{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:03:48Z","timestamp":1783044228136,"version":"3.54.6"},"reference-count":150,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Globally, alcohol-associated liver disease (ALD) has become an increased burden for society. Disulfirams, Benzodiazepines (BZDs), and corticosteroids are commonly used to treat ALD. However, the occurrence of side effects such as hepatotoxicity and dependence, impedes the achievement of desirable and optimal therapeutic efficacy. Therefore, there is an urgent need for more effective and safer treatments. Hovenia dulcis is an herbal medicine promoting alcohol removal clearance, lipid-lowering, anti-inflammatory, and hepatoprotective properties. Hovenia dulcis has a variety of chemical components such as dihydromyricetin, quercetin and beta-sitosterol, which can affect ALD through multiple pathways, including ethanol metabolism, immune response, hepatic fibrosis, oxidative stress, autophagy, lipid metabolism, and intestinal barrier, suggesting its promising role in the treatment of ALD. Thus, this work aims to comprehensively review the chemical composition of Hovenia dulcis and the molecular mechanisms involved in the process of ALD treatment.<\/jats:p>","DOI":"10.3389\/fphar.2024.1337633","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:30:30Z","timestamp":1712550630000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Yi-Xiang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1111\/j.1530-0277.2009.00956.x","article-title":"Understanding and treating patients with alcoholic cirrhosis: an update","volume":"33","author":"Addolorato","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"9603271211066843","DOI":"10.1177\/09603271211066843","article-title":"Myricetin (3,3('),4('),5,5('),7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats","volume":"41","author":"Ahmad","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.revmed.2019.02.001","article-title":"Alcohol withdrawal syndrome management: is there anything new?","volume":"40","author":"Airagnes","year":"2019","journal-title":"Rev. Med. Interne"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1053\/gast.2000.20189","article-title":"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial","volume":"119","author":"Akriviadis","year":"2000","journal-title":"Gastroenterology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mam.2007.09.004","article-title":"Oxidative mechanisms in the pathogenesis of alcoholic liver disease","volume":"29","author":"Albano","year":"2008","journal-title":"Mol. Asp. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1089\/jmf.2009.1387","article-title":"Comparative study of the efficacy of ascorbic acid, quercetin, and thiamine for reversing ethanol-induced toxicity","volume":"13","author":"Ambadath","year":"2010","journal-title":"J. Med. Food"},{"key":"B7","first-page":"143","article-title":"Chemical compositions of the genus hovenia","volume":"9","author":"Bao-Jun","year":"2003","journal-title":"Nat. Product. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3390\/ijms25010410","article-title":"Redox biology and liver fibrosis","volume":"25","author":"Bellanti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BFb0102306","article-title":"The Bcl-2 gene family and apoptosis","volume":"62","author":"Bruckheimer","year":"1998","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1600-6143.2009.02869.x","article-title":"Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry)","volume":"10","author":"Burra","year":"2010","journal-title":"Am. J. Transpl."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","volume":"17","author":"Canani","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/molecules29010127","article-title":"Research progress regarding the effect and mechanism of dietary polyphenols in liver fibrosis","volume":"29","author":"Chang","year":"2023","journal-title":"Molecules"},{"key":"B13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/s1050-1738(00)00066-9","article-title":"DGAT and triglyceride synthesis: a new target for obesity treatment?","volume":"10","author":"Chen","year":"2000","journal-title":"Trends Cardiovasc Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"111927","DOI":"10.1016\/j.biopha.2021.111927","article-title":"Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease","volume":"142","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"152338","DOI":"10.1016\/j.tox.2019.152338","article-title":"Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters","volume":"429","author":"Chen","year":"","journal-title":"Toxicology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/jgh.16282","article-title":"Alcohol and the mechanisms of liver disease","volume":"38","author":"Chen","year":"","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4103\/0973-1296.62900","article-title":"Protective effects of quercetin on liver injury induced by ethanol","volume":"6","author":"Chen","year":"2010","journal-title":"Pharmacogn. Mag."},{"key":"B18","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.phymed.2013.04.001","article-title":"Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats","volume":"20","author":"Chen","year":"2013","journal-title":"Phytomedicine"},{"key":"B19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"","journal-title":"Cell Death Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s12272-020-01271-w","article-title":"\u03b2-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake","volume":"43","author":"Chen","year":"","journal-title":"Arch. Pharm. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"13107","DOI":"10.3390\/ijms232113107","article-title":"Deubiquitinating enzyme USP12 regulates the pro-apoptosis protein Bax","volume":"23","author":"Choi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B22","first-page":"90","article-title":"The acute toxicological evaluation of dihydromyricetin and its control effect for alcoholic hepatic injury","volume":"11","author":"Donglin Su","year":"2009","journal-title":"Hunan Agric. Sci."},{"key":"B23","first-page":"8785","article-title":"Lutein prevents alcohol-induced liver disease in rats by modulating oxidative stress and inflammation","volume":"8","author":"Du","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.cld.2016.02.004","article-title":"Pathogenesis of alcoholic liver disease","volume":"20","author":"Dunn","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jhep.2009.12.021","article-title":"The place of liver transplantation in the treatment of severe alcoholic hepatitis","volume":"52","author":"Dureja","year":"2010","journal-title":"J. Hepatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pbb.2018.12.007","article-title":"Neuroimmune signaling in alcohol use disorder","volume":"177","author":"Erickson","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12906-019-2671-9","article-title":"Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK\/ACC\/CPT-1A and SREBP-1c\/FAS signaling pathways in LO2 cells","volume":"19","author":"Fang","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2187564","DOI":"10.1080\/13510002.2023.2187564","article-title":"Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3\/iNOS pathway","volume":"28","author":"Fang","year":"2023","journal-title":"Redox Rep."},{"key":"B29","first-page":"304","article-title":"Chemical constituents from the seeds of Hovenia acerba","volume":"32","author":"Fangfang Xu","year":"2011","journal-title":"J. Jinan Univ. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"771459","DOI":"10.3389\/fphar.2021.771459","article-title":"The potential application of Chinese medicine in liver diseases: a new opportunity","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3390\/foods12040773","article-title":"Multi-index comprehensive assessment optimized critical flavonoids extraction from semen hoveniae and their in vitro digestive behavior evaluation","volume":"12","author":"Fu","year":"2023","journal-title":"Foods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3390\/microorganisms3040759","article-title":"Gut microbiota and host reaction in liver diseases","volume":"3","author":"Fukui","year":"2015","journal-title":"Microorganisms"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"B34","first-page":"296","article-title":"The role of nutritional therapy in alcoholic liver disease","volume":"29","author":"Griffith","year":"2006","journal-title":"Alcohol Res. Health"},{"key":"B35","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/cphy.c120020","article-title":"Apoptosis and necrosis in the liver","volume":"3","author":"Guicciardi","year":"2013","journal-title":"Compr. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e1801393","DOI":"10.1002\/mnfr.201801393","article-title":"Myricetin ameliorates ethanol-induced lipid accumulation in liver cells by reducing fatty acid biosynthesis","volume":"63","author":"Guo","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"B37","first-page":"423","article-title":"Research progress on alcoholic liver diseases and gut microbiota","volume":"30","author":"Guohua Li","year":"2022","journal-title":"Res. Prog. Alcohol. liver Dis. gut microbiota"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.3390\/biomedicines10102530","article-title":"Alcohol-related liver disease: an overview on pathophysiology, diagnosis and therapeutic perspectives","volume":"10","author":"Ha","year":"2022","journal-title":"Biomedicines"},{"key":"B39","doi-asserted-by":"publisher","first-page":"117104","DOI":"10.1016\/j.saa.2019.05.009","article-title":"Molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes","volume":"220","author":"Hao","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"B40","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/17425255.2019.1628218","article-title":"Pharmacogenetics of alcohol use disorder treatments: an update","volume":"15","author":"Hartwell","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.3748\/wjg.v24.i16.1679","article-title":"Beneficial effects of naringenin in liver diseases: molecular mechanisms","volume":"24","author":"Hern\u00e1ndez-Aquino","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1007\/s11606-019-04899-7","article-title":"Symptom-triggered therapy for alcohol withdrawal syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"34","author":"Holleck","year":"2019","journal-title":"J. Gen. Intern Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3760\/cma.j.cn501113-20200522-00269","article-title":"Study on the role and possible mechanism of hemeoxygenase-1\/carbon monoxide system in protection of quercetin against ethanol-induced hepatocytes oxidative injury","volume":"28","author":"Hou","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3390\/molecules23071623","article-title":"Protective effect of glycyrrhizic acid on alcoholic liver injury in rats by modulating lipid metabolism","volume":"23","author":"Huo","year":"2018","journal-title":"Molecules"},{"key":"B45","doi-asserted-by":"publisher","first-page":"9198","DOI":"10.3748\/wjg.v19.i48.9198","article-title":"Long-term survival after liver transplantation for alcoholic liver disease","volume":"19","author":"Iruzubieta","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1201007","DOI":"10.3389\/fnut.2023.1201007","article-title":"Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation","volume":"10","author":"Janilkarn-Urena","year":"2023","journal-title":"Front. Nutr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3109\/15376516.2012.707255","article-title":"Anti-inflammatory role of naringenin in rats with ethanol induced liver injury","volume":"22","author":"Jayaraman","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"B48","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1472-8206.2010.00899.x","article-title":"Naringenin modulates circulatory lipid peroxidation, anti-oxidant status and hepatic alcohol metabolizing enzymes in rats with ethanol induced liver injury","volume":"25","author":"Jayaraman","year":"2011","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B49","first-page":"40","article-title":"Antialcoholism effects of curcuma botanical beverage in KM mice","volume":"38","author":"Jiaming Chen","year":"2022","journal-title":"Mod. Food Sci. Technol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1001\/jama.2014.3628","article-title":"Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis","volume":"311","author":"Jonas","year":"2014","journal-title":"Jama"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3390\/ijms20071751","article-title":"The potential role of iNOS in ovarian cancer progression and chemoresistance","volume":"20","author":"Kielbik","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.3390\/ijms20112712","article-title":"Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease","volume":"20","author":"Kong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3390\/cells9040929","article-title":"The endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","journal-title":"Cells"},{"key":"B54","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/sla.0000000000001831","article-title":"Three-year results of a pilot Program in early liver transplantation for severe alcoholic hepatitis","volume":"265","author":"Lee","year":"2017","journal-title":"Ann. Surg."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e13002","DOI":"10.1111\/jfbc.13002","article-title":"Relative protective activities of quercetin, quercetin-3-glucoside, and rutin in alcohol-induced liver injury","volume":"43","author":"Lee","year":"2019","journal-title":"J. Food Biochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","article-title":"CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease","volume":"58","author":"Leung","year":"2013","journal-title":"J. Hepatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"104214","DOI":"10.1016\/j.bse.2020.104214","article-title":"Chemical constituents from Hovenia dulcis Thunb. And their chemotaxonomic significance","volume":"94","author":"Li","year":"2021","journal-title":"Biochem. Syst. Ecol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.intimp.2013.05.023","article-title":"Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3\u03b2\/NF-\u03baB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats","volume":"17","author":"Li","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4147610","DOI":"10.1155\/2016\/4147610","article-title":"Iron-mediated lysosomal membrane permeabilization in ethanol-induced hepatic oxidative damage and apoptosis: protective effects of quercetin","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"B60","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1177\/0960327113499168","article-title":"Quercetin protects rat hepatocytes from oxidative damage induced by ethanol and iron by maintaining intercellular liable iron pool","volume":"33","author":"Li","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/aps.2014.50","article-title":"Alcohol use disorders and current pharmacological therapies: the role of GABA(A) receptors","volume":"35","author":"Liang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"B62","first-page":"220","article-title":"Relationships between nutrition, alcohol use, and liver disease","volume":"27","author":"Lieber","year":"2003","journal-title":"Alcohol Res. Health"},{"key":"B63","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3390\/nu14030658","article-title":"Improving lipophagy by restoring Rab7 cycle: protective effects of quercetin on ethanol-induced liver steatosis","volume":"14","author":"Lin","year":"2022","journal-title":"Nutrients"},{"key":"B64","first-page":"1141","article-title":"Alcoholic liver disease","volume":"16","author":"Lingshi Wang","year":"2001","journal-title":"Alcohol. liver Dis."},{"key":"B65","article-title":"The exploration of the mechanism of progression in ALD rats based on LPS\/TLR4 signaling pathway","volume":"35","author":"Ling Yang","year":"2022","journal-title":"J. Med. Postgraduates"},{"key":"B66","first-page":"6","article-title":"Research progress on the efficacy of hovenia dulcis thunb. And related food development","volume":"43","author":"Linzhi Kang","year":"2022","journal-title":"J. Shaoguan Univ."},{"key":"B67","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.tiv.2011.10.013","article-title":"Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage","volume":"26","author":"Liu","year":"2012","journal-title":"Toxicol Vitro"},{"key":"B68","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.tiv.2009.03.006","article-title":"Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes","volume":"24","author":"Liu","year":"2010","journal-title":"Toxicol Vitro"},{"key":"B69","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1039\/c8fo00650d","article-title":"Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"B70","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.3390\/ijms22105170","article-title":"Alcohol-related liver disease: basic mechanisms and clinical perspectives","volume":"22","author":"Liu","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000363413","article-title":"Emodin ameliorates ethanol-induced fatty liver injury in mice","volume":"94","author":"Liu","year":"2014","journal-title":"Pharmacology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"111121","DOI":"10.1016\/j.biopha.2020.111121","article-title":"Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism","volume":"134","author":"Liu","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B73","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jhep.2012.04.004","article-title":"EASL clinical practical guidelines: management of alcoholic liver disease","volume":"57","author":"Liver","year":"2012","journal-title":"J. Hepatol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.jhep.2007.10.010","article-title":"Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids","volume":"48","author":"Louvet","year":"2008","journal-title":"J. Hepatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids","volume":"45","author":"Louvet","year":"2007","journal-title":"Hepatology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.2174\/1381612824666180410091511","article-title":"Cytochrome P450s and alcoholic liver disease","volume":"24","author":"Lu","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e5578","DOI":"10.1002\/bmc.5578","article-title":"Comparative analysis of the liver-protective effects of raw and stir-fried semen of Hovenia dulcis in rats via gas chromatography-mass spectrometry-based serum metabolomic profiling and chemometrics","volume":"37","author":"Lv","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"B78","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.neuropharm.2017.04.032","article-title":"Emerging pharmacotherapies for alcohol use disorder","volume":"122","author":"Mason","year":"2017","journal-title":"Neuropharmacology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1053\/gast.1996.v110.pm8964410","article-title":"Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone","volume":"110","author":"Mathurin","year":"1996","journal-title":"Gastroenterology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1177\/1535370216654587","article-title":"Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema","volume":"241","author":"Matsuyama","year":"2016","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1001\/archinte.164.13.1405","article-title":"Management of alcohol withdrawal delirium. An evidence-based practice guideline","volume":"164","author":"Mayo-Smith","year":"2004","journal-title":"Arch. Intern Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/j.1530-0277.2010.01405.x","article-title":"Alcoholic liver disease and malnutrition","volume":"35","author":"McClain","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1007\/s10620-020-06159-9","article-title":"Early liver transplantation for severe alcoholic hepatitis","volume":"65","author":"Mellinger","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.3748\/wjg.v26.i24.3432","article-title":"Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology","volume":"26","author":"Meng","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3350\/cmh.2020.0142","article-title":"Programmed cell death in alcohol-associated liver disease","volume":"26","author":"Miyata","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jcrc.2015.11.022","article-title":"Barbiturates for the treatment of alcohol withdrawal syndrome: a systematic review of clinical trials","volume":"32","author":"Mo","year":"2016","journal-title":"J. Crit. Care"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1248\/bpb.26.1398","article-title":"Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver","volume":"26","author":"Molina","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"B88","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1128\/mcb.9.9.4099","article-title":"Transcription factor Sp1 binds to and activates a human hsp70 gene promoter","volume":"9","author":"Morgan","year":"1989","journal-title":"Mol. Cell Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cct.2013.08.002","article-title":"The efficacy and biobehavioural basis of baclofen in the treatment of alcoholic liver disease (BacALD): study protocol for a randomised controlled trial","volume":"36","author":"Morley","year":"2013","journal-title":"Contemp. Clin. Trials"},{"key":"B90","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bbrc.2011.09.077","article-title":"Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase","volume":"414","author":"Noh","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41416-022-02020-0","article-title":"50 years on and still very much alive: 'Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"128","author":"N\u00f6ssing","year":"2023","journal-title":"Br. J. Cancer"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.3390\/nu13061740","article-title":"High fat activates O-GlcNAcylation and affects AMPK\/ACC pathway to regulate lipid metabolism","volume":"13","author":"Pang","year":"2021","journal-title":"Nutrients"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.3390\/antiox11102041","article-title":"Potential therapeutic implication of herbal medicine in mitochondria-mediated oxidative stress-related liver diseases","volume":"11","author":"Park","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B94","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jff.2016.12.003","article-title":"Hovenia dulcis Thunb. pseudofruits as functional foods: phytochemicals and bioactive properties in different maturity stages","volume":"29","author":"Patricia","year":"2017","journal-title":"Funct. Foods"},{"key":"B95","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1124\/jpet.112.201137","article-title":"Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression","volume":"344","author":"Peng","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ptr.6503","article-title":"A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: evidence from preclinical studies","volume":"34","author":"Pingili","year":"2020","journal-title":"Phytother. Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies","volume":"8","author":"Pistritto","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"B98","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.toxlet.2017.04.009","article-title":"Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1\/Nrf2 pathway to alleviate ethanol-induced hepatic injury","volume":"274","author":"Qiu","year":"2017","journal-title":"Toxicol. Lett."},{"key":"B99","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.phymed.2018.09.209","article-title":"Semen hoveniae extract ameliorates alcohol-induced chronic liver damage in rats via modulation of the abnormalities of gut-liver axis","volume":"52","author":"Qiu","year":"2019","journal-title":"Phytomedicine"},{"key":"B100","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.2174\/1389201022666210625141526","article-title":"Gut microbiota as an emerging therapeutic avenue for the treatment of nonalcoholic fatty liver disease","volume":"27","author":"Ralli","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"B101","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1056\/nejm199202203260802","article-title":"A randomized trial of prednisolone in patients with severe alcoholic hepatitis","volume":"326","author":"Ramond","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/j.1749-6632.2009.04054.x","article-title":"Occludin phosphorylation in regulation of epithelial tight junctions","volume":"1165","author":"Rao","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.physbeh.2005.04.014","article-title":"Fatty acid metabolism as a target for obesity treatment","volume":"85","author":"Ronnett","year":"2005","journal-title":"Physiol. Behav."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3390\/antiox12071425","article-title":"Autophagy, oxidative stress, and alcoholic liver disease: a systematic review and potential clinical applications","volume":"12","author":"Salete-Granado","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.3390\/life13081662","article-title":"Pathogenesis of alcoholic fatty liver a narrative review","volume":"13","author":"Seitz","year":"2023","journal-title":"Life (Basel)"},{"key":"B106","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/s0024-3205(03)00358-8","article-title":"Role of naringin supplement in regulation of lipid and ethanol metabolism in rats","volume":"73","author":"Seo","year":"2003","journal-title":"Life Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/molecules26040903","article-title":"Hovenia dulcis thumberg: phytochemistry, pharmacology, toxicology and regulatory framework for its use in the European union","volume":"26","author":"Sferrazza","year":"2021","journal-title":"Molecules"},{"key":"B108","doi-asserted-by":"publisher","first-page":"535","DOI":"10.11569\/wcjd.v30.i12.535","article-title":"Progress in research of alcoholic liver disease","volume":"30","author":"Shang Zeng","year":"2022","journal-title":"World Chin. J. Dig."},{"key":"B109","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1523\/jneurosci.4639-11.2012","article-title":"Dihydromyricetin as a novel anti-alcohol intoxication medication","volume":"32","author":"Shen","year":"2012","journal-title":"J. Neurosci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1007\/s10620-012-2097-4","article-title":"Corticosteroid plus pentoxifylline is not better than corticosteroid alone for improving survival in severe alcoholic hepatitis (COPE trial)","volume":"57","author":"Sidhu","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.alcohol.2020.10.002","article-title":"Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK\/Sirt-1\/PGC-1\u03b1 signaling axis","volume":"91","author":"Silva","year":"2021","journal-title":"Alcohol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1111\/acer.14326","article-title":"Dihydromyricetin protects the liver via changes in lipid metabolism and enhanced ethanol metabolism","volume":"44","author":"Silva","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/j.2042-7158.2010.01123.x","article-title":"Carotenoid lutein protects rats from paracetamol-carbon tetrachloride- and ethanol-induced hepatic damage","volume":"62","author":"Sindhu","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/ajg.2017.469","article-title":"ACG clinical guideline: alcoholic liver disease","volume":"113","author":"Singal","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"S573","DOI":"10.33549\/physiolres.934606","article-title":"Does dihydromyricetin impact on alcohol metabolism","volume":"69","author":"Skotnicov\u00e1","year":"2020","journal-title":"Physiol. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1111\/bph.14573","article-title":"Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a\/Sirt1\/p53 and TGF-\u03b21\/Smads signalling","volume":"176","author":"Song","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"16530","DOI":"10.3390\/ijms242216530","article-title":"Protective effects and mechanism of polysaccharides from edible medicinal plants in alcoholic liver injury: a review","volume":"24","author":"Su","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"e13357","DOI":"10.1111\/asj.13357","article-title":"Regulation of the intestinal barrier by nutrients: the role of tight junctions","volume":"91","author":"Suzuki","year":"2020","journal-title":"Anim. Sci. J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neuro.2019.09.016","article-title":"Upregulation of CYP2E1 expression causes oxidative damage induced by 2-chloroethanol in primary cultured rat astrocytes","volume":"75","author":"Tang","year":"2019","journal-title":"Neurotoxicology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.fct.2012.02.008","article-title":"Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage","volume":"50","author":"Tang","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1186\/s12889-023-15645-4","article-title":"Epidemiological characteristics of alcohol-related liver disease in China: a systematic review and meta-analysis","volume":"23","author":"Tang","year":"2023","journal-title":"BMC Public Health"},{"key":"B123","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/MEG.0b013e3283435d76","article-title":"Prevention of hepatorenal syndrome in patients with cirrhosis and ascites: a pilot randomized control trial between pentoxifylline and placebo","volume":"23","author":"Tyagi","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"527","DOI":"10.4103\/0250-474x.58186","article-title":"Protective effect of quercetin in the regression of ethanol-induced hepatotoxicity","volume":"71","author":"Vidhya","year":"2009","journal-title":"Indian J. Pharm. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e925980","DOI":"10.12659\/aot.925980","article-title":"Expression of 6 biomarkers in liver grafts after pediatric liver transplantation: correlations with histology, biochemistry, and outcome","volume":"25","author":"Voutilainen","year":"2020","journal-title":"Ann. Transpl."},{"key":"B126","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cbi.2017.08.006","article-title":"Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPAR\u03b1-mediated lipogenic gene expression","volume":"275","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"B127","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1142\/s0192415x15500160","article-title":"Hepatoprotective effect of kaempferol against alcoholic liver injury in mice","volume":"43","author":"Wang","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"112771","DOI":"10.1016\/j.biopha.2022.112771","article-title":"Recent update on application of dihydromyricetin in metabolic related diseases","volume":"148","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B129","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1185\/030079902125000165","article-title":"Beyond LDL-C--the importance of raising HDL-C","volume":"18","author":"Wierzbicki","year":"2002","journal-title":"Curr. Med. Res. Opin."},{"key":"B130","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: new insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"key":"B131","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"e360107","DOI":"10.1590\/acb360107","article-title":"Beneficial role of oleuropein in sepsis-induced myocardial injury. Possible Involvement of GSK-3\u03b2\/NF-kB pathway","volume":"36","author":"Xing","year":"2021","journal-title":"Acta Cir. Bras."},{"key":"B133","first-page":"670","article-title":"Research on alcoholic liver disease","volume":"27","author":"Y","year":"2014","journal-title":"Med. Inf."},{"key":"B134","first-page":"2137","article-title":"Regulatory roles and mechanisms of hovenia dulcis thunb toward polarization of macrophage RAW264.7","volume":"10","author":"Yao","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"G1318","DOI":"10.1152\/ajpgi.00555.2007","article-title":"The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage","volume":"296","author":"Yao","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jhep.2007.02.008","article-title":"Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK\/Nrf2 pathways","volume":"47","author":"Yao","year":"2007","journal-title":"J. Hepatol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/nu8010027","article-title":"Quercetin attenuates chronic ethanol-induced hepatic mitochondrial damage through enhanced mitophagy","volume":"8","author":"Yu","year":"2016","journal-title":"Nutrients"},{"key":"B138","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13578-022-00909-0","article-title":"Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium","volume":"43","author":"Yuan","year":"2022","journal-title":"Food Sci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.fct.2018.12.028","article-title":"Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy","volume":"125","author":"Zeng","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"7291","DOI":"10.1021\/acs.jafc.6b02907","article-title":"Protective effects of genistein and puerarin against chronic alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms","volume":"64","author":"Zhao","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.3390\/nu10111754","article-title":"Protective effects of five structurally diverse flavonoid subgroups against chronic alcohol-induced hepatic damage in a mouse model","volume":"10","author":"Zhao","year":"2018","journal-title":"Nutrients"},{"key":"B143","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1142\/s0192415x10007816","article-title":"Protective effect of puerarin on acute alcoholic liver injury","volume":"38","author":"Zhao","year":"2010","journal-title":"Am. J. Chin. Med."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3390\/nu15051229","article-title":"Lutein prevents liver injury and intestinal barrier dysfunction in rats subjected to chronic alcohol intake","volume":"15","author":"Zhao","year":"2023","journal-title":"Nutrients"},{"key":"B145","doi-asserted-by":"publisher","first-page":"113569","DOI":"10.1016\/j.jep.2020.113569","article-title":"Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K\/Keap1\/Nrf2 signaling pathway","volume":"268","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4591134","DOI":"10.1155\/2022\/4591134","article-title":"Quercetin protects ethanol-induced hepatocyte pyroptosis via scavenging mitochondrial ROS and promoting PGC-1\u03b1-regulated mitochondrial homeostasis in L02 cells","volume":"2022","author":"Zhao","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B147","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12944-018-0933-z","article-title":"Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-\u03b3 and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet","volume":"18","author":"Zheng","year":"2019","journal-title":"Lipids Health Dis."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1142\/s0192415x1850057x","article-title":"Kaempferol's protective effect on ethanol-induced mouse primary hepatocytes injury involved in the synchronous inhibition of SP1, Hsp70 and CYP2E1","volume":"46","author":"Zhou","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2019.06.019","article-title":"Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway","volume":"141","author":"Zhu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B150","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000431316","article-title":"Sex-dependent claudin-1 expression in the liver of euthyroid and hypothyroid mice","volume":"4","author":"Zwanziger","year":"2015","journal-title":"Eur. Thyroid. J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1337633\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:31:42Z","timestamp":1712550702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1337633\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":150,"alternative-id":["10.3389\/fphar.2024.1337633"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1337633","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"article-number":"1337633"}}