{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:50:57Z","timestamp":1789948257877,"version":"4.0.1"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts of\n                    <jats:italic>V. diversifolium<\/jats:italic>\n                    (family Scrophulariaceae), a plant that is native to Lebanon, Syria and Turkey. Six extracts, namely, hexane, dichloromethane (DCM), ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, and water (aqueous) were prepared by maceration. The EtOH extract was predominated by the presence of rutin (4280.20\u00a0\u03bcg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and\n                    <jats:italic>p<\/jats:italic>\n                    -coumaric acid (3044.01\u00a0\u03bcg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) while the highest accumulation of kaempferol-3-glucoside (1537.38\u00a0\u03bcg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), caffeic acid (130.13\u00a0\u03bcg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and 4-hydroxy benzoic acid (465.93\u00a0\u03bcg\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was recorded in the 70% EtOH, aqueous, and EtOAc extracts, respectively. The EtOH (46.86\u00a0mg\u00a0TE\/g) and 70% EtOH (46.33\u00a0mg\u00a0TE\/g) extracts displayed the highest DPPH radical scavenging result. Both these extracts, along with the aqueous one, exerted the highest ABTS radical scavenging result (73.03\u201373.56\u00a0mg\u00a0TE\/g). The EtOH and 70% EtOH extracts revealed the most potent anti-AChE (2.66 and 2.64\u00a0mg GALAE\/g) and anti-glucosidase (1.07 and 1.09\u00a0mmol ACAE\/g) activities. The aqueous extract was the most efficacious in inhibiting the proliferation of prostate cancer (DU-145) cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 8.71\u00a0\u03bcg\/mL and a Selectivity Index of 3.7. In conclusion, this study appraised the use of\n                    <jats:italic>V. diversifolium<\/jats:italic>\n                    aerial parts as a potential therapeutic source for future development of phytopharmaceuticals that target specific oxidative stress-linked diseases including diabetes, cancer, cardiovascular disease, and Alzheimer\u2019s disease among others.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2024.1333865","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:07:18Z","timestamp":1706584038000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts"],"prefix":"10.3389","volume":"15","author":[{"given":"Sakina","family":"Yagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilofar","family":"Nilofar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi Ibrahim","family":"Uba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Angeloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Seker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131dvan","family":"Polat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiya Jahan","family":"Supti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria","family":"Tasnim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Al Dhaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3109\/13880209.2013.781194","article-title":"Syringic acid from Tamarix aucheriana possesses antimitogenic and chemo-sensitizing activities in human colorectal cancer cells","volume":"51","author":"Abaza","year":"2013","journal-title":"Pharm. 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