglycemic, lipid-regulation, anti-cancer, antibacterial, anti-oxidation, anti-inflammatory, and antidepressant. This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory status in order to provide a reference for further research and clinical application of berberine.<\/jats:p>","DOI":"10.3389\/fphar.2024.1331440","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T04:35:28Z","timestamp":1705898128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Research progress on antidepressant effects and mechanisms of berberine"],"prefix":"10.3389","volume":"15","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3390\/biom10060947","article-title":"Brain NMDA receptors in schizophrenia and depression","volume":"10","author":"Adell","year":"2020","journal-title":"Biomolecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e13936","DOI":"10.1111\/jfbc.13936","article-title":"Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways","volume":"45","author":"Akbar","year":"2021","journal-title":"J. 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